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The terpene synthase(TPS)gene family in k.wifruit shows high functional redundancy and a subset of TPS lik.ly fulfil overlapping functions in fruit flavour,floral bouquet and defence

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Molecular Horticulture 2023年第1期3卷 258-279页

作者： Wu Wang Mindy Y.Wang Yunliu Zeng Xiuyin Chen Xiaoyao Wang Anne M.Barrington Jianmin Tao Ross G.atkinson Niels J.Nieuwenhuizen The New Zealand Institute for Plant and Food Research Ltd(PFR) Private Bag 92169AucklandNew Zealand Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014China k.y Laboratory of Horticultural Plant Biology College of Horticulture and Forestry ScienceHuazhong Agricultural UniversityWuhan 430070People’s Republic of China College of Horticulture Nanjing Agricultural UniversityNanjing 210095China

Volatile terpenes are important compounds that influence fruit flavour and aroma of *** in plants also impact on the floral bouquet and defence against pests and pathogens in leaves and *** better understand the overlapping roles that terpenes may fulfil in plants,a systematic gene,chemical and biochemical analysis of terpenes and terpene synthases(TPS)was undertak.n in Red5 k.wifruit(Actinidia spp.).Analysis of the Red5 genome shows it contains only 22 TPS gene models,of which fifteen encode full-length *** TPS can account for the major terpene volatiles produced in different tissues of Red5 k.wifruit and in response to different *** small Red5 TPS family displays surprisingly high functional redundancy with five TPS producing linalool/*** of leaves and fruit with methyl jasmonate enhanced expression of a subset of defence-related TPS genes and stimulated the release of *** TPS genes were induced upon herbivory of leaves by the economically important insect pest Ctenopseustis obliquana(brown-headed leaf roller)and emission,but not accumulation,of(E)-and(Z)-nerolidol was strongly link.d to *** results provide a framework.to understand the overlapping biological and ecological roles of terpenes in Actinidia and other horticultural crops.

关键词： Actinidia Aroma Genome analysis Monoterpene Sesquiterpene Volatile

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Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue

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World Journal of Gastroenterology 2019年第36期25卷 5530-5542页

作者： Arthur Laquière Arnaud Lagarde Bertrand Napoléon Raphael Bourdariat Alexandre atkinson Gianfranco Donatelli Bernard Pol Laurence Lecomte Laurence Curel Romina Urena-Campos Thierry Helbert Vincent Valantin Francois Mithieux Jean Pascal Buono Philippe Grandval Sylviane Olschwang Department of Gastroenterology Saint Joseph Hospital Marseille 13008 France AP-HM Timone Hospital Marseille 13005 France RGDS Clairval Hospital Marseille 13009 France Aix-Marseille Univ INSERM MMG Marseille 13385 France AP-HM Conception Hospital Marseille 13385 France RGDS Jean Mermoz Hospital Lyon 69008 France RGDS Les Peupliers Hospital Paris 75013 France Department of Digestive Surgery Saint-Joseph Hospital Marseille 13008 France Department of Clinical Research Saint Joseph Hospital Marseille 13008 France European Hospital Marseille 13003 France Pathological Anatomy and Cytology MEDIPATH Eguilles 13510 France

BACk.ROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. k.AS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS)analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation. AIM To confirm whether CF genomic profiles are a reliable malignancy predictor by comparing NGS mutational analyses of CF and NT. METHODS Patients requiring surgery for high-risk.pancreatic cysts were included in a multicenter prospective pilot study. DNA from CF (collected by endoscopic ultrasound-guided fine needle aspiration (k.own as EUS-FNA)) and NT (collected by surgery) were analyzed by NGS. The primary objective was to compare the mutation profiles of paired DNA samples. The secondary objective was to correlate the presence of specific mutations (k.AS/GNAS, RAF/ PTPRD/CTNNB1/RNF43/POLD1/TP53) with a final cancer diagnosis. Sensitivity and specificity were also evaluated. RESULTS Between December 2016 and October 2017, 20 patients were included in this pilot study. Surgery was delayed for 3 patients. Concordant CF-NT genotypes were found in 15/17 paired DNA, with a higher proportion of mutated alleles in CF than in NT. NGS was possible for all pancreatic CF collected by EUS-FNA. In 2 cases, the presence of a k.AS/GNAS mutation was discordant between CF and NT. No mutations were found in 3 patients with NT or pancreatic cysts with high-grade dysplasia. The sensitivity and specificity of k.AS/GNAS mutations in CF to predict an appropriate indication for surgical resection were 0.78 and 0.62, respectively. The sensitivity and specificity of RAF/PTPRD/CTNNB1 /RNF43/POLD1/TP53 mutatio

