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Reproduction and beyond,kisspeptin in ruminants

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Journal of Animal Science and Biotechnology 2015年第3期6卷 264-268页

作者： Joseph A.Daniel Chad D.Foradori Brian K.whitlock James L.Sartin Department of Animal Science Berry College Department of Anatomy Physiology & PharmacologyAuburn University Department of Large Animal Clinical Sciences University of Tennessee

Kisspeptin （Kp） is synthesized in the arcuate nucleus and preoptic area of the hypothalamus and is a regulator of gonadotropin releasing hormone in the hypothalamus. In addition, Kp may regulate additional functions such as increased neuropeptide Y gene expression and reduced proopiomelanocortin （POMC） gene expression in sheep. Other studies have found a role for Kp to release growth hormone （GH）, prolactin and luteinizing hormone （LH） from cattle, rat and monkey pituitary cells. Intravenous injection of Kp stimulated release LH, GH, prolactin and follicle stimulating hormone in some experiments in cattle and sheep, but other studies have failed to find an effect of peripheral injection of Kp on GH release. Recent studies indicate that Kp can stimulate GH release after intracerebroventricular injection in sheep at doses that do not release GH after intravenous injection. These studies suggest that Kp may have a role in regulation of both reproduction and metabolism in sheep. Since GH plays a role in luteal development, it is tempting to speculate that the ability of Kp to release GH and LH is related to normal control of reproduction.

关键词： Growth hormone Leptin Luteinizing Neuropeptide Y POMC

Biology of tooth replacement in amniotes

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International Journal of Oral Science 2013年第2期5卷 66-70页

作者： John A whitlock Joy M Richman Department of Oral Health Sciences Faculty of DentistryLife Sciences InstituteUniversity of British Columbia

Tooth replacement is a common trait to most vertebrates, including mammals. Mammals, however, have lost the capacity for continuous tooth renewal seen in most other vertebrates, and typically have only 1-2 generations of teeth. Here, we review the mechanisms of tooth replacement in reptiles and mammals, and discuss in detail the current and historical theories on control of timing and pattern of tooth replacement and development.

关键词： dental lamina growth factor signalling mammal epithelial stem cells diphyodonty polyphyodonty reptile successional lamina tooth replacement Zahnreihen, zone of inhibition

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中信大厦

建筑学报 2019年第3期 6-11页

作者： Robert whitlock 李磊邵韦平吴晨奚悦 KPF建筑设计事务所北京市建筑设计研究院

地点/北京朝阳设计/2011-2015年/竣工/2019年Design Stage 2011-2015 Completion 2019业主中信和业投资有限公司建筑设计标地阶段概念设计:TFP Farrells、北京市建筑设计研究院概念调整和方案设计:KPF(设计牵头方)、北京市建筑设计研究院.

关键词：中信大厦北京朝阳设计竣工

An experimental approach for investigating many-body phenomena in Rydberg-interacting quantum systems

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Frontiers of physics 2014年第5期9卷 571-586页

作者： C. S. Hofmann G. Gunter H. Schempp N. L. M. Miiller A. Faber H. Busche M. Robert-de-Saint-Vincent S. whitlock M. Weidemuller Physikalisches Institut Universitiit Heidelberg Im Neuenheimer Feld 226 69120 Heidelberg Germany Center for Free-Electron Laser Science DESY Notkestrasse 85 22607 Hamburg Germany Department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Joint Quantum Centre (JQC) Durham-Newcastle Department of Physics Durham University Rochester Building South Road Durham DH1 3LE United Kingdom

Recent developments in the study of ultracold Rydberg gases demand an adwanced level of experimental sophistication, in which high atomic and optical densities must be combined with excellent control of external fields and sensitive Rydberg atom detection. We describe a tailored experimental system used to produce and study Rydberg-interacting atoms excited from dense ultracold atomic gases. The experiment has been optimized for fast duty cycles using a high flux cold atom source and a three beam optical dipole trap. The latter enables tuning of the atomic density and temperature over several orders of magnitude, all the way to the Bose--Einstein condensation transition. An elec- trode structure surrounding the atoms allows for precise control over electric fields and single-particle sensitive field ionization detection of Rydberg atoms. We review two experiments which highlight the influence of strong Rydberg---Rydberg interactions on different many-body systems. First, the Rydberg blockade effect is used to pre-structure an atomic gas prior to its spontaneous evolution into an ultracold plasma. Second, hybrid states of photons and atoms called dark-state polaritons are studied. By looking at the statistical distribution of Rydberg excited atoms we reveal correlations between dark-state polaritons. These experiments will ultimately provide a deeper understanding of many-body phenomena in strongly-interacting regimes, including the study of strongly-coupled plasmas and interfaces between atoms and light at the quantum level.

