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Numerical simulation on the multiple planar fracture propagation with perforation plugging in horizontal wells

Petroleum Science 2022年第5期19卷 2253-2267页

作者： Ming-Hui Li Fu-Jian Zhou bo Wang Xiao-Dong Hu Dao-Bing Wang Xiao-Ying Zhuang shao-bo han Guo-Peng Huang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing102249China Unconventional Oil and Gas Research Institute China University of Petroleum-BeijingBeijing102249China Institute of Photonics Leibniz Universitat HannoverHannover30167Germany Petroleum College China University of Petroleum-Beijing at KaramayXinjiang834000China Beijing Institute of Petrochemical Technology Beijing102240China

Intra-stage multi-cluster temporary plugging and diverting fracturing(ITPF)is one of the fastest-growing techniques to obtain uniform reservoir stimulation in shale gas ***,propagation geometries of multiple fractures during ITPF are not clear due that the existing numerical models cannot capture the effects of perforation *** this paper,a new three-dimensional FEM based on CZM was developed to investigate multiple planar fracture propagation considering perforation plugging during ***,the fluid pipe element and its subroutine were first developed to realize the flux partitioning before or after perforation *** results showed that the perforation plugging changed the original distribution of the number of perforations in each fracture,thus changing the flux partitioning after perforation plugging,which could eliminate the effect of stress interference between multiple fractures and promote a uniform fluid *** standard deviation of fluid distribution in the perforation plugging case was only 8.48%of that in the non-diversion ***,critical plugging parameters have been investigated ***,injecting more diverters will create a higher fluid pressure rise in the wellbore,which will increase the risk of wellbore *** considering pressure rise and fluid distribution,the number of diverters should be 50%of the total number of perforations(N_(pt)),whose standard deviation of fluid distribution of multiple fractures was lower than those in the cases of injecting 10%N_(pt),30%N_(pt)and 70%N_(pt).The diverters should be injected at an appropriate timing,i.e.40%or 50%of the total fracturing time(tft),whose standard deviation of the fluid distribution was only about 20%of standard deviations in the cases of injecting at20%tftor 70%tft.A single injection with all diverters can maintain high bottom-hole pressure for a longer period and promote a more uniform fluid distribu

关键词： Hydraulic fracturing Multi-cluster fracture propagation Perforation plugging Finite element method Fluid distribution

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The influence of multi-metal-veins on fractures propagation investigated by the experiment and simulation

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Petroleum Science 2023年第3期20卷 1707-1723页

作者： Xiao-Dong Hu shao-bo han Shou Ma Fu-Jian Zhou Yang Qiu Xin-Tong Li Ming-Hui Li Zhi-Yong Tu Unconventional Petroleum Research Institute China University of Petroleum-BejingBeijing102249China Sinofts Petroleum Service Ltd Bejing101100China

Fracture propagation is affected by multi-metal-veins formed by geological diagenesis in shale during the hydraulic ***,the influence of multi-metal-veins on fractures propagation remains *** solve the problem,based on the semi-circle bending(SCB)test and the extended finite element(XFEM)theory,the interaction between multi-metal-veins and fractures is *** experimental results reveal that the fractures usually deflect at the upper or lower interfaces between metal veins and rocks(*** specimen S-2),which is different from the propagation behavior of fractures in calcite ***,the fracture toughness of the specimen S-1 is 24.40%higher than that of the specimen S-2,indicating that the increasing of total thickness of multiple metal veins in-creases the resistance to the fracture vertical *** simulation results show that the increasing of the number,total thickness of veins,the modulus difference between veins and rock,the approach angle and the notch angle all increase the resistance of the fracture passing through metal *** maximum deviation distance(Dmax)of the fracture decreases with the number of veins,while thickness combination types of metal veins do not affect *** reduction of the notch angle leads to the more tortuous fracture propagation ***,we propose a new comprehensive fracture network *** networks are divided into two categories,including orthogonal fracture networks and sub-orthogonal fracture networks,and then divided into six sub-categories *** research results will provide reference for hydraulic fracturing of shale reservoirs containing multi-metal-veins.

