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Endoscopic submucosal dissection for early signet ring cell gastric cancer:A systematic review and meta-analysis

World Journal of Clinical Cases 2022年第20期10卷 6915-6926页

作者： Chun-Yan Weng shao-Peng sun Chang Cai Jing-Li Xu Bin Lv Department of Gastroenterology The First Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastrointestinal Surgery The First Clinical Medical University of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND The use of endoscopic submucosal dissection(ESD)for treating early signet ring cell carcinoma(SRC)is controversial due to the risk of lymph node *** To carry out a meta-analysis to evaluate ESD for therapeutic efficacy and safety in early signet ring cell gastric *** The PubMed,Web of Science,Cochrane Library,and EMBASE databases were used to search for relevant studies evaluating the therapeutic efficacy and safety of ESD in *** rates of recurrence,complete resection,incomplete resection,curative resection,en bloc resection,and adverse events were extracted and *** methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa *** bias was evaluated by the Egger’s *** review board approval and written consent were not needed for this *** This meta-analysis enrolled seven studies with 653 participants undergoing ESD treatment for early *** overall recurrence rate was 0.010[95%confidence interval(CI):0.000-0.040,Z=1.422,P=0.155].The total lymph-ovascular invasion rate was 0.038(95%CI:0.007-0.088,Z=3.026,P=0.002).The total en bloc resection rate was estimated at 0.984(95%CI:0.925-1.000,Z=19.463,P=0.000).The total complete and incomplete resection rates were estimated at 0.785(95%CI:0.596-0.928,Z=9.789,P=0.000)and 0.188(95%CI:0.016-0.468,Z=2.531,P=0.011),*** total procedureassociated gastric hemorrhage and perforation rates were estimated at 0.026(95%CI:0.005-0.061,Z=3.006 P=0.003)and 0.004(95%CI:0.000-0.028,Z=0.938,P=0.348),*** curative resection,vertical margin invasion,and lateral margin invasion rates were 72.1%(145/341),2.3%(8/348),and 34.45%(41/119),*** ESD constitutes a promising therapeutic approach for early undifferentiated SRC gastric ***,further improvements are required for increasing its treatment efficacy and reducing adverse outcomes.

关键词： Endoscopic submucosal dissection Endoscopy Early gastric cancer Signet ring cell Metaanalysis

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山东莱阳古梨树群系统的特征与保护实践

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安徽农业科学 2024年第2期52卷 29-33页

作者：孔维府于岩孙少君李兴佐中国农业大学烟台研究院山东烟台264670 莱阳梨产业协会山东莱阳265200

介绍了山东莱阳古梨树群系统概况,阐述了山东莱阳古梨树群系统的特征,包括历史、种质和生物物种资源、风土适应性、活态生产技艺、梨文化、沙地-古树景观及政策、科技、产品开发、管理和销售等方面,提出了山东莱阳古梨树群系统的保护措施。

关键词：莱阳古梨树农业文化遗产保护实践

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Eat at the right time: Regulation of ER-phagy receptors in plant response to environmental stresses

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Molecular Plant 2024年第2期17卷 236-239页

作者： Yang shao Jiaqi sun Huanquan Zheng The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China Department of Biology McGill UniversityMontrealQC H3A 1B1Canada

The endoplasmic reticulum(ER)is a cellular factory for biosynthesis of proteins and *** accommodate a wide array of biosynthetic demands in responses to environmental stresses,the plant ER remodels to maintain a structural and functional homeostasis.A key process facilitating this balance is selective autophagy of the ER(ER-phagy),where malfunctioned ER is recognized,engulfed by autophagosomes,and then delivered to the vacuole for degradation.

关键词： maintain accommodate function

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Numerical and experimental study on the response characteristics of warhead in the fast cook-off process

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Defence Technology（防务技术） 2021年第4期17卷 1444-1452页

作者： Min Zhu Sheng-ao Wang Huang Huang Gui Huang Fei Wu shao-hua sun Biao Li Zi-jian Xu College of Nuclear Science and Technology Naval University of EngineeringWuhan430033China

The response characteristics of the warhead under thermal stimuli conditions are important to the safety *** goal of this study is to obtain data on the warhead in the fast cook-off *** this paper,a numerical calculation method is proposed,whose reliability is supported by comparison with experimental *** the numerical calculation,the temperature distribution,temperature change,and ignition time are *** numerical results show that the ignition time is 76 s after the warhead started to burn and that the maximum temperature of the explosive’s outer surface is 238.3℃ at the ignition *** fast cook-off experiment of the warhead is implemented so as to get the flame temperature and reaction grades that are not available through numerical *** experimental results show that the overpressure fails to reach the preset minimumvalue which is equivalent to 6 kg of TNT and that the reaction grade is *** research results have reference value for the design of the warhead and the reduction of detonation risks.

