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Association between composite dietary antioxidant index and stroke among individuals with diabetes

World Journal of Diabetes 2024年第8期15卷 1742-1752页

作者： Hong-Qiang Zhang Jie Shi tong Yue Jia-hao Weng Xu-Lin Wang hao Wang Xiao-Yu Su Xue-Ying Zheng Si-Hui Luo Yu Ding Chao-Fan Wang Department of Cardiology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and *** composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this *** previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular *** To investigate the association between CDAI and stroke risk in individuals with *** Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with *** CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and *** logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke *** The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with *** analysis revealed a strong inverse relationship between CDAI levels and stroke ***,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various *** finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with *** Our findings suggested that CDAI was inversely associated with stroke prevalence among pa

关键词： Stroke Diabetes Composite dietary antioxidant index National Health and Nutrition Examination Survey Crosssectional study

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Approximations to Isentropic Planar Magneto-Hydrodynamics Equations by Relaxed Euler-Type Systems

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 413-440页

作者： Yachun LI Zhaoyang shang Chenmu WANG Liang Zhao School of Mathematical Sciences CMA-ShanghaiMOE-LSC and SHL-MACShanghai Jiao Tong UniversityShanghai 200240China School of Finance Shanghai Lixin University of Accounting and FinanceShanghai 201209China School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai 200240China School of Mathematical Sciences Harbin Engineering UniversityHarbin 150001China Mathematical Modelling&Data Analytics Center Oxford Suzhou Centre for Advanced ResearchSuzhou 215123JiangsuChina

In this paper, the authors consider an approximation to the isentropic planar Magneto-hydrodynamics(MHD for short) equations by a kind of relaxed Euler-type system. The approximation is based on the generalization of the Maxwell law for nonNewtonian fluids together with the Maxwell correction for the Ampe`re law, hence the approximate system becomes a first-order quasilinear symmetrizable hyperbolic systems with partial dissipation. They establish the global-in-time smooth solutions to the approximate Euler-type equations in a small neighbourhood of constant equilibrium states and obtain the global-in-time convergence towards the isentropic planar MHD equations. In addition, they also establish the global-in-time error estimates of the limit based on stream function techniques and energy estimates for error variables.

关键词： Planar MHD equations Relaxation limits Global convergence Stream function

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多策略改进的闪电连接过程算法及其应用

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控制与决策 2024年第8期39卷 2560-2568页

作者：付华刘尚霖韩冰管智峰韩昊通李琨刘昊辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125100 国网辽宁省电力有限公司盘锦供电公司辽宁盘锦124010 内蒙古电力(集团)有限责任公司乌兰察布供电分公司内蒙古乌兰察布012000

针对闪电连接过程算法鲁棒性欠佳、个体多样性有限等不足的问题,提出一种多策略改进的闪电连接过程算法.首先,采用透射学习策略和准对立学习策略有效提升初始化实验点个体质量,避免自有随机因子过度影响算法收敛性能;然后,设计实验点自... 详细信息

针对闪电连接过程算法鲁棒性欠佳、个体多样性有限等不足的问题,提出一种多策略改进的闪电连接过程算法.首先,采用透射学习策略和准对立学习策略有效提升初始化实验点个体质量,避免自有随机因子过度影响算法收敛性能;然后,设计实验点自适应动态跟随机制,在提升算法寻优性能的同时兼顾探索开发能力的协调;接着,采用镜像均值替代策略替换当前最优解和种群均值,防止算法因个体同化程度升高造成局部停滞;最后,选取基准测试函数进行智能算法对比寻优实验、改进算法对比寻优实验以及Wilcoxon符号秩检验实验,实验结果表明了所提出改进算法寻优性能的优越性以及改进策略的有效性.通过多策略改进的闪电连接过程算法优化长短时门循环控制单元参数进行变压器故障诊断工程应用实验,进一步验证所提出改进算法的工程实用性.

