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Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study

International Journal of Dermatology and Venereology 2024年第2期7卷 78-83页

作者： Jin Zhang Xiao-Yu Zhu Jing-Wei Liu Yue-Ping Yin shao-chun chen Reference Laboratory for STD Control Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNanjingJiangsu 210042China National Center for STD Control Chinese Center for Disease Control and PreventionNanjingJiangsu 210042China

Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and *** multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant *** results are described as ***:Seventy-four(3.6%)cephalosporin-resistant isolates were ***_(ST7363)was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLST_(ST7365)(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)***-R strains were mainly associated with penA-X(n=27,44.3%),penA-XIII(n=6,9.8%),penA-XVIII(n=5,8.2%),and CRO-R strains were mainly related to penA-XVIII(n=10,25.6%),penA-43(n=9,23.1%),penA-XIII(n=7,17.9%).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported *** CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are *** the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.

关键词： gonorrhea resistance cephalosporin cefixime ceftriaxone

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CONVERGENCE ANALYSIS OF MORLEY ELEMENT ON ANISOTROPIC MESHES

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Journal of Computational Mathematics 2006年第2期24卷 169-180页

作者： Shi-peng Mao shao-chun chen ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China Department of Mathematics Zhengzhou University Zhengzhou 450052 China

The main aim of this paper is to study tile convergence of a nonconforming triangular plate element-Morley element under anisotropic meshes. By a novel approach, an explicit bound for the interpolation error is derived for arbitrary triangular meshes （which even need not satisfy the maximal angle condition and the coordinate system condition ）, the optimal consistency error is obtained for a family of anisotropically graded finite element meshes.

关键词： Anisotropic meshes Interpolation error Consistency error Morley element.

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The influence of yttrium and manganese additions on the degradation and biocompatibility of magnesium-zinc-based alloys:In vitro and in vivo studies

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Journal of Magnesium and Alloys 2024年第2期12卷 608-624页

作者： Lei Shi Yang Yan chun-sheng shao Kun Yu Bo Zhang Liang-jian chen Third Xiangya Hospital Central South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong KongChina

The repair and regeneration of bone defects are highly challenging orthopedic ***,Mg-based implants have gained popularity due to their unique biodegradation and elastic modulus similar to that of human *** aim of our study is to develop a magnesium alloy with a controllable degradation that can closely match bone tissue to help injuries heal in vivo and avoid cytotoxicity caused by a sudden increase in ion *** this study,we prepared and modified Mg-3Zn,Mg-3Zn-1Y,and Mg-2Zn-1Mn by hot extrusion,and used Mg-2.5Y-2.5Nd was as a *** then investigated the effect of additions of Y and Mn on alloys'*** results show that Mn and Y can improve not only compression strength but also corrosion *** alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro,and for this reason we selected it for implantation in *** degraded Mg-2Zn-1Mn implanted a bone defect area did not cause obvious rejection and inflammatory reaction,and the degradation products left no signs of damage to the heart,liver,kidney,or ***,we find that Mg-2Zn-1Mn can promote an osteoinductive response in vivo and the formation of bone regeneration.

关键词： Magnesium alloy Biodegradation Biocompatibility Bone regeneration Bone defect repair

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Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-chen Zhang chun-Mei Lai Bang-Yue Luo Jing-Wei shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

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Aerial target threat assessment based on gated recurrent unit and self-attention mechanism

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Journal of Systems Engineering and Electronics 2024年第2期35卷 361-373页

作者： chen chen QUAN Wei shao Zhuang School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081China

Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced ***, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning.

关键词： target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)

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Elastic three-dimensional phononic topological insulators with Dirac hierarchy

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 54-62页

作者： shao-Yong Huo Qiu-Shuang Yang Jiu-Jiu chen Hong-Kang Li Long-Chao Yao Fu-chun He chun-Ming Fu College of Mechanical Engineering University of South ChinaHengyang 421001China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

Three-dimensional(3D)phononic topological insulators(TIs)featuring two-dimensional(2D)surface states and one-dimensional(1D)hinge states have opened up a new route for multi-dimensional robust wave transport,providing unprecedented methods for integrated acoustic sensors and energy harvesting ***,aiming at the elastic 3D phononic TI with gapless surface states and hinge states,the realization of elastic 3D phononic TIs with gapless surface states and hinge states is a significant challenge due to the complicated multi-mode polarization of elastic waves in 3D *** this study,we demonstrate an elastic 3D phononic TI with a Dirac hierarchy by elaborately operating the corresponding spatial symmetries of the chiral honeycomb ***,a 3D double Dirac cone of elastic wave can be achieved by doubling the lattice along the outof-plane direction to fold two iso-frequency Weyl *** topological phase transitions and 2D gapless two-fold Dirac surface states of elastic wave are realized by breaking the half-lattice spatial translation ***,based on the Brillouin zone folding along the in-plane direction,the 2D gapless two-fold surface Dirac cones are folded into four-fold surface Dirac ***,by inducing the relative radius of adjacent holes to break the in-plane spatial inversion symmetry,the fourfold surface Dirac cones are gapped and associated with a surface state inversion,in which the gapless 1D hinge Dirac dispersion is *** research offers a route for engineering the hierarchies of TIs in 3D elastic wave systems and provides new possibilities for designing 3D ultrasonic devices with unconventional functions.

