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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Li-Da SU~(1 2 3) Cheng-Long SUN~(1 2) Ying-Hong HU~3 Ying SHEN~(1 2 *) 1 Department of Neurobiology / institute of Neuroscience Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China 2 Key laboratory of Medical Neurobiology of Ministry of Health of China 3 Neuroscience care unit the Second affiliated hospital of Zhejiang University School of Medcine Hangzhou 310009 China

＜正＞Objective Metabotropic glutamate receptor 1（mGluR1） shows highest densities at the edge of the post- synaptic density and is required for distinct forms of synaptic plasticity expressed at parallel fiber and climbing fiber synapses in the *** glutamate transporters（termed as EAAT1-4）,except EAAT5,are distributed in molecular layer of adult cerebellum,especially at the excitatory synapses in Purkinje *** is widely proposed that glutamate reuptake facilitates chemical synaptic transmission by limiting receptor activation and by recycling released neurotransmitter ***,it is of interest to investigate possible roles of EAAT4 in Purkinje cell *** alcohol consumption causes deficits in motor coordination and gait,suggesting that cerebellum plays a role in the fine adjustment of *** has previously been shown that ethanol modulates inhibitory transmission in the cerebellum and affects synaptic transmission at excitatory climbing fiber to Purkinje cell ***,it has not been well examined how acutely ethanol application affects Purkinje cell *** By using whole-cell patch clamp technique combining pharmacologically applying DL-TBOA,D-aspartate and alcohol,we aimed to focus on contribution of EAAT4 and alcohol on properties of EPSC and LTD in Purkinje cells in cerebellar ***（1） Bath application of 300 liM TBOA slightly decreased peak amplitude of EPSCl by（6.8±0.4%） and markedly prolonged EPSC.（2） LTD induced in the presence of TBOA in external saline and 20 mM aspartate in the internal saline were much enhanced compared to control LTD at the time point of 25 min,suggesting that blockade of EAAT4 significandy enhanced the mGluR-dependant LTD in climbingfiber -Purkinje cell synapses.（3） Inhibition of glutamate transporter by bath application of 300μM TBOA during the tetanus and inhibition of EAAT4 by internal 20 mM Asp could rescue failed climbing fiber-Purkinje cell LTD.（4） Short-term application of 50 m

关键词： glutamate transporter EAAT4 alcohol Purkinje cell long-term depression metabotropic glutamate receptor

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Familial epilepsy with febrile seizures plus caused by SCNIA mutations and the role of mosaicism and mutation type in inheritance

Familial epilepsy with febrile seizures plus caused by SCNIA...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yi-Wu SHI Mei-Juan YU Wei-Yi DENG Xiao-Rong LIU Mei-Mei GAO Li CHEN Yue-Sheng LONG Yong-Hong YI Bing-Mei LI Tao SU Wei-Ping LIAO~* institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical College Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou 510260 China

＜正＞Mutations in SCNIA,SCN2A,SCNIB,and GABRG2 were found in familial generalized epilepsy with febrile seizures plus（GEFS+）.The role of each gene in epilepsies with febrile seizures plus（EFS+）,which include GEFS+ and others like severe myoclonic epilepsy in infancy（SMEI）,is *** mutations of SCNIA have been reported in SMEI,and suspected to cause other types of familial EFS+.Here we screened mutations in the 4 genes in familial EFS+ by denaturing HPLC and *** level was quantified by *** SCNIA mutations were identified in the 23 families screened（21.7%）,including 2 mosaic *** mosaic earner has a～25.0%c.5768A＞G/p. Q1923R mutation,showed febrile seizures;another one has a～12.5%c.4847T＞C/p.I1616T,being *** heterozygous children showed partial epilepsy with antecedent febrile *** accounts for 50%（6/12） of the origin of inherited truncating and splice site mutations in previous reports,all related to *** of published data showed that inherited SCNl A mutations were found in 3.1%（6/191） of truncating mutations,10.7%（6/56） of splice site type,and 17.7%（42/237） of missense type（%2 test,P＜0.01）,suggesting mutation type may affect *** study, from a general epilepsy population in one center,suggests SCNl A mutation is an important cause of familial EFS+. Truncating or splice site mutations of SCN 1A could rarely be inherited,except *** novel findings of mosaic SCNl A missense mutantions in milder familial EFS+ emphasized the importace of mosaicism in the origin of EFS+,which is significant in genetic counselling.

