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Left hepatic artery pseudoaneurysm complicating endoscopic retrograde cholangiopancreatography:A case report

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World Journal of Clinical Cases 2023年第24期11卷 5835-5839页

作者： Qiao-Mei Li Bin Ye shang-wen yang Huan Zhao Department of Gastroenterology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Pseudoaneurysms of the hepatic artery or its branches have been reported following abdominal trauma,iatrogenic injury at the time of many operations such as percutaneous transhepatic biliary drainage and *** artery pseudoaneurysms after endoscopic retrograde cholangiopancreatography(ERCP)are uncommon and potentially life threatening and should be identified and treated *** SUMMARY We report a case of intra-abdominal hemorrhage secondary to a left hepatic artery pseudoaneurysm resulting from guide wire injury at *** patient primary diagnosis was acute biliary pancreatitis with cholangitis,he underwent ERCP on the third day of *** ERCP,the left intrahepatic bile duct was cannulated three *** the sixth day,Contrast enhanced computed tomography scan demonstrated left hepatic lobe contusion and a pseudoaneurysm *** patient was successfully treated with the embolization of a small branch of left hepatic artery *** The common complications of ERCP are pancreatitis,bleeding and *** aneurysms occur as a result of damage to the wall of an *** far as we know,it is rare complication has been reported following *** advise urgent referral for angiographic embolization in this situation to avoid aneurysm rupture.

关键词： Endoscopic retrograde cholangiopancreatography ERCP complication Pseudoaneurysm Angioembolization Case report

Gastric syphilis mimicking gastric cancer: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7798-7804页

作者： Yan-Mei Lan shang-wen yang Mu-Gen Dai Bin Ye Fei-Yun He Department of Gastroenterology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Gastroenterology Lishui Chinese Medicine HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND The nonspecific clinical,radiological and pathological characteristics of gastric syphilis can establish it as an imitator of other gastric *** absence of primary or secondary lubricating lesions should not prevent consideration of gastric *** SUMMARY A 63-year-old female patient presented to the hospital with dull pain in the middle and upper abdomen without apparent cause for one week,which was aggravated for two *** patient had been sexually active with the same male partner for the past years,but her partner was *** contrastenhanced computed tomography(CT)and positron emission tomography/CT suggested gastric *** gastroscopy revealed an antral gastric ulcer with gastric retention,and also suggested gastric *** no cancer cells were found in the biopsies taken during the two *** pallidum(***)antibodies:ELISA positive,rapid plasma reagin titer 1:*** and eosin(HE)stain showed macrophage infiltration in the lamina *** spirochetes were observed by immunohistochemical staining using a monoclonal antibody against *** patient was finally diagnosed with gastric *** Only a few cases of gastric syphilis have been misdiagnosed as gastric *** can relieve symptoms of gastric syphilis.

关键词： Syphilis gastritis Misdiagnosis Gastric cancer Endoscopy Case report

Endoscopic retrograde appendicitis treatment for periappendiceal abscess: A case report

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World Journal of Clinical Cases 2024年第4期12卷 801-805页

作者： Qiao-Mei Li Bin Ye Jun-Wei Liu shang-wen yang Department of Gastroenterology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Acute appendicitis is the most common abdominal *** present,the main treatments for periappendiceal abscess include antibiotics and ***,the complications and mortality of emergency surgery are *** preferred therapy is conservative treatment with antibiotics first,ultrasound-guided puncture drainage or surgical treatment is followed when *** retrograde appendicitis therapy(ERAT)for acute uncomplicated appendicitis have been proved clinically effective,but it is rarely used in periap-pendiceal *** SUMMARY We report a patient admitted to hospital because of“right lower abdominal pain for six days”.The computerized tomography(CT)of patient showed that appendicitis with fecaliths and abscess in the *** patient was treated by CT-guided puncture and drainage of abdominal abscess combined with ERAT to remove appendiceal fecaliths,irrigation and stent *** The patient did not receive surgery because of impoverished *** pain did not recur during the follow-up *** case confirms the value of ERAT in the treatment of periappendiceal abscess.

