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Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression

Journal of Cancer metastasis and Treatment 2018年第1期4卷 606-614页

作者： Jessica Felton Kunrong Cheng Aaron C.Shang Shien Hu shannon m.larabee Cinthia B.Drachenberg Jean-Pierre Raufman Department of Surgery University of Maryland School of MedicineBaltimoreMD 21201USA Department of medicine University of Maryland School of MedicineBaltimoreMD 21201USA Department of Pathology University of Maryland School of MedicineBaltimoreMD 21201USA

Aim:Strong evidence reveals important differences between cancers in the proximal *** *** models of metastatic colon cancer are available but with varying degrees of reproducibility and several important *** explored whether there were regional differences in the location of murine colon cancers and assessed the utility of murine models to explore the biological basis for such ***:We re-analyzed data from our previous studies to assess the regional distribution of murine colon *** survival surgery experiments,we injected HT-29 human colon cancer cells into the wall of the cecum or distal colon of Nu(NCr)-Foxn1 nu or ***-Prkdc scid Il2rg Tim1Wji/SzJ mice and compared the development of primary tumors and ***:Within 7-17 weeks after intramural cecal injection of HT-29 cells,eight mice failed to develop solid primary tumors or *** contrast,within four weeks after cell injection into the distal colon,13 mice developed metastases-12 mice developed subcutaneous metastases;of these,four developed liver metastases and one developed both liver and lung *** mouse developed liver metastases *** examination confirmed these lesions were ***:Our findings reveal the preferential growth of murine colon neoplasia and invasive human orthotopic xenografts in the distal mouse *** new approach of injecting cells into the distal colon wall results in a pattern of colon cancer development that closely mimics the progression of metastatic colon cancer in *** novel model of colon neoplasia has great potential for exploring anatomical differences in colon cancer and testing novel therapeutics.

关键词： Colorectal cancer orthotopic tumor model mouse model HT-29 cells colon

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