关键词： epilepsy with febrile seizures plus+ SCN1A mosaicism inheritance

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肺癌适应性治疗中国专家共识

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循证医学 2024年第4期24卷 193-200页

作者：吴一龙陆舜程颖周清张嘉涛潘燚汪斌超韩宝惠陈海泉周清华王绿化陈明王洁周彩存刘晓晴马智勇黄诚宋启斌莫树锦钟文昭朱正飞宋勇陈蓉蓉陈克终刘基巍杨帆胡晓桦胡毅杨懿岳东升王群赵军范江陈椿孟庆威闫小龙董晓荣朱波邢力刚李兆澄李子明褚倩陈元林根段建春田攀文范云刘安文刘慧刘哲峰杨农汪步海张同梅信涛刘思阳王志杰马锐于起涛林劼涂海燕姚煜赵明芳王慧娟张海波蔡尚立张绪超李慧杜瀛瀛吴芳严令华崔久嵬王燕邬麟周建娅汪笑男黄媚娟冯卫能周进李力中国抗癌协会肺癌专业委员会广东省临床试验协会/中国胸部肿瘤研究协作组广东省肺癌研究所南方医科大学附属广东省人民医院(广东省医学科学院)广州510080 上海交通大学医学院附属胸科医院上海200030 吉林省肿瘤医院长春130021 复旦大学附属肿瘤医院上海200032 四川大学华西医院成都610041 中国医学科学院肿瘤医院深圳医院广东深圳518116 中山大学肿瘤防治中心广州510060 中国医学科学院肿瘤医院北京100021 同济大学附属上海市肺科医院上海200433 解放军总医院第五医学中心北京100039 郑州大学附属肿瘤医院/河南省肿瘤医院郑州450003 福建省肿瘤医院福州350011 武汉大学人民医院肿瘤中心武汉430060 香港中文大学医学院中国香港东部战区总医院南京210002 北京吉因加科技有限公司北京102206 北京大学人民医院北京100044 大连医科大学附属第一医院辽宁大连116011 广西医科大学第一附属医院南宁530020 解放军总医院北京100071 成都市第三人民医院/西南交通大学医学院成都610031 天津医科大学肿瘤医院天津300060 复旦大学附属中山医院上海200032 北京大学肿瘤医院北京100142 上海交通大学附属上海市第一人民医院上海200025 福建医科大学附属协和医院福州350001 哈尔滨医科大学附属肿瘤医院哈尔滨150081 空军军医大学唐都医院西安710038 华中科技大学同济医学院附属协和医院武汉430022 陆军军医大学第二附属医院-新桥医院重庆400037 山东省肿瘤医院济南250117 华中科技大学同济医学院附属同济医院武汉430030 中国医学科学院肿瘤医院山西医院太原030013 中国科学院大学附属肿瘤医院/浙江省肿瘤医院杭州310022 南昌大学附属第二医院南昌330006 湖南省第二人民医院长沙410035 南京大学医学院附属苏北人民医院江苏扬州225001 首都医科大学附属北京胸科医院北京101149 哈尔滨医科大学附属第二医院哈尔滨150001 暨南大学附属第一医院广州510630 辽宁省肿瘤医院沈阳110042 广西医科大学附属肿瘤医院南宁530012 昆明医科大学第二附属医院昆明650101 西安交通大学第一附属医院西安710061 中国医科大学附属第一医院沈阳110001 广东省中医院广州510120 广州燃石医学检验所有限公司广州510300 安徽医科大学第一附属医院合肥230022 中南大学湘雅二医院长沙410011 上海桐树生物科技有限公司上海200444 吉林大学白求恩第一医院长春130021 湖南省肿瘤医院长沙410013 浙江大学医学院附属第一医院杭州310031 南京世和基因生物技术股份有限公司南京210032 佛山市第一人民医院广东佛山528000 四川省肿瘤医院成都610042 陆军军医大学大坪医院重庆400042 不详

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第21届中国肺癌高峰论坛”于2024年3月2日在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物... 详细信息

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第21届中国肺癌高峰论坛”于2024年3月2日在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物对适应性治疗的指导价值等角度展开探讨并达成了专家共识。

关键词：肺癌适应性治疗共识

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Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)

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Journal of Pancreatology 2021年第2期4卷 67-75页

