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Differential physiological responses of the coastal cyanobacterium Synechococcus sp. PCC7002 to elevated pCO2 at lag, exponential,and stationary growth phases

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Science China Earth Sciences 2018年第10期61卷 1397-1405页

作者： shanli MOU Gang LI Hongmei LI Fazhong LI Zhisheng SHAO Jinsong LI Changfeng QU Yongyu ZHANG Key Laboratory of Biofuels Shandong Provincial Key Laboratory of Energy Genetics Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301 China Zhanjiang Branch of China National Offshore Oil Corporation Ltd. Zhanjiang 524000 China Key Laboratory of Marine Bioactive Substance the First Institute of OceanographyState Oceanic AdministrationQingdao 266061 China

We studied the effects of expected end-of-the-century p CO_2(1000 ppm)on the photosynthetic performance of a coastal marine cyanobacterium Synechococcus ***7002 during the lag,exponential,and stationary growth *** p CO_2significantly stimulated growth,and enhanced the maximum cell density during the stationary *** ambient p CO_2conditions,the lag phase lasted for 6 days,while elevated p CO_2shortened the lag phase to two days and extended the exponential phase by four *** elevated p CO_2increased photosynthesis levels during the lag and exponential phases,but reduced them during the stationary ***,the elevated p CO_2reduced the saturated growth light(Ik)and increased the light utilization efficiency(α)during the exponential and stationary phases,and elevated the phycobilisome:chlorophyll a(Chl a)***,the elevated p CO_2reduced the particulate organic carbon(POC):Chl a and particulate organic nitrogen(PON):Chl a ratios during the lag and stationary phases,but enhanced them during the exponential ***,Synechococcus showed differential physiological responses to elevated p CO_2during different growth phases,thus providing insight into previous studies that focused on only the exponential phase,which may have biased the results relative to the effects of elevated p CO_2in ecology or aquaculture.

关键词： Elevated pCO2 Lag Exponential and stationary phases Photosynthetic performance Synechococcus

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推拿对颈型颈椎病炎性痛的镇痛作用及对PI3K/AKT/mTOR通路RNA表达水平的影响

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中国医药指南 2024年第25期22卷 6-9页

作者：陈进城林志刚何坚陈水金江煜林荣杨一涵陈乐春张幻真蒋晶晶谷俊刚程静杨珊莉福建中医药大学附属康复医院福州350003 福建省康复技术重点实验室福州350003 福建中医药大学康复医学院福州350122 漳州卫生职业学院漳州363000

目的研究推拿治疗颈型颈椎病炎性痛的镇痛机制。方法将12只兔采用随机数字表法分为空白组、模型组、推拿组,模型组和推拿组用无创颈型颈椎病动物模型,推拿组采用推拿治疗,模型组和空白组不予干预。治疗后用HE染色观察颈后肌组织形态;经... 详细信息

目的研究推拿治疗颈型颈椎病炎性痛的镇痛机制。方法将12只兔采用随机数字表法分为空白组、模型组、推拿组,模型组和推拿组用无创颈型颈椎病动物模型,推拿组采用推拿治疗,模型组和空白组不予干预。治疗后用HE染色观察颈后肌组织形态;经酶联免疫吸附试验(ELISA)测定血清肿瘤坏死因子(TNF-α)和白细胞介素1β(IL-1β)。经RT-qPCR检测各组PI3K、AKT、mTOR通路的mRNA表达水平。结果推拿组肌纤维断裂处炎症细胞比模型组逐渐减少,肌原纤维排列整齐。模型组与空白组相比,血清TNF-α、IL-1β含量增高(P<0.01);推拿组较模型组的表达均下降(P<0.05);模型组较空白组PI3K、AKT、mTOR的mRNA表达上升(P<0.05);推拿组mRNA表达水平较模型组降低(P<0.05)。结论推拿能够降低颈型颈椎病炎性痛模型炎症因子TNF-α、IL-1β水平,可能通过降低PI3K/AKT/mTOR通路mRNA的表达发挥镇痛作用。

