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Journal of Pharmaceutical Analysis 2024年第4期14卷 585-600页

作者： Yuanyuan Qian Xiting Wang Lulu Cai Jiangxue Han Zhu Huang Yahui Lou Bingyue Zhang yanjie Wang Xiaoning Sun Yan Zhang Aisong Zhu Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome Zhejiang Chinese Medical UniversityHangzhou310000China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China Zhejiang Engineering Research Center for“Preventive Treatment”Smart Health of Traditional Chinese Medicine Zhejiang Chinese Medical UniversityHangzhou310000China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou310000China Affiliated hospital of Liaoning University of Traditional Chinese Medicine Shenyang110032China Academy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou310000China

Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex *** characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(Deeptcm).Deeptcm has gone through multilevel model calibration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(tcm).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the ***,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease ***,we experimentally confirmed the therapeutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and *** novel multiscale model opened up a new avenue to combine“disease syndrome”and“macro micro”system modeling to facilitate translational research in CHM formulas.

关键词： Chinese herbal medicine formulas Precision medicine Mathematical modeling Systems biology Coronary heart disease Depression Ischemia-reperfusion Inflammation

Analysis on the Therapeutic Effect of Acupuncture for 30 Cases of Coronary Heart Disease

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Analysis on the Therapeutic Effect of Acupuncture for 30 Cas...

Academic Conference of the Tenth Anniversary of World Federation of Acupuncture-Moxibustion

作者： Wang Shun shang yanjie Zhou Zhenkun (heilongjiang Province tcm hospital Harbin 150036)

＜正＞A total of 30 patients with coronary heart disease were divided into six types: Yin deficiency, Yang deficiency, Qi deficiency, phlegm stagnation, blood stasis and the mixed （two or more types together ）. Point groups: 1) Xinshu （BL 15）, Juque （RN 14）, Xinping （2 cun interior to Shaohai （HT 3）. 2）. Jueyinshu （BL 14）, Shanzhong （RN 17）, Neiguan （PC 6）. The two groups were used alternately, combined with other points based on differentiation of symptoms and signs. The treatment was

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从“虚气留滞”论治心房颤动

中医杂志 2024年第12期65卷 1235-1239页

作者：贾思涵连妍洁尚菊菊刘红旭首都医科大学附属北京中医医院北京市东城区100010 首都医科大学

基于“虚气留滞”阐释心房颤动的病因病机并指导治疗。认为“虚气”为心房颤动发病之本,根据病位可分为上焦心肺之宗气亏虚、中焦脾胃之中气亏虚、下焦肾之元气亏虚;瘀血、痰湿、寒湿等邪气留滞为心房颤动的病理基础,诸邪或郁而化热,或... 详细信息

基于“虚气留滞”阐释心房颤动的病因病机并指导治疗。认为“虚气”为心房颤动发病之本,根据病位可分为上焦心肺之宗气亏虚、中焦脾胃之中气亏虚、下焦肾之元气亏虚;瘀血、痰湿、寒湿等邪气留滞为心房颤动的病理基础,诸邪或郁而化热,或寒湿停聚,留滞于心脉而发病。论治时以补虚通滞为基本原则,常用清凉补气调脉汤以补宗益气、理气通脉,清凉化湿调脉汤以建中化痰、燥湿通脉,滋养温化调脉汤以培元滋阴补阳、散寒通脉。

关键词：心房颤动正气亏虚邪气留滞补虚通滞

基于血浊理论探讨氧化应激与心肌纤维化的关系及中医辨治

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北京中医药大学学报 2024年第6期47卷 741-746页

作者：贾思涵连妍洁尚菊菊刘红旭李思耐首都医科大学附属北京中医医院北京100010 首都医科大学北京市中医药研究所

心肌纤维化以细胞外基质病理性重构为主要特征,是多种心血管疾病发展至一定阶段的共同病理改变。脏腑气化失常,精微积聚停滞,血浊内生,导致疾病发生,血浊理论被广泛用于解释疾病的病理变化,并指导疾病的预防与治疗。血浊作为特殊的致病... 详细信息

