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Contact pattern,current immune barrier,and pathogen virulence determines the optimal strategy of further vaccination

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Infectious Disease Modelling 2023年第1期8卷 192-202页

作者： Xiaohao Guo Ziyan Liu Shiting Yang Zeyu zhao Yichao Guo Guzainuer Abudurusuli Shanlu Zhao Ge Zeng Shixiong Hu Kaiwei Luo Tianmu Chen State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen City361102Fujian ProvincePeople's Republic of China Hunan Provincial Center for Disease Control and Prevention 405 Furong Middle Road Section OneKaifu DistrictChangsha City410001Hunan ProvincePeople's Republic of China

Background:The current outbreak of novel coronavirus disease 2019 has caused a seriousdisease burden worldwide.Vaccines are an important factor to sustain the epidemic.Although with a relatively high-vaccination worldwide,the decay of vaccine efficacy andthe arising of new variants lead us to the challenge of maintaining a sufficient immunebarrier to protect the population.Method:A case-contact tracking data in Hunan,China,is used to estimate the contactpattern of cases for scenarios including school,workspace,etc,rather than ordinary susceptible population.Based on the estimated vaccine coverage and efficacy,a multi-groupvaccinated-exposed-presymptomatic-symptomatic-asymptomatic-removed model(VEFIAR)with 8 age groups,with each partitioned into 4 vaccination status groups isdeveloped.The optimal dose-wise vaccinating strategy is optimized based on the currentlyestimated immunity barrier of coverage and efficacy,using the greedy algorithm thatminimizes the cumulative cases,population size of hospitalization and fatality respectivelyin a certain future interval.Parameters of Delta and Omicron variants are used respectivelyin the optimization.Results:The estimated contact matrices of cases showed a concentration on middle ages,and has compatible magnitudes compared to estimations from contact surveys in otherstudies.The VEFIAR model is numerically stable.The optimal controled vaccination strategy requires immediate vaccination on the un-vaccinated high-contact population of age30e39 to reduce the cumulative cases,and is stable with different basic reproductionnumbers(R_(0)).As for minimizing hospitalization and fatality,the optimized strategy requires vaccination on the un-vaccinated of both aged 30e39 of high contact frequencyand the vulnerable older.Conclusion:The objective of reducing transmission requires vaccination in age groups ofthe highest contact frequency,with more priority for un-vaccinated than un-fully or fullyvaccinated.The objective of reducing total hospitalization and fatality requires not only tor

关键词： Vaccine Allocation strategy SARS-CoV-2 Optimal control Immune barrier Contact pattern Greedy algorithm

Transmission Dynamics and Epidemiological Characteristics of the SARS-CoV-2 Delta Variant ― Hunan Province, China, 2021

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China CDC weekly 2023年第3期5卷 56-62,I0006-I0009页

作者： Kaiwei Luo Yanpeng Wu Yan Wang Ziyan Liu Lan Yi Shanlu Zhao Xuemei Yan Hao Yang Kaiyuan Sun Marco Ajelli Shixiong Hu Hongjie Yu Hunan Provincial Center for Disease Control and Prevention Workstation for Emerging Infectious Disease Control and PreventionChinese Academy of Medical SciencesChangsha CityHunan ProvinceChina Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai MunicipalityChina School of Public Health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai MunicipalityChina Division of International Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaMDUSA Laboratory of Computational Epidemiology and Public Health Department of Epidemiology and BiostatisticsIndiana University School of Public HealthBloomingtonINUSA

Monitoring changes in the epidemiologic features between different severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants is key to understanding the evolution of viral fitness in the host population.Here,we analyzed a successfully contained local outbreak of the Delta variant that took place in Hunan,China,in July–August,2021.Detailed data on SARS-CoV-2 infections and their contacts were collected during the outbreak.By leveraging these data,we estimated key epidemiological parameters,including the incubation period,serial interval,and generation time.We constructed a generalized linear mixed-effects model(GLMM)to quantify risk factors for Delta infection and transmission.Between July 28 and August 15,2021,a total of 129 infections and their 2,118 close contacts were identified during the outbreak in Hunan Province.

