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Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice

Neuroscience Bulletin 2023年第1期39卷 29-40页

作者： Xiaoke Xie shangyue gong Ning Sun Jiazhu Zhu Xiaobin Xu Yongxian Xu Xiaojing Li Zhenhong Du Xuanting Liu Jianmin Zhang Wei gong Ke Si Department of Psychiatry The First Affiliated HospitalZhejiang University School of MedicineHangzhou310012China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou310012China Intelligent Optics&Photonics Research Center Jiaxing Research InstituteZhejiang UniversityJiaxing314001China Department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou310012China MOE Frontier Science Center for Brain Science&Brain-Machine Integration NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310012China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou310012China

Fear memory contextualization is critical for selecting adaptive behavior to *** fear conditioning(CFC)is a classical model for elucidating related underlying neuronal *** primary visual cortex(V1)is the primary cortical region for contextual visual inputs,but its role in CFC is poorly ***,our experiments demonstrated that bilateral inactivation of V1 in mice impaired CFC retrieval,and both CFC learning and extinction increased the turnover rate of axonal boutons in *** frequency of neuronal Ca^(2+)activity decreased after CFC learning,while CFC extinction reversed the decrease and raised it to the naïve *** to control mice,the frequency of neuronal Ca^(2+)activity increased after CFC learning in microglia-depleted mice and was maintained after CFC extinction,indicating that microglial depletion alters CFC learning and the frequency response pattern of extinction-induced Ca^(2+)*** findings reveal a critical role of microglia in neocortical information processing in V1,and suggest potential approaches for cellular-based manipulation of acquired fear memory.

关键词： Contextual fear conditioning Calcium imaging Primary visual cortex Cortical plasticity Microglial depletion Learning and memory

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