关键词： ultracold Rydberg gases ultracold plasmas Bose-Einstein condensation atom-light interactions many-body interactions

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.whitlock Zachary Michel Kristen Pan Jocelyn Taylor Vivian Szymczuk Brendan Boyce Daniel Martin Vardit Kram Rebeca Galisteo Kamran Melikov Leonid V.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

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适用于更高电压的新型聚合物

电线电缆 1991年第1期 34-36页

作者： Ken whitlock 何云南

在乙烯、丙烯和第三单体的聚合物(EPDM)中,当它们混合适当填料和硫化剂时,具有良好的电气性能及其它性能。这种 EPDM 已应用于高压电缆绝缘。

关键词：电缆绝缘材料乙丙橡胶高电压

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氰化物生物降解法的优越性

新疆环境保护 1990年第3期12卷 64-67页

作者： Jim whitlock 许孙曲

矿业加工废水中的氰化物的生物降解法和有毒金属的生物吸着法是具有许多起超于化学处理法的优越性的技术。其优点包括;成本效率高,处理性能好,抗干扰,产生的残渣少,金属脱除率与回收率高,灵敏的设计特性,接受流出液,液流的适应性好和有... 详细信息

矿业加工废水中的氰化物的生物降解法和有毒金属的生物吸着法是具有许多起超于化学处理法的优越性的技术。其优点包括;成本效率高,处理性能好,抗干扰,产生的残渣少,金属脱除率与回收率高,灵敏的设计特性,接受流出液,液流的适应性好和有随过程条件改变而自动调节的能力。

关键词：矿业废水氰化物生物降解法

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小马腺病毒性肺炎

中国兽医科学 1979年第2期 61-63页

作者：朱家驹,R.H.whitlock 天津市农业学校

一匹3周龄的小母马由于呼吸紊乱而住院,虽然采取对症疗法终于死亡。根据病理解剖学所见,疑为病毒性肺炎。从鼻咽抹子和死后在其他组织中均分离出马属动物腺病毒。电镜检查也证实为典型的腺病毒。认为腺病毒感染同该阿拉伯种小马在哺乳... 详细信息

一匹3周龄的小母马由于呼吸紊乱而住院,虽然采取对症疗法终于死亡。根据病理解剖学所见,疑为病毒性肺炎。从鼻咽抹子和死后在其他组织中均分离出马属动物腺病毒。电镜检查也证实为典型的腺病毒。认为腺病毒感染同该阿拉伯种小马在哺乳期出现的急性的和死亡率很高的肺炎综合征有关。死亡是由遗传上的免疫缺乏与继发性腺病毒的传染所造成。下面所介绍的为纽约州的第一个病例。

关键词：腺病毒小马马属动物阿拉伯腺病毒性肺炎免疫缺乏

体外循环术中应用甲基强的松龙并无必要：一项多中心随机对照试验结果

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心血管病学进展 2016年第3期37卷 330-330,F0003页

作者： whitlock RP Devereaux PJ Teoh KH 彭超(译) 蒋迎九(审校) 不详重庆医科大学附属第一医院胸心外科

体外循环是安全开展心内直视手术的必备基础技术,但其本身所触发的机体全身炎性反应综合征却可能会增加患者术后并发症甚至死亡的发生风险。由于糖皮质激素对炎性反应具有明确的抑制效应,因此从理论上讲,对接受体外循环心内直视手术的... 详细信息

体外循环是安全开展心内直视手术的必备基础技术,但其本身所触发的机体全身炎性反应综合征却可能会增加患者术后并发症甚至死亡的发生风险。由于糖皮质激素对炎性反应具有明确的抑制效应,因此从理论上讲,对接受体外循环心内直视手术的高风险患者,在术中应用糖皮质激素可能会获得较好的手术预后。作者设计的本项多中心、双盲、随机对照实验,旨在评估在体外循环心内直视术中应用糖皮质激素,

关键词：心内直视手术随机对照试验心内直视术糖皮质激素炎性反应手术预后术后并发症基础技术本项抑制效应