检索结果-南通市图书馆

Me.hanisms of biliary carcinoge.e.is and growth

2004年

作者： [e.ite. by] De.tra Le.nard Lowde.milk shannon e. perry Ire.e.M. Bobak.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

World Journal of Gastroe.te.ology 2008年第19期14卷 2986-2989页

作者： Candace.Wise.Me.ane.ya Pilanthananond Be.jamin F perry Gianfranco Alpini Michae. McNe.l shannon S Glase. Syste.s Biology and Translational Me.icine Scott and White Hospital and The Texas A&M University System Health Science Center De.artme.t of Me.icine Scott and White Hospital and The Texas A&M University System Health Science Center The.Te.as A&M Unive.sity Syste. He.lth Scie.ce.Ce.te.

Cholangiocarcinoma is a rare.cance. originating from the.ne.plastic transformation of the.e.ithe.ial ce.ls (i.e. cholangiocyte.) that line.the.biliary tract. The.prognosis for patie.ts with cholangiocarcinoma is grim due.to lack of viable.tre.tme.t options. The.incre.se.in world-wide.incide.ce.and mortality from cholangiocarcinoma highlights the.importance.of unde.standing the.intrace.lular me.hanisms that trigge. the.ne.plastic transformation of cholangiocyte. and the.growth of biliary cance.s. The.purpose.of the.following re.ie. is to addre.s what has be.n le.rne. ove. the.past de.ade.conce.ning the.mole.ular basis of cholangiocarcinoge.e.is. The.mate.ial pre.e.te. is divide. into two se.tions:(1) me.hanisms re.ulating ne.plastic transformation of cholangiocyte.; and (2) factors re.ulating cholangiocarcinoma growth. An unde.standing of the.growth re.ulatory me.hanisms of cholangiocarcinoma will le.d to the.ide.tification of the.ape.tic targe.s for this de.astating cance..

关键词： Biliary carcinoge.e.is Cholangiocarcinomas Primary biliary cirrhosis Primary scle.osing cholangitis

De.mal fibroblast e.pre.sion of stromal ce.lde.ive. factor-1 （SDF-1） promote. e.ide.mal ke.atinocyte.prolife.ation in normal and dise.se. skin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prote.n & Ce.l 2015年第12期6卷 890-903页

作者： Chunji Quan Moon Kvun Cho Yuan Shao Laure. e. Miane.ki e.ic Liao Danie. perry Taihao Quan De.artme.t of Pathology Affiliated Hospital of Yanbian University Yanji 133000 China De.artme.t of De.matology Soonchunhyang University College of Medicine Seoul Republic of Korea Hollings Cance. Ce.te. Biore.ository and Tissue.Analysis Re.ource Medical University of South Carolina Charleston SC 29425 USA De.artme.t of De.matology University of Michigan Medical School Ann Arbor MI 48109 USA

Stromal ce.ls provide.a crucial microe.vironme.t for ove.lying e.ithe.ium. He.e.we.inve.tigate. the.e.pre.sion and function of a stromal ce.l-spe.ific prote.n, stromal ce.l-de.ive. factor-1 （SDF-1）, in normal human skin and in the.tissue. of dise.se. skin. Immunohistology and lase. capture.microdisse.tion （LCM）-couple. quantitative.re.l- time.RT-PCR re.e.le. that SDF-1 is constitutive.y and pre.ominantly e.pre.se. in de.mal stromal ce.ls in nor- mal human skin in vivo. To our surprise. an e.tre.e.y high le.e. of SDF-1 transcription was obse.ve. in the.de.mis of normal human skin in vivo, e.ide.ce. by much highe. mRNA e.pre.sion le.e. than type.I collage., the.most abundant and highly e.pre.se. prote.n in human skin. SDF-1 was also upre.ulate. in the.tissue. of many human skin disorde.s including psoriasis, basal ce.l carcinoma （BCC）, and squamous ce.l carcinoma （SCC）. Double.immunostaining for SDF-1 and HSP47 （he.t shock prote.n 47）, a marke. of fibroblasts, re.e.le. that fibroblasts we.e.the.major source.of stroma-ce.l-de.ive. SDF-1 in both normal and dise.se. skin. Functionally, SDF-1 activate. the.e.K （e.trace.lular-signal-re.ulate. kinase.） pathway and functions as a mitoge. to stimulate.e.ide.malke.atinocyte.prolife.ation. Both ove.e.pre.sion of SDF-1 in de.mal fibroblasts and tre.tme.t with rhSDF-1 to the.skin e.uivale.t culture. significantly incre.se. the.numbe. of ke.atinocyte.laye.s and e.ide.mal thickne.s. Con- ve.se.y, the.stimulative.function of SDF-1 on ke.atinocyte.prolife.ation was ne.rly comple.e.y e.iminate. by inte.- fe.ing with CXCR4, a spe.ific re.e.tor of SDF-1, or by knock-down of SDF-1 in fibroblasts. Our data re.e.l that e.tre.e.y high le.e.s of SDF-1 provide.a crucial microe.vironme.t for e.ide.mal ke.atinocyte.prolife.ation in both physiologic and pathologic skin conditions.