关键词： Multi-metal-veins Fracture Fracture interaction Semi-circle bending test Numerical simulation

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ITTO薄膜的耐腐蚀稳定性和表面能研究

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材料保护 2017年第3期50卷 29-33,61页

作者：张波邵汉良赵培常州机电职业技术学院江苏常州213164 常州中科常泰等离子体技术有限公司江苏常州213032 中国科学院上海技术物理研究所上海200083

为了提高透明导电薄膜的综合性能,采用磁控溅射法制备了Ta掺杂ITO(ITTO)薄膜,对薄膜在不同模拟环境介质溶液中的电学稳定性及电化学行为进行了测试,分析了处于特定介质环境中薄膜的相对电阻变化和表面形貌;基于薄膜表面接触角的测量,计... 详细信息

为了提高透明导电薄膜的综合性能,采用磁控溅射法制备了Ta掺杂ITO(ITTO)薄膜,对薄膜在不同模拟环境介质溶液中的电学稳定性及电化学行为进行了测试,分析了处于特定介质环境中薄膜的相对电阻变化和表面形貌;基于薄膜表面接触角的测量,计算了薄膜的表面能和极性度。结果表明:薄膜在各环境介质中都发生了自钝化现象,ITTO薄膜显示了较好的化学稳定性和热稳定性,除了晶体结构的影响之外,稳定性较好的氧化钽也提高了薄膜的化学稳定性和热稳定性;掺杂使得薄膜的接触角减小,表面能增大,表面极性度增加,薄膜的表面状态和靠近费米能级处引入d轨道的活性高价原子的存在是促进表面能提高的主要原因。

关键词： Ta掺杂ITO薄膜磁控溅射化学稳定性电化学行为接触角表面能

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan bo Ma Wenyong Xie Na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan Fang Wen-Jie Fan Chen-Yu Zhang shao-Fei Wang Jing Hu Wei han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng han bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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基于优化算法的弹药贮存寿命预测方法

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装备环境工程 2023年第1期20卷 8-15页

作者：冯昌林邵渤涵程雨森中国人民解放军92942部队北京102400 中国船舶集团有限公司系统工程研究院北京100089 海军工程大学武汉430033

目的实现对缺失及不足的制导弹药贮存失效数据预测及补充的能力。方法首先通过4种不同的预测算法(GA-BP、PSO-BP、GA-SVM、PSO-SVM),对自然贮存条件下弹药贮存失效数据进行预测,其次根据最小二乘拟合法,实现弹药贮存寿命评估模型的构... 详细信息

目的实现对缺失及不足的制导弹药贮存失效数据预测及补充的能力。方法首先通过4种不同的预测算法(GA-BP、PSO-BP、GA-SVM、PSO-SVM),对自然贮存条件下弹药贮存失效数据进行预测,其次根据最小二乘拟合法,实现弹药贮存寿命评估模型的构建,再通过寿命评估模型,计算出不同方法下对应的贮存寿命。结果通过不同模型的构建,4种预测方法与无优化条件下均能实现弹药贮存失效数据的预测,并且在规定可靠度,GA-BP和PSO-BP预测精度比另外2种方法更低。结论 GA-SVM与PSO-SVM更适合弹药贮存失效数据的预测,且效果更好。

关键词：弹药贮存寿命遗传算法粒子群算法 BP神经网络支持向量机

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng bo shao Chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Child with Wiskott–Aldrich syndrome underwent atypical immune reconstruction after umbilical cord blood transplantation: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3622-3631页

作者： bo-han Li shao-Yan Hu Department of Hematology and Oncology Children’s Hospital of Soochow University

BACKGROUND Timely reconstitution of a donor-derived immune system is important for recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation(HSCT).We describe a case of Wiskott–Aldrich syndrome(WAS)treated by umbilical cord blood transplantation(UCBT)with atypical immune *** SUMMARY A 1-year-old Chinese male infant was diagnosed with *** gene sequencing identified the mutation c.777+1G>A(IVS8).On August 8,2017,he was admitted to our hospital for *** selected an unrelated Human leukocyte antigen 6/10-matched donor for *** HSCT,the immune reconstitution process was atypical,the lymphocytes reached 0.5×109/L on day 23,and the neutrophils reached 0.5×109/L on day *** patient’s recovery throughout the year was *** An increase in lymphocytes(especially T cells)earlier than granulocytes may be a marker of a good prognosis in UCBT.

关键词： Umbilical cord blood transplantation Wiskott-Aldrich syndrome Immune reconstruction Case report

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