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Interplay between Micro-Anisotropy and Macro-Isotropy on Evolution of Non-Equilibrium Morphology

Journal of Rare Earths 2006年第z1期24卷 208-212页

作者： Zhao shanrong liu Rong liu Huifang Wang Jiyang China University of Geosciences Wuhan 430074 China China University of Geosciences Wuhan 430074 China China University of Geosciences Wuhan 430074 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

Non-equilibrium morphology has received much attention from both scientific and engineering points of view for its intricate pattern selection mechanisms and useful industrial application. Most study of non-equilibrium is about the metal, alloy and other simple system. The complex silicate system is rarely involved. However, silicate is very important in geosciences and ceramic industry. In this paper, two kinds of non-equilibrium crystal morphologies of silicate: dendrite of diopside and spherulite of plagioclase, were introduced. Combining with the other kinds of non-equilibrium morphologies, the characteristics of micro-macro and anisotropy-isotropy of the non-equilibrium morphologies were discussed. Dendrite of diopside is micro- and macro-anisotropic, spherulite of plagioclase is micro-anisotropic, but macro-isotropic, fractal of NH4Cl is also micro-anisotropic, but macro-isotropic, dense-branching morphology (DBM) formed in non-crystalline system is micro-and macro-isotropic. Based on the micro-macro interplay on the pattern formation, it is proposed that the interplay between micro-anisotropy of crystal structure vs macro-isotropy of undercooling in crystal growth system will control the morphological evolution. The nucleation rate related to the anisotropy for the morphological evolution was also discussed. The fact that diopside develops dendrite and plagioclase develop spherulite in our experiment is due to their structural anisotropy difference.

关键词： crystal morphology silicate non-equilibrium anisotropy and isotropy

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Peptides encoded by noncoding genes: challenges and perspectives

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Signal Transduction and Targeted Therapy 2019年第1期4卷 127-138页

作者： Shuo Wang Chuanbin Mao shanrong liu Changhai Hospital Shanghai200433China Department of Chemistry and Biochemistry Stephenson Life Sciences Research CenterInstitute for Biomedical EngineeringScience and TechnologyUniversity of Oklahoma101 Stephenson ParkwayNormanOK73019-5300USA

In recent years,noncoding gene(NCG)translation events have been frequently *** resultant peptides,as novel findings in the life sciences,perform unexpected functions of increasingly recognized importance in many fundamental biological and pathological *** emergence of these novel peptides,in turn,has advanced the field of genomics while indispensably aiding living *** peptides from NCGs serve as important links between extracellular stimuli and intracellular adjustment *** peptides are also important entry points for further exploration of the mysteries of life that may trigger a new round of revolutionary biotechnological *** into NCG-derived peptides will assist in understanding the secrets of life and the causes of diseases,and will also open up new paths to the treatment of diseases such as ***,a critical review is presented on the action modes and biological functions of the peptides encoded by *** challenges and future trends in searching for and studying NCG peptides are also critically discussed.

关键词： has searching finding

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SNORA23 inhibits HCC tumorigenesis by impairing the 2'-O-ribose methylation level of 28S rRNA

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Cancer Biology & Medicine 2022年第1期19卷 104-119页

作者： Zhiyong liu Yanan Pang Yin Jia Qin Qin Rui Wang Wei Li Jie Jing Haidong liu shanrong liu Department of Laboratory Diagnostics Changhai HospitalSecond Military Medical UniversityShanghai 200433China Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Shanghai Institute of Pancreatic Diseases Shanghai 200433China Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200433 China Department of General Surgery Changzheng HospitalSecond Military Medical UniversityShanghai 200433China Shanghai Fourth People’s Hospital Tongji University School of MedicineShanghai 200081China

