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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Gavin McKenzie Paul K Witting Johannes-Peter Stasch Michael Hahn Dechaboon Changsirivathanathamrong Helen J Ball shane R thomas Vimal Kapoor David S Celermajer Andrew L Mellor John F Keaney,Jr Nicholas H Hunt Roland Stocker School of Medical Sciences University of New South WalesNSW 2052Australia School of Medical Sciences(Pathology)and Bosch Institute Faculty of MedicineUniversity of SydneyNSW 2006Australia Cardiovascular Research Bayer HealthCare WuppertalGermany Medicinal Chemistry Bayer HealthCareWuppertalGermany Centre for Vascular Research School of Medical Sciences(Pathology)and Bosch InstituteFaculty of MedicineUniversity of SydneyNSW 2006Australia Centre for Vascular Research University of New South WalesNSW 2052Australia School of Medicine and Pharmacology University of Western AustraliaPerth WA 6009Australia Royal Prince Alfred Hospital University of SydneyNSW 2006Australia Immunotherapy Center Medical College of GeorgiaAugusta GA 30912U.S.A

＜正＞Control of blood vessel tone is central to vascular *** we show that metabolism of tryptophan to kynurenine by indoleamine 2,3-dioxygenase（Ido） expressed in endothelial cells contributes to arterial vessel relaxation and the control of blood *** of mice with malarial parasites（Plasmodium berghei） or induction of endotoxemia in mice led to endothelial expression of Ido,decreased plasma tryptophan concentration, increased kynurenine concentration and *** inhibition of Ido increased blood pressure in systemically inflamed mice but not in mice deficient in Ido or interferon-γ,which is required for Ido *** tryptophan and kynurenine dilated preconstricted porcine coronary arteries;the dilating effect of tryptophan required the presence of active Ido and an intact endothelium,whereas the effect of kynurenine was endothelium *** arterial relaxation induced by kynurenine was mediated by activation of the adenylate and soluble guanylate cyclase *** administration decreased blood pressure in a dose-dependent manner in spontaneously hypertensive *** results identify tryptophan metabolism by Ido as a new pathway contributing to the regulation of vascular tone.

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北京肿瘤医院住院病人满意度连续性监测

北京肿瘤医院住院病人满意度连续性监测

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第十八届全国肿瘤医院管理学术研讨会

作者：隗铁夫杨辉管九苹季新强于新颖刘佳平 shane thomas 李萍萍北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所澳大利亚Monash大学北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所北京大学医学部研究生院北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所澳大利亚Monash大学北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所

＜正＞病人对医疗服务的满意和体验的信息,可以帮助医院管理者发现服务质量问题并制定相应的改进措施。高质量测量工具是制定有效循证卫生政策的重要前提。目前中国还没有全国统一的病人满意和体验测量工具,造成了多元开发和数量参差的...

＜正＞病人对医疗服务的满意和体验的信息,可以帮助医院管理者发现服务质量问题并制定相应的改进措施。高质量测量工具是制定有效循证卫生政策的重要前提。目前中国还没有全国统一的病人满意和体验测量工具,造成了多元开发和数量参差的现象。无论是文献中报告的工具,还是行政部门下发的规

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Bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women

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Bone Research 2014年第3期2卷 194-202页

作者： Bin Zhou Ji Wang Emily M Stein Zhendong Zhang Kyle K Nishiyama Chiyuan A Zhang thomas L Nickolas Elizabeth shane X Edward Guo Bone Bioengineering Laboratory Department of Biomedical Engineering Columbia University Division of Endocrinology Department of Medicine Columbia University Department of Orthopedic Surgery First Affiliated Hospital School of Medicine Shihezi University

Hispanic Americans of Caribbean origin are a fast-growing subset of the US population, but there are no studies on bone density, microstructure and biomechanical integrity in this minority group. In this study, we aimed to compare Caucasian and Caribbean Hispanic postmenopausal American women with respect to these characteristics. Thirty-three Caribbean Hispanics were age-matched to thirty-three Caucasian postmenopausal women. At the lumbar spine, the Hispanic women had significantly lower areal bone mineral density （aBMD）. At the radius by high-resolution peripheral quantitative computed tomography （HR-pQCT）, there were minimal differences between Hispanic and Caucasian women. At the tibia, Hispanic women had lower trabecular volumetric bone density and trabecular number, and higher trabecular separation. Individual trabecula segmentation （ITS） analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women. The differences in bone quantity and quality contributed to lower whole bone stiffness at the radius, and both whole bone and trabecular bone stiffness at the tibia in Hispanic women. In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

关键词： bone DXA Bone density microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women

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ANAGRAM PROBLEM-SOLVING AND LEARNING IN ANTERIOR PREFRONTAL CORTEX

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Journal of Innovative Optical Health Sciences 2008年第2期1卷 157-175页

作者： SHOKO NIOKA JOSEPH I.TRACY shane RAINES SCOTT BUNCE BRITTON CHANCE Department of Biochemistry-Biophysics Biostatistics University of PennsylvaniaPAUSA Department of Neurology and Radiology Thomas Jefferson University§Department of PsychologyDrexel University PhiladelphiaPAUSA

