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STAT1 is involved in signal transduction in the EPOinduced HEL cells

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Cell Research 1998年第2期8卷 105-117页

作者： JIANG CHU CHANG YUN GUI JIE FAN XIAO DA TANG RUO LAN QIAO(shanghai Institute of Cell Biology, Chinese Academy ofSciences, shanghai 200031, China )(Dept. of Urology, shanghai First People,s Hospital,shanghai 200081, China) Dept. of Urology Shanghai First People's Hospital Shangai 200081 China

Erythropoietin (EPO) is the ma jor regulator of mammalian erythropoisis, which stimulates the growth and differentiation of hematopoietic cells through interaction with its receptor (EPO-R). Here we use HEL cells (a human erythro-leukemia cell line) as a model to elucidate the pathway of signal transduction in the EPO-induced HEL cells. our data show that the EPOR (EPO receptor) on the surface of HEL cells interacts with the Janus tyrosine protein kinase (Jak2) to transduce intracellular signals through phosphorylation of cytoplasmic proteins in EPO-treated HEL cells. Both STAT1 and STAT5 in this cell line are tyrosine-phosphorylated and translocated to nucleus following the binding of EPO to HEL ***, the binding of both STAT1 and STAT5 proteins to specific DNA elements (SIE and PIE elements) is revealed in an EPO-dependent manner. Our data demonstrate that the pathway of signal transduction following the binding of EPO to HEL cells is similar to immature erythroid cell from the spleen of mice infected with anemia strain of Friend virus.

关键词： Erythropoietin HEL cells signal transduction

The effect of folic acid on the development of stomach and other gastrointestinal cancers

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Chinese Medical Journal 2003年第1期116卷 15-19页

作者：朱舜时施尧胡运彪李蓉蓉汪敏周怡和金冠球谢宇野shanghai Navy Hospital shanghai 200081 China 邬桂泉夏德凰shanghai Putuo People's Hospital 钱珍华宋海连shanghai Traditional and Western Medical Integrated Hospital 屠伯强张丽冬萧树东 Department of Gastroenterology The Renji Hospital and shanghai Institute of Digestive Disease shanghai First People's Hospital shanghai Navy Hospital shanghai Post and Telecommunication Hospital Tongji University Railway Hospital shanghai Traditional and Western Medical Integrated Hospital Human Nutrition Research Center on Aging

OBJECTIVE: To evaluate the roles of folic acid and beta-carotene in the chemoprevention of gastric and other gastrointestinal (GI) cancers. METHODS: In a randomized, double-blind, placebo-controlled trial, a total of 216 patients with atrophic gastritis were randomly assigned to one of the four groups: (1) folate (FA, 20 mg per day plus vitamin B(12) 1 mg, intramuscularly, per month for one year, then 20 mg two times a week plus 1 mg per three months for the next year); (2) natural beta-carotene (N-betaC, 30 mg per day for first year, then 30 mg two times a week for the next); (3) synthetic beta-carotene (S-betaC, administered as in N-betaC); and (4) placebo. Follow-ups continued from 1994 to 2001. RESULTS: A total of 7 new cases of gastrointestinal cancers were diagnosed with 3 stomach, 1 colon and 1 esophageal cancers occurring in the placebo group; 1 stomach cancer in both of the N-betaC and S-betaC groups, and no cancer occurring in FA group. In terms of GI cancers, there was a significant reduction in the FA group, compared with the placebo group (P = 0.04). A similar trend was observed in both N-betaC and S-betaC groups (P = 0.07 - 0.08). Taken together, the three intervention groups displayed a highly significant decrease in occurrence (P = 0.004, vs placebo), and a lower risk for GI cancers (OR = 0.12; 95% confidence interval, 0.03 - 0.51). For development of gastric cancer, any one of the three active-treated groups did not reach statistically significant reduction. The FA group showed obvious improvement of the gastric mucosal lesions with more patients displaying lesions reversed or stable atrophy and inflammation (P = 0.04), reversed intestinal metaplasia (P = 0.06) at the end of follow-up, and reversed displasia (P = 0.017) at 12 months. Two cases of false jaundice were found in beta-carotene groups with no influence on administration, and no side-effects were reported in FA group. CONCLUSIONS: This trial revealed the interventional effect of folic acid

关键词： Adult Aged Anticarcinogenic Agents Double-Blind Method Female Folic Acid Gastric Mucosa Gastrointestinal Neoplasms Humans Male Middle Aged Patient Compliance Research Support, Non-U.S. Gov't Stomach Neoplasms beta Carotene

Role of 3PL in retail sector in China——Case study:Tesco and LianHua

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Role of 3PL in retail sector in China——Case study:Tesco an...