关键词： Transparent cap Colonoscopy Endoscopic retrograde appendicitis therapy Periappendiceal abscess Case report

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

培菲康联合肠内营养支持对胃癌术后患者胃肠功能及营养评估指标的影响

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世界华人消化杂志 2020年第11期28卷 410-416页

作者：曾旭杨上文杨红琪陈义潘群婕丽水市中心医院重症医学科浙江省丽水市323000 湖州市中心医院营养科浙江省丽水市313000

背景胃癌(gastric cancer,GC)多见于中老年群体,近年来GC发生率呈逐渐升高趋势.GC根治术是治疗早期GC的首选方案,有报道指出部分患者术后易出现消化道异常,影响胃肠功能及营养状况同时.肠内营养支持为现代外科综合治疗的重要组成部分,... 详细信息

背景胃癌(gastric cancer,GC)多见于中老年群体,近年来GC发生率呈逐渐升高趋势.GC根治术是治疗早期GC的首选方案,有报道指出部分患者术后易出现消化道异常,影响胃肠功能及营养状况同时.肠内营养支持为现代外科综合治疗的重要组成部分,培菲康为肠道益生菌,能够改善肠道屏障功能,维持人体健康.本研究首次将培菲康联合肠内营养应用于GC术后患者,探究其对患者胃肠功能及营养评估指标的影响.目的探究培菲康联合肠内营养支持对GC术后患者胃肠功能及营养评估指标的影响.方法选取2017-09/2019-09我院107例GC患者,随机数字表法分为对照组(n=53)和研究组(n=54).两组均行胃部分切除术,对照组给予肠内营养支持,研究组给予培菲康联合肠内营养支持.比较两组胃肠功能恢复情况,生活质量提高率,不良反应发生率,治疗前后营养评估指标[前白蛋白(pre-albumin,PAB),转铁蛋白(transferrin,TFN),白蛋白(albumin,ALB)],肠屏障功能[二胺氧化酶(diamine oxidase,DAO),内毒素脂多糖(endotoxin lipopolysaccharide,LPS),D-乳酸]及肠道菌群.结果研究组肠鸣音恢复,首次排便,首次排气,首次进食等时间均短于对照(P0.05).结论采用培菲康联合肠内营养支持能显著改善GC术后患者肠道菌群水平及肠屏障功能,促进胃肠功能恢复,改善机体营养状况,提高患者生活质量,且具有一定安全性.

关键词：胃癌培菲康肠内营养支持胃肠功能生活质量

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儿童食管良性狭窄内镜下扩张疗效研究

中国内镜杂志 2017年第8期23卷 51-54页

作者：杨上文周桃梅练庆武浙江省丽水市中心医院消化内科浙江丽水323000

目的探究食管良性狭窄儿童内镜下扩张疗效。方法选取2013年6月-2016年6月该院及作者本人在马里医院援外期间收治的共98例食管良性狭窄儿童为研究对象,依据患儿狭窄病因将其分为A组、B组和C组,A组11例患儿为反流性食管狭窄,B组43例患儿... 详细信息

目的探究食管良性狭窄儿童内镜下扩张疗效。方法选取2013年6月-2016年6月该院及作者本人在马里医院援外期间收治的共98例食管良性狭窄儿童为研究对象,依据患儿狭窄病因将其分为A组、B组和C组,A组11例患儿为反流性食管狭窄,B组43例患儿为先天性食管闭锁术后狭窄,C组44例患儿为化学性烧伤行食管狭窄。比较3组患儿扩张治疗前狭窄段情况、扩张次数和并发症发生情况。结果扩张治疗前3组患儿狭窄段平均直径差异无统计学意义(P>0.05),C组患儿的平均长度大于A组和B组,且B组大于A组,差异具有统计学意义(P0.05),C组患儿的平均扩张次数高于A组和B组,且B组高于A组,差异具有统计学意义(P0.05)。结论内镜下扩张对食管良性狭窄儿童有较好的临床疗效,但化学性烧伤性食管狭窄患儿需要扩张较多次,且并发症较高,治疗难度较大。