作者： Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the chinese Pancreatic Surgery Association Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing Department of Hepatobiliary and Pancreatic Surgery the First Medical CenterChinese PLA General HospitalBeijing Pancreatic Center Guangdong Provincial People’s HospitalGuangzhouGuangdong Province Department of Pancreatic Surgery Huashan HospitalFudan UniversityShanghai Department of Pancreatic and Biliary Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning Province Department of Hepatopancreatobiliary Surgery Peking University Cancer HospitalBeijing Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalTianjin Department of General Surgery Fujian Medical University Union HospitalFuzhouFujian Province Department of General Surgery Guangdong Provincial People’s HospitalGuangzhouGuangdong Province Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Affiliated to Navy Medical UniversityShanghai Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi Province Department of Pancreatobiliary Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong Province Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu Province Department of General Surgery Xiangya HospitalCentral South UniversityChangshaHunan Province Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Medical CollegeZhejiang UniversityHangzhouZhejiang Province Department of Pancreatic Surgery West China HospitalSichuan UniversityChengduSichuan Province Department of General Surgery Zhongshan HospitalFudan UniversityShanghai Pancreas Center The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu Province Department of Gastrointestinal and Pancreatic Surgery Zhejiang Provincial People’s HospitalHangzhouZhejiang Province Department of General Surgery Pancreatic Disease CenterRuijin HospitalShanghai Jiao Tong University School of Med

Acute pancreatitis(AP)is a common acute abdominal condition of the digestive *** recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP *** the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and *** is expected to provide evidence support for the treatment of AP in the clinical setting in China.

关键词： Acute pancreatitis Diagnosis Follow-up Guideline Treatment

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老年人认知障碍评估中国专家共识(2022)

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中华老年医学杂志 2022年第12期41卷 1430-1440页

作者：倪秀石吴方宋娟安丽娜蒋倩雯白婷婷王建业于普林张存泰吴锦晖中华医学会老年医学分会上海交通大学附属第一人民医院老年医学科上海200080 上海交通大学医学院附属瑞金医院老年病科上海200025 四川大学华西医院老年医学中心国家老年疾病临床医学研究中心成都610041 北京医院国家老年医学中心中国医学科学院老年医学研究院北京100730 华中科技大学同济医学院附属同济医院老年病科武汉430030 不详

认知障碍是指因各种原因导致的不同程度的一个或多个认知域功能损害。认知障碍在老年人群中患病率高、危险因素多、病因复杂、危害性极大。对老年人进行认知障碍的早期筛查、早期诊断、早期干预具有重要意义,但目前我国对老年认知障碍... 详细信息

认知障碍是指因各种原因导致的不同程度的一个或多个认知域功能损害。认知障碍在老年人群中患病率高、危险因素多、病因复杂、危害性极大。对老年人进行认知障碍的早期筛查、早期诊断、早期干预具有重要意义,但目前我国对老年认知障碍的识别率低、漏诊率高、评估不规范。本共识综合国内外常用的认知功能评估量表,旨在推广普及老年认知障碍的筛查,规范老年认知障碍的评估方法和评估流程,及时做出临床诊断,制定干预随访计划。

关键词：认知障碍评估

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Coherence analysis of magnetoencephalography

Coherence analysis of magnetoencephalography

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yang ZHANG~1 Wen-Sheng HOU~(1 *) Wei-Na LI~2 Xiao-Ying WU~1 Guo-Cai WU~2 Hua FENG~2 Jun ZHENG~3 1 Department of Biomedical Engineering Chongqing University Chongqing 400044 China 2 Department of Neurosurgery Southwest Hospital Third Military Medical University Chongqing 400038 3 Department of Computer Science New Mexico institute of Mining and Technology Socorro NM 87801 USA

＜正＞Objective The present study is to obtain correlation between spatially separated brain regions,as well as the changes in time and frequency domain through analysis of the magnetoencephalography *** By means of the theory of coherence analysis,coherence coefficient of two signals corresponding to different cortical areas is computed, which reflects synchronization of the above two signals,as well as the correlation between spatially separated brain *** frequency analysis is also used to discuss the cortical correlation changes co-vary closely with time over the course of motor task in the three frequency band-α,βand lowγ.Results（1） By computing the coherence coefficient relative to the selected reference channel,it is suggested that channels with the most significant coherence are approximately in the same area,*** contralateral primary motor cortex and premotor ***,with the increase of frequency band both the coherence coefficient and the coupled area decline.（2） Changes of coherence co-varing with time inα,βand lowγband present the following characteristic:①The coherence shows such a trend that it increases firstly and then decreases over the course of motor task.②The most significant coherence,forαband,is observed from 0 to 0.3 second,while forβand lowγit appears at -0.2 *** The changes of coherence inα,βand lowγbands suggest that there are different neuronal modulations in the contralateral primary motor *** this modulation covaries with time,which consequently reflects the changes of correlation between different brain regions in time and frequency domain.

