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Improving Access to Quality Care in Family Planning:WHO’s Four Cornerstones of Evidence-based Guidance

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Journal of Reproduction and Contraception 2007年第2期18卷 63-71页

作者： shang-chun wu Yan ZOU K Church O Meirik National Research Institute for Population and Family Planning Beijing 100081 China Worm Health Organization Geneva

The four cornerstones of guidance in technique service of family planning are established by WHO based on high quality evidences. They have been updated according to the appearing new evidences, and the consensuses were reached by the international experts in this field. The four documents include Medical Eligibility Criteria for Contraceptive Use, Selected Practice Recommendations for Contraceptive Use, Decision-making Tool for Family Planning Clients and Providers and The Global Handbook for Family Planning Providers. The first two documents mainly face to the policymakers and programme managers and were treated as the important references for creating the local guideline. The other two documents were developed for the front-line health-care and family planning providers at different levels, which include plenty of essential technical information to help providers improve their ability in service delivery and counselling. China paid great attention to the introduction and application of WHO guidelines. As soon as the newer editions of these documents were available, the Chinese version would be followed. WHO guidelines have been primarily adapted with the newly issued national guideline, The Clinical Practical Skill Guidelines-Family Planning Part, which was established by China Medical Association. At the same time, the WHO guidelines have been introduced to some of the clinicians and family planning providers at different levels. In the future, more special training courses will be introduced to the township level based on the needs of grass-root providers.

关键词： family planning technique service evidence-based guideline

Evaluation of Training Course Effects on Integrated Sexual and Reproductive Health Counseling

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Journal of Reproduction and Contraception 2006年第3期17卷 158-163页

作者： Yu-yan LI Jun-qing wu Yu-ming SHF shang-chun wu shanghai Institute of Planned Parenthood Research Shanghai 200032 China National Population and Family Plamfing Committee. Beijing 100088 China National Research Institute for Family Plalming Beijing 100081. China

Objective To evaluate the training course effects on integrated sexual and reproductive health （SRH） counseling, so as to improve family planning providers＇ capacities of SRH counseling. Methods The SRH training course was conducted by using new curriculum and participatory training methods. The purpose was meeting the SRH needs of clients. Evaluations were done by pre- and post-training questionnaires to trainees. Results The average total scores of trainees were 54.9 before trained and 83.4 after trained respectively. As to trainees＇ self evaluation of the capacities, the capacity for comfortably discussing sexuality and related issues with clients increased from 9.9% to 90.7%, the capacity for helping clients to understand their sexual risk factors increased from 12.5% to 92.2%, the capacity for helping clients assessing their own needs for SRH services, information and emotional support increased from 16.0% to 87.8%, and the capacity for helping clients to develop negotiation and communication skills increased from 12.0% to 86. 0%. Conclusion The training course of integrated SRH counseling changed the traditional training types and services concept o f family planning service providers, and the trainees＇ capacities of implementing integrated SRH counseling also improved very much.

关键词： sexual and reproductive health (SRH) integrated counseling training effects

Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian chunlei shang Chaolei Zhang Xiaoye Zhou Honghui wu Shuize Wang Guilin wu Junheng Gao Jiaming Zhu Xinping Mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

cGAS-STING: mechanisms and therapeutic opportunities

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Science China Life Sciences 2025年

作者： Mengyuan Zhang Changxin wu Defen Lu Xing Wang Guijun shang Shanxi Medical University School and Hospital of Stomatology Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province Institutes of Biomedical Sciences Shanxi University College of Life Sciences Shanxi Agricultural University

The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA(dsDNA) in the cytoplasm and triggering downstream signal transduction. Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural features of cGAS and STING proteins, with a particular emphasis on their activation and inhibition mechanisms. We also discuss the novel discovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and antagonists of cGAS and STING, shedding light on their mechanisms of action. Deciphering the molecular intricacies of the cGAS-STING pathway holds significant promise for the development of targeted therapies aimed at maintaining immune homeostasis within both innate and adaptive immunity.

