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GPU-Based Simulation of Dynamic Characteristics of Ballasted Railway Track with Coupled Discrete-Finite Element Method

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Computer Modeling in Engineering & Sciences 2021年第2期126卷 645-671页

作者： Xu Li YingYan shuai shao Shunying Ji State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian116023China School of Civil Engineering Dalian Jiaotong UniversityDalian116028China Transportation Institute Inner Mongolia UniversityHohhot010070China

Considering the interaction between a sleeper,ballast layer,and substructure,a three-dimensional coupled discrete-finite element method for a ballasted railway track is proposed in this *** granules with irregular shapes are constructed using a clump model using the discrete element ***,concrete sleepers,embankments,and foundations are modelled using 20-node hexahedron solid elements using the finite element *** improve computational efficiency,a GPU-based(Graphics Processing Unit)parallel framework is applied in the discrete element ***,an algorithm containing contact search and transfer parameters at the contact interface of discrete particles and finite elements is developed in the GPU parallel environment accordingly.A benchmark case is selected to verify the accuracy of the coupling *** dynamic response of the ballasted rail track is analysed under different train speeds and ***,the dynamic stress on the substructure surface obtained by the established DEM-FEM model is compared with the in situ experimental ***,stress and displacement contours in the cross-section of the model are constructed to further visualise the response of the ballasted *** proposed coupling model can provide important insights into high-performance coupling algorithms and the dynamic characteristics of full scale ballasted rail tracks.

关键词： Ballasted track coupled discrete element-finite element method GPU parallel algorithm dynamic characteristics

Container-Based Privacy Preserving Scheme for Android Applications

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Chinese Journal of Electronics 2020年第4期29卷 731-737页

作者： CUI Haoliang shao shuai NIU shaozhang ZHANG Wen YUAN Yang Beijing Key Laboratory of Intelligent Telecommunication Software and Multimedia Beijing University of Posts and Telecommunications China Information Technology Security Evaluation Center

An application layer privacy data protection scheme combining dynamic and static analysis is *** component life cycle and system calls are first studied, and the taint propagation path under the cross-component scenario in static analysis is *** on the static analysis, a privacy preserving container is designed and implemented on both the Framework layer and the Native layer of *** scheme generates a privacy protection policy file by constructing leakage paths for privacy data propagation in Android applications, and monitors privacy leakage in the running environment of the target application according to the policy *** show that the proposed scheme can effectively protect user privacy while running third-party applications.

关键词： Privacy preserving Container Taint tracking

Proper Management of the Asia-Pacific Affairs—— On the Division-and-integration of the Asia-Pacific Region and the Regional Integration Strategy

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学术界 2015年第8期 257-261页

作者： shao shuai Guo Ping Department of Maritime Law Dalian Maritime University

The international administrative theory is the essential tool of the international and regional integration,but it lacks macro reference of history. Based on the regional society system of ancient China,this paper discusses international administrative tools including countries,nations and people,and makes comparison of the economic capital,administrative organization and institutional norm of Europe,America and Asia. Through research,this paper concludes that the regional theory of China has both historic and practical significance.

关键词：区域一体化国际管理亚太地区事务行政组织历史意义社会系统工具包

Spatial-variant contrast maximization autofocus algorithm for ISAR imaging of maneuvering targets

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Science China(Information Sciences) 2019年第4期62卷 41-43页

作者： shuai shao Lei ZHANG Hongwei LIU Yejian ZHOU National Lab of Radar Signal Processing Xidian University Collaborative Innovation Center of Information Sensing and Understanding Xidian University

Dear editor,High-resolution inverse synthetic aperture radar(ISAR) imaging is hypersensitive to range and azimuth spatial-variant phase errors [1, 2], which are usually caused by target’s maneuvering motion.

关键词： Spatial-variant contrast maximization autofocus algorithm for ISAR imaging of maneuvering targets

Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer

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World Journal of Gastroenterology 2019年第46期25卷 6713-6727页

作者： shuai shao Nuo-Ming Zhou Dong-Qiu Dai Department of Gastrointestinal Surgery the Fourth Affiliated Hospital of China Medical University