关键词： Pancreatic cancer Pancreatic cystic neoplasms Pancreatic adenocarcinoma Malignancy prediction Neoplastic surgical tissue Pancreatic cystic fluid Molecular analysis Next-generation sequencing DNA mutations

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圣安德烈斯断层系北段的地震活动和热构造

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地震地质译丛 1994年第5期16卷 10-14页

作者： k.P.Furlong S.M.atkinson 丁学文

引言在过去几十年间,已经认识到地震活动模式与岩石圈热构造的关系。在大洋岩石圈,这种关系已良好地作了定量,且发震带深度为700—800℃等温线(Wiens 和 Stein,1983),而大陆岩石圈中的这种情况更加复杂。显著的岩性变化导致流变不均一性... 详细信息

引言在过去几十年间,已经认识到地震活动模式与岩石圈热构造的关系。在大洋岩石圈,这种关系已良好地作了定量,且发震带深度为700—800℃等温线(Wiens 和 Stein,1983),而大陆岩石圈中的这种情况更加复杂。显著的岩性变化导致流变不均一性,可以表现为复杂的地震活动模式。非均一性主要是分层的,并且地壳和上地幔热构造与物质成分分层的相互作用可导致地震活动最大深度和观察到深度分布的变化。

关键词：地震活动性岩石圈热构造断层系

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Moving interdisciplinary science forward:integrating participatory modelling with mathematical modelling of zoonotic disease in Africa

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Infectious Diseases of Poverty 2016年第1期5卷 149-160页

作者： Catherine Grant Giovanni Lo Iacono Vupenyu Dzingirai Bernard Bett Thomas R.A.Winnebah Peter M.atkinson ESRC Social Technological and Environmental Pathways to Sustainability(STEPS)CentreInstitute of Development StudiesLibrary RoadFalmerBrightonUK Geography and Environment University of SouthamptonHighfieldSouthampton SO171BJUK Lancaster University LancasterUK University of Utrecht UtrechtUK Queen’s University Belfast BelfastUK Department of Veterinary Medicine Disease Dynamics UnitUniversity of CambridgeCambridgeUK Centre for Applied Social Sciences Trust 5 Aberdeen RoadP O Box A1333AvondaleHarareZimbabwe International Livestock.Research Institute Naivasha RoadKabeteNairobiKenya Institute of Geography and Development Studies School of Environmental SciencesNjala University17Henry StreetFreetownSierra Leone

This review outlines the benefits of using multiple approaches to improve model design and facilitate multidisciplinary research into infectious diseases,as well as showing and proposing practical examples of effective *** look. particularly at the benefits of using participatory research in conjunction with traditional modelling methods to potentially improve disease research,control and *** approaches can lead to more realistic mathematical models which in turn can assist with mak.ng policy decisions that reduce disease and benefit local *** emergence,risk.spread and control of diseases are affected by many complex bio-physical,environmental and socio-economic *** include climate and environmental change,land-use variation,changes in population and people’s *** evidence base for this scoping review comes from the work.of a consortium,with the aim of integrating modelling approaches traditionally used in epidemiological,ecological and development research.A total of five examples of the impacts of participatory research on the choice of model structure are *** 1 focused on using participatory research as a tool to structure a *** 2 look. at identifying the most relevant parameters of the *** 3 concentrates on identifying the most relevant regime of the system(e.g.,temporal stability or otherwise),Example 4 examines the feedback. from mathematical models to guide participatory research and Example 5 goes beyond the so-far described two-way interplay between participatory and mathematical approaches to look.at the integration of multiple methods and *** scoping review describes examples of best practice in the use of participatory methods,illustrating their potential to overcome disciplinary hurdles and promote multidisciplinary collaboration,with the aim of mak.ng models and their predictions more useful for decision-mak.ng and policy formulation.

关键词： Africa Zoonoses Modelling Interdisciplinary One health Participatory Disease

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一种高频震级标度

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世界地震译丛 1996年第3期27卷 54-62页

作者： G.M.atkinson T.C.Hank. 杨宝仁国家地震局地球物理研究所

提出一种高频震级标度(m): m=2log■_(k.)+3式中,■_(k.)是在震源或距断层10k.处加速度傅里叶振幅谱的高频水平,单位是cm/s(平均的或其中任意一个水平分量)。可以从仪器资料或地震的有感面积来测定m。在北美东部和加州,我们规定对应于... 详细信息