Objective:The dysregulation of ribosome biogenesis is associated with the progression of numerous tumors,including hepatocellular carcinoma(HCC).Small nucleolar RNAs(sno RNAs)regulate ribosome biogenesis by guiding the modification of ribosomal RNAs(r RNAs).However,the underlying mechanism of this process in HCC remains ***:RNA immunoprecipitation and sequencing were used to analyze RNAs targeted by ribosome *** biological functions of SNORA23 were examined in HCC cells and a xenograft mouse *** elucidate the underlying mechanisms,the 2′-O-ribose methylation level of r RNAs was evaluated by q PCR,and the key proteins in the PI3 K/Akt/m TOR pathway were detected using Western ***:Twelve sno RNAs were found to co-exist in 4 cancer cell lines using RPS6 pull-down ***23 was downregulated in HCC and correlated with the poor prognoses of HCC ***23 inhibited the proliferation,migration,and invasion of HCC cells both in vitro and in *** also found that SNORA23 regulated ribosome biogenesis by impairing 2′-O-ribose methylation of cytidine4506 of 28 S r ***,SNORA23,which is regulated by the PI3 K/Akt/m TOR signaling pathway,significantly inhibited the phosphorylation of 4 E binding protein ***23 and rapamycin blocked the PI3 K/AKT/m TOR signaling pathway and impaired HCC growth in ***:SNORA23 exhibited antitumor effects in HCC and together with rapamycin,provided a promising therapeutic strategy for HCC treatment.

关键词： SNORA23 ribosome biogenesis rRNA methylation HCC

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Identification of portal vein tumor thrombus with an independent clonal origin in hepatocellular carcinoma via multi-omics data analysis

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Cancer Biology & Medicine 2019年第1期16卷 147-156页

作者： Shupeng liu Zaixin Zhou Yin Jia Jie Xue Zhiyong liu Kai Cheng Shuqun Cheng shanrong liu Clinical Research Center Changhai Hospital Second Military Medical University Department of Laboratory Diagnostics Changhai Hospital Second Military Medical University Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery Hospital Second Military Medical University

Objective: Multiple mechanisms underlying the development of portal vein tumor thrombus(PVTT) in hepatocellular carcinoma(HCC) have been reported recently. However, the origins of PVTT remain unknown. Increasing multi-omics data on PVTTs in HCCs have made it possible to investigate whether PVTTs originate from the corresponding primary tumors(Ts).Methods: The clonal relationship between PVTTs and their corresponding primary Ts was investigated using datasets deposited in public databases. One DNA copy number variations dataset and three gene expression datasets were downloaded for the *** analysis was performed to investigate the clonal relationship between PVTTs and Ts from an individual *** gene expression analysis was applied to investigate the gene expression profiles of PVTTs and ***: One out of 19 PVTTs had no clonal relationship with its corresponding T, whereas the others did. The PVTTs with independent clonal origin showed different gene expression and enrichment in biological processes from the primary Ts. Based on the unique gene expression profiles, a gene signature including 24 genes was used to identify pairs of PVTTs and primary Ts without any clonal relationship. Validation in three datasets showed that these types of pairs of PVTTs and Ts can be identified by the 24-gene ***: Our findings show a direct evidence for PVTT origin and consolidate the heterogeneity of PVTTs observed in *** results suggest that PVTT investigation at a molecular level is clinically necessary for diagnosis and treatment.

关键词： Hepatocellular carcinoma portal vein tumor thrombus clonal origin copy number variation bioinformatics

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Non-coding RNAs:a promising target for early metastasis intervention

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Chinese Medical Journal 2023年第21期136卷 2538-2550页

作者： Yi Xiao Yijun Hu shanrong liu Department of Stomatology Changhai HospitalNaval Medical UniversityShanghai 200433China Clinical Research Center Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Laboratory Diagnostics Changhai HospitalNaval Medical UniversityShanghai 200433China

Metastases account for the overwhelming majority of cancer-associated *** dissemination of cancer cells from the primary tumor to distant organs involves a complex process known as the invasion-metastasis *** underlying biological mechanisms of metastasis,however,remain largely ***,the discovery and characterization of non-coding RNAs(ncRNAs)have revealed the diversity of their regulatory roles,especially as key contributors throughout the metastatic ***,we review recent progress in how three major types of ncRNAs(microRNAs,long non-coding RNAs,and circular RNAs)are involved in the multistep procedure of *** further examine interactions among the three ncRNAs as well as current progress in their regulatory *** also propose the prevention of metastasis in the early stages of cancer progression and discuss current translational studies using ncRNAs as targets for metastasis diagnosis and *** studies provide insights into developing more effective strategies to target metastatic relapse.

