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Frontiers of Medicine 2013年第3期7卷 301-305页

作者： Tingting Wang shanglong yao Zhengyuan Xia Michael G.Irwin Department of Anesthesiology and Critical Care Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Anesthesiology The University of Hong KongHong Kong SARChina

Systemic inflammatory response following myocardial ischemia-reperfusion injury(IRI)to a specific organ may cause *** post-conditioning(IPostC)has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical *** of endogenous nitric oxide(NO)is one of the major mechanisms by which IPostC confers ***,the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism is ***(APN)is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory *** levels of APN are decreased in obese subjects and in patients with type 2 *** supplementation has been shown to increase NO production and attenuate myocardial IRI in normal(non-diabetic)***,the effect of APN on myocardial injury in diabetic subjects,especially its potential in restoring the sensitivity of the diabetic heart to IPostC has not been *** the current paper,we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IPostC and also highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in *** review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.

关键词： adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes

Pro-resolution of inflammation： a potential strategy for treatment of acute lung injury/acute respiratory distress syndrome

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Chinese Medical Journal 2014年第5期127卷 801-802页

作者： yao shanglong ShangYou Department of Anesthesia

Acute lung injury （ALI） and its more severe form acute respiratory distress syndrome （ARDS） are acute clinical complications,which cause significant morbidity and mortality.1 Despite recent advances in our understanding of the pathophysiology and diagnosis of ALI and ARDS,the clinical strategies are restricted to mechanical ventilation and supportive treatments,such as fluid conservative management and glucocorticoids （GCs）.Mechanical ventilation is a common and life-saving strategy for the patients with *** protective ventilation strategy with lower tidal volumes can improve hypoxia and reduce the mortality in patients with ARDS.

关键词： acute lung injury acute respiratory distress syndrome resolution of inflammation

The Protective Effect of Propofol on Erythrocytes during Cardiopulmonary Bypass

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第1期21卷 65-67页

作者：张诗海姚尚龙 Department of Anesthesiology Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022

To evaluate the relationship between erythrocyte injury and intracellular calcium ion overload, and the protective effect of propofol on erythrocytes during cardiopulmonary bypass (CPB), 40 children with congenital heart diseases who underwent surgical repair under CPB were studied. The patients were randomly divided into two groups: control group (group C) and propofol group (group P). Anesthesia was maintained in the patients in group P with 6 mg·kg -1 ·h -1 propofol, and those in the group C inhaled 1 %-2 % isoflurane. The blood samples were taken before CPB, at the 30th min of CPB, at the end of CPB, and 2 h and 24 h after CPB to measure the content of erythrocyte intracellular calcium ion (E Ca 2+ ), Ca 2+ Mg 2+ ATPase and Na + K + ATPase activities, index filtration of erythrocytes (IF), mean corpuscular volume (MCV) and the concentration of plasma free hemoglobin (F HB). Results showed that in the control group, E Ca 2+ , IF, MCV and F Hb were gradually increased and Ca 2+ Mg 2+ ATPase and Na + K + ATPase activities were decreased. The increase of E Ca 2+ was linearly paralleled to IF, MCV and F Hb. In propofol group, all the above mentioned parameters were significantly improved ( P <0.05). This study suggests that erythrocyte injury is related to elevation of intracellular calcium during CPB and propofol has a protective effect on erythrocyte injury.

关键词： erythrocytes cardiopulmonary bypass propofol

Experience and Insights of Family Caregivers for Patients with Senile Dementia: A Qualitative Study

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Health 2021年第9期13卷 1010-1019页

作者： Jiamin Chen Shuyan Zhao Qinghong Chen shanglong yao Department of Operation Hubei Provincial Hospital of TCM Hubei University of Chinese Medicine Wuhan China Department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Background: Due to social, economic, cultural and other factors, the majority of dementia patients are taken care of by relatives or nannies at home in China. This family care model puts a heavy burden on caregivers. Objective: The main aim of this article is to explore the experience and needs of caregivers on dementia elderly, reveal the essence, and provide the basis for formulating relevant policies. Methods: A total of 10 caregivers of dementia elderly were intensively interviewed, and data were analyzed by using Colaizzi content analysis methods during May - October 2019. Results: Three themes were extracted from the interviews, including the burden and strain from the care, lack of trust in pension institutions, and experience and comprehension of care. Conclusion: The caregivers have suffered a lot of pressure from taking care of the patients with senile dementia. They lack trust in pension institutions, so it is appealed that targeted services for family caregivers of dementia patients, so as to reduce caregiver burden and improve the quality of care.

