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GPU-accelerated OCT imaging: Real-time data processing and artifact suppression for enhanced monitoring of 3D bioprinted tissues and vascular-like networks

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 67-82页

作者： shanshan yang Jinhao Zhou Hao Guo Ling Wang Mingen Xu Hangzhou Dianzi University Automation College HangzhouZhejiangP.R.China Zhejiang Provincial Key Laboratory of Medical Information and Biological 3D Printing Hangzhou ZhejiangP.R.China

Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological ***,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization *** technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data *** the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data ***,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further ***,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact ***,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data ***,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic ***,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like *** imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network ***,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.

关键词： SS-OCT GPU acceleration artifact noise 3D bioprinted microfluidic chip.

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Fast thermal responsive separators toward long-life and safe lithium metal batteries

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Nano Research 2024年第4期17卷 2746-2754页

作者： Pingan Li Zhifang Liu Yitong Peng shanshan yang Tao Meng Yunhuan Hu Yingjun Jiang Hao Sun Qi Li Xianluo Hu State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Lithium metal batteries(LMBs)have been extensively investigated during the past decades because of their ultrahigh energy *** the increasing demand for energy density,however,the safety issue of LMBs has become a significant *** particular,localized areas of increased temperature(namely,hotspots)may be induced and even exacerbated within LMBs by uneven current distribution,internal short circuits,or inadequate heat dissipation,which significantly sacrifices battery safety and cycle ***,we report the rational design and fabrication of a fast thermal responsive separator capable of inhibiting the growth of lithium dendrites and mitigating thermal propagation,thereby reducing the risk of thermal *** as-achieved separator comprises both an electrospun membrane using a phase change material with superior thermal-storage ability and a thermally conductive modification layer of hexagonal boron nitride nanosheets with a fast heat-transfer *** is demonstrated that such a unique integration of heat conduction and heat storage enables the functional separator with attractive abilities to mitigate hotspots and inhibit the growth of lithium dendrites upon the cycling of ***,pouch cells with the thermal-responsive separator,as well as numerical simulations,verify much enhanced safety and cycle life of *** work may offer a new conceptual design of intelligent separators that acts as a functional unit encapsulated within a single cell to boost in-situ thermal management,which will help to develop high-safety and energy-dense LMBs.

关键词： lithium metal batteries separators hotspots safety thermal management

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Improved simulation of winter wheat yield in North China Plain by using PRYM-Wheat integrated dry matter distribution coefficient

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Journal of Integrative Agriculture 2024年第4期23卷 1381-1392页

作者： Xuan Li Shaowen Wang Yifan Chen Danwen Zhang shanshan yang Jingwen Wang Jiahua Zhang Yun Bai Sha Zhang Research Center for Remote Sensing and Digital Earth College of Computer Science and TechnologyQingdao UniversityQingdao266071China Center for Geospatial Information Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Geographical Sciences Hebei Normal UniversityShijiazhuang 050024China

The accurate simulation of regional-scale winter wheat yield is important for national food security and the balance of grain supply and demand in ***,most remote sensing process models use the“biomass×harvest index(HI)”method to simulate regional-scale winter wheat ***,spatiotemporal differences in HI contribute to inaccuracies in yield simulation at the regional ***-series dry matter partition coefficients(Fr)can dynamically reflect the dry matter partition of winter *** this study,Fr equations were fitted for each organ of winter wheat using site-scale *** equations were then coupled into a process-based and remote sensingdriven crop yield model for wheat(PRYM-Wheat)to improve the regional simulation of winter wheat yield over the North China Plain(NCP).The improved PRYM-Wheat model integrated with the fitted Fr equations(PRYM-Wheat-Fr)was validated using data obtained from provincial yearbooks.A 3-year(2000-2002)averaged validation showed that PRYM-Wheat-Fr had a higher coefficient of determination(R^(2)=0.55)and lower root mean square error(RMSE=0.94 t ha^(-1))than PRYM-Wheat with a stable HI(abbreviated as PRYM-Wheat-HI),which had R^(2) and RMSE values of 0.30 and 1.62 t ha^(-1),*** PRYM-Wheat-Fr model also performed better than PRYM-Wheat-HI for simulating yield in verification years(2013-2015).In conclusion,the PRYM-Wheat-Fr model exhibited a better accuracy than the original PRYM-Wheat model,making it a useful tool for the simulation of regional winter wheat yield.

