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A micro amperometric immunosensor for detection of human immunoglobulin

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Science in China(Series F) 2006年第3期49卷 397-408页

作者： XU Yuanyuan XIA shanhong BIAN Chao chen Shaofeng State Key Laboratory of Transducer Technology Institute of Electronics Chinese Academy of SciencesBeijing 100080 China

A novel amperometric immunosensor based on the micro electromechanical systems （MEMS） technology, using protein A and self-assembled monolayers （SAMs） for the orientation-controlled immobilization of antibodies, has been developed. Using MEMS technology, an ＂Au, Pt, Pt＂ three-microelectrode system enclosed in a SU-8 micro pool was fabricated. Employing SAMs, a monolayer of protein A was immobilized on the cysteamine modified Au electrode to achieve the orientation-controlled immobilization of the human immunoglobulin （HIgG） antibody. The immunosensor aimed at low unit cost, small dimension, high level of integration and the prospect of a biosensor system-on-a-chip. Cyclic voltammetry and chronoamperometry were conducted to characterize the immunosensor. Compared with the traditional immunosensor using bulky gold electrode or screen-printed electrode and the procedure directly binding protein A to electrode for immobilization of antibodies, it had attractive advantages, such as miniaturization, compatibility with CMOS technology, fast response （30 s）, broad linear range （50-400 pg/L） and low detection limit （10 pg/L） for HIgG. In addition, this immunosensor was easy to be designed into micro array and to realize the simultaneously multi-parameter detection.

关键词： amperometric immunosensor micro electromechanical systems (MEMS) self-assembled monolay-ers (SAMs) protein A orientation-controlled immobilization biosensor system-on-a-chip.

A Micro Amperometric Immunosensor Based on MEMS

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稀有金属材料与工程 2006年第A3期35卷 339-341页

作者： Chao Bian Yuanyuan Xu Hongguang Sun Shaofeng chen shanhong Xia State Key Lab of Transducer Technology Institute of Electronics Chinese Academy of Sciences Beijing 100080 China

A micro amperometric immunosensor with the sensitive area of only 1mm^2 was fabricated on silicon using the technique of Micro-Electro-Mechanical Systems (MEMS).A double exposure of SU-8 photoresist process was developed to create both the sensitive pool and reaction *** was immobilized via cross-linking with glutaraldehyde on the sensitive area of the electrode surface,which was electropolymerized with polypyrrole *** immunosensor was characterized by detection of human immunoglobulin G (HIgG).The immunosensor displayed a good linear response to HIgG concentrations between 5ng/ml and 255ng/ml and demonstrated a fast response time of 3 minutes.

关键词： enzyme amperometric immunosensor MEMS polypyrrole IgG

Self-assembly of micro parts on normal glass substrate

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Progress in Natural Science:Materials International 2004年第10期14卷 94-96页

作者： ZHANG Jiangang ,XIA shanhong,chen Shaofeng,LIU Mei,SUN Hongguang and DENG Kai (State Key Laboratory of Transducer Technology,Institute of Electronics,Chinese Academy of Sciences,Beijing100080,China) Lab. of Transducer Technol. Inst. of Electron. Chinese Acad. of Sci. Beijing 100080 China

Fluidic self-assembly is an approach by which micro parts less than one millimeter in size can be driven by the capillary force of a certain adhesive liquid and be fixed onto the desired sites on some *** glass with the composition of Na 2 SiO 3 CaSiO 3 4SiO 2 has been widely used in fluidic microelectromechanical systems(MEMS)and bio-MEMS *** investigate the MEMS self-assembly experiment on normal glass *** results of scanning electron microscopy(SEM)show that micro-parts of400μm×400μm squares can be precisely assembled in the expected area of the normal glass substrate.

关键词： self-assembly microelectromechanical systems(MEMS) capillary force normal glass substrate

A MICROFABRICATED METAL GRATING OSCILLATOR FOR ELECTRIC FIELD DETECTION

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Journal of Electronics(China) 2005年第5期22卷 564-568页

作者： Deng Kai Xia shanhong Gong Chao chen Shaofeng Bai Qiang State Key Laboratory of Transducer Technology Institute of Electronics Chinese Academy of Sciences Beijing 100080 China

This letter proposes a novel design of a Micro Electro Mechanical System （MEMS） device featuring a metal grating vibratory mierostructure driven by electrostatic force to sense the spatial electric field. Due to the advantages in slide-film damping and large vibration amplitude, such a device makes atmospheric packaging a low-cost option for practical manufacture. In this letter, we present the operating principles and specifications, the design structure, as well as the finite element simulation. Computational analysis shows that our design obtains good results in device parameters setting, while its simplicity and low-cost features make it an attractive solution for applications.