关键词： Dirac topological hierarchy

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CONVERGENCE ANALYSIS FOR A NONCONFORMING MEMBRANE ELEMENT ON ANISOTROPIC MESHES

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Journal of Computational Mathematics 2005年第4期23卷 373-382页

作者： Dong-yang Shi shao-chun chen Ichiro Hagiwara Department of Mathematics Zhengzhou University Zhengzhou 450052 China Tokyo Institute of Technology 2-12-1 Ohokayama Megro Tokyo 152-8552 Japan

Regular assumption of finite element meshes is a basic condition of most analysis of finite element approximations both for conventional conforming elements and nonconforming elements. The aim of this paper is to present a novel approach of dealing with the approximation of a four-degree nonconforming finite element for the second order elliptic problems on the anisotropic meshes. The optimal error estimates of energy norm and L^2-norm without the regular assumption or quasi-uniform assumption are obtained based on some new special features of this element discovered herein. Numerical results are given to demonstrate validity of our theoretical analysis.

关键词： Anisotropic mesh Nonconforming finite element Optimal estimate

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Effect of rare earth and alloying elements on the thermal conductivity of austenitic medium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2017年第6期24卷 670-674页

作者： shao-chun chen Hong-xiang Ye Xin-qiang Lin School of Mechanical Engineering and Automation Fuzhou University Fuzhou 350116 China

The influence of different contents of Cr, Mo, and rare earth element(RE) additives on the thermal conductivity of austenitic medium manganese steel was studied and discussed. The results show that the addition of Cr in medium manganese steel can improved the ordering of C–Mn atomic clusters, so as to improve the steel's thermal conductivity. However, Cr will lead to precipitation of a great deal of carbides in medium manganese steel when its content is greater than 4wt%. These carbides would aggregate around the grain boundary, and as a result, the thermal conductivity is decreased. By the addition of Mo whose content is about 2wt%, spherical carbides will be formed, thus improving the thermal conductivity of the medium manganese steel. The interaction between rare earth elements and alloying elements will raise both the thermal conductivity and the wear-resisting property of medium manganese steel.

关键词： medium manganese steel alloying elements rare earth thermal conductivity

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Some Numerical Quadrature Schemes of a Non-conforming Quadrilateral Finite Element

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Acta Mathematicae Applicatae Sinica 2012年第1期28卷 117-126页

作者： Xiao-fei GUAN Ming-xia LI shao-chun chen Department of Mathematics Tongji UniversityShanghai 200092China School of Information Engineering China University of Ceosciences(Beijing)Beijing 100083China Department of Mathematics Zhengzhou UniversityZhengzhou 450052China

Numerical quadrature schemes of a non-conforming finite element method for general second order elliptic problems in two dimensional （2-D） and three dimensional （3-D） space are discussed in this paper. We present and analyze some optimal numerical quadrature schemes. One of the schemes contains only three sampling points, which greatly improves the efficiency of numerical computations. The optimal error estimates are derived by using some traditional approaches and techniques. Lastly, some numerical results are provided to verify our theoretical analysis.

关键词： numerical integration non-conforming quadrilateral finite element optimal error estimate

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Eigenstate properties of the disordered Bose-Hubbard chain

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Frontiers of physics 2024年第4期19卷 57-72页

作者： Jie chen chun chen Xiaoqun Wang Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physics Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Many-body localization(MBL)of a disordered interacting boson system in one dimension is studied numerically at the filling faction *** von Neumann entanglement entropy Svn is commonly used to detect the MBL phase transition but remains challenging to be directly *** on the U(1)symmetry from the particle number conservation,Svn can be decomposed into the particle number entropy S_(n) and the configuration entropy *** light of the tendency that the eigenstate's S_(c) nears zero in the localized phase,we introduce a quantity describing the deviation of S from the ideal thermalization distribution;finite-size scaling analysis illustrates that it shares the same phase transition point with Sv but displays the better critical *** observation hints that the phase transition to MBL might largely be determined by S and its fluctuations Notably,the recent experiments[***,et al.,Science 364,256(2019);***,et al.,***.19,481(2023)]demonstrated that this deviation can potentially be measured through the Sn ***,our investigations reveal that the thermalized states primarily occupy the low-energy section of the spectrum,as indicated by measures of localization length,gap ratio,and energy density *** low-energy spectrum of the Bose model closely resembles the entire spectrum of the Fermi(or spin XXZ)model,accommodating a transition from the thermalized to the localized ***,owing to the bosonic statistics,the high-energy spectrum of the model allows the formation of distinct clusters of bosons in the random potential *** analyze the resulting eigenstate properties and briefly summarize the associated *** distinguish between the phase regions at the low and high energies,a probing quantity based on the structure of S_(VN) is also *** work highlights the importance of symmetry combined with entanglement in the study of *** this regard,for the disordered Heisenberg XXZ

关键词： entanglement entropy decomposition U(1)symmetry thermalization-to-localization transition

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