BACKGROUND Aberrant methylation in DNA regulatory regions could downregulate tumor suppressor genes without changing the ***,our knowledge of secreted protein acidic and rich in cysteine(SPARC)and its aberrant methylation in gastric cancer(GC)is still *** the present research,we performed fundamental research to clarify the precise function of methylation on SPARC and its significance in *** To investigate promoter methylation and the effects of the SPARC gene in GC cells and tissues and to evaluate its clinical *** Plasmids that overexpressed the SPARC gene were transfected into human GC BGC-823 cells;non-transfected cells were used as a control group(NC group).Quantitative real-time polymerase chain reaction and western blotting(WB)were then used to detect the expression of ***-specific polymerase chain reaction was executed to analyze the gene promoter methylation *** viability was measured by the cell counting kit-8 *** migration and invasion ability of cells were detected by scratch assays and transwell chamber assays,*** cycle events and apoptosis were observed with a flow *** The expression of SPARC mRNA in GC tissues and cells was significantly lower and showed differing degrees of hypermethylation,respectively,than that in normal adjacent tissues and control *** with 5-Aza-2’-deoxycytidine(5-Aza-Cdr)was able to restore the expression of SPARC and reverse promoter *** of the SPARC gene significantly inhibited proliferation,migration,and invasion of GC cells,while also causing cell cycle arrest and apoptosis;the NC group exhibited the opposite *** This study demonstrated that SPARC could function as a tumor suppressor and might be silenced by promoter ***,in GC cells,SPARC inhibited migration,invasion,and proliferation,caused cell cycle arrest at the G0/G1 phase,and promoted apoptos

关键词： Gastric cancer Secreted protein acidic and rich in cysteine Hypermethylation Clinicopathological features Tumor suppressor gene

Complete Rupture of the Pregnant Uterus:A 10-year Retrospective Descriptive Study

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Current Medical Science 2022年第1期42卷 177-184页

作者： Qiong ZHOU Xuan ZHOU Ling FENG shao-shuai WANG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:The goal of this work is to analyze the incidence,etiology,clinical characteristics,maternal and neonatal outcomes of complete uterine rupture during ***:The information of complete uterine rupture between June 2010 and May 2020 was investigated retrospectively at a tertiary center,and included demographic data,delivery characteristics,intraoperative findings,and maternal and neonatal *** prevalence rate of uterine rupture in the early group(hospitalized from June 2010 to May 2015)and late group(June 2015 to May 2020)was compared and analyzed.

关键词： complete uterine rupture scarred uterine rupture spontaneous uterine rupture pregnancy outcome

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 93-99页

作者： shao-shuai WANG Fu-yuan QIAO Ling FENG Juan-juan LV Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. Methods: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched control subjects. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFR 677C→T, MTRR 66A→G and the relationship between these genotypes and the risk of Down syndrome was analyzed. Results: The results show that the MTHFR 677C→T polymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratio of 3.78 (95% confidence interval (CI), 1.78～8.47). In addition, the homozygous MTRR 66A→G polymorphism was independently associated with a 5.2-fold increase in estimated risk (95% CI, 1.90～14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than the presence of either alone, with an odds ratio of 6.0 (95% CI, 2.058～17.496). The two polymorphisms appear to act without a multiplicative interaction. Conclusion: MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome.

关键词： Tetrahydrofllate dehydrogenase Ligases Down syndrome Folate

Correction to“Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer”

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World Journal of Gastroenterology 2022年第25期28卷 3004-3005页

作者： shuai shao Nuo-Ming Zhou Dong-Qiu Dai Department of Gastroenterological Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina

We have replaced the misapplied images and the revised Figure 6C is provided.

关键词： Correction

Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1954-1965页

作者： Qinglan Guoy Huan Xiay Yuzhuo Wu shuai shao Chengbo Xu Tiantai Zhang Jiangong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Three new C20-diterpenoid alkaloids with a sulfonic acid unit,named aconicarmisulfonines B and C(1 and 2)and chuanfusulfonine A(3),respectively,were isolated from the Aconitum carmichaelii lateral roots("fu zi"in Chinese).Structures of 1-3 were determined by spectroscopic data *** chemical properties and reactions were observed for the C20-diterpenoid alkaloids:(a)specific selective nucleophilic addition of the carbonyl(C-12)in 1 with CD3 OD;(b)interconversion between 1 and 2 in D2 O;(c)stereo-and/or regioselective deuterations of H-11αin 1-3 and both H-11αand H-11βin aconicarmisulfonine A(4);(d)TMSP-2,2,3,3-d4 promoted cleavage of the C-12-C-13 bond of 4 in D2 O;(e)dehydrogenation of 4 in pyridine-d5,and(f)Na2 SO3-assisted dehydrogenation and N-deethylation of songorine(5,a putative precursor of 1-4).Biogenetically,1 and 2 are correlated with 4,for which the same novel carbon skeleton is proposed to be derived from semipinacol rearrangements via migrations of C-13-C-16 and C-15-C-16 bonds of the napelline-type skeleton,***,3 is a highly possible precursor or a concurrent product in the biosynthetic pathways of 1,2,and *** the acetic acid-induced mice writhing assay,at 1.0 mg/kg(i.p.),compounds 1,2,5,5 a,and 5 b exhibited analgesic effects against mice writhing.

关键词： Ranunculaceae Aconitum carmichaelii Sulfonated C20-diterpenoid alkaloid Aconicarmisulfonines Chuanfusulfonine A Analgesic effect