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Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo

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Cell Research 1999年第1期9卷 71-76页

作者： HUANG YONG XIAO YAN DING (shanghai Institute of Cell Biology, Chinese Academy of Science, shanghai 200031, China) 1shanghai Institute of Cell Biology Chinese Academy of Science Shanghai 200031 China 1shanghai Institute of Cell Biology Chinese Academy of Science Shanghai 200031 China

We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive effect. These results may offer us an new approach to study the differentiation of cement gland through the change of intracelluax calcium concentration.

关键词： Ni2+ cement gland gastrulation T-type calcium channel

STUDIES ON THE CRINUM ALKALOIDS PART I: SYNTHESIS OF ANHYDROLYCORINE-7-ONE

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Chinese Chemical Letters 1996年第1期7卷 13-14页

作者： Hua Wu SHAO Jun Chao CAI (shanghai Institute of Materia Medica, Chinese Academy of Sciences, shanghai, 200031) shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 200031

Palladium acetate catalyzed Cyclization of 1-[(6-bromo-1, 3 -benzodioxol- 5-yl)carbonyl 2, 3-dihydro-1H-indole(7a) leading to the anhydrolycorine- 7-one (1a) as the key step inanew Synthesis of Crinum alkaloids is de...

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Recent progress in neurodegenerative disorder research in China

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Science China(Life Sciences) 2010年第3期53卷 348-355页

作者： ZHOU JiaWei Institute of Neuroscience,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai,200031 1. Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Neurodegenerative disorders,including Alzheimer's disease(AD) and Parkinson's disease(PD),are common disorders of the central nervous system among aging *** the last 10 years insights concerning the etiology,diagnosis and pathogenesis of these diseases have come from research carried out by Chinese *** findings include the description of Chinese patients with autosomal recessive early-onset PD,the function of the tau protein,molecular mechanisms underlying protein aggregation,and the identification of biomarkers for AD diagnosis and molecules/compounds with potential neuroprotective activities.

关键词： neurodegenerative disorders pathogenesis diagnosis neuroprotection Alzheimer’s disease Parkinson’s disease

γ-Aminobutyric acid transporter (GAT1) overexpression in mouse affects the testicular morphology

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Cell Research 2000年第1期10卷 59-69页

作者： MA YING HUA JIA HUA HU XIAO GANG ZHOU ZHEN TONG MEI JIAN FEI LI HE GUO(shanghai Institute of Cell Biology, Chinese Academy of Science, shanghai 200031, China shanghai Institute of Physiology, Chinese Academy of Science, shanghai 200031, China) shanghaiInstituteofCellBiology ChineseAcademyofScience.

γ-Aminobutyric acid and GABAergic receptors were previously reported to be distributed in reproductive systems besides CNS and predicted to participate in the modulation of testicular function. γ-Aminobutyric acid transporter was implicated to be involved in this process. However, the potential role of γ-aminobutyric transporter in testis has not been explored. In this study, we investigated the existence of mouse γ-aminobutyric acid transporter subtype I (mGAT1) in testis. Wild-type and transgenic mice, which overexpressing mGAT1 in a variety of tissues, especially in testis, were primarily studied to approach the profile of mGAT1 in testis. Mice with overexpressed mGAT1 develop normally but with reduced mass and size of testis as compared with wild-type. Testicular morphology of transgenic mice exhibited overt abnormalities including focal damage of the spermatogenic epithelium accompanied by capillaries proliferation and increased diameter of seminiferous tubules lumen. Reduced number of spermatids was also found in some seminiferous tubules. Our results clearly demonstrate the presence of GAT1 in mouse testis and imply that GAT1 is possibly involved in testicular function.

关键词： γ-aminobutyric acid transporter testicular morphology mouse.

Total Synthesis of Przewaquinone A

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Chinese Chemical Letters 1997年第3期8卷 205-206页

作者： Wen Hu DUAN Jun Chao CAI (shanghai Institute of Materia Medica, Chinese Academy of Sciences, shanghai 200031) CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

Przewaquinone A, a natural orthoquinone was synthesized through several steps, the analytic data of the synthetic target compound was identical with that of przewaquinone A.

关键词： HRMS HNMR Total Synthesis of Przewaquinone A

Studies on the Crinum Alkaloids part Ⅱ~[1]: Synthes is of Crinasiadine and Trisphaeridine

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Chinese Chemical Letters 1997年第6期8卷 493-496页

作者： Hua Wu SHAO Jun Chao CAI (shanghai Institute of Nateria Medica, Chinese Academy of Sciences, shanghai, 200031) shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 200031 China

Crinasiadine 1 has been easily synthesized by palladium acetate catalyzed cyclization of N- (o-bromophenyl) -3, *** synthesis trisphearidine 8 with a practical type of palladium chloride catalyzed cyclization as th... 详细信息

关键词： OCH Synthesis of Crinasiadine and Trisphaeridine ppm Studies on the Crinum Alkaloids part

Axon guidance and neuronal migration research in China

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Science China(Life Sciences) 2010年第3期53卷 304-314页

作者： YUAN XiaoBing Institute of Neuroscience,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 200031,China 1. Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Proper migration of neuronal somas and axonal growth cones to designated locations in the developing brain is essential for the assembly of functional neuronal *** progress in research of axon guidance and neuronal migration has been made in the last twenty *** researchers began their exploration in this field ten years ago and have made significant contributions in clarifying the signal transduction of axon guidance and neuronal *** unique experimental approaches,including the migration assay of single isolated neurons in response to locally delivered guidance cues,have been developed by Chinese neuroscientists to investigate the molecular machinery underlying these guidance events.

关键词： axon guidance neuronal migration development neuronal circuits

The first protein ever synthesized in vitro—a personal reminiscence of the total synthesis of crystalline insulin

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Science China(Life Sciences) 2010年第1期53卷 16-18页

作者： ZHANG YouShang Institute of Biochemistry and Cell Biology,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences shanghai 200031,China 1. Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

The total synthesis of crystalline bovine insulin started in 1958 was fully accomplished in 1965. This formidable task was a collaboration of the Institute of Biochemistry in shanghai,

关键词： The first protein ever synthesized in vitro a personal reminiscence of the total synthesis of crystalline insulin

Identification of γ-aminobutyric acid transporter (GAT1)on the rat sperm

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Cell Research 2000年第1期10卷 51-58页

作者： HU JING HUA XIAO BING HE YUAN CHANG YAN (shanghai Institute of Cell Biology, Chinese Academy of Sciences, shanghai 200031) shanghaiInstituteofCellBiology ChineseAcademyofSciences.

Some recent studies indicated that GABAergic system is involved in mammalian sperm acrosome reaction (AR), but direct evidence pertaining to the expression of gat1 in mammalian sperm is not yet demonstrated. In this study, we evaluated the presence of 67kDa GAT1 protein and mRNA in rat testis by Western blotting and reverse transcription-polymerase chain reaction. Meanwhile, immunohistochemical and immunofluorescent analyses also identified GAT1 protein on the elongated spermatid and sperm. These results indicated that rat testis is a novel site of gat1 expression. Further studies should be taken to explore the role of GAT1 protein on sperm acrosome reaction.

关键词： Gat1 rat testis sperm expression.