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Inorganic hollow mesoporous spheres-based delivery for antimicrobial agents

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Frontiers of Materials Science 2023年第1期17卷 51-68页

作者： Yunping Qiao Yanyang Han Rengui guan Shiliang Liu Xinling Bi shanshan Liu Wei Cui Tao Zhang Tao He Department of Applied Chemistry School of Chemistry and Chemical EngineeringYantai UniversityClearspring RD 3OthLaishanYantai 264005China Weifang Branch Company Shandong Hl-speed Transportation Construction Group Co.Ltd.Qingzhou 262500China Shandong Jinhai Titanium Resources Technology Co. Ltd.Binzhou 256600China

Microorganisms coexist with human beings and have formed a complex relationship with us.However,the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents.Currently available antimicrobials,such as silver ions,antimicrobial peptides and antibiotics,have diverse concerns in chemical stability,biocompatibility,or triggering drug resistance.The“encapsulate-and-deliver”strategy can protect antimicrobials against decomposing,so to avoid large dose release induced resistance and achieve the controlled release.Considering loading capacity,engineering feasibility,and economic viability,inorganic hollow mesoporous spheres(iHMSs)represent one kind of promising and suitable candidates for real-life antimicrobial applications.Here we reviewed the recent research progress of iHMSs-based antimicrobial delivery.We summarized the synthesis of iHMSs and the drug loading method of various antimicrobials,and discussed the future applications.To prevent and mitigate the spread of an infective disease,multilateral coordination at the national level is required.Moreover,developing effective and practicable antimicrobials is the key to enhancing our capability to eliminate pathogenic microbes.We believe that our conclusion will be beneficial for researches on the antimicrobial delivery in both lab and mass production phases.

关键词： antimicrobial inorganic hollow mesoporous sphere encapsulate-and-deliver drug delivery

不断完善技能型人才培养体系——对英国继续教育政策十年发展变化的解析

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职业技术教育 2021年第27期42卷 70-79页

作者：关珊珊华东师范大学国家教育宏观政策研究院上海200062

英国近十年来不断强调继续教育的重要性,继续教育政策过去十年的变化趋势是:从关注低水平劳动力到兼顾低技能人群和高级技能人才,逐渐形成继续教育专项助学贷款,形成丰富且呼应就业市场需求的继续教育证书体系,不断减少政府干预和不断... 详细信息

英国近十年来不断强调继续教育的重要性,继续教育政策过去十年的变化趋势是:从关注低水平劳动力到兼顾低技能人群和高级技能人才,逐渐形成继续教育专项助学贷款,形成丰富且呼应就业市场需求的继续教育证书体系,不断减少政府干预和不断提升继续教育声誉,持续关注技能与市场需求的匹配度并不断提供前沿技术的培训,从就业信息的推广到落实院校责任制。对我国继续教育发展的启示是:扩大技能类非学历继续教育的高质量供给,建设技能型社会;继续教育不断回应市场需求,提升企业在继续教育中的重要性;适应科技的发展开设新的课程,不断提升继续教育声誉;创建以"就业"为导向的继续教育,提供个性化的就业服务。

关键词：继续教育英国技能型人才政策

社会主义核心价值观主导下的道德榜样教育研究

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洛阳理工学院学报（社会科学版） 2022年第1期37卷 15-19页

作者：关珊珊洛阳理工学院马克思主义学院河南洛阳471023

社会主义核心价值观与道德榜样教育之间关系紧密。社会主义核心价值观是道德榜样教育的基本遵循,为道德榜样教育提供思想引领和行动指南。道德榜样教育是社会主义核心价值观的重要载体,可以承载、传播、引领社会主义核心价值观。道德榜... 详细信息

社会主义核心价值观与道德榜样教育之间关系紧密。社会主义核心价值观是道德榜样教育的基本遵循,为道德榜样教育提供思想引领和行动指南。道德榜样教育是社会主义核心价值观的重要载体,可以承载、传播、引领社会主义核心价值观。道德榜样教育应遵循坚持社会主义核心价值观主导原则、与时俱进原则、客观真实原则、以人为本原则。同时,还应完善道德榜样教育的选树机制、宣传机制和践行机制,并在此基础上促进榜样教育与社会主义核心价值观的契合与互动。