关键词：食管良性狭窄儿童内镜下扩张疗效

放大内镜联合窄带成像在胃部早期肿瘤性病变患者中的应用效果

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中国内镜杂志 2017年第7期23卷 85-90页

作者：叶慧玲朱建丽杨上文浙江省丽水市中心医院体检中心浙江丽水323000 浙江省丽水市中心医院门诊部浙江丽水323000 浙江省丽水市中心医院消化内科浙江丽水323000

目的探讨放大内镜联合窄带成像(ME-NBI)在胃部早期肿瘤性病变患者中的应用效果。方法选取2013年1月-2016年6月于该院消化内镜中心行内镜检查的151例可疑胃早癌患者为研究对象,所有患者先行普通白光内镜(WLE)检查,然后行ME-NBI检查和靶... 详细信息

目的探讨放大内镜联合窄带成像(ME-NBI)在胃部早期肿瘤性病变患者中的应用效果。方法选取2013年1月-2016年6月于该院消化内镜中心行内镜检查的151例可疑胃早癌患者为研究对象,所有患者先行普通白光内镜(WLE)检查,然后行ME-NBI检查和靶向活检,重点测量腺管间质距离(以下简称腺间距),根据病理结果分为早癌组[高级别上皮内瘤变(HGIN)、黏膜内癌、黏膜下癌,n=72]和非早癌组[低级别上皮内瘤变(LGIN),n=79]。比较两组的基线资料和ME-NBI征象,采用受试者工作曲线下面积(AUC)来评价其对胃早癌的诊断价值。结果早癌组的边界线、不规则的黏膜微血管、不规则的表面腺管和腺间距升高的发生率明显高于非早癌组,差异有统计学意义(P<0.05)。ME-NBI对胃早癌的AUC为0.947,高于WLE的0.832,具有较高的诊断价值,其灵敏度(Se)、特异度(Sp)、阳性预测值(PPV)、阴性预测值(NPV)和Youden指数分别为97.2%、84.8%、85.4%、97.1%和0.820。腺间距对胃早癌的AUC为0.907,高于传统微血管纹理与表面结构(VS)分型的0.889,且VS分型与腺间距进行联合诊断的AUC达到0.933,其Se、Sp、PPV、NPV和Youden指数分别为95.8%、83.5%、84.1%、95.7%和0.794。结论 ME-NBI是胃早癌的重要诊断方法,腺间距具有客观性强、简便易行和可重复性好的优点,能辅助传统VS分型来判断病变性质。

关键词：放大内镜窄带成像腺管间质距离胃癌早期诊断

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao Han Yi-yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

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橡胶林种植对白蚁群落结构和多样性的影响

生态学杂志 2017年第10期36卷 2847-2854页

作者：林小兵刘胜杰肖海峰夏尚文杨效东中国科学院西双版纳热带植物园热带森林生态学重点实验室云南勐仑666303 中国科学院大学北京100049

采用样带法对西双版纳纳板河自然保护区自然林(热带雨林和常绿阔叶林)和橡胶林白蚁群落进行了调查,探讨了橡胶林种植对白蚁群落结构、食性类群组成和多样性的影响。结果表明:(1)在3种森林类型中,共收集白蚁样本397份,隶属于2科10属20种... 详细信息

采用样带法对西双版纳纳板河自然保护区自然林(热带雨林和常绿阔叶林)和橡胶林白蚁群落进行了调查,探讨了橡胶林种植对白蚁群落结构、食性类群组成和多样性的影响。结果表明:(1)在3种森林类型中,共收集白蚁样本397份,隶属于2科10属20种,热带性白蚁种属组成突出;(2)季节对白蚁群落多度和丰富度有显著影响,总体表现为雨季高于旱季;(3)自然林中白蚁多度、丰富度和多样性指数显著高于单一橡胶林,且橡胶林中白蚁稀有种数量显著减少,同时土木食性白蚁的数量比例显著低于自然林,而木食性白蚁比例增加。研究认为,热带地区大面积单一橡胶林种植可对"生态系统工程师"白蚁群落结构和多样性产生较大的负面影响,应重视发展复合橡胶林模式保护白蚁生物多样性。

关键词：白蚁森林类型橡胶林生物多样性