关键词： MicroRNAs Long non-coding RNAs Circular RNAs Metastasis Early intervention

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Pluripotency transcription factors and cancer stem cells:small genes make a big difference

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Chinese Journal of Cancer 2013年第9期32卷 483-487页

作者： Anfei liu Xiya Yu shanrong liu Changhai Hospital Second Military Medical University

Cancer stem cells(CSCs)are thought to drive uncontrolled tumor growth,and the existence of CSCs has recently been proven by direct experimental evidence,including tracing cell lineages within a growing ***,CSCs must be analyzed in additional cancer *** stem cell-like cells(CSCLCs)are a good alternative system for the study of CSCs,which hold great promise for clinical ***4,NANOG,and SOX2 are three basic transcription factors that are expressed in both CSCLCs and embryonic stem cells(ESCs).These transcription factors play critical roles in maintaining the pluripotence and self-renewal characteristics of CSCLCs and *** this review,we discuss the aberrant expression,isoforms,and pseudogenes of OCT4,NANOG,and SOX2 in the CSCLC niche,which contribute to the major differences between CSCLCs and *** also highlight an anticancer therapy that involves killing specific cancer cells directly by repressing the expression of OCT4,NANOG,or ***,OCT4,NANOG,and SOX2 provide great promise for clinical applications because reducing their expression or blocking the pathways in which they function may inhibit tumor growth and turn-off the cancer"switch."In the future,a clear understanding of transcription factor regulation will be essential for elucidating the roles of OCT4,NANOG,and SOX2 in tumorigenesis,as well as exploring their use for diagnostic and therapeutic purposes.

关键词：肿瘤干细胞转录因子癌症因子和多能性 NANOG 胚胎干细胞肿瘤生长

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检验医学真实世界研究的策略与展望

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中华检验医学杂志 2019年第8期42卷 618-622页

作者：郭杰刘善荣海军军医大学附属长海医院实验诊断科上海200433

真实世界研究因其获得的证据来源于真实临床实践而受到越来越多研究者的关注,随着检验大数据的形成及诊断标志物转化遇到的壁垒,真实世界研究的概念也被引入到检验医学中.本文就真实世界研究会对检验医学的发展带来什么样的契机和要求,... 详细信息

真实世界研究因其获得的证据来源于真实临床实践而受到越来越多研究者的关注,随着检验大数据的形成及诊断标志物转化遇到的壁垒,真实世界研究的概念也被引入到检验医学中.本文就真实世界研究会对检验医学的发展带来什么样的契机和要求,以及检验人员如何开展真实世界研究进行了初步探讨.

关键词：医学检验科学临床实验室技术临床研究

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实验室自建项目在精准医学及临床实验诊断发展中的作用

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中华检验医学杂志 2019年第9期42卷 741-744页

作者：贾音刘善荣海军军医大学附属长海医院实验诊断科上海200433

现代实验室自建项目(LDTs),在精准医学和临床实验诊断学科发展中起到非常重要的作用。完善的LDTs检测平台不仅需要严格的质量控制体系和管理标准,更需要高端专业团队的技术支持。本文通过梳理LDTs的发展历程,就其在精准医疗背景下开展... 详细信息

现代实验室自建项目(LDTs),在精准医学和临床实验诊断学科发展中起到非常重要的作用。完善的LDTs检测平台不仅需要严格的质量控制体系和管理标准,更需要高端专业团队的技术支持。本文通过梳理LDTs的发展历程,就其在精准医疗背景下开展的意义,对检验医学学科的发展和对检验人才的培养方面所起到的积极作用,以及如何有效开展LDTs进行了探讨。

关键词：医学检验科学临床实验室技术精准医学

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COL14A1 promotes self-renewal of human liver cancer stem cells through activation of ERK signaling

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Journal of Bio-X Research 2021年第1期4卷 10-17页

作者： Ruijiao Kong Haidong liu Yi Shi Qiuhong Man shanrong liu Shanghai Fourth People’s Hospital Tongji University School of Medicine Department of Laboratory Diagnostic Changhai HospitalNaval Military Medical UniversityShanghaiChina