关键词： dry matter partition remote sensing model winter wheat yield North China Plain

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Microbially-mediated formation of Ca-Fe carbonates during dissimilatory ferrihydrite reduction:Implications for the origin of sedimentary ankerite

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Science China Earth Sciences 2024年第1期67卷 208-221页

作者： Deng LIU Jinpeng CAO shanshan yang Yating YIN Pengcong WANG Dominic PAPINEAU Hongmei WANG Xuan QIU Genming LUO Zongmin ZHU Fengping WANG State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China School of Environmental Studies China University of GeosciencesWuhan 430074China London Centre for Nanotechnology University College LondonLondon WC1H 0AHUK Department of Earth Sciences University College LondonLondon WC1E 6BTUK Center for Planetary Sciences University College London and Birkbeck College LondonLondon WC1E 6BTUK State Key Laboratory of Microbial Metabolism State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The origin of sedimentary dolomite has become a long-standing problem in the Earth *** carbonate minerals like ankerite have the same crystal structure as dolomite,hence their genesis may provide clues to help solving the dolomite *** purpose of this study was to probe whether microbial activity can be involved in the formation of ***-carbonation experiments associated with microbial iron reduction were performed in batch systems with various concentrations of Ca^(2+)(0–20 mmol/L),with a marine iron-reducing bacterium Shewanella piezotolerans WP3 as the reaction mediator,and with lactate and ferrihydrite as the respective electron donor and *** biomineralization data showed that Ca-amendments expedited microbially-mediated ferrihydrite reduction by enhancing the adhesion between WP3 cells and ferrihydrite *** bioreduction,siderite occurred as the principal secondary mineral in the Ca-free ***,Ca-Fe carbonates were formed when Ca^(2+)ions were *** CaCO_(3) content of microbially-induced Ca-Fe carbonates was positively correlated with the initial Ca2+*** Ca-Fe carbonate phase produced in the 20 mmol/L Ca-amended biosystems had a chemical formula of Ca_(0.8)Fe_(1.2)(CO_(3))_(2),which is close to the theoretical composition of *** ankeritelike phase was nanometric in size and spherical,Ca-Fe disordered,and structurally *** simulated diagenesis experiments further demonstrated that the resulting ankerite-like phase could be converted into ordered ankerite under hydrothermal *** introduced the term“proto-ankerite”to define the Ca-Fe phases that possess near-ankerite stoichiometry but disordered cation *** the basis of the present study,we proposed herein that microbial activity is an important contributor to the genesis of sedimentary ankerite by providing the metastable Ca-Fe carbonate precursors.

关键词： Ankerite Proto-ankerite Microbial iron reduction Dolomite problem Mineral transformation

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Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing shanshan yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

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A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

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Protein & Cell 2024年第2期15卷 98-120页

作者： shanshan yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng Yiyuan Zhang Shuhui Sun Kang Wang jian Yin Shuai Ma Si Wang Juan Carlos Izpisua Belmonte Weiqi Zhang Jing Qu Guang-Hui Liu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Xuanwu Hospital Capital Medical University Beijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Aging Biomarker Consortium Beijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Aging increases the risk ofliver diseases and systemic susceptibility to aging-related ***,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely ***,we constructed the first single-nucleus transcriptomic landscape of primate liver aging,in which we resolved cell type-specific gene expression fluctuation in hepatocytes across three liver zonations and detected aberrant cell-cell interactions between hepatocytes and niche *** in-depth dissection of this rich dataset,we identifed impaired lipid metabolism and upregulation of chronic inflammation-related genes prominently associated with declined liver functions during *** particular,hyperactivated sterol regulatory element-binding protein(SREBP)signaling was a hallmark of the aged liver,and consequently,forced activation of SREBP2 in human primary hepatocytes recapitulated in vivo aging phenotypes,manifesting as impaired detoxification and accelerated cellular *** study expands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases.