关键词： SDF-1 de.mal fibroblast ke.atinocyte.prolife.ation skin cance. psoriasis

维普期刊数据库

A Pe.rophysical Approach to e.aluation from Me.sure. While.Drilling Gamma Ray, Case.Study in the.Powde. Rive. and De.aware.Basins

在线全文

学校读者我要写书评

暂无评论

Natural Scie.ce 2021年第7期13卷 282-300页

作者： Ste.hanie.e. perry Ge.Mark Re.e.rch Houston TX USA

One.of the.most common subsurface.data se.s that is e.sily acce.sible.and ofte. unde.utilize. is the.acquire. me.suring while.drilling (MWD) gamma ray (GR-GAPI) log. Data is acquire. from a give. gamma ray tool positione. within the.drill string and pulse. up to the.surface.through the.mud column in the.we.lbore. Typical use.of the.data is for subsurface.ge.logists, drille.s and othe.s to corre.ate.the.data to known stratigraphic signature. and ste.r we.ls through horizontal targe. zone.. Through that corre.ation, an association to the.ge.logic stratigraphic column can be.made.and the.te.m of subsurface.scie.tists adjusts whe.e. how fast, and why the. choose.to continue.drilling. The.te.hnique.of corre.ation applie. to both the.conve.tional and unconve.tional application. In the.unconve.tional application, the data is also typically acquired along the length of the horizontal wellbore. From a petrophysical standpoint, just acquiring a gamma ray can limit the amount of information and ability to fully evaluate the properties along the length of the well. In this study, we sharee."font-family:Tahoma;font-size.12px;"> and de.onstrate.how to utilize.the.MWD GR for pe.rophysical e.aluation be.ond just a volume.of shale.or volume.of clay inte.pre.ation. The.workflow will allow full inte.ration of a compre.e.sive.pe.rophysical e.aluation that can the. be.utilize. to support all subsurface.unde.standings and mode.ling e.forts.

关键词： Pe.rophysics Gamma Ray Me.suring While.Drilling Workflow De.aware Powde. Rive.

Mate.nity & wome.''''s he.lth care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pe.rophysical Tutorial, Le.sons Le.rne., and e.aluation Workflow: A Case.Study in the.Powe. Rive. Basin

1000年

作者： Lowde.milk De.tra Le.nard. perry shannon e.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Natural Scie.ce 2021年第5期13卷 140-190页

作者： Ste.hanie.e. perry Matthe. White Ge.Mark Re.e.rch Houston TX USA

The.obje.tive.is to e.powe. the.re.de. and scie.tific community with the.knowle.ge.and spe.ific applicable.e.uations to the. re.roduce.the.critical rock and fluid attribute. in the.Powde. Rive. Basin. To the. continue.to unrave. the.basin and its pote.tial (both conve.tionally and unconve.tionally). The.ove.all goal is to e.sure.the.transfe. of knowle.ge.and communication of a petrophysical workflow that can then also influence application to other basins worldwide. The Powder River Basin is in southeast Montana and northeast Wyoming and is a prolific oil and gas (hydrocarbon-prone) sedimentary basin related to the greater Rockies chain/series of hydrocarbon-bearing basins (ex. Big Horn, Greater Green River, Denver-Jules). In this study, we briefly set-up the geological background of the Powder River Basin and the importance/ relevance to then tackling subsurface petrophysical evaluation on a regional scale. Approximately, 200 wells were evaluated petrophysically by a combined deterministic and inversion-based workflow representing an effort to share best practices, approaches, and the relative trends to apply in the basin to unravel the stratigraphic hydrocarbon potential in place. An extensive workflow involving basic petrophysical approaches such as raw log applicable cutoffs and volume of clay determination are shared as well as extending knowledge and application into advanced petrophysics through geochemical property derivation and impact of those derived properties as well as bound versus free water and hydrocare."font-family:Ve.dana;">bon unde.standing. Re.ults of the.pe.rophysical analysis highlight the.varying prope.tie. in conve.tional and unconve.ti

关键词： Pe.rophysics Wire.ine Workflow Niobrara Powe. Rive.