关键词：智能优化算法闪电连接过程算法门控循环单元变压器故障诊断油中溶解气体分析

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DeepRisk:A deep learning approach for genome-wide assessment of common disease risk

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Fundamental Research 2024年第4期4卷 752-760页

作者： Jiajie Peng Zhijie Bao Jingyi Lia Ruijiang Han Yuxian Wang Lu Han Jinghao Peng Tao Wang Jianye hao Zhongyu Wei Xuequn shang AI for Science Interdisciplinary Research Center Schoolof Computer ScienceNorthwestern Polyechnical UniversityXi'an 129China Key Laboratoryof Bg Data Sorage and Management Northwestern Polytechnical UniversityMinisty of Industy and Information TechnologyX'an 129Chin College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Data Science Fudan UniversityShanghai 200433China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518000China

The potential for being able to identify individuals at high disease risk solely based on genotype data has garnered significant *** widely applied,traditional polygenic risk scoring methods fall short,as they are built on additive models that fail to capture the intricate associations among single nucleotide polymorphisms(SNPs).This presents a limitation,as genetic diseases often arise from complex interactions between multiple *** address this challenge,we developed DeepRisk,a biological knowledge-driven deep learning method for modeling these complex,nonlinear associations among SNPs,to provide a more effective method for scoring the risk of common diseases with genome-wide genotype *** demonstrated that DeepRisk outperforms existing PRs-based methods in identifying individuals at high risk for four common diseases:Alzheimer's disease,inflammatory bowel disease,type 2diabetes,and breast cancer.

关键词： Disease risk prediction Deep learning Polygenic risk score Common disease risk Disease prevention

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基于电力客户画像的电费风险防控

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山西财经大学学报 2024年第S01期46卷 184-186页

作者：尚尔媛佟鹏吴昊国网内蒙古东部电力有限公司供电服务监管与支持中心内蒙古通辽028000

在当前快速的经济环境中,行业用电和客户用电需求的改变促使电力公司进行变革或创新,以为消费者带来最佳的客户体验。为了有效地降低“一户一策”中提出的电费风险,国网公司计划建立一套完善的电费风险评估和防控管理体系,以便及时发现... 详细信息

在当前快速的经济环境中,行业用电和客户用电需求的改变促使电力公司进行变革或创新,以为消费者带来最佳的客户体验。为了有效地降低“一户一策”中提出的电费风险,国网公司计划建立一套完善的电费风险评估和防控管理体系,以便及时发现和预测客户的电费风险,并有效地控制和减少此类风险,实现更加有序、有力的电费管理。本文通过构建电费风险防控及信用评估智能算法来推进电力客户分类信用管理,并辅助电费风险防控应用工作的开展。

关键词：电力客户电费风险防控

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基于LoRaWAN自适应数据速率的地下无线传感网络性能评估

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同济大学学报（自然科学版） 2024年第6期52卷 982-990页

作者：郝彤赵国政同济大学测绘与地理信息学院上海200092 同济大学空间信息科学与可持续发展应用中心上海200092

随着城镇化进程的不断加快和物联网技术的迅速进步,地下复杂土壤介质中的无线传感网络正成为新的研究热点。在此背景下,首先概述了基于LoRaWAN的地下无线传感网络基本架构和研究现状,接着搭建了网络仿真器并实现了自适应数据速率(ADR)... 详细信息

随着城镇化进程的不断加快和物联网技术的迅速进步,地下复杂土壤介质中的无线传感网络正成为新的研究热点。在此背景下,首先概述了基于LoRaWAN的地下无线传感网络基本架构和研究现状,接着搭建了网络仿真器并实现了自适应数据速率(ADR)调节机制在传感器节点端和网络服务端的2个优化算法,最后依据网络整体数据接收率和网络能耗等性能指标,分别从传感器节点的地下部署环境(土壤含水量和传感器埋藏深度)和LoRa物理层参数两方面进行了网络性能定量评估。结果表明,针对土壤这一复杂介质,ADR调节机制对LoRaWAN中的物理层参数具有较好的调节能力,该机制可为地下无线网络性能优化提供有利手段,有望大幅降低网络能耗。