关键词： single-nucleus RNA sequencing liver hepatocytes aging senescence SREBP2

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Pancreatic β-cell failure,clinical implications,and therapeutic strategies in type 2 diabetes

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Chinese Medical Journal 2024年第7期137卷 791-805页

作者： Daxin Cui Xingrong Feng Siman Lei Hongmei Zhang Wanxin Hu shanshan yang Xiaoqian Yu Zhiguang Su Molecular Medicine Research Center and Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Clinical Translational Innovation Center West China HospitalSichuan UniversityChengduSichuan 610041China

Pancreaticβ-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes(T2D).Reserving insulin-producingβ-cells and hence restoring insulin production are gaining attention in translational diabetes research,andβ-cell replenishment has been the main focus for diabetes *** findings inβ-cell proliferation,transdifferentiation,pluripotent stem cell differentiation,and associated small molecules have served as promising strategies to regenerateβ-*** this review,we summarize current knowledge on the mechanisms implicated inβ-cell dynamic processes under physiological and diabetic conditions,in which genetic factors,age-related alterations,metabolic stresses,and compromised identity are critical factors contributing toβ-cell failure in *** article also focuses on recent advances in therapeutic strategies for diabetes treatment by promotingβ-cell proliferation,inducing non-β-cell transdifferentiation,and reprograming stem cell *** a significant challenge remains for each of these strategies,the recognition of the mechanisms responsible forβ-cell development and mature endocrine cell plasticity and remarkable advances in the generation of exogenousβ-cells from stem cells and single-cell studies pave the way for developing potential approaches to cure diabetes.

关键词： Pancreaticβ-cell regeneration Diabetes Insulin Dedifferentiation Transdifferentiation Stem cell

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溶解性二价铁-铁氧化物非均相体系氧化还原电位的电化学测定方法探究

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岩矿测试 2024年第3期43卷 407-416页

作者：牛爱钰李欣刘菲杨珊珊中国地质大学(北京)水利部地下水保护重点实验室(筹) 北京100083 中国地质大学(北京)水资源与环境工程北京市重点实验室北京100083

溶解性二价铁(Fe_(aq)^(2+)-)-铁氧化物非均相体系的氧化还原能力显著影响含水层中有毒重金属和有机污染物的迁移转化行为。然而,非均相体系氧化还原电位(Eh)的测定存在平衡缓慢和结果不稳定等难题,故亟待开发与优化电化学法快速准确测... 详细信息

溶解性二价铁(Fe_(aq)^(2+)-)-铁氧化物非均相体系的氧化还原能力显著影响含水层中有毒重金属和有机污染物的迁移转化行为。然而,非均相体系氧化还原电位(Eh)的测定存在平衡缓慢和结果不稳定等难题,故亟待开发与优化电化学法快速准确测定Eh,实现Fe_(aq)^(2+)-铁氧化物非均相体系氧化还原能力的定量表征。本文选取针铁矿作为常见的铁氧化物,探讨了介导和非介导电位法测定Fe_(aq)^(2+)-针铁矿非均相体系Eh的优化实验条件,研究了介导物质的类型与添加顺序以及工作电极预处理方法等条件对Eh测定的影响,并通过能斯特方程验证电位法的可行性。结果表明:工作电极的表面状态、介导物质的选择以及针铁矿-工作电极之间平衡的建立对Eh测定十分关键。介导法能有效地缩短测定时间,但需要选择合适的介导物质;非介导法需确保工作电极与针铁矿之间平衡的建立。同时,利用非介导法测定了不同pH和Fe_(aq)^(2+)-浓度下不同粒径针铁矿与Fe_(aq)^(2+)-非均相体系的Eh,根据能斯特方程和最小二乘法多元线性拟合得到不同粒径针铁矿的标准氧化还原电位(Eh0),对于粒径为200、700和1000nm的针铁矿Eh0分别为815、802和782mV,验证了优化后电位法的可行性。本文的结论可为矿物非均相体系Eh的测定提供方法学参考,也为预测Fe_(aq)^(2+)-铁氧化物非均相体系参与的污染物衰减速率提供理论支撑。

关键词：溶解性二价铁铁氧化物非均相体系氧化还原电位针铁矿

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基于OCT和机器学习的肿瘤类器官多维形态表征及药物作用研究

