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Study on the anti-inflammatory mechanism of moxibustion in rheumatoid arthritis in rats based on phospholipaseA2 signaling inhibition by Annexin 1

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Journal of Traditional Chinese Medicine 2024年第4期44卷 753-761页

作者： GUO Yanding LUO Kun ZHANG Linlin LU Wenting shang yanan ZHONG Yumei HU Danhui YANG Xin ZHOU Haiyan Department of Acupuncture-Moxibustion and Tuina the Third Affiliated HospitalChengdu University of Traditional Chinese MedicineChengdu 610075China External Treatment Center First People's Hospital of ChengduChengdu 610095China Department of Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital Chengdu 610075China Department of Health Rehabilitation School Chengdu University of Traditional Chinese MedicineChengdu 610075China

OBJECTIVE:To determine whether moxibustion had an anti-inflammatory effect on rheumatoid arthritis(RA)by regulating Annexin 1 expression and interfering with the phospholipaseA2 signaling ***:Thirty male Sprague-Dawley rats were randomly categorized into five groups(six rats per group):blank control(CON)group,RA model(RA)group,moxibustion(MOX)group,Annexin 1 lentiviral intervention(RNAi-Anxa1)group,and Annexin 1 lentiviral intervention+moxibustion(RNAi-Anxa1+MOX)*** rats in the RNAi-Anxa1 and the RNAi-Anxa1+MOX groups were injected with the lentiviral vector-mediated RNAi-Anxa1 into the rat foot *** experimental RA rat model was established by injecting Freund's complete adjuvant(FCA)into the RA,MOX,RNAi-Anxa1,and RNAi-Anxa1+MOX *** in the MOX and RNAiAnxa1+MOX groups received moxibustion *** modeling,using moxibustion“Shenshu(BL23)”and“Zusanli(ST36)”,each point is 5 times,bilateral alternating,once a day,6 times for a course of treatment,between the courses of rest for a one day.A total of three treatment courses were *** bilateral pad thicknesses were measured using Vernier calipers on experimental days 1,7,14,21,and *** expression of cPLA2αsignaling in the synovium of diseased joints was observed using Western *** pathology of the rat ankle synovium was observed using hematoxylineosin(HE)***(IL)-1β,IL-10,prostaglandin E2(PGE2),and leukotriene B4(LTB4)were detected using enzyme-linked immunosorbent ***:Moxibustion increased the levels of Annexin 1 and decreased the inflammatory response in rats with *** increasing the expression of Annexin 1,the phosphorylated expression of cPLA2αwas inhibited,the serum levels of IL-1β,PGE2,and LTB4 decreased,and the level of IL-10 *** moxibustion treated RA rats after the Annexin 1 lentiviral intervention,the serum levels of IL-1β,PGE2,LTB4,and IL-10 were almost ***:Moxibustion enhanced the negative regulation of

关键词： annexins group IV phospholipases A2 signal transduction moxibustion arthritis,rheumatoid

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Moxibustion of Zusanli(ST36)and Shenshu(BL23)alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling

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Journal of Traditional Chinese Medicine 2024年第2期44卷 353-361页

作者： ZHANG Linlin ZHONG Yumei LU Wenting shang yanan GUO Yanding LUO Xiaochao CHEN Yang LUO Kun HU Danhui YU Huiling ZHOU Haiyan Acupuncture and Moxibustion College Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Painology First People's Hospital of ChengduChengdu 610095China Chinese Evidence-Based Medicine Centre West China HospitalSichuan UniversityChengdu 610044China Traditional Chinese Medicine College Chongqing Medical UniversityChongqing 400016China External treatment center First People's Hospital of ChengduChengdu 610095China

OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fifty male Sprague-Dawley rats were randomly divided into five groups(n=10 each):blank Control(CON)group,RA Model(RA)group,Moxibustion(MOX)group,MIF inhibitor(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)group,and Moxibustion+MIF inhibitor ISO-1(MOX+ISO-1)*** in the ISO-1 group and ISO-1+MOX group were intraperitoneally injected with the inhibitor *** rats in the RA group,ISO-1 group,MOX group,and ISO-1+MOX group were injected with Freund's complete adjuvant(FCA)in the right hind footpad to establish an experimental RA rat *** the MOX group and MOX+ISO-1 group,rats were treated with *** thickness of the footpads of the rats in each group was measured at three-time points before,after modeling and after moxibustion *** contents of serum MIF,corticosterone(CORT),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were detected by enzyme-linked immunosorbent assay;and the contents of synovial MIF were detected by Western ***-eosin(HE)staining method was used to observe the pathological changes of synovial tissue under a section light microscope,and pathological scoring was performed according to the grading standard of the degree of synovial tissue ***:Moxibustion was found to reduce the level of MIF and alleviate inflammation in RA rats in this *** addition,after inhibiting the expression of MIF,the level of CORT increased,and the level of TNF-α *** RA rats with inhibited MIF by moxibustion,the level of CORT was almost unchanged,but the level of TNF-α further *** correlation analysis data suggested that MIF was positively related to the expression of TNF-α and negatively correlated with the expression of ***:Reducing MIF to

关键词： rheumatoid arthritis macrophage migration inhibitory factor moxibustion corticosterone glucocorticoids

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Stability and regeneration of metal catalytic sites with different sizes in Fenton-like system

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中国化学快报:英文版 2023年第8期34卷 142-146页

作者： yanan shang Yujiao Kan Xing Xu School of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China School of Environmental Science and Engineering Shandong UniversityQingdao 266237China

Metal-based catalysts with different site sizes(e.g.,metal nanoparticles(NPs)and single atom catalysts(SACs))demonstrated outstanding catalytic activities in versatile Fenton-like ***,the surface/structural instability is a critical issue,which will result in rapid passivation in Fenton-like reaction and fail in long-term *** catalytic stability of the catalysts with different metal sizes considering versatile peroxides(H_(2)O_(2),peroxymonosulfate(PMS),and peroxodisulfate(PDS))should be *** addition,strategies for catalyst regeneration and recyclability improvement are also important to realize the metal-based catalysts for practical *** this review,catalytic stability of catalysts with different metal sizes in the backgrounds of versatile peroxides and water matrixes in Fenton-like reactions were first *** of metal catalytic sites with different methods were also ***,major challenges and development of methods concerning the stability and regeneration of metal catalytic sites with different sizes were discussed to understand the future researches of metal catalytic sites in Fenton-like reactions.

关键词： Size effect Metal nanoparticles catalysts Single atom catalysts Fenton-like

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Carbon-based single atom catalyst: Synthesis, characterization, DFT calculations

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Chinese Chemical Letters 2022年第2期33卷 663-673页

作者： yanan shang Xiaoguang Duan Shaobin Wang Qinyan Yue Baoyu Gao Xing Xu Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityJi’nan 250100China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Carbon-based single-atom catalysts(SACs) with atomic sizes of active sites have become the promising candidates for a variety of catalytic systems because of their high atom utilization, and unique electronic structures. Different types of single-atom sites can be fabricated via multiple preparation strategies, which would demonstrate distinct different coordination configurations and electronic features, and ultimately affected the structure-catalysis relationship of SACs in targeted reactions. As a result, it is necessary to identify the active sites of SACs and understand the structure-catalysis relationship of SACs at the atomic scale. In this review, a variety of preparation strategies of carbon-based SACs were documented. Then, the recent development on versatile characterization techniques and computational achievements were summarized regarding in understanding the electronic and geometric characteristics of carbon-based ***, major challenges and development directions concerning single-atom sites identification and advanced tools development are discussed to shed light on future research of carbon-based SACs.