作者： CHEN Xiaoyu (shanghai Chic Logisitcs Co., Ltd, shanghai 200081, China)

＜正＞The role of 3PL in retail sector are explored and analyzed from the view of retailing and 3PL industry. Through the use of literature, market data and other relative information, the problems on both sides are identified by revealing the current application of 3PL in retail sector and the partnership between the retailers and 3PL providers is analyzed. A case study is also introduced in order to identify the difference between west and china on successful 3PL solution for retailers and specify the key factors to success.

关键词： 3PL China retail retailing logistics

来源： cnki会议评论

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睫状体脉络膜脱离55例的临床观察

眼外伤职业眼病杂志 2008年第4期30卷 281-284页

作者：左磊上海交通大学附属上海市第一人民医院分院眼科上海200081

目的探讨睫状体脉络膜脱离的病因、临床特点,检查和治疗方法。方法收集睫状体脉络膜脱离55例(56眼)检查和治疗的相关临床资料,进行回顾性分析。结果对睫状体脉络膜脱离进行眼B超和超声生物显微镜等检查时均有典型征象。超声生物显微镜... 详细信息

目的探讨睫状体脉络膜脱离的病因、临床特点,检查和治疗方法。方法收集睫状体脉络膜脱离55例(56眼)检查和治疗的相关临床资料,进行回顾性分析。结果对睫状体脉络膜脱离进行眼B超和超声生物显微镜等检查时均有典型征象。超声生物显微镜在检查眼前段的睫状体脉络膜脱离及进行房角漏的定位时,更有帮助。55例睫状体脉络膜脱离的治疗方法包括药物、各种手术等。结论睫状体脉络膜脱离的诊断需要综合运用各种检查方法并结合临床体征及病史采集等。通过正确的诊断和及时恰当的治疗,其预后较好。

关键词：睫状体脉络膜脱离超声生物显微镜房角漏

简化估算肾小球滤过率模型算法的参考限及临床特性

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检验医学 2010年第4期25卷 266-271页

作者：叶解明上海市第一人民医院分院检验科上海200081

目的调查不同估算肾小球滤过率（eGFR）公式的参考范围及其临床应用特性。方法测定健康人群血清肌酐（苦味酸法、酶法）及半胱氨酸蛋白酶抑制剂C（Cys C）,统计参考限。把肌酐及Cys C测定值代入不同的eGRF公式（美国2个、中国3个、日本... 详细信息

目的调查不同估算肾小球滤过率（eGFR）公式的参考范围及其临床应用特性。方法测定健康人群血清肌酐（苦味酸法、酶法）及半胱氨酸蛋白酶抑制剂C（Cys C）,统计参考限。把肌酐及Cys C测定值代入不同的eGRF公式（美国2个、中国3个、日本3个、Cys C 4个）,统计其95%可信区间（CI）。测定83例肾功能异常患者（男43例、女40例）血清肌酐及Cys C,代入不同的eGRF公式,以相关分析观察其一致性。改变某一变量（测定浓度、年龄和干扰）,考核对eGFR模型的影响程度。综合归纳eGFR方法适用范围。结果肌酐苦味酸法95%CI男、女分别为73-120、55-97μmol/L;酶法分别为34-106、18-75μmol/L;Cys C为0.38-0.98 mg/L。肌酐苦味酸法、酶法99%CI分别为41-132、26-120μmol/L。全国推荐法、美国法、美国IDMS法、瑞金医院、中山医院、日本推荐法、日本苦味酸法、日本酶法、Cys C66.8、Cys C91.6、Cys C77.24、Cys C中山医院eGFR 95%CI分别为53-123、49-110、48-227、52-110、38-85、36-85、44-96、36-169、50-190、75-227、59-213、57-81 mL/（min.1.73 m^2）。全国推荐法与美国法及日本法男性组间差异无统计学意义（P〉0.05）,其余组有明显差异（P〈0.05）。回归方程分别为：Y美国法=2.65＋0.9X全国推荐法,R^2=1;Y美国IDMS法=-0.81＋1.5X全国推荐法,R^2=0.98;Y瑞金医院=8.33＋0.8X全国推荐法,R^2=0.99;Y中山医院=2.04＋0.7X全国推荐法,R^2=1;Y日本推荐法=2.63＋0.66全国推荐法,R^2=0.99;Y日本苦味酸法=2.31＋0.79X全国推荐法,R^2=1;Y日本酶法=-0.656＋1.11X全国推荐法,R^2=0.98;YCys C 66.8=-11.79＋1.41X全国推荐法,R^2=0.90;YCys C 91.6=-4.96＋1.67X全国推荐法,R^2=0.92;YCys C 77.24=-11.65＋1.58X全国推荐法,R^2=0.91;YCys C中山医院=32.52＋0.4X全国推荐法,R^2=0.95（P均〈0.001）。严重黄疸会使苦味酸法eGFR偏高,严重溶血、脂血会使酶法eGFR偏高,药物对eGFR的影响可忽略不计。eGFR的临界区域为45-53 mL/（min.1.73 m^2）,敏感区域为5-60 mL/（min.1.73 m^2）。结论不同eGFR公式的参考区间不同。肌酐eGFR的一致性优于Cys C。肌酐对eGFR的影响远高于年龄。eGFR的敏感区为5-60 mL/（min.1.73 m^2）,介于肌酐浓度90-1 000μmol/L之间。内源性干扰会引起eGFR假性增高,需重新认识eGFR临界区[45-53 mL/（min.1.73 m^2）]对临床的价值。