关键词：颈型颈椎病推拿炎性痛 PI3K/AKT/mTOR通路

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CLOSURE OF ANALYTIC FUNCTIONS OF THE BOUNDED MEAN OSCILLATION IN LOGARITHMIC BLOCH SPACES

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Acta Mathematica Scientia 2023年第1期43卷 43-50页

作者：叶善力周智慧 School of Science Zhejiang University of Science and TechnologyHangzhou310023China

For anyα∈R,the logarithmic Bloch space BLαconsists of those functions f which are analytic in the unit disk D with.■In this paper,we characterize the closure of the analytic functions of bounded mean oscillation B... 详细信息

关键词： closure logarithmic Bloch spaces BMOA

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On a Standard Parametric Modeling Method of Micro-Structure of Plain Woven Composite

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Journal of Textile Science and Technology 2016年第3期2卷 56-66页

作者： shanli Wang Information Center Tianjin Polytechnic University Tianjin China

A new standard parametric modeling method of the micro-structure of plain woven composite is proposed. It is based on good analysis of the mechanical property of the yarn, weaving law of plain woven, and other factors. The method implements a woven fabric composite visual engineering modeling process standardization, and it gives five steps to calculate the key micro-structural parameters of the yarn including the cross-section and the trajectory of the central Line. On the basis, the digital model of a plain woven composite has been constructed. The experimental result shows that the forecast for the mechanical property of the model using finite-element simulation analysis is consistent with the actual value. The shape and the structure of the model are also consistent with the solid.

关键词： Plain Woven Composite Micro-Structure Parametric Modeling Standardization Process

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240 nm AlGaN-based deep ultraviolet micro-LEDs:size effect versus edge effect

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Journal of Semiconductors 2024年第1期45卷 55-62页

作者： Shunpeng Lu Jiangxiao Bai Hongbo Li Ke Jiang Jianwei Ben shanli Zhang Zi-Hui Zhang Xiaojuan Sun Dabing Li State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Electronic Materials and Devices of Tianjin School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China

240 nm AlGaN-based micro-LEDs with different sizes are designed and ***,the external quantum efficiency(EQE)and light extraction efficiency(LEE)are systematically investigated by comparing size and edge ***,it is revealed that the peak optical output power increases by 81.83%with the size shrinking from 50.0 to 25.0μ***,the LEE increases by 26.21%and the LEE enhancement mainly comes from the sidewall light *** notably,transversemagnetic(TM)mode light intensifies faster as the size shrinks due to the tilted mesa side-wall and Al reflector ***,when it turns to 12.5μm sized micro-LEDs,the output power is lower than 25.0μm sized *** underlying mechanism is that even though protected by SiO2 passivation,the edge effect which leads to current leakage and Shockley-Read-Hall(SRH)recombination deteriorates rapidly with the size further ***,the ratio of the p-contact area to mesa area is much lower,which deteriorates the p-type current spreading at the mesa *** findings show a role of thumb for the design of high efficiency micro-LEDs with wavelength below 250 nm,which will pave the way for wide applications of deep ultraviolet(DUV)micro-LEDs.

关键词： AlGaN deep ultraviolet micro-LEDs light extraction efficiency size effect edge effect

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Geochronology and Geochemical Characteristics of Intrusion in the Jinchangliang Gold Deposit,Inner Mongolia and Their Tectonic Significance

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Acta Geologica Sinica(English Edition) 2015年第6期89卷 1947-1962页

作者： SUN Zhenjun SUN Guosheng YU Henan TIAN Yi LIU shanli XIANG Zhu MENG Jian XUE Huaiyu LU Lina Department of Earthquake Science Institute of disaster prevention Science and Technology College of Earth Sciences Jilin University Liaoning Survey Academy of Geology and Mineral Resources Geophysical Research Institute of Jilin Province