关键词： Warhead Explosives Fast cook-off Numerical calculations

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Projected increases in population exposure of daily climate extremes in eastern China by 2050

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Advances in Climate Change Research 2021年第6期12卷 804-813页

作者： sun shao DAI Tan-Long WANG Zun-Ya CHOU Jie-Ming CHAO Qing-Chen SHI Pei-Jun Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing100081China Cooperative Institute for Research in Environmental Sciences University of ColoradoBoulderCO80309USA Faculty of Geographical Science Beijing Normal UniversityBeijing100875China

Climate extremes pose severe threats to human health,economic stability and environmental sustainability,especially in densely populated *** is generally believed that global warming drives increase in frequency,intensity and duration of climate extremes,and socioeconomic exposure plays a dominant role in climate *** order to promote climate risk governance at regional level,the historical and projected trends in the population exposure to climate extremes are quantified in eastern China using downscaled climate simulations and population growth *** frequency of temperature extremes(tx35days)is projected to more than double by 2050 in nearly half of prefecture-level cities in eastern China,leading to an 81.8%increment of total exposure under SSP2-4.5 *** increasing trend is also detectable in the frequency of precipitation extremes(r20mm)in eastern China,and the exposure increment is projected to be 22.9%by 2050,with a near equivalent contributions of both climate change and population ***,temperature exposure mainly grows in southern Hebei,western Shandong and inland Guangdong provinces,while precipitation exposure raises principally in southeast coastal areas of *** on the historical baseline and projected amplification of population exposure,we identify some hotspot cities such as Guangzhou,Shanghai,Dongguan and Hangzhou that response to climate change dramatically and confront greater potential risk of climate extremes in the coming future.

关键词： Climate projection Extreme events Population exposure Future scenario Eastern China

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Helicobacter pylori eradication:Exploring its impacts on the gastric mucosa

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World Journal of Gastroenterology 2021年第31期27卷 5152-5170页

作者： Chun-Yan Weng Jing-Li Xu shao-Peng sun Kai-Jie Wang Bin Lv Department of Gastroenterology The First Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Gastrointestinal Surgery The First Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

Helicobacter pylori(***)infects approximately 50%of all humans *** *** infection causes multiple gastric and extragastric diseases,indicating the importance of early diagnosis and timely *** eradication produces dramatic changes in the gastric mucosa,resulting in restored ***,to better understand the importance of *** eradication and clarify the subsequent recovery of gastric mucosal functions after eradication,we summarize histological,endoscopic,and gastric microbiota changes to assess the therapeutic effects on the gastric mucosa.

关键词： Helicobacter pylori Gastric mucosa Histology Endoscopic findings Gastrointestinal microbiota Eradication therapy

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Identifying MicroRNA and mRNA Expression Profiles in Embryonic Stem Cells Derived from Parthenogenetic,Androgenetic and Fertilized Blastocysts

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Journal of Genetics and Genomics 2013年第4期40卷 189-200页

作者： Xiang-Shun Cui Xing-Hui Shen shao-Chen sun sun-Wha Cho Young-Tae Heo Yong-Kook Kang Teruhiko Wakayama Nam-Hyung Kim Department of Animal Science Chungbuk National UniversityGaeshin-dongCheongjuChungbuk 361-763South Korea Department of Histology and Embryology Harbin Medical UniversityHarbin 150081China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China Laboratory of Development and Differentiation Korea Research Institute of Bioscience and BiotechnologyDaejeon 305-806South Korea Center for Developmental Biology RIKEN KobeKobe 650-0047Japan

MicroRNAs（miRNAs） are a class of highly conserved small non-coding RNA molecules that play a pivotal role in several cellular *** this study,miRNA and messenger RNA（mRNA） profiles were examined by Illumina microarray in mouse embryonic stem cells（ESCs） derived from parthenogenetic,androgenetic,and fertilized *** global analysis of miRNA-mRNA target pairs provided insight into the role of miRNAs in gene *** showed that a total of 125 miRNAs and 2394 mRNAs were differentially expressed between androgenetic ESCs（aESCs） and fertilized ESCs（fESCs）,a total of 42 miRNAs and 87 mRNAs were differentially expressed between parthenogenetic ESCs（pESCs） and fESCs,and a total of 99 miRNAs and 1788 mRNAs were differentially expressed between aESCs and *** addition,a total of 575,5 and 376 miRNA-mRNA target pairs were observed in aESCs ***,pESCs ***,and aESCs ***,***,15 known imprinted genes and 16 putative uniparentally expressed miRNAs with high expression levels were confirmed by both microarray and real-time ***,transfection of miRNA inhibitors was performed to validate the regulatory relationship between putative maternally expressed miRNAs and target mRNAs. Inhibition of miR-880 increased the expression of Peg3,Dyrklb,and Prrg2 mRNA,inhibition of miR-363 increased the expression of Nfat5 and Soatl mRNA,and inhibition of miR-883b-5p increased Nfat5,Tacstd2,and Ppapdc1 *** results warrant a functional study to fully understand the underlying regulation of genomic imprinting in early embryo development.

