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Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells

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Current Medical Science 2023年第6期43卷 1096-1106页

作者： shang-wen PAN Li-sha HU Han WANG Rui-ting LI Ya-jun HE You shang Zhong-liang DAI Li-xin CHEN Wei xiong Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Qingdao Women and Children’s HospitalQingdao UniversityQingdao266034China Department of Anesthesiology The Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhen518020China Department of Pharmacology Medical CollegeJinan UniversityGuangzhou510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou510632China

Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral *** is a catabolic process responsible for maintaining cellular *** recent years,autophagy has been demonstrated to play an important role in *** D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving ***,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further *** present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding *** Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow *** RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with ***,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)***,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)***,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent *** The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.

关键词： resolvin D1 microglia mTOR-independent autophagy ATG5-dependent autophagy phagocytosis

Effect of substrate curvature on thickness distribution of polydimethylsiloxane thin film in spin coating process

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Chinese Physics B 2018年第6期27卷 479-487页

作者： Ying Yan Ping Zhou shang-xiong Zhang Xiao-Guang Guo Dong-Ming Guo Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education Dalian University of Technology Dalian 116024 China

The polymer spin coating is critical in flexible electronic manufaction and micro-electro-mechanical system（MEMS）devices due to its simple operation, and uniformly coated layers. Some researchers focus on the effects of spin coating parameters such as wafer rotating speed, the viscosity of the coating liquid and solvent evaporation on final film *** this work, the influence of substrate curvature on film thickness distribution is considered. A new parameter which represents the edge bead effect ratio（re） is proposed to investigate the influence factor of edge bead effect. Several operation parameters including the curvature of the substrate and the wafer-spin speed are taken into account to study the effects on the film thickness uniformity and edge-bead ratio. The morphologies and film thickness values of the spin-coated PDMS films under various substrate curvatures and coating speeds are measured with laser confocal microscopy. According to the results, both the convex and concave substrate will help to reduce the edge-bead effect significantly and thin film with better surface morphology can be obtained at high spin speed. Additionally, the relationship between the edge-bead ratio and the thin film thickness is like parabolic curve instead of linear dependence. This work may contribute to the mass production of flexible electronic devices.

关键词： spin coating non-planar substrate film thickness distribution edge-bead effect

基于等容热力学的超临界CO_(2)管道减压波传播特性研究

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低碳化学与化工 2024年第7期49卷 129-138页

作者：李欣泽姜星宇王德中孙晨邹炜杰尚妍熊小琴邢晓凯中国石油大学(北京)克拉玛依校区工学院新疆克拉玛依834000 新疆多介质管道安全输送重点实验室新疆乌鲁木齐830011

CO_(2)管道泄漏的减压行为预测和断裂控制是CO_(2)管道输送安全的重要研究方向,现有减压波预测模型存在气液两相声速计算误差大,临界点计算不易收敛等问题。基于等容热力学改进了当地声速计算方法,建立了新的减压波预测模型,计算分析了... 详细信息

CO_(2)管道泄漏的减压行为预测和断裂控制是CO_(2)管道输送安全的重要研究方向,现有减压波预测模型存在气液两相声速计算误差大,临界点计算不易收敛等问题。基于等容热力学改进了当地声速计算方法,建立了新的减压波预测模型,计算分析了气体组成、初始相态、起始压力和起始温度等对减压波曲线和降压曲线的影响,并对实际工程中CO_(2)管道泄漏的减压行为进行了预测。结果表明,相比燃烧后捕集或燃烧前捕集,富氧燃烧捕集气体下的初始减压波波速降低约26%,减压平台压力提高22%。随着减压过程进行,管内介质温度和压力工况点不再沿气液平衡线移动,而是直接进入气液两相区。超临界态的降压曲线与CO_(2)泡点线的交点所对应的饱和压力比密相态的高约26%,减压平台压力较高。低运行温度和高运行压力能够有效降低减压平台压力。由于管道沿程运行参数的差异,管道断裂风险由管道起点依次降低,前段管段是高风险管段。本研究可为CO_(2)管道设计和工程应用提供理论依据。