Discovered and mined in recent years, the Jinchangliang gold deposit has not yet been studied in its genetic type. In this paper, the geological features of ore deposit, S isotopic composition, metallogenic age and elements geochemical of the granite closely related to mineralization were discussed. The results of the geological features of ore deposit and S isotopic composition show that ore-bearing hydrothermal solution was closely related with the intrusion of magmatic. The granite is characteristic of high silica SiO2=72.38%–72.98%, high aluminum and Al2O3=14.22%–14.35%, low calcium CaO=0.16% –0.26%, and low value of FeOT/MgO（6.86–7.73）, and rich in alkalis Na2O+K2O=9.11%–9.24%, suggesting that it is high-K calc-alkaline, highly fractionated, weak aluminum A-type granite. The REE patterns are inclined to right and show intense fractionation between LREE and HREE, without obvious negative Eu anomaly（δEu=0.80–0.84）. The primitive mantle-normalized spidergrams are characterized by depletion of Ba, U, Ta, Nb, Zr, Ti and P, which implies that the granite has the characteristics of the crust-mantle mixing. S isotopes also indicate that the material source of gold deposit is closely related to the granite rocks. The LA-ICP-MS Zircon UPb age of the Damiao rock mass medium-fine grained monzogranite（belonging to the early IndoChina） is（245±1） Ma. It shows that Jinchangliang gold deposit was not formed in Yanshanian, but the early Indo-China. Specifically speaking, the deposit was formed in the collision stage of the North China plate and the Siberian plate.

关键词： Geochemistry LA-ICP-MS zircon U-Pb dating Early Indo-China diagenesis and metallogenic Aohanqi Inner Mongolia

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Superantigen-SEA gene modified tumor vaccine for hepatocellular carcinoma:An in vitro study

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World Journal of Gastroenterology 2004年第1期10卷 53-57页

作者： Shao-YingLu Yan-FangSui Zeng-shanli Jing-Ye Hai-LongDong PingQu Xiu-MinZhang Yu-SongLi DepartmentofPathology FourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina DepartmentofPathology FourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina

AIM: To construct an eukaryotic superantigen gene expression vector containing the recombinant gene of SEA and CD80 molecule transmembrane region (CD80TM), and to expresss taphylococcus enterotoxin A (SEA) on the membrane of hepatocellular carcinoma (HCC) cell to form a superantigen gene modified tumor vaccine for HCC. METHODS: SEA and linker-CD80TM gene were amplified through PCR from plasmid containing cDNA of SEA and *** fragments were then subcloned into the multiple cloning sites of retroviral vector pLXSN. Recombinant plasmid was transferred into HepG2 cells mediated with lipofectamine,positive clones were selected in culture medium containing G418. RT-PCR and indirect immunofluorescence studies confirmed that SEA was expressed specifically on HCC cell membrane. INFT-ELISPOT study demonstrated that SEA protein was expressed on the membrane of HCC *** of HepG2-SEA primed CTLs (SEA-T) was analyzed by^51Cr release assay. T cells cultured with rhIL-2 (IL-2-T) were used as control. RESULTS: Restriction digestion and sequence analyses confirmed the correctness of length, position and orientation of inserted fusion genes. SEA was expressed on the surface of HepG2 cells, HepG2-SEA had strong stimulating effect on production of HepG2 specific CTL (P<0.001). SEA-T had enhanced cytotoxicity to HepG2 cells (P<0.05). CONCLUSION: Tumor cell membrane expressed superarfdgen can be used to reinforce the immune effect of tumor cell vaccine for HCC, which provides a new method of the enhanced active immunotherapy for HCC.

关键词：超抗原-SEA基因肿瘤疫苗肝细胞癌体内试验免疫疗法

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Development and application of stem cells

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Chinese Medical Journal 2005年第10期118卷 795-798页

作者： HUIGuo-zhen shanli-dong DepartmentofNeurosurgery FirstAffiliatedHospitalofSoochowUniversitySuzhou215006China aboratoryofNeurobiology MedicalSchoolofSoochowUniversitySuzhou215007China

Stem cells are defined by two important characteristics: the ability to proliferate by a process of self-renewal and the potential to form at least one specialized cell type. Transient population of pluripotent or multipotent stem cells first appear during the development at the first days post coitum. The cells of the inner cell mass (ICM) of the blastocyst, of which embryonic stem cells (ES) are the in vitro counterpart, can give rise to any differentiated cell type in the three primary germ layers of the embryo (endoderm, mesoderm and ectoderm).^(1-3) These cells gradually mature into committed, organ- and tissue-specific stem cells or adult stem cells, such as neural stem cells, mesenchymal stem cells, hematopoietic stem cells, etc. Over the past years, studies have focused on two aspects: molecular level and application, and some new methods and technology have been used.