We utilized Near-Infrared(NIR)spectroscopy to closely investigate the activation change in anterior prefrontal cortex(aPFC)during verbal anagram problem-solving and *** used a parametric design of anagram-solving with three difficulty levels and evaluated anagram skill with two sets of subjects and *** first protocol was a one-time evaluation of untrained subjects(n=10)and the second protocol evaluated subjects over 6 weeks of training(n=6).The untrained subjects in the first protocol demonstrated blood oxygenation corresponding to neuronal activation in the aPFC in response to medium and hard difficulty levels of the stimuli,while the easy anagram task deoxygenated the aPFC bilaterally,corresponding to *** performers have more aPFC activation than lower performers in the medium difficulty level anagram-solving *** weeks of training in the second protocol showed that training reduced oxygenation in *** particular,subjects with lower baseline skill in anagram production showed a larger reduction in oxygenation where true performance gains occurred(medium difficulty)and smaller reduction where the performance gains were limited(hard anagrams).Association of the aPFC activation with the difficulty of the complex task suggests that aPFC is a part of a circuit for execution of task *** addition,more use of aPFC by untrained high performers suggests that the role of the aPFC is to increase efficiency of a problem-solving ***,the NIR spectroscopy showed that the aPFC is a key structure in the circuit implementing the development of anagram skill.

关键词： Anagram anterior prefrontal cortex hemoglobin NIR oxygenation training effects difficulty

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Potentially life-threatening intravenous acetaminophen overdose in a 3-month-old (40 weeks’ post-menstrual age), 2.3 kg baby girl

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Open Journal of Pediatrics 2013年第3期3卷 186-187页

作者： shane Campbell thomas Engelhardt James McLay Brian Anderson Department of Anaesthesia Royal Aberdeen Children’s Hospital Aberdeen UK Intensive Care Medicine Auckland Children’s Hospital Auckland New Zealand

A case is presented of a serious, potentially life-threatening intravenous acetaminophen overdose in a 3-month-old (40 weeks’ post menstrual age),2.3 kgbaby girl. The neonate was scheduled for urgent laser therapy for retinopathy of prematurity. Instead of an intended intravenous Hartmann’s solution bolus of 10 ml·kgˉ1, the neonate received a 17 ml bolus of correctly labelled intravenous 1% acetaminophen. The National Poisons Bureau was immediately contacted for advice and in the absence of data suggested a treatment with N-acetylcysteine for a 24-hour period. Baseline blood samples for clotting, liver function, urea and electrolytes, full blood count and plasma acetaminophen concentration were taken 30 min, 8.25 h, 12.5 h, 18.5 h and 120 h after the overdose. Acetaminophen concentration was 78 mg·Lˉ1 at 30 min, but it was undetectable at any other time. Using a recent and complete PK-PD dataset we are able to show that the measured plasma acetaminophen concentration fits well on PK estimates for acetaminophen in this neonate. The non-detectable (low) plasma acetaminophen concentration at >8 h is also consistent with this model, especially if clearance is slightly increased in the premature nursery graduate. Medical errors are rarely the fault of an individual and they are often due to a combination of factors. Contributing factors, in this case, are described under the following headings: Catalyst event, system fault, loss of situational awareness, and human error.

关键词： Neonate Acetaminophen Overdose No Sequelae PK Models Drug Error

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Newly established autonomous adaptive low-power instrument platform(AAL-PIP) chain on East Antarctic Plateau and operation

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Advances in Polar Science 2019年第4期30卷 362-374页

作者： Zhonghua XU Michael DHARTINGER Robert CLAUER Daniel WEIMER Kshitija DESHPANDE Hyomin KIM Stephen MUSKO Anna WILLER thomas EDWARDS shane COYLE Yuxiang PENG Dong LIN John BOWMAN Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24061USA Center for Space Plasma Physics Space Science InstituteBoulderCO 80301USA Department of Physical Sciences Embry-Riddle Aeronautical UniversityDaytona BeachFL 32114USA Center for Solar-Terrestrial Research New Jersey Institute of TechnologyNewarkNJ 07102USA Space Physics Research Laboratory College of EngineeringUniversity of MichiganAnn ArborMI48109USA DTU Space National Space InstituteTechnical University of DenmarkKongens LyngbyDenmark

An autonomous adaptive low-power instrument platform(AAL-PIP)chain of six stations has been newly established on East Antarctic Plateau along the 40°geomagnetic meridian,to investigate interhemispheric geomagnetically conjugate current systems,waves,and other space weather phenomena in Polar *** six stations,PG0 to PG5,which host low-power magnetometers(Fluxgate and Searchcoil),dual frequency GPS receivers,HF radio experiment,and run autonomously with solar power and two-way satellite communication,are designated at the geomagnetically conjugate(based on the International Geomagnetic Reference Field)locations of the West Greenland geomagnetic chain covering magnetic latitudes from 70°to 80°.We present the development,deployment,and operation of this chain,as well as the data collected by the chain and some preliminary scientific results showing evidence of interhemispheric asymmetries,which are important to better understand Solar Wind–Magnetosphere–Ionosphere(SWMI)coupling in Polar *** investigations focus on magnetic impulse(MI)events,traveling convection vortices(TCVs),and ultra-low frequency(ULF)waves in the coupled southern and northern hemispheres.

关键词： magnetometers magnetic perturbation magnetic conjugate

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