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中国激光 2024年第15期51卷 78-89页

作者：毛川伟杨珊珊梁霄王玲徐铭恩杭州电子科技大学自动化学院浙江杭州310018 浙江省医学信息与生物三维打印重点实验室浙江杭州310018 浙江大学医学院附属邵逸夫医院普外科浙江杭州310018

肿瘤类器官是研究肿瘤生物学和个体患者药物敏感性的新工具。现有人工接种类器官和破坏性终点测试相结合的方法可以表征类器官药物作用,但要求样本间具有高度均一性,并且缺乏对药物作用的时序分析。本课题组拟构建一种类器官簇生长的综... 详细信息

肿瘤类器官是研究肿瘤生物学和个体患者药物敏感性的新工具。现有人工接种类器官和破坏性终点测试相结合的方法可以表征类器官药物作用,但要求样本间具有高度均一性,并且缺乏对药物作用的时序分析。本课题组拟构建一种类器官簇生长的综合评价方法,探讨类器官簇生长的形态特征与药物作用关联机制,为基于患者来源肿瘤类器官(PDOs)的癌症新药筛选或临床药敏检测提供新的表征手段。本课题组提出了结合光学相干层析成像(OCT)和基于机器学习的类器官分割与分类技术,并对类器官簇内成百上千个类器官进行了纵向、准确、无标记、并行形态学表征。在欠采样处理的基础上,对多个类器官样本(3个类别)进行聚类分析,获取类器官簇内类器官类别信息以及基于类别的多维形态参数统计信息,进而对各类别数目及形态参数统计信息进行特征筛选和主成分分析(选择特征值大于1的4个主成分),构建类器官簇生长水平综合评价模型。研究结果显示,类器官对药物的反应与形态变化紧密关联,尤其是囊状类器官因药物作用转变而成的实体类器官。此外,本文提出的基于三维OCT和机器学习技术的类器官簇生长水平综合评价模型的综合评价得分与传统生化测试三磷酸腺苷(ATP)值之间的一致性高(82.9%),而基于综合评价模型的相对生长值与ATP值有更高的一致性(90.4%)。该方法可以揭示药物作用下类器官的形态学变化规律,也可以为基于PDOs的癌症新药筛选或临床药敏检测提供新技术和新平台。

关键词：光学相干层析成像类器官形态表征药物作用

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中医适宜技术小儿推拿在儿童保健中的临床应用

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首都食品与医药 2024年第7期31卷 166-168页

作者：杨闪闪西安庆华医院陕西西安714500

目的分析儿童保健中应用中医适宜技术小儿推拿的临床应用价值。方法选择2022年3月-2024年3月期间到西安庆华医院中医儿科进行诊疗的100名儿童作为研究对象,使用电脑将此100名研究对象随机分为观察组(50例)和对照组(50例)。对照组使用常... 详细信息

目的分析儿童保健中应用中医适宜技术小儿推拿的临床应用价值。方法选择2022年3月-2024年3月期间到西安庆华医院中医儿科进行诊疗的100名儿童作为研究对象,使用电脑将此100名研究对象随机分为观察组(50例)和对照组(50例)。对照组使用常规保健法,观察组在对照组基础上应用中医适宜技术小儿推拿,对比分析两组儿童的保健护理满意度、保健效果、体格发育状况和疾病发生率。结果保健后,观察组儿童的保健护理满意度为74.00%,高于对照组儿童的保健护理满意度,差异有统计学意义(P<0.05);观察组患者的保健效果总分为(89.21±5.30)分,高于对照组患者的保健效果总分(73.23±4.98)分,差异有统计学意义(P<0.05);观察组儿童的头围、体重、身高指标均优于对照组儿童,差异有统计学意义(P<0.05);观察组儿童的各项疾病发生率均低于对照组儿童的疾病发生率,差异有统计学意义(P<0.05)。结论中医适宜技术小儿推拿不仅能够提高保健护理满意度并降低儿童的疾病发生率,还能促进儿童体格发育,保健效果好,具有显著的临床推广价值。

关键词：小儿推拿儿童保健应用价值体格发育

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