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Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

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Food Science and Human Wellness 2024年第2期13卷 842-855页

作者： Qihong Jiang Lin Chen Rui Wang Yin Chen shanggui deng Guoxin Shen Shulai Liu Xingwei Xiang College of Food Science and Technology Zhejiang University of TechnologyHangzhou 310014China Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province Hangzhou 310014China National R&D Branch Center for Pelagic Aquatic Products Processing(Hangzhou) Hangzhou 310014China Institute of Sericultural and Tea Zhejiang Academy of Agricultural SciencesHangzhou 310021China College of Food and Pharmacy Zhejiang Ocean UniversityZhoushan 316000China

Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human *** investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and ***(5.1×10^(3) Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and *** could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin ***-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin *** increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid *** study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.

关键词： Tegillarca granosa polysaccharide Type 2 diabetes mellitus Glycolipid metabolism PI3K/Akt signaling pathway

Antibacterial and antibiofi lm activity of peptide PvGBP2 against pathogenic bacteria that contaminate Auricularia auricular culture bags

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Food Science and Human Wellness 2022年第6期11卷 1607-1613页

作者： Shen Yang Zijin Yuan Jude Juventus Aweya shanggui deng Wuyin Weng Yueling Zhang Guangming Liu College of Food and Biological Engineering Xiamen Key Laboratory of Marine Functional FoodJimei UniversityXiamen 361021China Department of Biology Guangdong Provincial Key Laboratory of Marine BiotechnologyShantou UniversityShantou 515063China College of Food and Pharmacy Zhejiang Ocean UniversityZhoushan 316000China

Bacteria contamination in Auricularia auricular culture bags reduces yield and increases the risk of food *** this study,5 species of bacteria,mainly gram-positive bacteria including three species of Bacillus spp.,Arthrobacter arilaitensis and Staphylococcus warneri,were isolated and identifi ed from bacteria-contaminated *** culture *** in silico predicted antimicrobial peptide from theβ-1,3-glucan-binding protein sequence of Penaeus vannamei,designated Pv GBP2(FLKLGRKSRYGMLKL),was screened and its antibacterial effect and mechanism of action on the isolated Bacillus *** minimal inhibitory concentrations(MIC)of Pv GBP2 on Bacillus *** 15.6–31.25μg/m *** Pv GBP2 could inhibit Bacillus subtilis in *** culture bags to maintain growth and yield of *** electron microscopy(TEM)revealed that Pv GBP2 kills bacteria by perforating the cell wall,destroying membrane integrity and resulting in the leakage of intracellular *** addition,Pv GBP2 inhibits biofi lm formation by *** by 90.6%at 1×***,peptide Pv GBP2 could be potentially applied as an antibacterial agent to control bacterial infection of *** cultivation and the spread of foodborne pathogens.

关键词： Auricularia auricular Antimicrobial peptide Penaeus vannamei β-1,3-Glucan-binding protein Bacillus spp.e

Effect of Paecilomyces cicadae polysaccharide Pc0-1 on cyclophosphamide-induced immunosuppression and regulation of intestinal flora in mice

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Food Bioscience 2023年第1期51卷 1237-1247页

作者： Shiwei Yao Xingwen Yang Weijie Wu Qihong Jiang shanggui deng Bin Zheng Lin Chen Yin Chen Xingwei Xiang College of Food Science and Technology Zhejiang University of TechnologyHangzhou310014China Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province Hangzhou310014China National R&D Branch Center for Pelagic Aquatic Products Processing(Hangzhou) Hangzhou310014China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian116034China Institute of Sericultural and Tea Zhejiang Academy of Agricultural SciencesHangzhou Zhejiang310021China Food and Pharmacy College Zhejiang Ocean UniversityZhoushan316000China

Paecilomyces cicadae are rich in resources and have promising research value and applications.A neutral branched heteropolysaccharide Pc0-1 has been extracted from it in our laboratory previously,the structural features and in vitro activity were also *** this basis,the present research intended to investigate the potential mechanism by which Pc0-1 ameliorated cyclophosphamide(Cy)-induced immunosuppression in *** results demonstrated that Pc0-1 could alleviate the atrophy of immune organs and restore the tissue structure of the ***0-1 could also alleviate oxidative stress and inflammatory response through reducing the level of lipid peroxidation in serum and maintaining the balance of Th1 and ***,Pc0-1 was also able to activate the Nrf2-Keap1 signaling pathway and stabilize Nrf2 by decreasing Keap1 activity,thus promoting the role of NQO1 in maintaining redox stability and HO-1 in preventing ***,gut microbial sequencing indicated that Pc0-1 prevented the differential expansion of flora,increased the abundance of beneficial bacteria Lactobacillus and Lachnospiraceae_NK4A136_group,decreased the abundance of harmful bacteria Desulfovibrio and Alistipes,and promoted the production of short-chain fatty acids(SCFAs).All these results demonstrated that Pc0-1 could regulate Cy-induced immunosuppression and improve the structure of intestinal flora,providing some theoretical basis for the in-depth development and application of Pc0-1 as an immunomodulator.