Objective:Liver cancer stem cells(CSCs)are the culprits of hepatocellular carcinoma metastasis and *** by eliminating tumor stem cells can malignant tumors be fundamentally *** study aimed to identify the role and underlying mechanism of aberrant Collagen Type XIV Alpha 1 Chain(COL14A1)overexpression in liver CSCs,and improve understanding of the molecular basis of hepatocellular carcinoma metastasis and ***:First,quantitative real-time polymerase chain reaction was used to confirm aberrant high-expression of COL14A1 in liver ***,interference experiments were performed to determine the key role of *** explore the mechanism of COL14A1 overexpression in liver CSCs,putative microRNA(miRNAs)targeting COL14A1 were analyzed using the miRTarBase ***,quantitative real-time polymerase chain reaction,western blotting,and luciferase reporter assays were performed to verify the interaction between miR-7108-3p and ***,key target proteins of the COL14A1-extracellular-regulated signal kinase(ERK)signaling pathway were identified through western blotting *** study was approved by the Ethics Committee of Shanghai Fourth People’s Hospital,Tongji University School of Medicine,China(approval No.2019tjdx17)on February 21,***:COL14A1 is abnormally highly expressed in liver CSCs,which is necessary for liver CSCs to maintain their self-renewal ***,COL14A1 is post-transcriptionally regulated by miR-7108-3p in a negative *** expression of miR-7108-3p increased translation of COL14A1,which subsequently activated ERK signaling,ultimately maintaining the self-renewal and stem cell-like properties of liver ***:COL14A1,which is negatively regulated by miR-7108-3p,was found to play a crucial role in maintaining the selfrenewal and stem cell-like properties of liver CSCs through activation of ERK signaling.

关键词： COL14A1 ERK signaling hepatocellular carcinoma liver cancer stem cells miR-7108-3p

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COL14A1 promotes self-renewal of human liver cancer stem cells through activation of ERK signaling

COL14A1 promotes self-renewal of human liver cancer stem cel...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Ruijiao Kong Haidong liu Yi Shi Qiuhong Man shanrong liu Shanghai Fourth People’s Hospital 海军军医大学第一附属医院(上海长海医院)

Objective: Liver cancer stem cells(CSCs) are the culprits of hepatocellular carcinoma metastasis and recurrence. Only by eliminating tumor stem cells can malignant tumors be fundamentally cured. This study aimed to identify the role and underlying mechanism of aberrant Collagen Type XIV Alpha 1 Chain(COL14 A1) overexpression in liver CSCs, and improve understanding of the molecular basis of hepatocellular carcinoma metastasis and ***: First, quantitative real-time polymerase chain reaction was used to confirm aberrant highexpression of COL14 A1 in liver CSCs. Next, interference experiments were performed to determine the key role of COL14 A1. To explore the mechanism of COL14 A1 overexpression in liver CSCs,putative microRNA(miRNAs) targeting COL14 A1 were analyzed using the miRTarBase ***, quantitative real-time polymerase chain reaction, western blotting, and luciferase reporter assays were performed to verify the interaction between miR-7108-3 p and COL14 A1. Lastly, key target proteins of the COL14 A1-extracellular-regulated signal kinase(ERK) signaling pathway were identified through western blotting analysis. This study was approved by the Ethics Committee of Shanghai Fourth People’s Hospital, Tongji University School of Medicine, China(approval No.2019 tjdx17) on February 21, ***: COL14 A1 is abnormally highly expressed in liver CSCs, which is necessary for liver CSCs to maintain their self-renewal capability. Mechanistically, COL14 A1 is post-transcriptionally regulated by miR-7108-3 p in a negative manner. Low expression of miR-7108-3 p increased translation of COL14 A1, which subsequently activated ERK signaling, ultimately maintaining the self-renewal and stem cell-like properties of liver ***: COL14 A1, which is negatively regulated by miR-7108-3 p, was found to play a crucial role in maintaining the self-renewal and stem cell-like properties of liver CSCs through activation of ERK signaling.

关键词： COL14A1 ERK signaling hepatocellular carcinoma miR-7108-3p liver cancer stem cells

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