关键词： Dementia Caregiver Qualitative Research

Effects of Ethyl Pyruvate on High Mobility Group Box1 gene expression in septic lung of rat

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Journal of Nanjing Medical University 2005年第6期19卷 316-320页

作者： Lian Zeng shanglong yao Dong Liu Yuelan Wang Department of Anesthesiology Union Hospital Tongji Medical College Huazlmng Science and Technology University Wuhan 430022 China

Objective: Ethyl Pyruvate (EP) has been shown to be an effective anti-inflammatory agent in a variety of model systems. The aim of this study was to investigate the effects of EP on High Mobility Group Box1(HMGB1) genes expression and the possible mechanisms of EP protecting against acute lung injury induced by sepsis. Methods: Forty Wistar rats were randomly divided into normal controls,sham operation,acute lung injury,and EP treatment (40 mg/kg intra-peritoneally every 6 hrs) groups. At the time points of 24 hours the animals in each group were sacrificed, and the lungs were harvested. Wet/dry lung weight ratio, the protein in the bronchoalveolar lavage fluid(BALF),and pulmonary permeability index(PPI) were determined. The histological morphology of lung was observed under microscope. The expression of HMGB1 mRNA was measured using semi-quantitative RT-PCR. Results: EP treatment decreased wet/dry lung weight ratio, the protein in the BALF,and PPI (P<0.01). The histological morphology of lung injury was ameliorated. EP significantly inhibited the HMGB1 mRNA expression(P<0.01). HMGB1 mRNA expression in lungs positively correlation with wet/dry lung weight ratio, the protein in the BALF,and PPI. Conclusion: EP administered inhibits HMGB1 mRNA expression, and protects the lungs against acute injury induced by sepsis.

关键词： Ethyl Pyruvate acute lung injury High Mobility Group Boxl

Effects of resolvin D1 on inflammatory responses and oxidative stress of lipopolysaccharide-induced acute lung injury in mice

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Chinese Medical Journal 2014年第5期127卷 803-809页

作者： Yuan Ruixia Wang Lei yao Chengyue Wu Qingping Marie Christelle Xie Wanli Zhang Xingcai Sun Wei Wang Huiqing yao shanglong Department of Anesthesia and Critical Care Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan Hubei 430022 China

Background A variety of inflammatory mediators and effector cells participate together in acute lung injury,and lead to secondary injury that is due to an inflammatory cascade and secondary diffuse lung parenchyma *** is associated with an oxidative stress reaction,which is produced in the development of airway inflammation,and which has positive feedback on inflammation *** D1 can reduce the infiltration of neutrophils,regulate cytokine levels and reduce the inflammation reaction,and thereby promote the resolution of *** purpose of this study is to investigate the effects of resolvin D1 on an inflammatory response and oxidative stress during lipopolysaccharide （LPS）-induced acute lung *** LPS （3 mg/kg） was used to induce the acute lung injury *** resolvin D1 （100 ng/mouse） was given to mice 30 minutes before inducing acute lung *** were observed at 6 hours,12 hours,1 day,2 days,3 days,4 days and 7 days after LPS was administrated,then they were humanely *** collected bronchoalveolar lavage fluid （BALF） and the lung tissues for further *** section and HE staining of the lung tissues were made for histopathology *** of the lung tissues were evaluated for wet-to-dry （W/D） weight *** necrosis factor （TNF）-α,inter leukin （IL）-1β,IL-10 and myeloperoxidase （MPO） were detected by enzyme-linked immunosorbent assay （ELISA）.A lipid peroxidation malondialdehyde （MDA） assay kit was used to detect MDA.A total superoxide dismutase assay kit with WST-1 was used to analyze superoxide dismutase （SOD）.We determined the apoptosis of neutrophils by Flow Cytometry.A real-time quantitative PCR Detecting System detected the expression of mRNA for heme oxygenase （HO）-*** Pretreatment with resolvin D1 reduced the pathological damage in the lung,decreased the recruitment of neutrophils and stimulated their *** markedly decreased the expressions of TNF-α,IL-

关键词： acute lung injury resolvin D1 resolvins oxidative stress

Edaravone rescues the lung by inhibiting lipid peroxidation and pro-inflammatory cytokines in a rat model

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Chinese Medical Journal 2014年第5期127卷 968-970页

作者： Wu Zhouyang Ming Yu Zhang Zhao Wu Jing Wu Zhilin yao shanglong Department of Anesthesia and Critical Care Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan Hubei 430022 China

Acute lung injury/acute respiratory distress syndrome （ALI/ARDS） is a frequent complication in critically ill patients and cause significant mortality.1 Effects of reactive oxygen species （ROS） on alveolar epithelial cells are involved in the pathophysiology of ALI/*** can provoke DNA damage,lipid peroxidation,and activation of various genes coding for proteins involved in inflammation and cell damage.