关键词： Paecilomyces cicadae Pc0-1 Cyclophosphamide Intestinal flora Immunosuppression

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一种舟山海域光参蛋白粉的制备工艺

中国食品学报 2018年第5期18卷 151-158页

作者：霍健聪邓尚贵励建荣浙江海洋学院食品与医药学院浙江舟山316000 渤海大学化学化工与食品安全学院辽宁锦州121013

采用嫩化光参为原料,研究其酶解和喷雾干燥工艺,光参蛋白粉营养成分指标。研究结果表明:采用风味酶为酶制剂,酶解嫩化光参的最佳参数:每100 g光参肉糜中风味酶用量1 200 U/g蛋白、温度50℃、pH 6.5、时间4 h、蒸馏水2 500 m L。用该工... 详细信息

采用嫩化光参为原料,研究其酶解和喷雾干燥工艺,光参蛋白粉营养成分指标。研究结果表明:采用风味酶为酶制剂,酶解嫩化光参的最佳参数:每100 g光参肉糜中风味酶用量1 200 U/g蛋白、温度50℃、pH 6.5、时间4 h、蒸馏水2 500 m L。用该工艺制备的光参酶解液中相对分子质量100~1 000的寡肽约占水解产物85%。光参酶解液最佳喷雾干燥条件:进料量25%、进风温度180℃、进料温度30℃、进料速度12 m L/min,由该工艺参数制备的光参蛋白粉各特性指标较好,呈白色粉状,吸湿性较强;光参蛋白粉同某市售品牌蛋白粉相比,蛋白质、脂肪和碳水化合物略低,而活性物质皂甙及Na、Ca、Fe等矿物元素含量较高,具备较强的商品开发潜力。

关键词：舟山海域光参蛋白粉制备喷雾干燥

鱼腥草黄酮的制备及其对枯草芽孢杆菌的抑制机理

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中国食品学报 2017年第9期17卷 82-89页

作者：霍健聪邓尚贵励建荣浙江海洋大学食品与医药学院浙江舟山316000 渤海大学化学化工与食品安全学院辽宁锦州121013

目的:探讨鱼腥草黄酮制备工艺及其对枯草芽孢杆菌的抑制机理。方法:采用醇提法提取鱼腥草黄酮物质,用牛津杯双层平板法确定鱼腥草黄酮物质的抑菌特性,用数码显微照相和透射电镜技术研究鱼腥草黄酮物质对枯草芽孢杆菌的抑菌机理,结果表明... 详细信息

目的:探讨鱼腥草黄酮制备工艺及其对枯草芽孢杆菌的抑制机理。方法:采用醇提法提取鱼腥草黄酮物质,用牛津杯双层平板法确定鱼腥草黄酮物质的抑菌特性,用数码显微照相和透射电镜技术研究鱼腥草黄酮物质对枯草芽孢杆菌的抑菌机理,结果表明:鱼腥草抑菌提取物的最佳提取工艺:料液比1∶20、乙醇体积分数75%、提取温度55℃和提取时间4 h;鱼腥草黄酮对枯草芽孢杆菌等多种供试菌种具有较好的抑制效果,对枯草芽孢杆菌和金黄色葡萄球菌的MIC达到0.1 g/m L;抑菌机理:鱼腥草黄酮物质对细胞壁的破坏作用;结论:鱼腥草提取物主要通过破坏细菌细胞壁,造成细胞内容物泄漏来实现抑菌功效,符合大部分黄酮物质抑菌机理。

关键词：鱼腥草黄酮枯草芽孢杆菌抑菌机理

一种舟山海域光参与刺参成分及结构的比较分析

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中国食品学报 2019年第12期19卷 269-276页

作者：周光东霍健聪邓尚贵浙江海洋学院食品与医药学院浙江舟山316000 浙江省海产品健康危害因素关键技术研究重点实验室浙江舟山316000

比较了一种舟山产光参与普通刺参的基础营养成分及体壁结构特征,为舟山海域光参的精深加工利用提供基础数据。结果表明:光参蛋白质含量低于刺参,粗蛋白含量达53.28%,以胶原蛋白为主,且光参胶原蛋白具有典型胶原蛋白特征,分离得到的α链... 详细信息