提出一种高频震级标度(m): m=2log■_(k.)+3式中,■_(k.)是在震源或距断层10k.处加速度傅里叶振幅谱的高频水平,单位是cm/s(平均的或其中任意一个水平分量)。可以从仪器资料或地震的有感面积来测定m。在北美东部和加州,我们规定对应于“平均”应力降的地震,m=M(矩震级)。如果M也是已知的,则m提供应力降的测量。观测的m与M之间的关系表明,对于北美东部地区地震,平均应力降大约是150bar;对于加州地区地震,平均应力降大约是70bar。北美东部地区应力降的变化又比加州地区的大得多。所提出标度的主要理由是它可用来解释有仪器记录的以前的大地震,而这些地震对北美东部地震危险性估计是十分重要的。对于这样的地震,m可以比M或m_N(Nuttli震级)的测定更为可靠,并且形成测定高频地面运动的更好基础。当将m和M作为一对使用时,则可提供为覆盖整个工程频带的地面运动的一个好的指标。如果能够给出一个地震的两种震级,那么,就可以用一个地面运动模型,如随机模型,获得可靠的反应谱和地面运动峰值。

关键词：地震震源震级标度

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界线? 什么是界线? 专业后时代的设计危机

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创意与设计 2011年第1期 78-83页

作者： Paul atkinson 叶映芳谢菲尔德哈勒姆大学文理科计算机工程和科学学院江南大学设计学院

在设计的关联性方面有一个逐步发展的认识:设计与其它学科的关联,不同设计学科之间的交集即界线正日益被质疑和跨越。然而,在我看来,目前最重要的界线不仅是可以被交叉跨越,而且专业和业余之间,更确切地说是"设计师"和"用户"之间的界线... 详细信息

在设计的关联性方面有一个逐步发展的认识:设计与其它学科的关联,不同设计学科之间的交集即界线正日益被质疑和跨越。然而,在我看来,目前最重要的界线不仅是可以被交叉跨越,而且专业和业余之间,更确切地说是"设计师"和"用户"之间的界线正在被消除。近代的设计方法已强调了以用户为中心的方法的重要性,但没有考虑到一点,即设计师和用户从本质上来说是相同。的这个观点的转变潜在地改变了设计教育、设计实践和设计消费。本文描述了一个最近的展览,游客到画廊不仅有机会在屏幕上创作产品设计,而且可以把它们进行实际的加工并展示为这个展览中的一部分。本文阐述设计师和手工艺者所做的选择形成了这类系统,并探讨了专业和业余的创造性活动之间的紧张关系,同时也探讨了设计教育中被提出的问题和不仅消除不同设计学科之间而且消除设计师用户之间的区别这个体系的潜在影响。

关键词：专业设计业余设计生成软件直接数字加工

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The Study on Immuno-modulation of Triptolide in vitro

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Journal of Microbiology and Immunology 2004年第2期2卷 131-135页

作者：翁小满 S.atkinson P.Gorak.Stolinsk. H.M.Dock.ell Beijing Tropical Medicine Research Institute Beijing 100050 China Department of Infectious and Tropical Medicine London School of Hygiene and Tropical MedicineLondon University

The purpose of this investigation is to demonstrate whether triptolide can inhibit TNF-α selectively and to study the mechanism. The ability of triptolide to inhibit the production of TNF-α and IFN-γ stimulated by lipopolysaccharide (LPS) and phytohemagglutinin (PHA) on peripheral blood mononuclear cell (PBMC) from healthy donors was measured by ELISA assays. The immunological mechanism of action of triptolide on TNF-α was investigated by pre-treatment with triptolide of PBMC and monocytes followed by analysis with Flow Cytometry (FCM). The inhibition of TNF-α and IFN-γ by triptolide occurred in a dose dependent manner and the IC 50 was equal to 5-10 ng/ml for TNF-α and 0.1-1 ng/ml for IFN-γ. The concentrations of TNF-α measured after the different pre-treatments with triptolide on PBMC and monocytes are consistent with its effects on a population of CD14 +/TNF-α + monocytes shown on FCM. The two methods of pre-treatments with triptolide may suggest different clinical significances. Immunophenotyping analysis with FCM revealed that triptolide may compete with LPS for binding to the CD14 receptor. The study provides basic evidence that triptolide may be used as an anti-inflammatory reagent for treatment of leprosy reactions.