关键词： magnetoencephalography coherence time frequency analysis

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Functional deprivation promotes amyloid plaque formation in the olfactory bulb and piriform cortex in a transgenic mouse model of Alzheimer’s disease

Functional deprivation promotes amyloid plaque formation in ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Kun XIONG~1,Xue-Mei ZHANG~2,Yan CAI~1,Jia-Chun FENG~2,Ju-Fang HUANG~1,Xue-Gang LUO~1,Huai-Bin CAI~3,Xiao-Xin YAN~(4,*) 1 Department of Anatomy and Neurobiology,Central South University Xiangya Medical School,Changsha,410013, China 2 Department of Neurology,The First Hospital of Jilin University,Changchun,130021,China 3 Laboratory of Neurogenetics,National institute on Aging,National institutes of Health,Bethesda,Maryland,USA, 20892 4 Departments of Anatomy,Southern Illinois University School of Medicine,Carbondale,Illinois 62901,USA

＜正＞Cerebral hypometabolism is closely associated with the development of Alzheimer’s disease（AD） according to imaging ***,brain or neuronal activity might play a role in AD etiology based on many epidemiological studies suggesting that cognitive and physical activities appear to delay the onset of *** transgenic mouse models of AD, certain stimulative experimental paradigms,such as physical,cognitive or environment enrichment,are found to lower centralβ-amyloid peptide（Aβ） levels,ameliorate plaque development and improve cognitive ***,it is of particular interest to investigate if and how physiological neuronal activity might affect the process of plaque formation in anatomically defined brain area or *** recently identified a clear inverse correlation between endogenous neuronal metabolism and BACE1 expression at the olfactory glomeruli,the first synaptic relay of the olfactory pathway （Yan et al.,2007）.Biochemical analysis in that study confirmed elevated BACE1 protein levels,activity and products including APP C-terminal fragments and Aβ40 in the deprived relative to the non-deprived *** Tg2576 mice as an experimental model,the present study characterized a promotive effect of functional deprivation on amyloid pathology in the olfactory *** naris-occlusion in young transgenic mice caused BACE1 elevation in neuronal terminals in the deprived relative to the non-deprived bulb and transneuronally in the piriform cortex as *** unilateral narisocclusion resulted in increased BACE1 labeling in association with amyloid plaques first in the piriform cortex（at～9 month-old） then within the bulb mostly over the granule cell and subependymal layers on the deprived relative to the nondeprived side（from 12 to 24 month-old）.Double immunofluorescence detected a complete overlap of Aβdeposits with dystrophic axonal neurites that co-expressed BACE1,β-amyloid precursor protein and presenilin-1,forming compact-like

关键词： hypometabolism secretase amyloidogenesis neuroplasticity axonopathy

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人体健康态监测与评估规范

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中华健康管理学杂志 2022年第12期16卷 809-832页

作者：科技部人体健康态评估规范研究及人体健康态信息评价规范研究课题组王煜非于伟泓不详上海交通大学医学院附属第六人民医院上海市糖尿病研究所上海市糖尿病重点实验室上海200233 中国医学科学院北京协和医院眼科中国医学科学院眼底病重点实验室北京100730

2018年科技部推出“主动健康和老龄化科技应对”的重点专项研究,旨在为健康监测产品和人体健康态评估的安全有效体系及标准体系建立提供理论和实践依据。课题组围绕人体健康态数据采集产品质量评价共性技术,跟踪国内外新技术及相关标准... 详细信息

2018年科技部推出“主动健康和老龄化科技应对”的重点专项研究,旨在为健康监测产品和人体健康态评估的安全有效体系及标准体系建立提供理论和实践依据。课题组围绕人体健康态数据采集产品质量评价共性技术,跟踪国内外新技术及相关标准,通过实验室标准参考方法及相关医用级检查设备作为对照参考,研究并提出基于健康数据采集产品和人体相关生理指标的健康态评估规范。本规范涵盖日常健康、心电、血压、血管弹性、脑电、呼吸睡眠、糖代谢及眼健康等八大类22项人体健康态生理指标和功能状态的监测与评估,将有助于确立非医疗级健康数据采集产品的有效性和准确性评估方法,对基层医疗机构、健康体检中心及家庭自我健康规范监测和管理具有一定指导意义。

