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Diets,Gut Microbiota and Metabolites

Phenomics 2023年第3期3卷 268-284页

作者： Yilian Liu Wanglei Zhong Xiao Li Feng Shen Xiaonan Ma Qi Yang shangyu hong Yan Sun State Key Laboratory of Genetic Engineering and School of Life Sciences Human Phenome InstituteFudan University2005 Songhu RoadYangpu DistrictShanghai 200433China Department of Hepatobiliary Surgery Dongfeng HospitalHubei University of MedicineShiyan 442001HubeiChina Masonic Medical Research Institute 2150 Bleecker StUticaNY 13501USA

The gut microbiota refers to the gross collection of microorganisms,estimated trillions of them,which reside within the gut and play crucial roles in the absorption and digestion of dietary *** the past decades,the new generation‘omics’(metagenomics,transcriptomics,proteomics,and metabolomics)technologies made it possible to precisely identify microbiota and metabolites and describe their variability between individuals,populations and even different time points within the same *** massive efforts made,it is now generally accepted that the gut microbiota is a dynamically changing population,whose composition is influenced by the hosts’health conditions and *** is one of the major contributors to shaping the gut *** components in the diets vary in different countries,religions,and *** special diets have been adopted by people for hundreds of years aiming for better health,while the underlying mechanisms remain largely *** studies based on volunteers or diet-treated animals demonstrated that diets can greatly and rapidly change the gut *** unique pattern of the nutrients from the diets and their metabolites produced by the gut microbiota has been linked with the occurrence of diseases,including obesity,diabetes,nonalcoholic fatty liver disease,cardiovascular disease,neural diseases,and *** review will summarize the recent progress and current understanding of the effects of different dietary patterns on the composition of gut microbiota,bacterial metabolites,and their effects on the host's metabolism.

关键词： Gut microbiota Metabolites Diets Nutrients Metabolic diseases

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Impacts of exercise interventions on different diseases and organ functions in mice

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Journal of Sport and Health Science 2020年第1期9卷 53-73页

作者： Shanshan Guo Yiru Huang Yan Zhang He Huang shangyu hong Tiemin Liu School of Kinesiology Shanghai University of SportShanghai 20043&China State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200032China Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education College of Life ScienceJilin UniversityChangchun 130012China Department of Endocrinology and Metabolism State Key Laboratory of Genetic EngineeringSchool of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China

Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related ***'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to "in 10 years,^ and one that sorted the results as "best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different ***'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrat

关键词： Diseases Exercise intervention Mice Organ functions

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内质网应激通过不依赖脂质从头合成的通路诱导非酒精性脂肪肝病

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复旦学报（自然科学版） 2023年第4期62卷 518-526,534页

作者：钟王磊戴晨洪尚宇复旦大学遗传工程国家重点实验室上海200438 复旦大学生命科学学院上海200438

内质网应激对代谢状态失衡具有重要影响。近年来研究人员发现内质网应激可以诱导小鼠非酒精性脂肪肝病(NAFLD)的发生发展。但是内质网应激引发肝脏脂肪堆积的机制尚不完全清楚。二脂酰甘油酰基转移酶(DGAT1)是催化甘油三酯合成的关键酶... 详细信息

内质网应激对代谢状态失衡具有重要影响。近年来研究人员发现内质网应激可以诱导小鼠非酒精性脂肪肝病(NAFLD)的发生发展。但是内质网应激引发肝脏脂肪堆积的机制尚不完全清楚。二脂酰甘油酰基转移酶(DGAT1)是催化甘油三酯合成的关键酶之一,对肝脏脂质合成具有重要意义。在此前的研究中,尚未有人报道过DGAT1在内质网应激诱导NAFLD中的作用。在本研究中,我们通过给小鼠腹腔注射衣霉素,成功诱导了小鼠肝脏内质网应激,发现衣霉素处理的小鼠肝脏有更高的甘油三脂含量并出现较为明显的脂滴堆积。然而,转录水平的检测结果显示该应激并没有上调脂质从头合成关键基因在肝脏中的表达,反而是下调了这些基因的表达。进一步分析发现内质网应激导致小鼠肝脏游离脂肪酸含量显著升高,同时引起肝脏DGAT1表达上调,但并不影响DGAT2的表达。综上,我们的结果表明衣霉素诱导的内质网应激并非通过引发肝脏脂质的从头合成导致肝脏脂肪堆积,而是通过上调肝脏脂肪酸含量以及提高DGAT1的表达,从而促进甘油三酯的合成,导致肝脏脂滴堆积。

关键词：衣霉素内质网应激非酒精性脂肪肝病二脂酰甘油酰基转移酶1

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Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese

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National Science Review 2022年第8期9卷 22-25页

作者： Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin shangyu hong Yan Zheng Junbo Ge Department of Cardiology Zhongshan HospitalFudan University Shanghai Institute of Cardiovascular Disease BGI Genomics BGI-Shenzhen State Key Laboratory of Genetic Engineering School of Life Sciences and Human PhenomeInstituteFudan University BGI-Shenzhen State Key Laboratory of Genetic Engineering School of Life Sciences and Human Phenome InstituteFudan University

Despite the advances made over the past decades, the known loci for coronary artery disease(CAD) still only explain<20% of the genetic variation in risk[1,2]. The known loci with the strongest effects usually confer a 20%–37% increased CAD risk and the most loci modulate risk by ≤10% [1]. While most of the current data are from European populations, the use of trans-ethnic analyses could be helpful to identify additional loci. Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD).