关键词： Single atom Synthesis DFT calculations Characterization Catalysis

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Adsorptive removal of phosphate by the bimetallic hydroxide nanocomposites embedded in pomegranate peel

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Journal of Environmental Sciences 2020年第5期32卷 189-198页

作者： Muhammad Akram Xing Xu Baoyu Gao Qinyan Yue shang yanan Rizwan Khan Muhammad Ali Inam Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266200China Department of Chemical Engineering Quaid-e-Awam University of EngineeringScience and Technology(QUEST)Naiuabshah 67480SindfiPakistan Institute of Environmental Sciences and Engineering(IESE) School of Civil and Environmental Engineering(SCEE)National University of Sciences and Technology(NUST)H-12 CampusIslamabad 44000Pakistan

This study aimed to fabricate new and effective material for the efficiency of phosphate *** types of adsorbent materials,the zirconium hydroxides embedded in pomegranate peel(Zr/Peel)and zirconium-lanthanum hydroxides embedded in pomegranate peel(Zr-La/Peel)were *** electronic microscopy(SEM),x-ray photoelectron spectroscopy(XPS)and x-ray diffraction(XRD)were evaluated to give insight into the physicochemical properties of these ***-La/Peel exceeded the adsorption efficiency of Zr/Peel adsorbents in batch adsorption experiments at the same pH *** peel as a host can strive to have a strong"shielding effect"to increase the steadiness of the entrenched Zr and La *** and Zr are hydroxide metals that emit many hydrogen ions during the hydrolysis reaction,which contribute to protonation and electrostatic *** highest adsorption capacity of La-Zr/Peel for phosphate was calculated to be40.21 mg/g,and pseudo second-order equation is very well fitted for kinetic *** adsorption efficiency was reduced by an increase of *** the background of coexisting Cl-,little effect on adsorption efficiency was observed,while adsorption capacities were reduced by almost 20-30%with the coexistence of SO42-,NO3-and humic acid(HA).

关键词： Bimetallic hydroxides Pomegranate peel Phosphate Adsorption

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Machine learning and microstructure design of polymer nanocomposites for energy storage application

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High Voltage 2022年第2期7卷 242-250页

作者： Yu Feng Wenxin Tang Yue Zhang Tiandong Zhang yanan shang Qingguo Chi Qingguo Chen Qingquan Lei Department of High Voltage Key Laboratory of Engineering Dielectrics and Its ApplicationMinistry of EducationHarbin University of Science and TechnologyHarbinChina School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbinChina

Film dielectric capacitors have been widely used in high‐power electronic *** design of microstructure and the choice of fillers play an important role in nano-composites'energy storage *** learning methods can classify and summarise the limited data and then explore the promising composite *** this work,a dataset has been established,which contained a large amount of data on the maximum energy storage density of *** using processed visual image infor-mation to express the internal information of composite,the prediction accuracy of the prediction models built by three machine learning algorithms increase from 84.1%to 91.9%,80.9%to 68.9%,70.6%to 81.6%,*** calculating the branch weight in the random forest prediction model,the influence degree of different descriptors on the energy storage performance of nanocomposites is analysed.A total of 10 groups of composites with different structure and filler amount were prepared in the laboratory,which were used to verify the reliability of prediction ***,the effective filler's structure is explored by three prediction models and some suggestions for the interface design of filler are given.

关键词： composites composite prediction

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Comparative study of raw and HNO_(3)-modified porous carbon from waste printed circuit boards for sulfadiazine adsorption: Experiment and DFT study

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Chinese Chemical Letters 2023年第7期34卷 256-259页

作者： Yujiao Kan Ruxin Zhang Xing Xu Bo Wei yanan shang School of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China Faculty of Light Industry Qilu University of Technology(Shandong Academy of Sciences)Ji'nan 250353China Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266237China Environment Research Institute ShandongUniversityQingdao266237China

A huge amount of waste printed circuit boards(WPCBs) was produced while the electronic manufacturing industry developed rapidly. WPCBs mainly consist of organic compounds, which makes it possible to prepare them into porous carbon as valuable adsorbent. However, WPCBs are also rich in valuable *** makes up the most of these metals. It is worth studying whether the residual metal will affect the application of carbon materials. In this study, the porous active carbon(AC) was prepared from WPCBs as an adsorbent. Sulfadiazine(SD), a widely detected antibiotic contaminant, was used as a target *** acid(HNO_(3)) was used to modify AC(AC-HNO_(3)) to remove the residual Cu. The experiment results showed that the adsorption kinetics of SD by AC(k = 0.0025) and AC-HNO_(3)(k = 0.0029) can be described better using a pseudo-second-order kinetic equation. The adsorption isotherms of AC and AC-HNO_(3) on SD could be fitted by the Langmuir model. AC had a larger adsorption capacity than AC-HNO_(3). Density functional theory(DFT) calculation results suggested that the-OH group and Cu on the surface of AC could be the adsorption sites and promote the SD adsorption. This work provides practical methods to recycle WPCBs into wealth and realized waste control by waste.