关键词：健康状况健康促进人体健康态监测与评估规范

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chinese Experts Consensus on Pre-examination and Triage in Dermatology Clinics during the COVID-19 Outbreak

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International Journal of Dermatology and Venereology 2020年第2期3卷 65-67页

作者： Ma Lin Wang Gang Mu Qi-Ri Ran Yu-Ping Liu Quan-Zhong Xiao Sheng-Xiang Zhang Xue-Jun Zhang Jian-Zhong Zhang Fu-Ren He Li Chen Ai-Jun Chen Xiang Zheng Jie Yang Rong-Ya Yao Zhi-Rong Tu Ping Li Yu-Zhen Gao Xing-Hua Xu Jin-Hua Gu Heng Cheng Bo Lai Wei Lu Qian-Jin chinese Society of Dermatology Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Department of Dermatology Xijing HospitalThe Fourth MilitaryMedical UniversityXi’anShaanxi 710032China Department of Dermatology InnerMongolia Autonomous Region People’s HospitalHohhotInner Mongolia 010017China Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan 610000China Department of Dermatology Tianjin Medical UniversityGeneral HospitalTianjin 300052China Department of Dermatology and Venereology TheSecond Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology Institute of DermatologyAnhui Medical UniversityHefeiAnhui 230032China Department of Dermatology Peking University People’sHospitalBeijing 100044China Skin Disease Hospital Affiliated to Shandong FirstMedical University JinanShandong 250022China Department of Dermatology FirstAffiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Dermatology The First Affiliated Hospital of Chongqing MedicalUniversityChongqing 400016China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology Seventh Medical Center of PLA General HospitalBeijing 100191China Department of Dermatology Xinhua HospitalShanghai Jiao TongUniversity School of MedicineShanghai 200092China Department of Dermatology Peking University First HospitalBeijing 100034China Department of Dermatology TheSecond Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology Huashan HospitalFudanUniversityShanghai 200040China Hospital for Skin Diseases(institute ofDermatology) Chinese Academy of Medical Sciences and Peking Union Medical

The SARS-CoV-2 infection has brought a great challenge in prevention and control of the national epidemic of coronavirus disease 2019(COVID-19)in *** the COVID-19 epidemic,properly carrying out pre-examination and triage for patients with skin lesions and fever has become a practical problem encountered in hospitals for skin diseases and dermatology clinics in general *** of the carriers of the SARS-CoV-2 and patients with COVID-19 in the early stage may not present with any symptoms of COVID-19,while certain other skin diseases can also cause ***,to properly deal with the patients presenting at dermatology clinics,the chinese Society of Dermatology organized experts to formulate principles and procedures for the pre-examination and triage of patients at dermatology clinics during the COVID-19 epidemic.

关键词： SARS-CoV-2 COVID-19 fever skin disease pre-examination triage

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Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)

引用

Journal of Pancreatology 2021年第2期4卷 49-66页

作者： Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the chinese Pancreatic Surgery Association Department of General Surgery Peking University First HospitalBeijing Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Medical CollegeZhejiang UniversityHangzhouZhejiang Province Departments of Endoscopy Peking University First HospitalBeijing institute of Hepatobiliary Surgery of PLA Chinese PLA General HospitalBeijing Department of Pancreatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong Province Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing Department of Hepatobiliary Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong Province Department of Pancreatic Surgery Huashan Hospital Fudan UniversityShanghai Department of General Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning Province Department of Imaging Peking University First HospitalBeijing Department of Hepato-Pancreato-Biliary Surgery Peking University Cancer Hospital&InstituteBeijing Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalTianjin Department of General Surgery Fujian Medical University Union HospitalFuzhouFujian Province Department of General Surgery Guangdong Provincial People’s HospitalGuangzhouGuangdong Province Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Affiliated to Navy Medical UniversityShanghai Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi Province Department of Pancreatobiliary Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong Province Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu Province Department of General Surgery Xiangya HospitalCentral South UniversityChangshaHunan Province Department of Radiation Oncology Peking University First H

The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great *** present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,chinese Pancreatic Association,the chinese Society of Surgery,chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic *** recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation *** guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer.

关键词： Diagnosis Guideline Multidisciplinary team Pancreatic cancer Treatment

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