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Propagating subduction initiation of the Caroline Plate at the Mussau Trench

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Science China Earth Sciences 2025年第1期68卷 253-269页

作者： chun-Feng LI Yongkang DENG Tao wu Dongdong DONG Guoliang ZHANG Jiazheng ZHANG Yutao LIU Yaqing LI Fugui TANG Lulu ZHANG Department of Marine Sciences Zhejiang University Laboratory of Marine Mineral Resources Laoshan Laboratory Key Lab of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Key Lab of Ocean and Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Science & Technology on Integrated Information System Lab Institute of Software Chinese Academy of Sciences

New seismic imaging from the Mussau Trench confirms that, under horizontal compression on an oceanic plate boundary, it is within the young and weak oceanic plate that a trench will develop, and it is the young plate, not so long after its birth, that starts to subduct toward the old plate. The Mesozoic Pacific Plate cannot easily bend, under the joint horizontal compression and vertical gravity pull, even with a pre-existing weak zone in place and with a large age offset across the plate boundary. The bending of the Caroline Plate near the northern end of the Mussau Trench started only after a long-time span of trench migration, and/or after a prolonged transition from initial compression to trench development. Highly contrasting trench deformation and sedimentary accretion between two parallel seismic sections support an evident migration of underthrusting or significant longitudinal heterogeneity along the trench. The swift transition from underthrusting to non-thrusting can be explained by a counter-clockwise rotation of the Caroline Plate. That miniature accretionary wedges develop even before the subduction initiates imply strong compression and uplifting before the underthrusting can kick-start. Rotation of the Caroline Plate have been halted as the Mussau Trench is seismically rather quiet and the Lyra Trough to the east shows relaxational extension.

关键词： Mussau Trench Subduction initiation Seismic reflection Caroline Plate

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放置IUD服务质量与IUD下移取器关系的巢式病例对照研究

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生殖与避孕 2010年第6期30卷 390-395页

作者：贾贤杰张开宁吴尚纯蚌埠医学院流行病学教研室蚌埠230000 昆明医学院健康与发展研究所昆明650031 国家人口与计划生育委员会科学技术研究所北京100081

目的:探讨云南省农村地区育龄妇女IUD下移取器与手术人员服务质量间的关联。方法:采用巢式病例对照研究方法,从队列中获得246例IUD下移取器病例,按1:1的比例分别匹配以末次妊娠结局、所置IUD种类相同、地区、年龄相当的对照,调查分析为... 详细信息

目的:探讨云南省农村地区育龄妇女IUD下移取器与手术人员服务质量间的关联。方法:采用巢式病例对照研究方法,从队列中获得246例IUD下移取器病例,按1:1的比例分别匹配以末次妊娠结局、所置IUD种类相同、地区、年龄相当的对照,调查分析为此组患者施术人员的相关服务质量。结果:单因素条件logistic回归分析显示施术人员本调查置器时间点前一年(2004年)所置IUD数量、是否有计划生育手术上岗合格证、5年内IUD相关培训次数、置环、取环术熟练程度、对放置IUD绝对禁忌证的了解程度、所施行过的手术种类与IUD下移取器有统计学关联(P<0.05),进一步用多因素条件logistic回归分析,施术人员5年内IUD相关培训次数、2004年置环数量、置环、取环术熟练程度与IUD下移取器有统计学关联(P<0.05),OR值分别为0.35(95%CI:0.18～0.66)、0.50(95%CI:0.33～0.77)和2.46(95%CI:1.89～3.20),其他各因素对致育龄妇女IUD下移取器未显示有统计学意义。结论:影响IUD下移取器有关服务质量的因素包括施术人员的服务水平和培训情况,今后需进一步探讨IUD技术服务质量管理模式,提高人民的生殖健康水平。

关键词： IUD 服务质量下移取器巢式病例对照研究

早孕药物流产时米非司酮剂量和不同作用时间对蜕膜类固醇受体表达的影响

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生殖与避孕 2008年第8期28卷 467-470,476页