心肌纤维化以细胞外基质病理性重构为主要特征,是多种心血管疾病发展至一定阶段的共同病理改变。脏腑气化失常,精微积聚停滞,血浊内生,导致疾病发生,血浊理论被广泛用于解释疾病的病理变化,并指导疾病的预防与治疗。血浊作为特殊的致病因素与病理产物,在心肌纤维化氧化应激过程中发挥了关键作用。心脾气虚,血浊伏脉,心血不畅,无力维持心肌细胞氧化还原系统平衡,为病起之本。血浊蓄积,痰瘀互结,心脉壅塞,代谢产物积累为病进之渐。浊久蕴毒,心体胀大,心神涣散,细胞外基质重构为病重之势。治疗早期以扶正运脾、降浊复清为主,中期以化痰逐瘀、祛浊留清为要,晚期以解毒化浊、和脉复清为重。遵循病机特点运用中药干预,可以抑制氧化应激,避免细胞外基质病理性重构,改善心肌纤维化。

关键词：血浊理论心肌纤维化氧化应激辨证论治

Organic Integration of Traditional Chinese and Western Medicines—Future of Clinical Practice Guidelines of Integrated Traditional Chinese and Western Medicines

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Chinese Journal of Integrative Medicine 2024年第4期30卷 359-365页

作者： XIE Ying-lan HAN Fei JIN Ying-hui DING Yan-bing GUO Jing JI Dong-xiao ZHANG Teng CHENXiao-min shang Hong-cai Department of Traditional Chinese Medicine Encephalopathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan(430074)China Department of Traditional Chinese Medicine Encephalopathy Hubei Province Traditional Chinese Medicine Research InstituteWuhan(430074)China Xuanwu hospital of Traditional Chinese Medicine Beijing(100000)China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan(430074)China College of Acupuncture and Massage College of Health and RehabilitationNanjing University of Chinese MedicineNanjing(210023)China Department of Ophthalmology Huaihe Hospital of Henan UniversityKaifengHenan Province(475000)China Ministry of Education and Beijing Key Laboratory of Internal Medicine of Traditional Chinese Medicine Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine/Ministry of Education and Beijing Key Laboratory of Internal Medicine of Traditional Chinese MedicineBeijing(100700)China

The transformation and implementation of clinical practice guidelines for integrated traditional Chinese medicine(tcm)and Western medicine(WM)is crucial to the adoption of medical science and technological findings and is an important way for tcm to be made available to the ***,clinical practice guidelines(CPGs)of tcm and WM integration in recent years was analyzed to clarify the current situation and problems in the existing guidelines according to the following four perspectives:(1)perspective of tcm and WM integration in guidelines,(2)diagnosis Using integrated tcm and WM,(3)integration of tcm and WM treatment,(4)promoting tcm and WM ***,the information and quality evaluation of CPGs for integrated Chinese and Western medicine in 2020–2022 were analyzed to explore the degree and methods of integration of Chinese and Western medicine *** last this study aimed to lay a foundation for the further establishment of Chinese characteristic,repeatable,and calculable clinical practice guidelines of tcm and WM integration.

关键词： clinical practice guidelines integrated traditional Chinese and Western medicine organic integration

Deciphering the mechanism of Liu Wei Di Huang Wan in treating premature ovarian failure:a comprehensive exploration through network pharmacology and molecular docking analysis

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Journal of Chinese Pharmaceutical Sciences 2024年第9期33卷 805-818页

作者： Ping shang Lin Liu Yi Fang Chongqing Health Center for Women and Children Women and Children's Hospital of Chongqing Medical UniversityChongqing 401147China