关键词：地下无线传感网络物理层参数自适应数据速率(ADR)调节机制地下空间

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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

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Genes & Diseases 2024年第3期11卷 351-367页

作者： Xinzhu Quiu Hongbo He hao Zeng Xiaopeng tongg Can Zhang Yupeng Liu Zhan Liao Qing Liu Department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China Department of Sports Medicine Research Center of Sports MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China

MYBL2(MYB proto-oncogene like 2)is an emerging prognostic marker for malignant tumors,and its potential role in osteosarcoma and its relationship with immune infiltration in pan-cancer is yet to be *** constructed a transcription factor activity profile of os-teosarcoma using the single-cell regulatory network inference algorithm based on single-cell RNA sequencing data obtained from the Gene Expression ***,we calcu-lated the extent of MYBL2 activation in malignant proliferative *** also explored the association between MYBL2 and chemotherapy resistance in ***,we systematically correlated MYBL2 with immunological signatures in the tumor microenviron-ment in pan-cancer,including immune cell infiltration,immune checkpoints,and tumor immu-notherapy ***,we developed and validated a risk score(MRGS),derived an osteosarcoma risk score nomogram based on MRGS,and tested its ability to predict ***2 and gene enrichment analyses in osteosarcoma and pan-cancer revealed that MYBL2 was positively correlated with cell proliferation and tumor immune ***2 expres-sion positively correlated with SLC19A1 in pan-cancer and osteosarcoma cell ***-cancer immune infiltration analysis revealed that MYBL2 was correlated with myeloid-derived sup-pressor cells,Th2 cell infiltration,CD276,RELT gene expression,and tumor mutation burden.

关键词： Biomarker Immunecheckpoint MYBL2 Osteosarcoma Pan-cancer

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Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji tong Yin Chao Gao Danqi Liangwen Mengqi hao Cuimin Chen Jianhua Zhuang Jie Gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

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Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis

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Biosafety and Health 2024年第3期6卷 133-142页

作者： Jin Sun Xiaoxu Han Hongxia Yan Xin Zhang Taiyi Jiang tong Zhang hao Wu Grigory Kaminskiy Yingmin Ma Eduard Karamov Bin Su Beijing Key Laboratory for HIV/AIDS Research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China State Health Organization Tula Regional Center for Control and Prevention of AIDS and Infectious Diseases Tula 300002Russia Department of Respiratory and Critical Care Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Gamaleya National Research Centre for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation Moscow 123098Russia

The high morbidity and mortality rate of individuals with human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)coinfected with Mycobacterium tuberculosis(MTB)is a tough challenge for current global tuberculosis prevention and control ***/MTB coinfection is more complex than a single infection,and the interaction between the two diseases aggravates the deterioration caused by the disease,resulting in increased hospitalizations and *** screening and early diagnosis facilitate the timely initiation of anti-tuberculosis treatment in HIV/MTB coinfected individuals,thereby reducing transmission and the incidence of adverse *** date,pathogenic detection has remained the gold standard for diagnosing tuberculosis,but its sensitivity and specificity are greatly affected by the body's immune status,which limits its application in the diagnosis of HIV/MTB ***,immunology and molecular detection technology has developed *** detection technologies,such as interferon-γ release assays,interferon-gamma inducible protein 10,and GeneXpert MTB/RIF assay have overcome the limitations of traditional detection methods,significantly improved the sensitivity and specificity of tuberculosis diagnosis,and brought new hope to the detection of HIV/MTB *** this article,the principle,scope of application,and latest research progress of relevant detection methods are reviewed to provide a reference for the early diagnosis of HIV/MTB coinfection.

关键词： Human immunodeficiency virus(HIV) Mycobacterium tuberculosis(MTB)coinfection Mycobacterium tuberculosis(MTB) Early diagnosis

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