关键词： embryonic stem cells neural stem cells inner cell mass new methods in vitro

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Rapid inactivation of human respiratory RNA viruses by deep ultraviolet irradiation from light-emitting diodes on a high-temperatureannealed AlN/Sapphire template

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Opto-Electronic Advances 2023年第9期6卷 31-43页

作者： Ke Jiang Simeng Liang Xiaojuan Sun Jianwei Ben Liang Qu shanli Zhang yang Chen Yucheng Zheng Ke Lan Dabing Li Ke Xu State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Institute for Vaccine Research Animal Biosafety Level 3 LaboratoryWuhan UniversityWuhan 430072China

Efficient and eco-friendly disinfection of air-borne human respiratory RNA viruses is pursued in both public environment and portable *** AlGaN-based deep ultraviolet(DUV)light-emission diode(LED)has high practical potentials because of its advantages of variable wavelength,rapid sterilization,environmental protection,and ***,whether the emission wavelength has effects on the disinfection as well as whether the device is feasible to sterilize various respiratory RNA viruses under portable conditions is ***,we fabricate AlGaN-based DUV LEDs with different wavelength on high-temperature-annealed(HTA)AlN/Sapphire templates and investigate the inactivation effects for several respiratory RNA *** AlN/AlGaN superlattices are employed between the template and upper n-AlGaN to release the strong compressive stress(SCS),improving the crystal quality and interface *** LEDs with the wavelength of 256,265,and 278 nm,corresponding to the light output power of 6.8,9.6,and 12.5 mW,are realized,among which the 256 nm-LED shows the most potent inactivation effect in human respiratory RNA viruses,including SARS-CoV-2,influenza A virus(IAV),and human parainfluenza virus(HPIV),at a similar light power density(LPD)of~0.8 mW/cm2 for 10 *** results will contribute to the advanced DUV LED application of disinfecting viruses with high potency and broad spectrum in a portable and eco-friendly use.

关键词： AlGaN DUV LED superlattice SARS-CoV-2 influenza A virus

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Toeplitz Operators and Algebras on Dirichlet Spaces

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Communications in Mathematical Research 1999年第1期 1-4页

作者： Cao Guangfu (Department of Mathematics, Sichuan University, Chengdu, 610064) Sun shanli

ＬｅｔＤｂｅｔｈｅｕｎｉｔｄｉｓｋｉｎｔｈｅｃｏｍｐｌｅｘｐｌａｎｅＣ，ａｎｄｄＡ（ｚ）＝１πｄｘｄｙｔｈｅｎｏｒｍａｌｉｚｅｄＬｅｂｅｓｇｕｅｍｅａｓｕｒｅｏｎＤ．ＴｈｅＳｏｂｏｌｅｖｓｐａｃｅＬ２，１ｉｓｄｅｆｉ... 详细信息

ＬｅｔＤｂｅｔｈｅｕｎｉｔｄｉｓｋｉｎｔｈｅｃｏｍｐｌｅｘｐｌａｎｅＣ，ａｎｄｄＡ（ｚ）＝１πｄｘｄｙｔｈｅｎｏｒｍａｌｉｚｅｄＬｅｂｅｓｇｕｅｍｅａｓｕｒｅｏｎＤ．ＴｈｅＳｏｂｏｌｅｖｓｐａｃｅＬ２，１ｉｓｄｅｆｉｎｅｄｔｏｂｅｔｈｅｃｏｌｅｃｔｉ...

关键词： Dirichlet Space Toeplitz Operator Toeplitz Algebra

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