关键词： Hunan population Province

A follow up study of cycle threshold values of SARS-CoV-2 in Hunan Province,China

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Infectious Disease Modelling 2023年第1期8卷 203-211页

作者： Guzainuer Abudurusuli Kaiwei Luo Xiaohao Guo Zeyu zhao Yichao Guo Buasiyamu Abudunaibi Shiting Yang Hongjie Wei Shanlu Zhao Zhihui Dai Qianlai Sun Hao Yang Shixiong Hu Tianmu Chen State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen CityFujian ProvincePeople's Republic of China Hunan Provincial Center for Disease Control and Prevention Changsha City410001Hunan ProvincePeople's Republic of China

Since the epidemic of the severe acute respiratory syndrome coronavirus 2(SARS-COV-2),many governments have used reverse transcription polymerase chain reaction(RT-PCR)to detect the virus.However,there are fewer measures of CT values information based on RT-PCR results,and the relationship between CT values and factors from consecutive tests is not clear enough.So in this study,we analyzed the connection between CT values and the factors based on cohort data from Delta variant of SARS-CoV-2 in Hunan Province.Previous studies have showed that the mean age of the cases was 33.34 years(±18.72 years),with a female predominance(55.03%,n=71),and the greatest proportion of clinical symptoms were of the common type(60.47%,n=78).There were statistical differences between the N and ORF1ab genes in the CT values for the cases.Based on the analysis of the association between CT values and the factors,the lowest CT values were obtained for the unvaccinated,older and clinically symptomatic group at 3e10 days,the maximum peak of viral load occurred.Therefore,it is recommended to use patient information to focus on older,clinically symptomatic,unvaccinated patients and to intervene promptly upon admission.

关键词： SARS-COV-2 CT values Delta variant Influencing factors

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某型飞行模拟器荷兰滚模态的验证研究

电子测试 2018年第19期29卷 35-36,24页

作者：赵善禄闫思齐空军航空大学吉林长春130000

针对某型飞行模拟器,首先对短周期模态的阻尼比和自振频率进行了验证研究,然后提取了该型模拟器荷兰滚模态四个相关参数的时间历程曲线,其次在时域内运用平均标准化距离检验方法和灰色关联分析方法对飞行模拟仿真数据和飞参数据进行了... 详细信息

针对某型飞行模拟器,首先对短周期模态的阻尼比和自振频率进行了验证研究,然后提取了该型模拟器荷兰滚模态四个相关参数的时间历程曲线,其次在时域内运用平均标准化距离检验方法和灰色关联分析方法对飞行模拟仿真数据和飞参数据进行了一致性检验,在频域内运用经典谱估计的方法完成了飞行模拟仿真数据和飞参数据的量化评估,并改进了证据理论,从而合成了时域和频域的一致性检验结果。

关键词：模拟器阻尼比自振频率一致性逼真度

Viologen-based flexible electrochromic devices

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Journal of Energy Chemistry 2024年第6期93卷 453-470页

作者： Wenwen Wu shanlu Guo Jing Bian Xingyu He Haizeng Li Jianmin Li College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts and Telecommunications Department of Pathology College of Medicine University of Cincinnati Optics and Thermal Radiation Research Center Institute of Frontier and Interdisciplinary Science Shandong University

Electrochromic technology has gained significant attention in various fields such as displays,smart windows,biomedical monitoring,military camouflage,human-machine interaction,and electronic skin due to its ability to provide reversible and fast color changes under applied voltage.With the rapid development and increasing demand for flexible electronics,flexible electrochromic devices(FECDs) that offer smarter and more controllable light modulation hold great promise for practical applications.The electrochromic material(ECM) undergoing color changes during the electrochemical reactions is one of the key components in electrochromic devices.Among the ECMs,viologens,a family of organic small molecules with 1,1’-disubstituted-4,4’-dipyridinium salts,have garnered extensive research interest,due to their well-reversible redox reactions,excellent electron acceptance ability,and the ability to produce multiple colors.Notably,viologen-based FECDs demonstrate color changes in the liquid or semisolid electrolyte layer,eliminating the need for two solid electrodes and thus simplifying the device structure.Consequently,viologens offer significant potential for the development of FECDs with high optical contrast,fast response speed,and excellent stability.This review aims to provide a comprehensive overview of the progress and perspectives of viologen-based FECDs.It begins by summarizing the typical structure and recent exciting developments in viologen-based FECDs,along with their advantages and disadvantages.Furthermore,the review discusses recent advancements in FECDs with additional functionalities such as sensing,photochromism,and energy storage.Finally,the remaining challenges and potential research directions for the future of viologen-based FECDs are addressed.

关键词： Electrochromism Flexible electrochromic devices Flexible electronics Multifunctional devices Optical modulation Viologens

绘画与建筑空间相遇——“钦博特项目”与汉斯·霍夫曼晚期风格的形成

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艺术学研究 2022年第2期 102-111页

作者：王珊禄中国美术学院艺术人文学院

汉斯·霍夫曼晚期绘画风格以“砖块画”著称,这种绘画风格的形成与其1950年参与的城市壁画创作“钦博特项目”有密切关系。正是在这个项目中,绘画与建筑空间的相遇,促使霍夫曼必须面对尺幅巨大的壁画,从而引发霍夫曼在原有绘画原则下,... 详细信息