关键词： acute lung injury edaravone free radical scavenger inflammation

改良型一次性无菌可控单侧支气管封堵导管和双腔支气管导管用于单肺通气的比较

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华中科技大学学报（医学版） 2010年第6期39卷 797-801页

作者：王磊姚尚龙华中科技大学同济医学院附属协和医院麻醉科武汉430022

目的比较改良型一次性无菌可控单侧支气管封堵导管(BBs)和双腔支气管导管(DLT)用于单肺通气的效果。方法 120例胸外科需在单肺通气下行择期手术患者,随机分组:DLT组,插入双腔支气管导管(60例);BBs组,插入改良型一次性无菌可控单侧支气... 详细信息

目的比较改良型一次性无菌可控单侧支气管封堵导管(BBs)和双腔支气管导管(DLT)用于单肺通气的效果。方法 120例胸外科需在单肺通气下行择期手术患者,随机分组:DLT组,插入双腔支气管导管(60例);BBs组,插入改良型一次性无菌可控单侧支气管封堵导管(60例)。记录插管时间、肺隔离时间、定位时间及通过声门尝试次数和肺萎陷程度,术后声嘶、咽痛发生率。结果与DLT组比较,BBs组术中肺萎陷良好,术野暴露满意,且插管时间、定位时间、肺隔离时间、通过声门尝试次数、术后咽痛、声嘶发生率均降低(均P<0.05)。结论改良型一次性无菌可控单侧支气管封堵导管在单肺通气中的应用具有与双腔支气管导管相同的临床效果,使用安全、操作简便,且术后声音嘶哑、咽喉疼痛等并发症发生较双腔支气管导管更低。

关键词：改良型支气管封堵导管双腔支气管导管单肺通气

鞘内注射氟代柠檬酸对切口痛大鼠痛阈和脊髓TNF-α mRNA表达的影响

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华中科技大学学报（医学版） 2010年第4期39卷 515-518页

作者：周子超姚尚龙南方医科大学附属奉贤医院麻醉科上海201400 华中科技大学同济医学院附属协和医院麻醉科武汉430022

目的观察鞘内注射氟代柠檬酸对切口痛大鼠痛阈及脊髓组织TNF-α mRNA表达的影响。方法取60只雌性SD大鼠制备切口疼痛模型,并随机分为对照组和实验组,每组30只,手术后分别鞘内注射10μL生理盐水、1 nmol氟代柠檬酸(10μL)。测量两组大鼠... 详细信息

目的观察鞘内注射氟代柠檬酸对切口痛大鼠痛阈及脊髓组织TNF-α mRNA表达的影响。方法取60只雌性SD大鼠制备切口疼痛模型,并随机分为对照组和实验组,每组30只,手术后分别鞘内注射10μL生理盐水、1 nmol氟代柠檬酸(10μL)。测量两组大鼠手术前、手术后4、8、16及24 h机械痛阈、热痛阈及脊髓组织TNF-α mRNA表达。结果手术后,大鼠机械痛阈和热痛阈均较术前下降(P<0.05或P<0.01),且术后实验组均高于同一检测时点的对照组(P<0.05或P<0.01);脊髓组织TNF-α mRNA表达上调(P<0.05或P<0.01),实验组低于对照组(P<0.05或P<0.01)。结论脊髓胶质细胞激活并促进TNF-α mRNA表达上调可能参与了切口痛的发生和维持。

关键词：切口疼痛鞘内注射氟代柠檬酸机械痛阈热痛阈肿瘤坏死因子α

Effects of Intraoperative Autologous Blood Donation and Tepid Temperature Cardiopulmonary Bypass on Blood System

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2000年第2期20卷 151-153页

作者：张诗海姚尚龙 Department of Anesthesiology Xiehe Hospital Tangji Medical University Wuhan

The effects of the intraoperative autologous bind donation and tepid temperature cardiopulmonary bypass (CPB) on blood system were investigated. Twenty-four patients with rheumatic heart valve diseases scheduled for open heart surgery were selected and divided randomly into group A (intraoperative autologous blood donation and tepid temperature, nasopharyngeal temperature was at 32-34 ℃ during CPB) and group B (control, nasopharyngeal temperature was at 25-28 ℃ during CPB). The plasmatic concentrations of GMP-140 and D-Dimer and the plasmatic activities of 6- ketoPGF1α and AT- Ⅲ were measured by using ELISA or substrate luminescence techniques before operation, at the end of CPB, after discontinuation of CPB and postoperatively. Red blood cell count, platelet count, hematocrit, the amount of blood drainage and the amount of blood transfusion needed were measured or recorded postoperatively. The results showed the plasmatic concentrations of GMP140 and D-Dimer in group A were significantly less (P<0. 05) than those in group B during and after operation. The activity of 6-keto--PGF1α in group A was higher (P<0. 05) than that in group B during and after operation. The AT- Ⅲ activity in group A was less (P<0. 05) during CPB but higher 30 min after discontinuation of CPB than that in group B. The amount of postoperative blood loss (283± 166 versus 722± 194 ml, P

关键词： cardiopulmonary bypass blood system autologous blood donation tepid temperature