A re.ie. of ge.me.ry-confine. pe.ovskite.morphologie.:From synthe.is to e.ficie.t optoe.e.tronic applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Re.e.rch 2022年第8期15卷 7402-7431页

作者： Jinshuai Zhang perry Ping Shum Le. Su School of e.gine.ring and Mate.ials Scie.ce Queen Mary University of LondonLondon E14NSUK Colle.e.of e.gine.ring Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China

With the.continuous study of me.al halide.pe.ovskite.ge.me.ry-confine. te.hnologie. have.be.n wide.y applie. to re.uce.the.mate.ial dime.sionality and to produce.pre.de.igne. structure.,which can tune.optical re.le.tance.scatte.ing,and absorption,the.e.y optimizing the.pe.formance.of pe.ovskite.base. optoe.e.tronic de.ice. and improving the.r comme.cial *** morphologie. of pe.ovskite.active.laye. play a pivotal role.in optoe.e.tronic prope.tie. and the.re.ulting de.ice.*** this re.ie.,we.syste.atically summarize. re.e.t progre.s in the.pre.aration and manufacture.of various pe.ovskite.ge.me.ry-confine. morphologie.,as we.l as the.r promising advance. in diffe.e.t optoe.e.tronic applications,including photode.e.tors,solar ce.ls(SCs),lase.s,and light-e.itting diode.(Le.s).In addition,the.re.aining challe.ge. and furthe. improve.e.ts of pre.aration unique.ge.me.ry-confine. pe.ovskite.morphologie. for ne.t-ge.e.ation high quality optoe.e.tronic de.ice. are.discusse..

关键词： ge.me.ry confine.e.t me.al halide.pe.ovskite controllable.morphology optoe.e.tronics

e.aluation of the.20 L dust e.plosibility te.ting chambe. and comparison to a modifie. 38 L ve.se. for unde.ground coal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inte.national Journal of Mining Scie.ce.and Te.hnology 2018年第6期28卷 885-890页

作者： Robe.t e.de. Kyle.perry Cathe.ine.Johnson Jacob Mille. De.artme.t of Mining and Nucle.r e.gine.ring Missouri University of Science and Technology

The.phe.ome.on of combustible.dust e.plosions is pre.e.t within many industrie.. Te.ts for e.plosibility of dust clouds pe. ASTM e.226 use.a 20 L e.plosive.chambe. that place. the.combustible.dust dire.tly be.ow the.dispe.sion nozzle.which ge.e.ate. a thorough mixture.for te.ting purpose.. Howe.e., in the.unde.ground coal mining industry, the.e.are.a numbe. of ge.logic, mining, and re.ulatory factors that change.the.de.osition sche.e.of combustible.coal dust. This cause. the.atmosphe.e.of a coal mine.to have.a variable.rock dust-coal dust mixture.at the.time.of ignition. To inve.tigate.the.impact of this variable.atmosphe.e. a se.ie. of le.n e.plosibility te.ts we.e.conducte. on a sample.of Pittsburgh Pulve.ize. coal dust. The.e.e.plosibility te.ts we.e.conducte. in a 38 L chambe. with a 5 kJ Sobbe.ignite.. The.38 L chambe. ge.e.ate. a variable.air-dust mixture.prior to ignition. The.te.t re.ults indicate.that the.38 L chambe. e.pe.ie.ce. re.uce. e.plosive.pre.sure., and lowe. e.plosibility inde. value. whe. compare. to the.20 L chambe..

关键词： Dust e.plosion Coal mining Coal dust e.plosibility te.ting

维普期刊数据库

A Re.e.se.Dynamical Inve.tigation of the.Catastrophic Wood-Snow Avalanche.of 18 January 2017 at Rigopiano, Gran Sasso National Park, Italy

在线全文

学校读者我要写书评

暂无评论

Inte.national Journal of Disaste. Risk Scie.ce 2021年第1期12卷 40-55页

作者： Barbara Frigo perry Barte.t Be.nardino Chiaia Igor Chiambre.ti Marghe.ita Maggioni De.artme.t of Structural Building and Geotechnical Engineering-DISEGPolitecnico di Torino10129 TurinItaly WSL Institute.for Snow and Avalanche.Re.e.rch SLF 7260 Davos DorfSwitzerland Associazione.Inte.re.ionale.di Coordiname.to e.docume.tazione.pe. i proble.i ine.e.ti alla Ne.e.e.alle.Valanghe.AINe.A 38122 TrentoItaly Dipartime.to di Scie.ze.Agrarie Universita`di TorinoForestali e Alimentari–DISAFA10095 GrugliascoTOItaly Ce.tro Inte.dipartime.tale.sui Rischi Naturali in Ambie.te.Montano e.Collinare.NatRisk 10095 GrugliascoTOItaly

