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抑郁症近10年研究进展及热点问题

中华精神科杂志 2025年第2期58卷 94-102页

作者：王刚田姗姗张玲李安宁首都医科大学附属北京安定医院北京100088

近10年,全球在抑郁症研究领域取得了稳健进展。流行病学研究显示,抑郁症呈现高患病率、年轻化和职业化趋势以及负担重等现状。在病因学方面,通过全基因组关联研究阐明了抑郁症的遗传度,通过影像学研究区分了抑郁症不同生物亚型,通过多... 详细信息

近10年,全球在抑郁症研究领域取得了稳健进展。流行病学研究显示,抑郁症呈现高患病率、年轻化和职业化趋势以及负担重等现状。在病因学方面,通过全基因组关联研究阐明了抑郁症的遗传度,通过影像学研究区分了抑郁症不同生物亚型,通过多组学研究探讨了抑郁症潜在生物标志物。在临床治疗学方面,新型治疗药物的研发和神经调控技术的应用,为抑郁症治疗提供了新策略;数字疗法的兴起,为患者提供了个性化的全病程管理。本文中总结了近10年抑郁症在流行病学、病因学和临床治疗学方面的主要研究进展和热点问题,旨在促进临床医生对抑郁症研究现状和前景的了解。

关键词：抑郁症流行病学发病机制临床治疗方法

Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea

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Acta Geologica Sinica(English Edition) 2011年第1期85卷 243-253页

作者： SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong tian shanshan ZHANG Cuimei Key Laboratory of Tectonics and Petroleum Resources （China University of Geosciences） Ministry of Education Wuhan 430074 China CAS Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Department of Technology Zhanjiang Branch of CNOOC Zhanjiang 524057 China

The study of new seismic data permits the identification of sediment gravity flows in terms of internal architecture and the distribution on shelf and abyssal setting in the Qiongdongnan Basin （QDNB）. Six gravity flow types are recognized：（1） turbidite channels with a truncational basal and concordant overburden relationship along the shelf edge and slope, comprising laterally-shifting and vertically-aggrading channel complexes; （2） slides with a spoon-shaped morphology slip steps on the shelf-break and generated from the deformation of poorly-consolidated and high water content sediments; （3） slumps are limited on the shelf slope, triggered either by an anomalous slope gradient or by fault activity; （4） turbidite sheet complexes （TSC） were ascribed to the basin-floor fan and slope fan origin, occasionally feeding the deep marine deposits by turbidity currents; （5） sediment waves occurring in the lower slope-basin floor, and covering an area of approximately 400 km2, were generated beneath currents flowing across the sea bed; and （6） the central canyon in the deep water area represents an exceptive type of gravity flow composed of an association of debris flow, turbidite channels, and TSC. It presents planar multisegment and vertical multiphase characteristics. Turbidite associated with good petrophysical property in the canyon could be treated as a potential exploration target in the QDNB.

关键词： gravity flow slope and abyssal system Qiongdongnan Basin South China Sea

A non-fluorinated liquid-like membrane with excellent anti-scaling performance for membrane distillation

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Chinese Chemical Letters 2025年第1期36卷 521-528页

作者： Jianwen Zhao Shuai Wang shanshan Zhao Liwei Chen Fangang Meng Xuelin tian State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510006China Key Laboratory for Polymeric Composite&Functional Materials of Ministry of Education Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable DevicesSun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology School of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou 510006China