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生酮饮食通过肠道微生物依赖的机制诱导肠道ROS升高

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工业微生物 2023年第4期53卷 151-153页

作者：杨洁戴晨洪尚宇复旦大学生命科学学院遗传工程国家重点实验室上海200438

目前尚无研究表明生酮饮食会影响肠道中微生物的活性氧水平。对此,文章利用DHE染色和DCFH-DA探针发现生酮饮食能显著提高小鼠肠道中的ROS水平和抗氧化应激基因的表达。通过粪菌移植实验得出肠道微生物是生酮饮食引起肠道ROS升高的关键... 详细信息

目前尚无研究表明生酮饮食会影响肠道中微生物的活性氧水平。对此,文章利用DHE染色和DCFH-DA探针发现生酮饮食能显著提高小鼠肠道中的ROS水平和抗氧化应激基因的表达。通过粪菌移植实验得出肠道微生物是生酮饮食引起肠道ROS升高的关键中介。结合16S rRNA微生物的多样性分析,发现特定肠道微生物与生酮饮食所诱导的肠道ROS水平的升高显著相关。文章还拓展了对生酮饮食诱导表型改变的认知,为了解肠道微生物在生酮饮食诱导的独特表型中的作用提供了新的见解。

关键词：生酮饮食肠道微生物活性氧

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Prediction of second-order rate constants between carbonate radical and organics by deep neural network combined with molecular fingerprints

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Chinese Chemical Letters 2022年第1期33卷 438-441页

作者： Peizhe Sun Huixin Ma shangyu Li hong Yao Ruochun Zhang School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality Safeguard Department of Municipal and Environmental EngineeringSchool of Civil EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim Tianjin UniversityTianjin 300072China

Carbonate radical is among the most important environmental relevant reactive species which govern the transformation and fate of pharmaceutical contaminants(PCs).However,reaction rate constants between carbonate radical and most of the PCs have not been experimentally determined,and quantitative structural-activity relationships(QSARs)have not been established for rate *** study applied Max Min data processing method and used molecular fingerprints(MF)as the input of a deep neural network(DNN)to predict the rate constants between carbonate radical and organic *** parameters and the hyper-structure of the DNN were adjusted to yield satisfactory accuracy of rate *** vector length of 512 bits with radius of 1 for MF and 5 hidden layers gave the best *** optimized MaxMin-MF-DNN model was compared with some of the most commonly used QSARs and machine learning methods,including random data splitting,molecular descriptors,supporting vector machine,decision tree,*** showed that the MF-DNN model out-performed the other methods by more than 10%increase in prediction *** this MF-DNN model,we estimated reaction rates between carbonate radical and pharmaceuticals used in human medicine(1576)and veterinary practice(390).Among them,46 drugs were identified as fast-reacting compounds,suggesting the important relations of their environmental fate with carbonate radical.

关键词： Deep neural network Carbonate radical Molecular fingerprints QSAR Pharmaceuticals

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世界主要经济体能源领域面向未来的战略布局及启示

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世界科技研究与发展 2024年第1期46卷 8-20页

作者：丁上于张超星李宏代维中国科学院大学公共政策与管理学院北京100049 中国科学院科技战略咨询研究院北京100190 粤港澳大湾区战略研究院广州510070

在国家提出“双碳”目标和高质量发展的战略背景下,正确把握未来我国主要能源发展方向以及部署未来能源领域战略决策,是帮助我国取得国际竞争优势、抢占未来能源领域发展先机的关键所在。本文基于2017—2021年美国、英国、日本、澳大利... 详细信息

在国家提出“双碳”目标和高质量发展的战略背景下,正确把握未来我国主要能源发展方向以及部署未来能源领域战略决策,是帮助我国取得国际竞争优势、抢占未来能源领域发展先机的关键所在。本文基于2017—2021年美国、英国、日本、澳大利亚、欧盟等世界主要经济体能源领域面向未来的政府规划、科技计划和智库报告等数据,系统梳理了各主要经济体在能源领域的未来重点关切方向、具体做法和布局特点,并针对我国能源领域的未来发展和系统转型提出了一些建议:1)全面评估我国能源资源结构及消费结构和研发现状,制定符合我国国情的未来能源部署及发展路线;2)全面梳理和评估能源领域从基础研究到产业化链条各环节存在的问题,有的放矢,为未来能源的高效发展铺平道路;3)全面调研世界各国能源管理机构的组织模式和运作机制,为未来能源的发展提供良好的政策环境。