汉斯·霍夫曼晚期绘画风格以“砖块画”著称,这种绘画风格的形成与其1950年参与的城市壁画创作“钦博特项目”有密切关系。正是在这个项目中,绘画与建筑空间的相遇,促使霍夫曼必须面对尺幅巨大的壁画,从而引发霍夫曼在原有绘画原则下,对“装饰活力”“图画空间”“推拉原理”和“纪念碑性”等概念进行更为深入的探索,最终推动其架上绘画走向一种多矩形、大色块和纯色调的表达方式。

关键词：汉斯·霍夫曼图画空间建筑空间钦博特

青鹏软膏联合针刺推拿治疗青藏地区膝骨关节炎患者的临床效果研究

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中国医药 2023年第9期18卷 1396-1400页

作者：保善录赵亮祁永红陈鲜霞高彤赵秀红唐纯志青海省人民医院中西医结合科西宁810000 青海省人民医院影像科西宁810000 青海省人民医院超声科西宁810000 广州中医药大学针灸康复临床医学院广州510006

目的观察青鹏软膏联合针刺推拿治疗青藏地区膝骨关节炎(KOA)患者的临床效果。方法选取2021年3月至2022年3月青海省人民医院门诊收治的KOA患者80例,按照随机数字表法分为对照组和观察组,各40例。对照组给予口服硫酸氨基葡萄糖片;观察组... 详细信息

目的观察青鹏软膏联合针刺推拿治疗青藏地区膝骨关节炎(KOA)患者的临床效果。方法选取2021年3月至2022年3月青海省人民医院门诊收治的KOA患者80例,按照随机数字表法分为对照组和观察组,各40例。对照组给予口服硫酸氨基葡萄糖片;观察组给予青鹏软膏联合针刺推拿治疗。比较2组患者治疗前、治疗后、停止治疗3个月后血清炎症因子白细胞介素1β(IL-1β)、IL-6、肿瘤坏死因子α(TNF-α)水平,患侧膝关节视觉模拟量表(VAS)疼痛评分、Lysholm膝关节功能评分、患膝关节被动屈曲度(PROM)。比较2组患者临床疗效。结果治疗后,观察组IL-6水平低于对照组,差异有统计学意义(P0.05)。停止治疗3个月后,观察组总有效率明显高于对照组[95.0%(38/40)比52.5%(21/40)](P<0.05)。结论青鹏软膏联合针刺推拿治疗KOA短期疗效明显,长期疗效维持较好,能有效缓解患者膝关节痛和活动功能障碍。

关键词：膝骨关节炎青鹏软膏针刺推拿

欧洲现代主义艺术观念向美国的流动——以汉斯·霍夫曼为例

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湖北美术学院学报 2020年第3期23卷 75-81页

作者：王珊禄中国美术学院

抽象表现主义的形成,使美国一跃成为世界的艺术中心,这种中心的形成,并非完全由本土艺术家主导,更多的原因来自于全球艺术人口的迁徙。分析这些主导艺术家艺术风格与艺术思想的形成与变化,有利于理解抽象表现主义艺术不同风格的来源,也... 详细信息

抽象表现主义的形成,使美国一跃成为世界的艺术中心,这种中心的形成,并非完全由本土艺术家主导,更多的原因来自于全球艺术人口的迁徙。分析这些主导艺术家艺术风格与艺术思想的形成与变化,有利于理解抽象表现主义艺术不同风格的来源,也从宏观上有利于理解艺术思想的传播,以及这种传播对目标区域艺术所产生的可能的影响。本文将以汉斯·霍夫曼为例,分析欧洲现代艺术理念向新大陆流动的过程,探讨抽象表现主义运动艺术思想的欧洲源头。

关键词：艺术的界定 “看”艺术城市化余虹

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华兹华斯“童年主题”诗歌及其教育启示

豫章师范学院学报 2021年第5期36卷 110-113页

作者：徐珊璐豫章师范学院学前教育学院江西南昌330103

华兹华斯是英国浪漫主义诗派的代表人物,在家庭生活和自然环境的滋养下,他创作了许多与童年有关的作品。华兹华斯的童年诗歌风格轻快,内容充满灵性,体现了童年的凝思,童年的乐趣,童年的品性。诗歌中蕴含的推崇幼儿美德,尊重幼儿天性,相... 详细信息

华兹华斯是英国浪漫主义诗派的代表人物,在家庭生活和自然环境的滋养下,他创作了许多与童年有关的作品。华兹华斯的童年诗歌风格轻快,内容充满灵性,体现了童年的凝思,童年的乐趣,童年的品性。诗歌中蕴含的推崇幼儿美德,尊重幼儿天性,相信幼儿能力在当今学前教育和家庭教育的实践中仍能发挥持续而深远的教育启示作用。

关键词：华兹华斯诗歌童年主题教育启示