Membrane distillation(MD)has gained extensive attention for treating highly saline ***,membrane scaling during the MD process has hindered the rapid development of this *** approaches to mitigate scaling in membrane distillation focus primarily on achieving enhanced hydrophobicity and even superhydrophobicity via utilizing fluorinated fibrous membrane or introducing perfluorosilane *** the environmental hazards posed by fluorinated compounds,it is highly desirable to develop non-fluorinated membranes with enhanced anti-scaling properties for effective membrane *** this study,we present a non-fluorinated liquid-like MD membrane with exceptional anti-scaling *** membrane was facilely fabricated by grafting linear polydimethylsiloxane(LPDMS)onto a hydrophilic polyether sulfone(PES)membrane pre-coated with the intermediate layers of polydopamine and silica(denoted as LPDMS-PES).Remarkably,LPDMS-PES manifested a drastically improved scaling resistance in continuous MD tests than its perfluorinated counterpart,i.e.,1H,1H,2H,2H-perfluorooctyltrichlorosilane-modified PES membrane(PFOS-PES),in both heterogeneous nucleation-dominated and crystal deposition-dominated scaling processes,despite the latter having a smaller surface ***-PES demonstrated a reduction of crystal accumulation of approximately 85%for Na Cl and 73%for Ca SO_(4) in the heterogeneous nucleation-dominated scaling process compared to ***,in the crystal deposition-dominated scaling process LPDMS-PES exhibited a reduction of about 70%in scale *** results explicitly evidenced the great potential of the liquid-like membrane to minimize scaling in membrane distillation by inhibiting both scale nucleation and adhesion onto the *** believe the findings of this study have important implications for the design of high-performance MD membranes,particularly in the quest for environmentally susta

关键词： Surface modification Liquid-like membranes Anti-scaling Non-fluorinated Direct contact membrane distillation

Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer

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Science China(Life Sciences) 2023年第2期66卷 298-312页

作者： Longtao Huangfu Xiaoyang Wang shanshan tian Junbing Chen Xueying Wang Biao Fan Qian Yao Gangjian Wang Cong Chen Jing Han Xiaofang Xing Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pharmacy Peking University Cancer Hospital&InstituteBeijing 100142China National Institute on Drug Dependence Peking UniversityBeijing 100191China Gastrointestinal Cancer Center Peking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology Peking University Cancer Hospital&InstituteBeijing 100142China

The effects and regulation of Beclin-1-an autophagy-related protein-have not been fully defined, however, a negative correlation has been reported between Beclin-1 expression and carcinogenesis. Meanwhile, no compound has been shown to directly inhibit its activity. Here, we evaluate piceatannol, a naturally occurring polyphenolic compound, as a potential targeting agonist of Beclin-1, to assess its efficacy as an antitumor agent against gastric cancer. More specifically, we determine the effects of piceatannol treatment on cell viability using a monitoring system and colony forming assay. Piceatannol was found to efficiently inhibit the proliferation of several human gastric cancer cell lines. Autophagic flux is increased by piceatannol treatment, and correlates with inhibition of cell proliferation and colony formation. Additionally, microscale thermophoresis and surface plasmon resonance results show a direct interaction between piceatannol and Beclin-1, which reduces the phosphorylation activity of Beclin-1 at the Ser-295 site. Notably, piceatannol impairs the binding of Beclin-1 to Bcl-2 and enhances the recruitment of binding of UV radiation resistance-associated gene protein, which further triggers Beclin-1-dependent autophagy signaling. An increase in autophagic activity via treatment with the mTOR inhibitor, everolimus, effectively sensitizes piceatannol-induced antitumor effects. Xenograft models confirmed that piceatannol inhibits tumor development and elicits a potent synergistic effect with everolimus in vivo. Taken together, the findings of this study strongly support the application of combinatorial piceatannol and everolimus therapy in future clinical trials for gastric cancer patients.

关键词： piceatannol Beclin-1 autophagy everolimus gastric cancer drug synergy

Research on township enterprises＇ problems and countermeasures of human resource management in China

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International English Education Research 2016年第5期 55-56页

作者： ZHANG Libo SHI Minghong tian shanshan Shanghai University of Engineering Science China

After the reform and opening up in China, the development of township enterprises is growing very fast. Tt has made outstanding contributions to China＇s development, and has become an important part of China＇ s economy. However, with the new economy＇s coming, the exterior and interior environment of human resource managementhas been changed greatly and the old human resource management system of township enterprises has restrictedtheir development. Based on the analysis on the problems existing in the human resource management of townshipenterprises, the paper advances a series of countermeasuresto elevate the level of the human resource management of township enterprises, to enhance their competence.