关键词：能源政策可再生能源氢能风能

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Privacy preserving divisible double auction with a hybridized TEE‑blockchain system

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Cybersecurity 2021年第1期4卷 580-593页

作者： Bingyu Liu shangyu Xie Yuanzhou Yang Rujia Wang Yuan hong Illinois Institute of Technology 10 West 35th StreetChicagoIL 60616USA

Double auction mechanisms have been designed to trade a variety of divisible resources(e.g.,electricity,mobile data,and cloud resources)among distributed *** such divisible double auction,all the agents(both buyers and sellers)are expected to submit their bid profiles,and dynamically achieve the best *** practice,these agents may not trust each other without a market ***,smart contract is extensively used to ensure digital agreement among mutually distrustful *** consensus protocol helps the smart contract execution on the blockchain to ensure strong integrity and ***,severe privacy risks would emerge in the divisible double auction since all the agents should disclose their sensitive data such as the bid profiles(i.e.,bid amount and prices in different iterations)to other agents for resource allocation and such data are replicated on all the nodes in the ***,the consensus requirements will bring a huge burden for the blockchain,which impacts the overall *** address these concerns,we propose a hybridized TEE-Blockchain system(system and auction mechanism co-design)to privately execute the divisible double *** designed hybridized system ensures privacy,honesty and high efficiency among distributed *** bid profiles are sealed for optimally allocating divisible resources while ensuring truthfulness with a Nash ***,we conduct experiments and empirical studies to validate the system and auction performance using two real-world applications.

关键词： Privacy Truthfulness Blockchain Smart contract TEE Auction design

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Discovering communities for microgrids with spatial-temporal net energy

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Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1536-1546页

作者： shangyu XIE Han WANG Shengbin WANG Haibing LU Yuan hong Dong JIN Qi LIU Department of Computer Science Illinois Institute of Technology10 W 31st StreetChicagoIL 60616USA School of Business College of New Jersey2000 Pennington Rd.EwingNJ 08628USA Department of Information Systems and Analytics Santa Clara University500 El Camino RealSanta ClaraCA 95053USA College of Business University of Rhode Island7 Lippitt RoadKingstonRI 02881USA

Smart grid has integrated an increasing number of distributed energy resources to improve the efficiency and flexibility of power generation and consumption as well as the resilience of the power *** energy consumers on the power grid,e.g.,households,equipped with distributed energy resources can be considered as"microgrids"that both generate and consume *** this paper,we study the energy community discovery problems which identify energy communities for the microgrids to facilitate energy management,e.g.,load balancing,energy sharing and trading on the ***,we present efficient algorithms to discover such communities of microgrids considering both their geo-locations and net energy(NE)over any ***,we experimentally validate the performance of the algorithms using both synthetic and real datasets.

关键词： Smart grid Microgrid Community discovery Net energy(NE) Clustering

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高光谱相干拉曼散射技术及其应用

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激光与光电子学进展 2022年第6期59卷 47-66页

作者：吴凡李商羽洪维礼岳蜀华王璞北京航空航天大学生物与医学工程学院北京市生物医学工程高精尖创新中心北京100191 北京大学生物医学前沿创新中心北京100871

生物样品存在着丰富的物质信息,每一种物质都有其自身独特的性质及功能,对这些物质在生物体内的产生、转运、分布等进行研究可以使我们更加深入地了解生物系统。具备良好化学特异性的光学显微镜为这些研究提供了强大且可靠的工具。拉曼... 详细信息

生物样品存在着丰富的物质信息,每一种物质都有其自身独特的性质及功能,对这些物质在生物体内的产生、转运、分布等进行研究可以使我们更加深入地了解生物系统。具备良好化学特异性的光学显微镜为这些研究提供了强大且可靠的工具。拉曼散射技术由于解决了荧光显微镜所需的外源性标记所带来的问题,极大地促进了生物医学的发展。高光谱相干拉曼散射(hyperspectral coherent Raman scattering,HS-CRS)技术可对不同成分物质进行无标记化学成像,通过同时提供图像和光谱信息,对样品内物质的性质、含量和分布状况做出判断,为科研人员提供了更多维度的物质信息。HS-CRS技术在近几十年内进行了不断的技术更新并在生物医学领域完成新的技术应用,本文对主要的HS-CRS技术的实现形式及方案进行了介绍,并总结了HS-CRS技术在生物医学领域的应用。

关键词：高光谱成像相干拉曼散射显微术无标记成像医用光子学

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