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Toxicity of a s.afood toxin， domoic acid， in the retina via modulation of the NRF2 and NF-κB pathways

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Food s.ience and Human Wellnes. 2024年

作者： Gabriel Mbuta Tchivelekete Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agos.inho Francis.o Cachapa s.bas.i?o Tumitangua James.reilly Patricia E.Martin Xinhua s.u Department of Biological and Biomedical s.iences Glas.ow Caledonian Univers.ty Department of Marine Biology Faculty of Natural s.ience Univers.ty of Namibe Puai Medical s.hool s.aoyang Univers.ty Department of Vis.on s.ience Glas.ow Caledonian Univers.ty

Domoic acid (DA)， a biotoxin， is.produced by s.veral s.ecies.of marine dinoflagellate and diatom during harmful algal bloom events. DA is.a neurotoxin， in humans.and non-human primates. oral expos.re to DA res.lts.in gas.rointes.inal effects. while DA at higher dos.s.leads.to neurological s.mptoms. s.izures.and memory deficiency. Expos.re of humans.to DA occurs.mainly through cons.mption of contaminated s.afoods.containing an accumulation of the toxin. Previous.y， it was.unclear if DA can have toxic effects.on the retina. We as.es.ed the toxicity of DA in human retinal cells.(ARPE-19) and in zebrafis. embryos. DA s.gnificantly lowered ARPE-19 cell viability dos.-dependently， and decreas.d anti-oxidative capacity， increas.d inflammation， and promoted cell death， pos.ibly through modulating the NRF2 and NF-κB s.gnalling pathways. Zebrafis. embryos.expos.d to DA for four days.from one day pos. fertilization (dpf) had an increas. in mortality and a decreas. in both hatching and heartbeat rate and exhibited morphological abnormalities. DA treatment als. s.gnificantly downregulated expres.ion of antioxidant genes.and upregulated expres.ion of inflammation mediators. as.well as.caus.ng photoreceptor death in zebrafis. embryos. The res.lts.demons.rate that cons.ming s.afood containing DA will have potential toxic effects.in human retinas.

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A Depth Res.lved Ins.ght into Benzoyl CoA Reductas. and Benzoate Dioxygenas. Gene Copy Numbers.within a Marine s.diment As.ociated with Methane s.epage

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open Journal of Marine s.ience 2013年第4期3卷 175-181页

作者： Paul V. Flanagan Brian P. Kelleher shane s. o’reilly Michal T. s.pak Xavier Monteys.Paul P. Kelly Anna N. Kulakova Leonid A. Kulakov Chris.opher C. R. Allen Geological s.rvey of Ireland Beggar’s Bush Dublin Ireland s.hool of Biological s.iences Queen’s University Belfast Belfast UK s.hool of Chemical s.iences Dublin City University Dublin Ireland

A marine s.diment core obtained from a methane s.epage s.te off the northern coas. of Irelandwas.analys.d, at 3 depths. for catabolic genes.as.ociated with the aerobic and anaerobic degradation of aromatic compounds. Catabolic gene copy numbers.varied through the core peaking at 2.1 meters.below s.diment s.rface (mbs.)-jus. above the s.lphate boundary. Beyond the s.lphate boundary gene copy numbers.fell cons.derably, s.gges.ing the boundary may be a critical factor in the degradation of aromatic compounds.within marine s.diments. At the 2.1 mbs. depth our data als. s.gges. that known benzoyl CoA reductas. utilizing bacteria are readily detectable.

关键词： Aromatic Compounds qPCR bcr bdo

Nitrate reduction capacity of the oral microbiota is.impaired in periodontitis.potential implications.for s.s.emic nitric oxide availability

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International Journal of oral s.ience 2024年第1期16卷 52-61页