Premature ovarian failure(POF)is a prevalent gynecological disorder with significant implications for the physical and mental well-being of affected *** Wei Di Huang Wan(LWDHW),a Chinese herbal compound,has demonstrated efficacy in alleviating the effects of ***,the underlying mechanism of action of LWDHW remains *** study aimed to elucidate the potential molecular mechanism of LWDHW in treating POF using network pharmacology and molecular docking *** active ingredients of LWDHW were initially screened through the tcmSP *** the same time,the relevant target genes associated with POF were identified using databases such as Disgenet,TTD,Drugbank,Gene Cards,OMIM,and Pharm *** analysis was conducted using the R language,Cytoscape,and STRING to construct and analyze the traditional Chinese medicine(tcm)regulatory network and protein-protein interaction(PPI)network ***,GO and KEGG enrichment analyses were performed using the R ***,molecular docking was carried out between the protein receptors of the core genes and the corresponding small-molecule *** study revealed 49 components and 189 predicted targets(after de-duplication)of LWDHW,along with 4524 targets(after de-duplication)associated with *** comparative analysis,163 potential genes were identified as common targets of LWDHW and POF,participating in biological processes such as response to chemical substances,molecular function regulation,and signaling receptor *** biological pathways implicated included the MAPK signaling pathway,IL-17 signaling pathway,and HIF-1 signaling pathway,among *** docking results demonstrated a robust binding ability between the core genes of LWDHW and their corresponding *** conclusion,this comprehensive analysis provided insights into the potential molecular mechanisms of LWDHW in treating *** identified common targets and associated pathways contributed to

关键词： Network pharmacology Liu Wei Di Huang Wan Premature ovarian failure Molecular docking

Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You Min Li Jian-bo Guo Xin-bin Song Jing-yi Ding Xiao-long Xie An-qi Li shang-jin Li Xiang-jun Yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

基于Web of Science分析胞葬在动脉粥样硬化中的相关研究热点和发展态势

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中华全科医学 2024年第1期22卷 148-153页

作者：连妍洁刘子豪刘红旭张赫怡尚菊菊来晓磊首都医科大学附属北京中医医院心血管科北京100010 首都医科大学中医药临床医学院北京100069

目的通过对动脉粥样硬化(AS)胞葬相关英文文献进行计量及可视化分析,探索该领域研究现状、热点及动态前沿。方法以Web of Science数据库中的核心合集为数据源,对建库至2022年12月1日收录的AS胞葬相关文献进行可视化法分析,借助VOSvie... 详细信息

目的通过对动脉粥样硬化(AS)胞葬相关英文文献进行计量及可视化分析,探索该领域研究现状、热点及动态前沿。方法以Web of Science数据库中的核心合集为数据源,对建库至2022年12月1日收录的AS胞葬相关文献进行可视化法分析,借助VOSviewer对国家/地区、机构、期刊、作者分布进行分析,借助CiteSpace 6.1.R4软件绘制关键词可视化图谱。结果纳入258篇SCI文章,发文量呈逐年增加趋势。高产作者TABAS I A发文数量及被引次数均最多,高产国家包括美国、中国、德国等。收录AS胞葬相关SCI文献质量均较高(JCR分区Q1、Q2),其中《Arteriosclerosis Thrombosis And Vascular Biology》杂志收录最多。“apoptotic cell”“activation”“expression”是重要的关键词,“macrophage”“NLRP3 inflammasome”“inflammation resolution”等是近3年的突变词。结论本领域研究热点包括凋亡细胞、炎症、激活、巨噬细胞、吞噬作用等,预测未来将围绕AS胞葬的机制、巨噬细胞、AS的治疗策略继续深入研究。

关键词：动脉粥样硬化胞葬 CiteSpace Web of Science 可视化分析

Surgical management of adult hand macrodactyly in a 49-year-old patient:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5236-5244页

作者： Chao-Jian Pang Xiao-Yan Huo Yuan Liu Zong-You Yang Lu Liu Xiao-Bo Fan shang-Wen Xu Department of Orthopaedic Surgery The First Hospital of HandanHandan 050000Hebei ProvinceChina Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Health Management Hebei Provincial Hospital of Traditional Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Hand Surgery The First Hospital of HandanHandan 050000Hebei ProvinceChina

BACKGROUND Macrodactyly is a rare congenital malformation characterized by an increase in the size of all structures of a digit,accounting for less than 1%of all congenital upper extremity *** SUMMARY We report a case involving a 49-year-old woman who presented for the first time with untreated,radial-sided hand *** performed soft tissue debulking,amputation,median nerve neurotomy and coaptation,and carpal tunnel *** the 6-year follow-up,no significant growth was observed in the bone or soft tissue of the affected *** Tissue overgrowth in patients with progressive macrodactyly can continue and progress excessively with *** nerve neurotomy and coaptation play a crucial role in preventing recurrence of the deformity.

关键词： Macrodactyly Surgery Management Hand Case report