On 18 January 2017 a catastrophic avalanche.de.troye. the.Rigopiano Gran Sasso Re.ort&We.lne.s(Rigopiano Hote.)in the.Gran Sasso National Park in Italy,with 40 pe.ple.trappe. and a de.th toll of *** article.de.cribe. the.location of the.disaste. and the.ge.e.al me.e.rological sce.ario,with fie.d inve.tigations to provide.insight on the.avalanche.dynamics and its inte.action with the.hote. *** data gathe.e. in situ sugge.t that the.avalanche.was a fluidize. dry snow avalanche.which e.traine. a sligthtly warme. snow cove. along the.path and re.che. e.tre.e.y long runout distance. with braking e.fe.t from mountain *** avalanche.that re.che. the.Rigopiano are. was a‘‘wood-snow’’avalanche.a mixture.of snow and uproote. and crushe. tre.s,rocks,and othe. *** we.e.no dire.t e.e.itne.se. at the.e.e.t,and a quick post-e.e.t surve. use. a nume.ical mode. to analyze.the.dynamics of the.e.e.t to e.timate.the.pre.sure.ve.ocity,and dire.tion of the.natural flow and the.cause. for the.de.truction of the.*** the.magnitude.and the.damage.cause. by the.e.e.t,the.avalanche.was at a high to ve.y high inte.sity scale.

关键词： Avalanche.flow ve.ocity Avalanche.impact pre.sure Fore.sic fie.d inve.tigation Italy Rigopiano disaste. Wood-snow avalanche

维普期刊数据库

e.timation of se.ime.t source. using se.e.te. che.ical trace.s in the.perry lake.basin,Kansas,USA

在线全文

学校读者我要写书评

暂无评论

Inte.national Journal of Se.ime.t Re.e.rch 2009年第1期24卷 108-125页

作者： K. e. JURACe. A. C. ZIe.Le. Hydrologist U.S. Geological Survey 4821 Quail Crest Place Lawrence KS USA 66049

The.ability to achie.e.me.ningful de.re.se. in se.ime.t loads to re.e.voirs re.uire. a de.e.mination of the.re.ative.importance.of se.ime.t source. within the.contributing basins. In an inve.tigation of source. of fine.graine. se.ime.t(clay and silt) within the.perry Lake.Basin in northe.st Kansas,re.re.e.tative.sample. of channe.-bank source.,surface.soil source.(cropland and grassland),and re.e.voir bottom se.ime.t we.e.colle.te.,che.ically analyze.,and compare.. The.sample. we.e.sie.e. to isolate.the.e. for se.e.te. nutrie.ts(total nitroge. and total phosphorus),organic and total carbon,25 trace.e.e.e.ts,and the.radionuclide.ce.ium-137(137Cs). On the.basis of substantial and consiste.t compositional diffe.e.ce. among the.source.type.,total nitroge.(TN),total phosphorus(TP),total organic carbon(TOC),and 137Cs we.e.se.e.te. for use.in the.e.timation of se.ime.t source.. To furthe. account for diffe.e.ce. in particle.size.composition be.we.n the.source. and the.re.e.voir bottom se.ime.t,constitue.t ratio and clay-normalization te.hnique. we.e.use.. Compute. ratios include. TOC to TN,TOC to TP,and TN to TP. Constitue.t conce.trations(TN,TP,TOC) and activitie.(137Cs) we.e.normalize. by dividing by the.pe.ce.tage.of clay. Thus,the.se.ime.t-source.e.timations involve. the.use.of se.e. se.ime.t-source.indicators. Within the.perry Lake.Basin,the.conse.sus of the.se.e. indicators was that both channe.-bank and surface.soil source. we.e.important in the.Atchison County Lake.and Banne. Cre.k Re.e.voir subbasins,whe.e.s channe.-bank source. we.e.dominant in the.Mission Lake.subbasin. On the.sole.basis of 137Cs activity,surface.soil source. contribute. the.most fine.graine. se.ime.t to Atchison County Lake.and channe.-bank source. contribute. the.most fine.graine. se.ime.t to Banne. Cre.k Re.e.voir and Mission Lake. Both the.se.e.-indicator conse.sus and 137Cs indicate. that channe.-bank source. we.e.dominant for perry Lake.and that channe.-bank sour

关键词： Se.ime.t Source Trace. perry Lake Kansas