关键词：超临界CO_(2) 管道输送等容热力学减压波曲线降压曲线

From Mind to Products:Towards Social Manufacturing and Service

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 47-57页

作者： Gang xiong Fei-Yue Wang Timo R. Nyberg Xiuqin shang Mengchu Zhou Zhen Shen Shuangshuang Li Chao Guo Key Laboratory for Management and Control of Complex Systems Institute of Automation Beijing 100190 China School of Science at Aalto University Aalto FI-00076 Finland Laboratory for Discrete Event Systems New Jersey Institute of Technology NJ-07102 USA Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Beijing 100190 China Qingdao Academy of Intelligent Industries Qingdao 266109 China Cloud Computing Center Dongguan 523808 China IEEE

After reviewing the development of industrial manufacturing, a novel concept called social manufacturing(SM) and service are proposed as an innovative manufacturing solution for the coming personalized customization era. SM can realize a customer's requirements of "from mind to products", and fulfill tangible and intangible needs of a prosumer, i.e., producer and consumer at the same time. It represents a manufacturing trend,and is expected to become popular in more and more ***, a comparison between mass customization and SM is given out, and the basis and motivation from social network to SM is analyzed. Then, its basic theories and supporting technologies,like Internet of Things(Io T), social networks, cloud computing,3 D printing, and intelligent systems, are introduced and analyzed,and an SM platform prototype is developed. Finally, three transformation modes towards SM and 3 D printing are suggested for different user cases.

关键词： Big data cloud computing intelligent system social manufacturing social networks 3D printing

Social Manufacturing for High-end Apparel Customization

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IEEE/CAA Journal of Automatica Sinica 2018年第2期5卷 489-500页

作者： Xiuqin shang Fei-Yue Wang Gang xiong Timo R. Nyberg Yong Yuan Sheng Liu Chao Guo Sen Bao State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China School of Science at Aalto University Aalto FI-00076 Finland Qingdao Academy of Intelligent Industries Qingdao 266109 China IEEE

Social manufacturing(SM), a novel distributed,collaborative and intelligent manufacturing mode, is proposed and developed for high-end apparel customization. The main components of SM cloud are designed, and its research topics are summarized. Then, SM's key technologies are studied. 3D technologies for apparel customization, like 3D modeling, 3D fitting mirror and 3D customization, are developed to improve the customization precision and user experience. Information based collaborative management is realized to share, communicate,and handle the information efficiently among all groups and individuals of SM cloud. Suppliers' evaluation mechanism is designed to support the optimal decisions making. Next, SM cloud is constructed in five layers for high-end apparel *** using SM cloud based crowd-sourcing, social resources can be allocated rationally and utilized efficiently, consumer can customize the product in any processes like innovation, design,making, marketing and service, and traditional apparel enterprise can be upgraded into SM mode for keeping it competitive in the future customization markets.

关键词： Index Terms-Big data collaborative management social man-ufacturing cloud 3D apparel customization.

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高校化学实验室危化品安全运行管理

当代化工研究 2024年第7期 188-190页

作者：尚艳雪王琼超李宇吴安军熊海蓉湖南农业大学化学与材料科学学院湖南410128

本文对高校实验室危化品安全的管理进行改进。针对以前实验室存在的安全意识淡薄、试剂混放、消防设施不到位等问题,通过加强实验人员的安全培训、健全危化品安全制度、进行多方位安全检查、运用信息化手段进行安全管理等方面对高校化... 详细信息

本文对高校实验室危化品安全的管理进行改进。针对以前实验室存在的安全意识淡薄、试剂混放、消防设施不到位等问题,通过加强实验人员的安全培训、健全危化品安全制度、进行多方位安全检查、运用信息化手段进行安全管理等方面对高校化学实验室危化品安全运行机制进行改进。

关键词：高校化学实验室危化品安全管理

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经济型电子导向胶轮系统应用研究探讨

现代城市轨道交通 2024年第9期 50-54页

作者：尚雄李春宇孟帅军王猛吕玉凯中车城市交通规划设计研究院江苏南京210031 中车智能交通工程技术有限公司北京100071

目前城市轨道交通行业高速发展,大运量城市轨道交通市场已趋于成熟,随着国家审批政策的转变,中低运量已成为城市轨道交通未来的发展方向。在低运量城市轨道交通领域,电子导向胶轮系统作为一种采用虚拟轨道运行的新型交通制式,具备运量... 详细信息