作者：顾向应李丽范庆春赵璐吴尚纯岳天孚天津医科大学总医院天津300052 国家计划生育和人口委员会科研所北京100081

目的:探讨米非司酮不同给药方案对孕早期子宫蜕膜上类固醇受体表达的影响。方法:采用随机对照性临床研究,将150例早孕妇女按停经≤49d、50-56d、57-63d随机分入5组,分别口服100mg米非司酮,24±2h(A组)或48±2h(B组)后阴道置米索前列醇80... 详细信息

目的:探讨米非司酮不同给药方案对孕早期子宫蜕膜上类固醇受体表达的影响。方法:采用随机对照性临床研究,将150例早孕妇女按停经≤49d、50-56d、57-63d随机分入5组,分别口服100mg米非司酮,24±2h(A组)或48±2h(B组)后阴道置米索前列醇800μg;分别口服200mg米非司酮,24±2h(C组)或48±2h(D组)后阴道置米索前列醇800μg;并以负压吸宫术终止妊娠为对照(E组);每组30例(3个不同妊娠期限各10例)。用免疫组织化学SP法检测流产蜕膜组织上PR、ER、糖皮质激素受体(GR)的表达。结果:PR、ER在蜕膜上的表达不受米非司酮的用量和米索前列醇用药时间的影响;但米非司酮能抑制GR在蜕膜间质细胞上的表达,各实验组与对照组在各妊娠期限的差异均有统计学意义(P<0.05)。结论:米非司酮对PR、ER的表达无影响,对蜕膜间质中GR的表达有抑制作用;此抑制作用可能是米非司酮抗早孕作用机理之一。另100mg米非司酮24h后阴道置800μg米索前列醇终止≤63d妊娠是可行的。

关键词：米非司酮雌激素孕激素糖皮质激素受体

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu Hui Hong Wei Quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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宫内节育器综合评价指标体系研究

生殖与避孕 2010年第10期30卷 684-690页

作者：崔丹房莉毛宗福吴尚纯李丽董敬武汉大学公共卫生学院武汉430071 国家人口计生委科学技术研究所北京100081

目的:建立宫内节育器(IUD)综合评价指标体系,为临床应用及政府采购、推广和新产品研发提供理论依据。方法:借鉴卫生服务三环节评价理论和产品评价理论构建指标体系框架,经多次专家讨论确定初始指标体系,结合临床随访资料,利用相关系数... 详细信息

目的:建立宫内节育器(IUD)综合评价指标体系,为临床应用及政府采购、推广和新产品研发提供理论依据。方法:借鉴卫生服务三环节评价理论和产品评价理论构建指标体系框架,经多次专家讨论确定初始指标体系,结合临床随访资料,利用相关系数法、变异系数法和因子分析法筛选指标,运用主成分分析结合专家意见法计算指标的权重,用TOPSIS法、综合指数法、秩和比法和模糊数学法对元宫Cu300 IUD、TCu380A IUD和活性165 IUD进行综合评价。结果:①构建出由服务提供、产品性能、经济性3个一级指标,服务过程、随访、产品有效性、副反应、并发症、可接受性6个二级指标,放置不顺利率、带器妊娠率、并发症率和避孕效果满意率等16个三级指标组成的IUD综合评价指标体系。②TOPSIS法、综合指数法和模糊数学法对3种IUD的综合评价结果为:元宫Cu300 IUD排名第一,TCu380A IUD第二,活性165 IUD第三。秩和比法的排序为:元宫Cu300 IUD第一,活性165 IUD第二,TCu380A IUD第三。结论:指标体系的构建由理论基础、专家的丰富经验以及大样本临床随访资料做支撑,采用主客观相结合的方法筛选指标,构建过程科学、严谨。利用指标体系评价3种IUD的结果具有一致性,与临床经验相符,说明具有现实可行性和可操作性。

关键词：宫内节育器(IUD) 指标体系综合评价