关键词： township enterprises human resource human resource management

Photoluminescence Enhancement of Porous Silicon by Adding Titanium Sol during Electrochemically Etching

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材料科学与工程（中英文版） 2010年第4期4卷 77-83页

作者： Lei Yu Huaixiang Li Hao tian shanshan Chen College of Chemistry Chemical Engineering and Material Science Shandong Normal University Jinan 250014 China

Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis

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Science China(Life Sciences) 2023年第10期66卷 2433-2436页

作者： shanshan tian Longtao Huangfu Sizhi Ai Junwei Zheng Le Shi Wei Yan Ximei Zhu Qianwen Wang Jiahui Deng Yanping Bao Suhua Chang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Department of Cardiology Heart CenterThe First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Chinese Academy of Medical Sciences Research Unit(No.2018RU006) Peking UniversityBeijing 100191China Peking-Tsinghua Center for Life Sciences PKU-IDG/McGovern Institute for Brain ResearchBeijing 100871China

Dear Editor,Cancer is the second leading cause of death worldwide,and the cancer situation is becoming more complicated(Zhou et al.,2022).The International Agency for Research on Cancer(IARC)Monographs Working Group c... 详细信息

关键词： Cancer death

Recent advances in metal-loaded MOFs photocatalysts:From single atom,cluster to nanoparticle

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Chinese Chemical Letters 2025年第1期36卷 68-79页

作者： Shenglan Zhou Haijian Li Hongyi Gao Ang Li tian Li shanshan Cheng Jingjing Wang Jitti Kasemchainan Jianhua Yi Fengqi Zhao Wengang Qu Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China National Key Laboratory of Energetic Materials Xi’an Modern Chemistry Research InstituteXi’an 710065China Shunde Innovation School University of Science and Technology BeijingShunde 528399China School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Department of Chemical Technology Chulalongkorn UniversityBangkok 10330Thailand

Photocatalysis is widely regarded as a highly promising sustainable technique for addressing the challenges posed by environmental pollution and energy *** recent years,metal-loaded MOFs has become a rising star within the domain of photocatalysis due to its high specific surface area and porosity,adjustable structure,diverse and abundant catalytic components,which has exhibited excellent photocatalytic activity and exhibit great potential in a range of *** this paper,the principles for evaluating the photocatalytic performance of MOFs-based materials were firstly introduced,and some typical examples were also listed *** with this,particular emphasis is paid to the main factors affecting the photocatalytic performance of metal-loaded *** the synthesis and design strategies of MOFs loaded metal entities of varying sizes(single atoms,nanoclusters,and nanoparticles),and their applications in photocatalytic CO_(2)reduction,hydrogen production,photooxidation and photocatalytic hydrogenation were summarized and ***,the opportunities and challenges faced in this kind of MOFs-based composites were analyzed from different *** report is expected to help researchers design and develop high-performance MOFs-based photocatalytic materials.

关键词： Metal-loaded MOFs Photocatalysis Single atom catalysts Nanoclusters Nanoparticles

终结法国模式:法国大学自治化改革难以完成的使命

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现代大学教育 2024年第3期40卷 59-68,F0003页

作者：田珊珊东华大学外语学院上海201620

在全球高等教育竞争日趋激烈的背景下,法国于2007年开启了以建设世界一流大学为目标的大学自治化改革。这次改革受知识经济和新公共管理理念的影响,主要有三大举措:引入政署化代理和市场性竞争、调整大学治理架构和推行高校重组。改革... 详细信息

在全球高等教育竞争日趋激烈的背景下,法国于2007年开启了以建设世界一流大学为目标的大学自治化改革。这次改革受知识经济和新公共管理理念的影响,主要有三大举措:引入政署化代理和市场性竞争、调整大学治理架构和推行高校重组。改革在大学治理方式、政府管理机制、资源整合配置等方面取得了一些成效。改革触动了法国现行高等教育体制的基本原则,引发了人们对法国模式会被终结的担忧。深入考察改革的制度逻辑、改革路径与理念局限可以发现,法国大学自治化改革对法国模式的突破仅限于政策层面,远未触及理念层面。法国高等教育的公共属性和双轨制在法国社会的文化价值观体系下难以改变。这决定了法国高等教育改革的方向只能是完善结构而非改变结构,这也是法国经验的重要启示。

关键词：世界一流大学法国模式大学自治化改革文化价值观

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