目前城市轨道交通行业高速发展,大运量城市轨道交通市场已趋于成熟,随着国家审批政策的转变,中低运量已成为城市轨道交通未来的发展方向。在低运量城市轨道交通领域,电子导向胶轮系统作为一种采用虚拟轨道运行的新型交通制式,具备运量大、准时正点、RAMS水平高、节能环保、维护成本低以及部署灵活等优点。文章以既有产品为基础,结合审批政策对低运量系统的要求,对市场需求、运营模式、线路规划、系统配置等顶层技术指标以及全寿命周期成本等进行分析研究,并提出一套全面而经济的电子导向胶轮系统方案,旨在为城市交通行业提供一套切实可行的经济型电子导向胶轮系统解决方案。

关键词：城市轨道交通经济型电子导向胶轮系统

Interfacial engineering of 3D hollow CoSe_(2)@ultrathin MoSe_(2)core@shell heterostructure for efficient pH-universal hydrogen evolution reaction

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Nano Research 2022年第4期15卷 2895-2904页

作者： Lili Zhang Yuanting Lei Danni Zhou Chengli xiong Zhuoli Jiang Xinyuan Li Huishan shang Yafei Zhao Wenxing Chen Bing Zhang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Chemistry Tsinghua UniversityBeijing 100084China

Rational design and construction of low-cost and highly efficient electrocatalysts for hydrogen evolution reaction(HER)is meaningful but ***,a robust three dimensional(3D)hollow CoSe_(2)@ultrathin MoSe_(2)core@shell heterostructure(CoSe_(2)@MoSe_(2))is proposed as an efficient HER electrocatalyst through interfacial *** from the abundant heterogeneous interfaces on CoSe_(2)@MoSe_(2),the exposed edge active sites are maximized and the charge transfer at the hetero-interfaces is accelerated,thus facilitating the HER *** exhibits remarkable performance in pH-universal ***,it only needs an overpotential(η10)of 108 mV to reach a current density of 10 mA·cm^(-2)in 1.0 M KOH,outperforming most of the reported transition metal selenides *** functional theory(DFT)calculations unveil that the heterointerfaces synergistically optimize the Gibbs free energies of H2O and H^(*)during alkaline HER,accelerating the reaction *** present work may provide new construction guidance for rational design of high-efficient electrocatalysts.

关键词： transition metal selenides hydrogen evolution reaction core@shell heterostructure pH-universal

Microstructure evolution and mechanical properties of Ti2AlNb/TiAl brazed joint using newly-developed Ti–Ni–Nb–Zr filler alloy

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Progress in Natural Science:Materials International 2020年第3期30卷 410-416页

作者： Xinyu Ren Haishui Ren Yonglai shang Huaping xiong Kai Zhang Jinghua Zheng Dong Liu Jianguo Lin Jun Jiang Welding and Plastic Forming Division Beijing Institute of Aeronautical Materials HH Wills Physics Laboratory School of Physics University of Bristol Department of Mechanical Engineering Imperial College London

Joining of TiAlNb alloy to TiAl intermetallics was conducted by the newly-developed Ti–Ni–Nb–Zr brazing filler *** microstructure evolution of the joints was investigated by scanning electron microscope (SEM),energy dispersive spectrometer (EDS) and electron backscatter diffraction (EBSD).The macro-micro mechanical properties were studied by shear test and nano-indentation *** interfacial microstructures across the brazing seam were TiAlNb substrate,α-TiAl+β-Ti,γ-TiAl+TiNi+TiNi+α-TiAl,α-TiAl+β-Ti,TiAl *** TiNi phase were firstly dissolved in the joints brazed at 1000°C for 10 min and then precipitated after a prolonged holding time of 15 *** nano-indentation test revealed that TiNi phase exhibited the highest hardness of 12.60 *** joints brazed at 1000°C/15 min presented the maximum shear strength of271 *** dissolution and precipitation behavior of TiNi phase was also discussed.

关键词： Brazing TiAl Ti 2 AlNb EBSD Microstructure evolution Nano-indentation