关键词：估算肾小球滤过率肌酐半胱氨酸蛋白酶抑制剂C

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固定式塔吊的几种不同类型基础比较分析

施工技术 2006年第S2期35卷 220-221页

作者：王满林上海城建建设实业(集团)有限公司上海200081

通过对固定式塔吊的几种不同类型基础进行综合比较分析,择优选择技术上可行、经济上合理的塔吊基础设计方案。

关键词：塔吊基础安全性稳定性基础

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工程施工信息化管理的作用

施工技术 2000年第11期29卷 3-5页

作者：周茂刚上海广运科技发展有限公司上海200081

工程施工的信息化管理已成为国内施工企业改善经营管理水平 ,提高市场竞争力的重要途径 ,本文从工程算量、预算管理、物料管理、进度管理、成本管理等方面阐述了信息化管理所应发挥的作用。

关键词：工程施工信息化施工管理计算机应用

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基质效应及定标方式对氯电极测定的影响

上海医学检验杂志 2002年第1期17卷 16-18页

作者：叶解明上海市第四人民医院生化室上海200081

目的　研究不同定标方式 ,基质效应对氯电极测定的影响。方法　用HITACHI 715 0氯电极实验 ,以参考方法作对比分析。结果　测定范围在 5 0～ 138mmol/L间 ,用血清基质定标与参考法结果差异无显著性(n =30 ,P >0 .0 5 ) ,而水溶液基质定... 详细信息

目的　研究不同定标方式 ,基质效应对氯电极测定的影响。方法　用HITACHI 715 0氯电极实验 ,以参考方法作对比分析。结果　测定范围在 5 0～ 138mmol/L间 ,用血清基质定标与参考法结果差异无显著性(n =30 ,P >0 .0 5 ) ,而水溶液基质定标的测定明显高于参考方法 (n =30 ,P≤ 0 .0 1) ,高出约 3～ 8mmol/L。氯电极性能不佳时 ,水溶液定标的结果平均低于参考法 5mmol/L(n =30 )。 0 .1%叠氮钠对氯电极测定的干扰 ,在不同的基质中高达 6～ 2 9mmol/L(测定范围 10～ 10 4mmol/L)。氯电极线性在 80～ 130mmol/L内良好 ,与参考法相关r =0 .999,但受定标方式和基质影响明显 ,同时对低氯样品不敏感。由电极性能及样品的基质效应所造成的偏差达 - 13～ +5mmol/L。结论　 715 0氯电极测定受到电极本身性能 ,定标方式和样品基质效应的影响。

关键词：氯电极测定基质效应定标方式

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加速斜板作用下的自由面波动

水动力学研究与进展（A辑） 1992年第A12期7卷 552-557页

作者：施小民陶明德国家海洋局上海海洋预报台上海200081 复旦大学应用力学系上海200433

本文应用Largrange方法,计算了不同倾角的加速斜板作用下的自由面位移。对于垂直板,本文结果精确符合Chwang的结果。

关键词：自由面接触点拉格朗日方法