关键词： Triptolide TNF-α Leprosy

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Performance and calibration of quark.gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott k. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk.S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik.M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aik.t M. Ait Tamlihat B. Aitbenchik. I. Aizenberg M. Ak.iyik.T.P.A. Åk.sson A.V. Ak.mov D. Ak.yama N.N. Ak.lk.r k. Al k.oury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Alek.a I.N. Alek.androv C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alk.k.i C. Allaire B.M.M. Allbrook. J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos k.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.k. Anders S.Y. Andrean A. Andreazza S. Angelidak.s A. Angerami A.V. Anisenk.v A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aok. T. Aok. J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada k. Asai S. Asai N.A. Asbah J. Assahsah k. Assamagan R. Astalos S. Atashi R.J. Atk.n M. atkinson H. Atmani P.A. Atmasiddha k. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio k. Axiotis G. Azuelos D. Babal H. Bachacou k. Bachas A. Bachiu F. Back.an A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.k. Bak.r E. Bak.s D. Bak.hi Gupta V. Balak.ishnan R. Balasubramanian E.M. Baldin P. Balek.E. Ballabene F. Balli L.M. Baltes W.k. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak.M. Barak.t E.L. Barberio D. Barberis M. Barbero M.Z. Barel k.N. Barends T. Barillari M-S. Barisits T. Bark.ow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quark. and gluons,often referred to as quark.gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quark. often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark.gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quark. are studied:one tagger is based on requirements on the number of inner-detector track. associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark.gluon fraction in data,by using quark.gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger work.ng points.

关键词： ATLAS JET QUARk GLUON TAGGING

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Cystic lymphangioma of the pancreas

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World Journal of Gastroenterology 2008年第44期14卷 6873-6875页

作者： Radoje B Colovic Nik.ca M Grubor Marjan T Micev Henry Dushan E atkinson Vitomir I Rank.vic Mihajlo M Jagodic Institute for Digestive Diseases Clinical Center of SerbiaFirst Surgical ClinicKoste Todorovica 6Belgrade11000Serbia Imperial College School of Medicine St Mary's HospitalPraed StreetLondon W21NYUnited Kingdom

Lymphangioma of the pancreas is an extremely rare benign tumour of lymphatic origin, with fewer than 60 published cases. Histologically, it is polycystic, with the cysts separated by thin septa and lined with endothelial cells. Though congenital, it can affect all age groups, and occurs more frequently in females. Patients usually present with epigastric pain and an associated palpable mass. Complete excision is curative, even though, depending on the tumour location, surgery may be simple or involve extensive pancreatic resection and anastomoses. The authors present a 49-year-old woman in whom a polycystic septated mass, 35 mm× 35 mm in size, was discovered by ultrasonography （US） in the body of the pancreas during investigations for epigastric pain and nausea. At surgery, a well circumscribed polycystic tumor was completely excised, with preservation of the pancreatic duct. The postoperative recovery was uneventful. Histology confirmed a microcystic lymphangioma of the pancreas. Immunohistochemistry showed cystic endothelial cells reactivity to factor Ⅷ -RA （＋＋）, CD31 （＋＋＋） and CD34 （-）. Postoperatively, abdominal pain disappeared and the patient remained symptomfree for 12 mo until now. Although extremely rare, lymphangioma of the pancreas should be tak.n into consideration as a differential diagnosis of a pancreatic cystic lesion, especially in women.

关键词： Pancreas Cystic lymphangioma Localsurgical excision

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Use of prototype two-channel endoscope with elevator enables larger lift-and-snare endoscopic mucosal resection in a porcine model

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Gastroenterology Report 2014年第1期2卷 54-57页

作者： Matthew atkinson Chik. Chuk.umah Jeffrey Mark. Amitabh Chak Case Western Reserve University College of Medicine CincinnatiOhioUSA

Back.round:Flat and depressed lesions are becoming increasingly recognized in the esophagus,stomach,and *** techniques have been described for endoscopic mucosal resection(EMR)of these ***:To evaluate the efficacy of lift-grasp-cut EMR using a prototype dual-channel forward-viewing endoscope with an instrument elevator in one accessory channel(dual-channel elevator scope)as compared to standard dual-channel ***:EMR was performed using a lift-grasp-cut technique on normal flat rectosigmoid or gastric mucosa in live porcine models after submucosal injection of 4mL of saline using a dual-channel elevator scope or a standard dual-channel *** the dual-channel elevator scope,the elevator was used to attain further lifting of the *** primary endpoint was size of the EMR specimen and the secondary endpoint was number of ***:Twelve experiments were performed(six gastric and six colonic).Mean specimen diameter was 2.27 cm with the dual-channel elevator scope and 1.34 cm with the dual-channel endoscope(P=0.018).Two colonic perforations occurred with the dual-channel endoscope,vs no complications with the dual-channel elevator ***:The increased lift of the mucosal epithelium,through use of the dual-channel elevator scope,allows for larger EMR when using a lift-grasp-cut *** the thin nature of the porcine colonic wall,use of the elevator may also mak. this technique safer.

关键词： endoscopic mucosal resection endoscopic polypectomy gastric cancer

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