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Products of methotrexate during chlorination

Journal of Environmental Sciences 2017年第5期29卷 100-108页

作者： Jie yin Yumin Niu Bing shao Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Research Center for Preventive Medicine Beijing 100013 China.

Methotrexate （MTX） is a cytotoxic drug widely used in the treatment of tumors, autoimmune diseases and severe asthma, jen00883This drug has been frequently detected in the aquatic environment with concentrations up to μg/L levels. The MTX present in environmental water might be transformed and removed during chlorination disinfection treatment. In this work, the fate of MTX during aqueous chlorination was investigated in laboratory batch experiments, and the transformation products of MTX were identified. Aqueous solutions of MTX （1 mg/L） were chlorinated by sodium hypochlorite solution at room temperature under neutral pH conditions. Chlorinated products were pre-concentrated with solid-phase extraction （SPE） cartridges and determined by liquid chromatography electrospray ionization tandem mass spectrometry （LC-ESI-MS/MS）. The reaction of MTX chlorination exhibited pseudo-first-order kinetics and the half-life time of MTX degradation was calculated to be 1.65 min, when the initial chlorine concentration was 2 mg/L. Two chlorinated MTX congeners, 4-amino-3-chlorinated-N10-methylpteroylglutamic （monochloro-MTX） and 4-amino-3,5-dichloro-N10-methylpteroylglutamic （dichloro-MTX） were found in the chlori- nated solution. Monochloro-MTX was successfully fractionated by high performance liquid chromatography （HPLC） and its structure was further identified using 1H nuclear magnetic resonance （NMR） analysis. The presence of the two products in real hospital wastewater was then examined and both compounds were detected. Finally, the effects of MTX and monochloro-MTX on the cell cycle progression in vitro were evaluated using zebrafish liver cell line. It was found that both compounds could inhibit the proliferation of zebrafish liver cells through S phase arrest and their effects on the cell cycle profile had no significant difference.

关键词： Methotrexate Chlorination Chlorinated methotrexate Cell cycle arrest

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腰椎间盘突出症术后的中远期疗效分析

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现代生物医学进展 2015年第29期15卷 5732-5734,5800页

作者：杨淮河邹鸿星俞新胜邵银初李浩林立波张军解放军第九四医院骨科江西南昌330002

目的:回顾性分析腰椎间盘突出症患者术后的中远期疗效和预后情况并对手术疗法的效果作出评价。方法:以1995年12月到2014年12月期间在我院骨科接受治疗的腰椎间盘突出患者825例作为研究对象,对患者进行术后的跟踪回访,观察其术后的中远... 详细信息

目的:回顾性分析腰椎间盘突出症患者术后的中远期疗效和预后情况并对手术疗法的效果作出评价。方法:以1995年12月到2014年12月期间在我院骨科接受治疗的腰椎间盘突出患者825例作为研究对象,对患者进行术后的跟踪回访,观察其术后的中远期疗效。结果:患者经术后随访效果均较佳,中期随访的患者优良率为94.2%,中长期随访的患者优良率为85.3%,超长期随访患者的优良率为80.0%;其中,中期效果最佳,与另外两组比较差异有统计学意义(P<0.05)。患者的治疗后改善指数均在60%以上,患者恢复效果较佳。中期、长期及超长期随访的患者改善指数分别为87.3%、81.2%和72.8%。中期随访的患者疗效最好,效果最明显,与超长期比较差异有统计学意义(P<0.05)。采用开窗髓核取出、全椎板切除减压及半椎板切除减压方法治疗,前两组的疗效比第三组预后好,优良率分别为94.1%、86.7%、85.5%,差异有统计学意义(P<0.05)。结论:采用手术治疗腰椎间盘突出症的中远期疗效较佳,患者预后恢复理想,腰椎功能恢复优良,临床推广使用价值高。

关键词：腰椎间盘突出中远期手术疗效

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Molecular Structure Tailoring of Organic Spacers for High‑Performance Ruddlesden–Popper Perovskite Solar Cells

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Nano-Micro Letters 2025年第2期17卷 314-357页

作者： Pengyun Liu Xuejin Li Tonghui Cai Wei Xing Naitao Yang Hamidreza Arandiyan Zongping shao shaobin Wang shaomin Liu School of Materials Science and Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580People’s Republic of China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049People’s Republic of China Centre for Applied Materials and Industrial Chemistry(CAMIC) School of ScienceRMIT UniversityMelbourneVic 3000Australia WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Engineering Great Bay UniversityDongguan 523000People’s Republic of China

Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)***,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic ***,these issues can be readily resolved by rationally designing spacer cations of *** review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic *** firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of *** we brought three aspects to attention for designing organic ***,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP *** proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications.

关键词： Ruddlesden-Popper perovskites Low-dimensional perovskite solar cells Organic spacers Molecular structure Design strategies

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Model Predictive Control for Vapor Compression Cycle of Refrigeration Process

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International Journal of Automation and computing 2018年第6期15卷 707-715页

作者： Xiao-Hong yin shao-Yuan Li Department of Automation Shanghai Jiao Tong University and Key Laboratory of System Control and Information Processing Ministry of Education of China

A model predictive controller based on a novel structure selection criterion for the vapor compression cycle （VCC） of refrigeration process is proposed in this paper. Firstly, those system variables are analyzed which exert significant influences on the system performance. Then the structure selection criterion, a trade-off between computation complexity and model performance, is applied to different model structures, and the results are utilized to determine the optimized model structure for controller design. The controller based on multivariable model predictive control （MPC） strategy is designed, and the optimization problem for the reduced order models is formulated as a constrained minimization problem. The effectiveness of the proposed MPC controller is verified on the experimental rig.