关键词： Miniature Electric Field Sensor(MEFS) Anodic bonding Deep Reactive Ion Etching(DRIE)

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

探讨手掌(TRICK-ARM)血管成像扫描技术在临床中的应用价值

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现代医用影像学 2021年第5期30卷 818-820页

作者：陈沿陈珊红广东医科大学附属第二医院影像科广东湛江524003

目的:探讨手掌(TRICK-MRA)血管成像扫描技术在临床中的应用价值。方法:20例疑为手掌血管性病变患者采用磁共振TRICK-MRA成像技术进行15-20期扫描,通过3D后处理重建技术对其进行分析。结果:20例疑为手掌血管性病变患者,17例为手掌动脉瘤,... 详细信息

目的:探讨手掌(TRICK-MRA)血管成像扫描技术在临床中的应用价值。方法:20例疑为手掌血管性病变患者采用磁共振TRICK-MRA成像技术进行15-20期扫描,通过3D后处理重建技术对其进行分析。结果:20例疑为手掌血管性病变患者,17例为手掌动脉瘤,3例未见明显异常。结论:手掌采用TRICK-MRA成像技术在鉴别血管性疾病中有重要应用价值。

关键词：手掌 TRICK-MRA 血管成像扫描技术临床应用价值

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热塑性弹性体材料在汽车轻量化研究中的应用

江苏科技信息 2018年第15期35卷 35-37页

作者：周杉鸿陈俊琛五行科技股份有限公司江苏泰州225510 五行科技股份有限公司上海分公司上海200233

汽车轻量化已成为世界汽车技术发展的趋势,热塑性弹性体作为汽车轻量化的关键材料,在汽车领域具有很好的应用前景。文章通过详细介绍苯乙烯类、聚烯烃类、聚氨酯类、聚酯类等热塑性弹性体的性能及在汽车零部件领域的应用等,体现了热塑... 详细信息

汽车轻量化已成为世界汽车技术发展的趋势,热塑性弹性体作为汽车轻量化的关键材料,在汽车领域具有很好的应用前景。文章通过详细介绍苯乙烯类、聚烯烃类、聚氨酯类、聚酯类等热塑性弹性体的性能及在汽车零部件领域的应用等,体现了热塑性弹性体对汽车轻量化的积极促进作用,并指出了热塑性弹性体的未来发展方向。

关键词：热塑性弹性体汽车轻量化汽车零部件

MSCT鉴别诊断儿童肾上腺神经母细胞瘤和肾母细胞瘤的征象研究

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国际医药卫生导报 2014年第13期20卷 1964-1967页

作者：林昌能陈杜芳陈珊红张杨贵湛江市第二人民医院放射科 524003 湛江市第二人民医院病理科 524003

目的探讨儿童肾上腺神经母细胞瘤和肾母细胞瘤的CT鉴别征象,以提高儿童肾上腺神经母细胞瘤和肾母细胞瘤的诊断正确率.方法对经病理证实并行CT平扫及增强扫描的儿童肾上腺神经母细胞瘤26例和肾母细胞瘤22例患儿资料进行回顾性分析,对... 详细信息

目的探讨儿童肾上腺神经母细胞瘤和肾母细胞瘤的CT鉴别征象,以提高儿童肾上腺神经母细胞瘤和肾母细胞瘤的诊断正确率.方法对经病理证实并行CT平扫及增强扫描的儿童肾上腺神经母细胞瘤26例和肾母细胞瘤22例患儿资料进行回顾性分析,对比各项CT指标并行统计学处理.结果病灶有无跨越中线、有无包绕腹膜后大血管、有无钙化以及肾脏轮廓是否完整4项CT指标对儿童肾上腺神经母细胞瘤和肾母细胞瘤鉴别有统计学意义（P=0.010,0.005,0.025,0.005）.结论对两者的鉴别诊断,病灶有无跨越中线、有无包绕腹膜后大血管、有无钙化以及肾脏轮廓是否完整等征象起重要作用.

关键词：儿童肾上腺神经母细胞瘤肾母细胞瘤体层摄影术 X线计算机鉴别

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硫唑嘌呤在自身免疫性肝病中的应用研究进展

胃肠病学和肝病学杂志 2024年第7期33卷 926-929页

作者：陈洁王雪汤善宏成都医学院临床医学院四川成都610500 中国人民解放军西部战区总医院消化内科

自身免疫性肝病(autoimmune liver disease,AILD)主要是免疫功能障碍所引起的一类慢性肝病,免疫抑制治疗是AILD的主要药物治疗方案,而硫唑嘌呤在AILD中应用广泛,本文介绍了硫唑嘌呤在AILD中的作用机制,同时归纳了在AILD中包括自身免疫... 详细信息

自身免疫性肝病(autoimmune liver disease,AILD)主要是免疫功能障碍所引起的一类慢性肝病,免疫抑制治疗是AILD的主要药物治疗方案,而硫唑嘌呤在AILD中应用广泛,本文介绍了硫唑嘌呤在AILD中的作用机制,同时归纳了在AILD中包括自身免疫性肝炎、原发性胆汁性胆管炎、原发性硬化性胆管炎、IgG4相关性硬化性胆管炎,以及重叠综合症等各个疾病中的具体应用,总结该药物临床应用的不良反应以及应用的局限性,为临床AILD的治疗提供思路。

关键词：自身免疫性肝病硫唑嘌呤药物疗法治疗