关键词： WPCBs DFT Sulfadiazine Porous carbon

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关于高校官方微信公众平台发展策略的几点思考——以沧州师范学院官方微信公众平台为例

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沧州师范学院学报 2020年第1期36卷 111-113页

作者：商雅楠沧州师范学院党委宣传部

微信公众平台已成为移动时代高校宣传的重要平台。沧州师院为充分发挥微信公众平台的宣传优势,积极探索发展策略,从内容、表现形式、时效性、影响力及团队建设等多个方面进行了实践,取得了显著成绩,为促进高校官方微信公众平台的发展积... 详细信息

微信公众平台已成为移动时代高校宣传的重要平台。沧州师院为充分发挥微信公众平台的宣传优势,积极探索发展策略,从内容、表现形式、时效性、影响力及团队建设等多个方面进行了实践,取得了显著成绩,为促进高校官方微信公众平台的发展积累了经验、提供了有益借鉴。

关键词：高校官方微信公众平台沧州师范学院发展策略

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分解协调式节点阻抗矩阵生成算法的并行实现

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电网技术 2011年第9期35卷 99-104页

作者：曾飞苗世洪尚亚男夏文龙熊玮林湘宁华中科技大学电气与电子工程学院湖北省武汉市430074

将互联大电网以节点撕裂方式分解为相互无电磁联系的独立子网,各子网通过撕裂节点间的虚拟断路器桥接。在各子网并行求得独立节点阻抗矩阵后,采用分解协调法来计及各子网的电磁联系,并利用大变化灵敏度理论修正各子网的独立节点阻抗矩阵... 详细信息

将互联大电网以节点撕裂方式分解为相互无电磁联系的独立子网,各子网通过撕裂节点间的虚拟断路器桥接。在各子网并行求得独立节点阻抗矩阵后,采用分解协调法来计及各子网的电磁联系,并利用大变化灵敏度理论修正各子网的独立节点阻抗矩阵,从而得到整个电网的节点阻抗矩阵。最后,通过仿真实验验证了该并行算法的有效性和正确性。

关键词：分解协调法节点阻抗矩阵并行计算在线整定

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Survey and Analysis of Postoperative Quality of Life in Gynaecological Oncology Patients

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Journal of Advances in Medicine Science 2024年第1期7卷 7-14页

作者： Yujing Zhou Fengjuan Yuan Moyu shang Xiaoyu Chang Haiyue Huang Shirui Wang Xuanxiang Bian Qixuan Gao yanan Dai Pingdingshan University PingdingshanHenan467000China

Goal:To investigate the current status of quality of life of postoperative patients with gynaecological tumours,and to analyse the relevant factors affecting the quality of life of postoperative patients with gynaecological ***:One hundred and fifty-three postoperative gynecological oncology patients who attended the gynaecology and oncology departments of three tertiary hospitals in Henan Province from June 2023 to March 2024 were investigated by convenience sampling *** patients’postoperative survival quality was investigated through the General Information Survey Scale and Quality of Life Score ***:The quality of life measurement scale score of postoperative gynaecological oncology patients in this study was(121.27±10.87),in which there was a difference in the quality of life of postoperative gynaecological oncology patients of different age,education level,marital status,and per capita monthly income of the family,p<***:The quality of life level of postoperative gynaecological oncology patients is generally good,and age,literacy,marital status,and per capita monthly family income are important factors in the postoperative quality of life of gynaecological oncology *** professionals should focus on patients with older age,lower education level,unstable marital status,and poor economic status,and provide personalised targeted interventions to improve their quality of life.

关键词： Gynaecological oncology Quality of life Current status survey

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