关键词： Embryonic stem cell Parthenogenetic Androgenetic Fertilized Microarray miRNA-mRNA network

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Isolated Pancreatic Tuberculosis in Non-immunocompromised Patient Treated by Whipple's Procedure:a Case Report

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Chinese Medical Sciences Journal 2014年第1期29卷 58-60页

作者： shao-long sun Feng Gao Dong-xu Cui Bao-sheng Wang Department of General Surgery Shengjing Hospital of China Medical University

PANCREATIC tuberculosis(TB)is a rare disease and its diagnosis is difficult because of the lack of specific clinical *** tomography(CT)and magnetic resonance imaging(MRI)have some diagnostic values in this disease,but it is easy to misdiagnose pancreatic TB as a pancreatic tumor.1 In this article,we present a case of non-immunocompromised patient developing an isolated pancreatic TB,report the CT and MRI findings,and the surgical procedure for it.

关键词： pancreatic tuberculosis Whipple's procedure computed tomography

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Atomically Dispersed Zinc Active Sites Efficiently Promote the Electrochemical Conversion of N_(2) to NH_(3)

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Energy & Environmental Materials 2024年第3期7卷 175-181页

作者： Yanjiao Wei Xinyu Wang Mengjie sun Min Ma Jian Tian Minhua shao School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077China Energy Institute and Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong China

At present,the research on highly active and stable nitrogen reduction reaction catalysts is still challenging work for the electrosynthesis of ammonia(NH_(3)).Herein,we synthesized atomically dispersed zinc active sites supported on N-doped carbon nanosheets(Zn/NC NSs)as an efficient nitrogen reduction reaction catalyst,which achieves a high ammonia yield of 46.62μg h^(-1)mg^(-1)_(cat).at-0.85 V(vs RHE)and Faradaic efficiency of 95.8%at-0.70 V(vs RHE).In addition,Zn/NC NSs present great stability and selectivity,and there is no significant change in NH_(3)rate and Faradaic efficiencies after multiple *** structural characterization shows that the active center in the nitrogen reduction reaction process is the Zn-N_(4)sites in the *** calculation confirms that Zn/NC with Zn-N_(4)configuration has a lower energy barrier for the formation of^(*)NNH intermediate compared with pure N-doped carbon nanosheets(N-C NSs),thus promoting the hydrogenation kinetics in the whole nitrogen reduction reaction process.

关键词： electrocatalysis nitrogen reduction single-atom catalyst Zn-N_(4)

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单侧双通道内镜技术治疗腰椎融合后邻椎病的短期临床疗效

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局解手术学杂志 2024年第7期33卷 575-578页

作者：孙绍铜刘军刘莛予吴骏任伟剑辽宁省人民医院骨五科辽宁沈阳110000

目的探讨单侧双通道内镜(UBE)技术治疗腰椎融合术后邻椎病的短期临床疗效。方法回顾性分析2020年3月至2023年1月于我院应用UBE技术治疗并术后随访时间超过3个月的21例腰椎融合术后邻椎病患者的临床资料。记录患者手术时间、术前1 d与术... 详细信息

目的探讨单侧双通道内镜(UBE)技术治疗腰椎融合术后邻椎病的短期临床疗效。方法回顾性分析2020年3月至2023年1月于我院应用UBE技术治疗并术后随访时间超过3个月的21例腰椎融合术后邻椎病患者的临床资料。记录患者手术时间、术前1 d与术后1 d血红蛋白降低值、术区引流量、卧床时间及并发症情况。使用日本骨科协会(JOA)评分于术前1 d、术后3 d、术后3个月进行腰椎功能评估,明确改善情况。使用视觉模拟量表(VAS)评分于术前1 d、术后3 d、术后3个月评估下肢疼痛情况。结果手术时间60~175 min,平均(95.38±18.64)min;血红蛋白降低值2~6 g/L,平均(1.42±0.18)g/L;卧床时间27~88 h,平均(36.42±15.33)h;术区引流量50~315 mL,平均(85.56±15.65)mL;术中出现硬膜撕裂1例,转行开放手术修补硬膜囊。术前VAS评分与术后3 d、术后3个月比较,差异有统计学意义(P<0.05);术前JOA评分与术后3 d、术后3个月比较,差异有统计学意义(P<0.05)。结论应用UBE技术治疗腰椎融合术后邻椎病疗效确切,具有创伤小、出血少、卧床时间短等优点,但邻近节段退变较重、椎管严重狭窄病例术中可能出现硬膜撕裂,一旦出现应积极修补,避免马尾神经疝出崁顿坏死,必要时转行开放手术。

关键词：脊柱内镜手术疗效微创脊柱外科并发症邻椎病

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