比较了一种舟山产光参与普通刺参的基础营养成分及体壁结构特征,为舟山海域光参的精深加工利用提供基础数据。结果表明:光参蛋白质含量低于刺参,粗蛋白含量达53.28%,以胶原蛋白为主,且光参胶原蛋白具有典型胶原蛋白特征,分离得到的α链和β链分子质量分别为98 ku和102 ku,未分离得到γ链;光参蛋白质的氨基酸评分低于刺参,第一限制性氨基酸为赖氨酸;光参含有多种维生素,其中VE含量显著高于刺参,达到2.18 mg/100 g,其余维生素含量较低;光参中含有多种矿物元素,铁含量达150 mg/kg,显著高于刺参(2.3 mg/kg),且光参铅和砷含量较低;光参中含有23种脂肪酸,以单不饱和脂肪酸和多不饱和脂肪酸为主,含量分别达到35.06%,30.86%;光参肌纤维较为致密,且呈现不规则网状结构,这可能是光参硬度较大的主要原因。

关键词：舟山海域光参成分结构

The Study on Ozone Ice in the Freshness Keeping of Fishery Products

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肉类研究 2009年第4期23卷 91-93页

作者： XU Tao deng shanggui ZHENG Haiping College of Food and Medicine Zhejiang Ocean University Zhoushan Zhejiang 316000 China

The effects of ozone ice on the shelf life of Pseudosciaena crocea and cuttlefish, stored under refrigeration (4±0.5℃) were studied by monitoring the microbiological, chemical and sensory changes for a period of 17 days. Results showed that the shelf life could be lengthened 4～5 days preserved by 4mg/kg ozone ice. The total volatility basis nitrogen (TVB-N) was reduced and the bacteria colony was decreased by 92%. The bactericidal effectiveness of ozone ice is strong enough to attain better preservation effect. As a convenient, simple and environmental friendly method, it could be used in the preservation and transportation of fishery products.

关键词：鱼类产品臭氧保鲜技术贮藏温度

低温等离子体对中华管鞭虾(Solenocera crassicorni)菌相变化及品质特性的影响

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食品科学 2021年第19期42卷 141-147页

作者：胡晓梦陈静邓尚贵胡嘉惠浙江海洋大学食品与药学学院浙江舟山316022 浙江省海产品健康危害因素关键技术研究重点实验室浙江舟山316000

为研究低温等离子体对虾类保鲜贮藏期间的作用机理,本实验以中华管鞭虾为研究对象,利用低温等离子体对其进行处理,考察中华管鞭虾在贮藏过程中菌相及品质变化。以(4±1)℃为贮藏条件,对其微生物多样性进行分析,并对比分析了经低温等离... 详细信息

为研究低温等离子体对虾类保鲜贮藏期间的作用机理,本实验以中华管鞭虾为研究对象,利用低温等离子体对其进行处理,考察中华管鞭虾在贮藏过程中菌相及品质变化。以(4±1)℃为贮藏条件,对其微生物多样性进行分析,并对比分析了经低温等离子体处理后中华管鞭虾的挥发性盐基氮(total volatile basic nitrogen,TVB-N)含量、菌落总数、弹性、咀嚼性及肌肉微观结构的变化。结果表明,未处理组中假单胞菌属(Pseudomonas)与腐败希瓦氏菌属(Shewanella)为优势腐败菌,两者相对丰度在贮藏6 d时分别达到49.01%和28.6%,而处理组的优势菌株为气单胞菌属(Aeromonas),贮藏6 d时相对丰度为43.16%;未处理组的TVB-N含量在4 d已经达到(28.03±1.98)mg/100 g,但处理组仅在8 d时接近限值(30 mg/100 g),在物性指标中,处理组与未处理组相比弹性、咀嚼性均下降缓慢;在电子显微镜下观察,在第4天时,未处理组的肌纤维空隙出现絮状结构,而处理组的肌肉微观结构与新鲜状态时无明显差异。综上,低温等离子处理可有效延缓因微生物作用导致的管鞭虾腐败,并显著改变其微观形态,有利于提高贮运品质。本研究结果可为该新型技术应用于水产品保鲜提供理论参考。

关键词：中华管鞭虾低温等离子体微生物多样性品质特性微观结构

Rapid Detection of Nitrate in Aquatic Products by K-model of Characteristic Absorbance Points

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肉类研究 2010年第5期24卷 93-96页

作者： YE Ting XU Tao deng shanggui College of Food and Medicine Zhejiang Ocean University Zhoushan 316000 China

Nitrate is closely related to the content of nitrosamine,which is known to be toxic and is determined in aquatic *** this paper,a new sensitive UV spectrophotometry method based on K-model for rapid determination of nitrate in different kinds of samples was *** UV characteristic absorbance points of nitrate were selected and *** the optimized experimental conditions the calibration equation and K-model were *** calibration curve is linear in the concentration range of 1 to 100μg/ml (R2=0.9973).This method was found to exhibit good accuracy,precision and *** developed method could be applied to the determination of nitrate in aquatic products and other food products.

关键词：肉类制品标准产品质量摘要