关键词： Vapor compression refrigeration cycle model structure structure selection criterion model reduction model predictive control.

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Cracking behaviors and strength of rock-like samples with steps of different geometries under shear stress

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Journal of Mountain Science 2021年第5期18卷 1352-1370页

作者： LE Hui-lin WEI Ji-hong SUN shao-rui ZHANG chu-chu Department of Geology Engineering Hohai UniversityNanjing 210098China China Energy Engineering Group Jiangsu Power Design Institute Co. Ltd.Nanjing 210098China

Steps are distinctive features for estimating the movement of the upper and lower block of ***,studies about the influence of steps as a special type of discontinuity on cracking behaviors and strength of rock masses are *** this research,rock-like samples with steps and preexisting flaws were *** height h and the inclination angle of gentle slope of the stepαwere set to different *** shear tests were conducted on these samples under different normal *** experimental results reveal that the inclination angle of the gentle slope of the stepα,step height h,and normal stress have an influence on the strength,crack initiation,and crack propagation of the *** experimental results show that crack behaviors and shear strength were affected by step inclination anglesαand step height *** the normal stress increases,the improvement of the strength of samples with a large step height is larger than that of samples with a small step height,the improvement of the strength of samples withαof 10°is larger than that of samples withαof 0°and-10°.The discrete element method was used to simulate the shear *** results show five different types of displacement vectors,which can be used to determine whether the cracks are tensile cracks or shear *** above conclusions can provide help for estimating mechanical properties and failure modes of rock masses with steps of different geometries.

关键词： Step Preexisting flaw Direct shear test Crack behavior Shear stress Numerical test

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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To be or not to be direct:The role of neuromedin U in neuro-eosinophil crosstalk

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Science Bulletin 2024年第2期69卷 148-150页

作者： Ruichao Liu Wenhao shao Jun Xu Coco chu SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine Taiyuan 030001China Insttute for Immunogy Department of Basic Medical SciencesSchool of Medicinesinghua UnierstyBejing 100084China Tsinghua-Peking Center for Life Sciences Tsinghua UniversityBeijing 100084China Shanxi Medical University Taiyuan 030012China Department of Surgery First Hospital of Shanxi Medical UniversityShanxi Provincial Key Laboratory for Digestive Diseases and Organ TransplantationTaiyuan 030001China Beijing Key Laboratory for Immunological Research on Chronic Diseases Tsinghua UniversityBejing 100084China

With the development of new experimental techniques(e.g.,single-cell RNA sequencing(scRNA-seq),light sheet microscopy,and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9),emerging studies have begun to uncover the interactions between the nervous system and the immune system,both in health and *** example,in mucosal tissues such as the lung and the intestine,neurotransmitters including acetylcholine[1]and adrenaline[2]can directly regulate the immune cell functions thus affect the results of allergy,asthma,and anti-pathogen host defense[3].

关键词： intestine lung asthma

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Optimization of formation for multi-agent systems based on LQR

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Frontiers of Information Technology & Electronic Engineering 2016年第2期17卷 96-109页

作者： Chang-bin YU yin-qiu WANG Jin-liang shao School of Automation Hangzhou Dianzi University Hangzhou 310018 China Research School of Engineering The Australian National University Canberra ACT 0200 Australia School of Mathematics Science University of Electronic Science and Technology of China Chengdu 611731 China

In this paper,three optimal linear formation control algorithms are proposed for first-order linear multiagent systems from a linear quadratic regulator(LQR) perspective with cost functions consisting of both interaction energy cost and individual energy cost,because both the collective ob ject(such as formation or consensus) and the individual goal of each agent are very important for the overall ***,we propose the optimal formation algorithm for first-order multi-agent systems without initial physical *** optimal control parameter matrix of the algorithm is the solution to an algebraic Riccati equation(ARE).It is shown that the matrix is the sum of a Laplacian matrix and a positive definite diagonal ***,for physically interconnected multi-agent systems,the optimal formation algorithm is presented,and the corresponding parameter matrix is given from the solution to a group of quadratic equations with one ***,if the communication topology between agents is fixed,the local feedback gain is obtained from the solution to a quadratic equation with one *** equation is derived from the derivative of the cost function with respect to the local feedback *** examples are provided to validate the effectiveness of the proposed approaches and to illustrate the geometrical performances of multi-agent systems.

关键词： Linear quadratic regulator (LQR) Formation control Algebraic Riccati equation (ARE) Optimalcontrol Multi-agent systems

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Identifying Influencing Factors for Data Transactions:A Case Study from Shanghai Data Exchange

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 697-708页

作者： Qifeng Tang Zhiqing shao Lihua Huang Wenyi yin Yifan Dou Department of Computer Science and Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Data Exchange Corporation Shanghai 200436China School of Management Fudan UniversityShanghai 200433China

In the age of artificial intelligence,firms'internal data are increasingly valuable when merged with each other for inter-firm analysis and ***,the inter-firm data transactions represent a novel challenge on pricing due to the complex nature of data,such as quality information asymmetry,lack of pricing standards,and the negligible marginal *** paper conducts a case study at Shanghai Data Exchange to explore the factors that can facilitate the data transactions between buyers and *** use interview transcripts from 18 participating firms to construct our three theoretical dimensions:increasing the perceived value,mitigating the cost,and improving the market *** then browse through 18 factors to assess their value for further *** managerial implications are also discussed.

关键词： Big data two-sided market pricing information goods case study

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