关键词：社会主义核心价值观道德榜样教育选树宣传践行

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二语写作理论模式与本土化研究路径分析

黑河学院学报 2022年第11期13卷 104-105,109页

作者：关珊珊河南农业大学外国语学院河南郑州450046

二语写作的理论研究和本土化,是我国的重点课题。其理论框架研究模式日渐地扩展,研究方法、研究内容丰富多样,二语写作的理论模式和本土化应与语言的差异、文化背景的多样复杂联系在一起。

关键词：二语写作本土化二语本土化

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抗疫实践和文化自信的互动关系探究

洛阳师范学院学报 2022年第3期41卷 92-95页

作者：关珊珊洛阳理工学院马克思主义学院河南洛阳471023

抗疫实践和文化自信相互作用,坚定的文化自信是抗击疫情的精神源泉,而抗疫实践进一步彰显和提升文化自信。中华优秀传统文化、革命文化、社会主义先进文化是抗击疫情的根基和动力,中医防控、白衣为甲、全民抗疫增强了文化自信。文化自... 详细信息

抗疫实践和文化自信相互作用,坚定的文化自信是抗击疫情的精神源泉,而抗疫实践进一步彰显和提升文化自信。中华优秀传统文化、革命文化、社会主义先进文化是抗击疫情的根基和动力,中医防控、白衣为甲、全民抗疫增强了文化自信。文化自信的继续提升要以抗疫精神为主题,以理论宣讲为渠道,以网络平台为依托,促进文化自信落地生根。

关键词：抗疫文化自信优秀传统文化

Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice

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Neuroscience Bulletin 2020年第11期36卷 1259-1270页

作者： Maosheng Xia Zexiong Li Shuai Li shanshan Liang Xiaowei Li Beina Chen Manman Zhang Chengyi Dong Alexei Verkhratsky Dawei guan Baoman Li Practical Teaching Centre School of Forensic MedicineChina Medical UniversityShenyang 110122China Department of Orthopaedics The First HospitalChina Medical UniversityShenyang 110001China Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUK Department of Forensic Pathology School of Forensic MedicineChina Medical UniversityShenyang 110122China Department of Poison Analysis School of Forensic MedicineChina Medical UniversityShenyang 110122China

Chronic loss of sleep damages health and disturbs the quality of life.Long-lasting sleep deprivation(SD)as well as sleep abnormalities are substantial risk factors for major depressive disorder,although the underlying mechanisms are not clear.Here,we showed that chronic SD in mice promotes a gradual elevation of extracellular ATP,which activates astroglial P2X7 receptors(P2X7Rs).Activated P2X7Rs,in turn,selectively down-regulated the expression of 5-HT2B receptors(5-HT2BRs)in astrocytes.Stimulation of P2X7Rs induced by SD selectively suppressed the phosphorylation of AKT and FoxO3 a in astrocytes,but not in neurons.The overexpression of FoxO3a in astrocytes inhibited the expression of 5-HT2BRs.Down-regulation of 5-HT2BsRs instigated by SD suppressed the activation of STAT3 and relieved the inhibition of Ca2+-dependent phospholipase A2.This latter cascade promoted the release of arachidonic acid and prostaglandin E2.The depression-like behaviors induced by SD were alleviated in P2X7R-KO mice.Our study reveals the mechanism underlying chronic SD-induced depression-like behaviors and suggests 5-HT2BRs as a key target for exploring therapeutic strategies aimed at the depression evoked by sleep disorders.

关键词： Astrocyte Sleep deprivation P2X7 receptor 5-HT2B receptor FoxO3a

High nitrogen stainless steel drug-eluting stent-Assessment of pharmacokinetics and preclinical safety in vivo

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Bioactive Materials 2020年第4期5卷 779-786页

作者： shanshan Chen Zhifeng Yao Yongbiao guan Hui Yang M.Babar Shahzad Yizhe Wu Bingchun Zhang Li Shen Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China Shanghai Institute of Cardiovascular Diseases Department of CardiologyZhongshan HospitalFudan University180 Fenglin RoadShanghai200032China National Beijing Center for Drug Safety Evaluation and Research Beijing Institute of Pharmacology and ToxicologyAcademy of Military Medical Sciences27 Taiping RoadHaidian DistrictBeijing100850People's Republic of China

Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation,while one sirolimus-eluting stent was implanted into one of their coronary artery.At different time points,the residual sirolimus on the stent,delivered locally(to artery wall),regionally(to adjacent and downstream muscle)and systemically(to plasma and visceral organs),was detected throughout 120 days.Preclinical safety evaluation was performed using 32 pigs for 180-days implantation to study the safety of metal platform material and the effectiveness of sirolimus eluting coating on the HNS stent.The neointima area,restenosis rate and inflammatory grade for HNS and control group stents were detected and analyzed.Approximately 80%sirolimus was eluted from the sirolimuseluting stents after 30-days implantation in vivo.Additionally,there was sustained sirolimus in the artery wall,cardiac muscle and heart throughout 120-days implantation,and sirolimus accumulated to the peak at 90-days implantation.It was inferred that the sirolimus eluting stent in this study was covered by neointima before 90-days implantation,indicating that the sirolimus eluting coating on the HNS stent was safe and effective.Very little sirolimus was distributed in visceral organs after 14-days implantation.HNS sirolimus-eluting stent exhibited lower restenosis rate and lower inflammatory grade than control group,which verified that the sirolimus-eluting coating design in this study was reasonable and practical.In addition,there were no significant difference in restenosis rate and inflammatory score between HNS bare-metal stent and drug-eluting stents,illustrating that HNS has good bio-compatibility and is suitable to use as coronary artery stent material.

关键词： Sirolimus-eluting stent Pharmacokinetics Preclinical safety Tissue response

Cascade adsorptive separation of light hydrocarbons by commercial zeolites

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Journal of Energy Chemistry 2022年第9期31卷 299-305,I0009页

作者： shanshan Liu Yinlin Chen Bin Yue Yuanxin Nie Yuchao Chai guangjun Wu Jiangnan Li Xue Han Sarah JDay Stephen PThompson Naijia guan Sihai Yang Landong Li School of Materials Science and Engineering Nankai UniversityTianjin 300350China Department of Chemistry The University of ManchesterManchester M139PLUnited Kingdom Diamond Light Source Harwell Science CampusOxfordshire OX110DEUnited Kingdom Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Adsorptive separation of light hydrocarbons by porous solids provides an energy-efficient alternative to state-of-the-art cryogenic distillation.However,an optimal balance between the cost,performance and stability of the sorbent material is yet to be achieved for industrial applications.Here,we report the efficient separation of C2 and C3 hydrocarbons by a faujasite zeolite(Na-X,Si/Al=1.23).A tandem configuration of two fixed-beds packed with Na-X affords complete dynamic separation of the ternary mixture of C_(2)H_(2)/C_(2)H_(4)/C_(2)H_(6)(1/49.5/49.5;v/v/v)under ambient conditions.Pressure-swing desorption on the latter fixed-bed gives ethylene(>99.50%,1.80 mmol g^(-1))and ethane(>99.99%,1.41 mmol g^(-1)).In situ synchrotron X-ray powder diffraction revealed the binding sites for C_(2)H_(2)and C_(2)H_(4)in Na-X.This study highlights the potential application of commercial zeolites for challenging industrial separations.

关键词： Zeolites C2 hydrocarbons Ethylene Adsorptive separation

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伟大抗疫精神融入高校思政课教学的三重维度

金融理论与教学 2023年第5期 102-105页

作者：张闪闪官爽哈尔滨金融学院马克思主义学院黑龙江哈尔滨150030

伟大抗疫精神是对中国人民“战”疫精神风貌的高度凝练,也是中国共产党人精神谱系的重要构成。从价值维度上看,将伟大抗疫精神融入思政课教学是高校落实立德树人根本目标和提升思政课教学实效性的迫切需要;从理论维度上说,高校思政课要... 详细信息

伟大抗疫精神是对中国人民“战”疫精神风貌的高度凝练,也是中国共产党人精神谱系的重要构成。从价值维度上看,将伟大抗疫精神融入思政课教学是高校落实立德树人根本目标和提升思政课教学实效性的迫切需要;从理论维度上说,高校思政课要积极寻找结合点,准确把握伟大抗疫精神融入思政课教学的主题内容;在实践维度上,高校思政课要主动融入抗疫精神,用心讲好“抗疫故事”,巧妙设计实践教学。

关键词：抗疫精神融入高校思政课教学三重维度