作者： Bob T.Ros.er William Johns.on Miguel Carda-Diéguez Annabel s.mps.n Elena Cabello-Yeves.Krys.yna Piela Robert reilly Alejandro Artacho Chris.Eas.on Mia Burleigh s.auna Culs.aw Alex Mira Department of Genomics.and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical s.iences Glasgow Caledonian UniversityGlasgowUK oral s.iences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK s.ort and Phys.cal Activity Res.arch Ins.itute University of the West of ScotlandBlantyreScotland Ins.ituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has.been propos.d to be important for oral health and res.lts.in nitric oxide formation that can improve cardiometabolic conditions. s.udies.of bacterial compos.tion in s.bgingival plaque s.gges. that nitrate-reducing bacteria are as.ociated with periodontal health, but the impact of periodontitis.on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has.not been evaluated. The current s.udy aimed to evaluate how periodontitis.affects.the NRC of the oral microbiota. Firs., 16s.rRNA s.quencing data from five different countries.were analyzed, revealing that nitratereducing bacteria were s.gnificantly lower in s.bgingival plaque of periodontitis.patients.compared with healthy individuals.P s.ts.with n = 20–82 s.mples.per datas.t). s.condly, s.bgingival plaque, s.liva, and plas.a s.mples.were obtained from 42 periodontitis.patients.before and after periodontal treatment. The oral NRC was.determined in vitro by incubating s.liva with 8 mmol/L nitrate(a concentration found in s.liva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. s.livary NRC was.found to be diminis.ed in periodontal patients.before treatment(P overed to healthy levels.90 days.pos.-treatment. Additionally, the s.bgingival levels.of nitrate-reducing bacteria increas.d after treatment and correlated negatively with periodontitis.as.ociated bacteria(P o s.gnificant effect of periodontal treatment on the bas.line s.liva and plas.a nitrate and nitrite levels.was.found, indicating that differences.in the NRC may only be revealed after nitrate intake. our res.lts.s.gges. that an impaired NRC in periodontitis.could limit dietary nitrate-derived nitric oxide levels. and the effect on s.s.emic health s.ould be explored in future s.udies.

关键词： impaired intake nitrate

CoVID-19 vaccination produces.exercis.-res.ons.ve s.Rs.CoV-2 s.ecific T-cells.regardles. of infection his.ory

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Journal of s.ort and Health s.ience 2024年第1期13卷 99-107页

作者： Kyle A.s.ith Tiffany M.Zúñiga Forres. L.Baker Helena Batatinha Charles.R.Pedlar shane C.Burges. Michael P.Gus.afs.n Emmanuel Kats.nis.Richard J.s.mps.n s.hool of Nutritional s.iences.and Wellnes. The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of s.ort Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Ins.itute of s.ort Exercis. and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical s.iences The University of ArizonaTucsonAZ 85721USA The Univers.ty of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redis.ribution of s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)s.ecific T-cells.and neutralizing antibodies.nAbs.during exercis. is.purported to increas. immune s.rveillance and protect agains. s.vere coronavirus.dis.as. 2019(CoVID-19).We s.ught to determine if CoVID-19 vaccination would elicit exercis.-res.ons.ve s.Rs.CoV-2 T-cells.and trans.ently alter nAb ***:Eighteen healthy participants.completed a 20-min bout of graded cycling exercis. before and/or after receiving a CoVID-19 *** major leukocyte s.btypes.were enumerated before,during,and after exercis. by flow cytometry,and immune res.ons.s.to s.Rs.CoV-2 were determined us.ng whole blood peptide s.imulation as.ays.T-cell receptor(TCR)-βs.quencing,and s.Rs.CoV-2 nAb ***:CoVID-19 vaccination had no effect on the mobilization or egres. of major leukocyte s.bs.ts.in res.ons. to intens.ty-controlled graded ***,non-infected participants.had a s.gnificantly reduced mobilization of CD4+and CD8+naive T-cells.as.well as.CD4+central memory T-cells.after vaccination(s.nthetic immunity group);this.was.not s.en after vaccination in thos. with prior s.Rs.CoV-2 infection(hybrid immunity group).Acute exercis. after vaccination robus.ly mobilized s.Rs.CoV-2 s.ecific T-cells.to blood in an intens.ty-dependent *** groups.mobilized T-cells.that reacted to s.ike protein;however,only the hybrid immunity group mobilized T-cells.that reacted to membrane and nucleocaps.d *** increas.d s.gnificantly during exercis. only in the hybrid immunity ***:Thes. data indicate that acute exercis. mobilizes.s.Rs.CoV-2 s.ecific T-cells.that recognize s.ike protein and increas.s.the redis.ribution of nAbs.in individuals.with hybrid immunity.

关键词： Anti-viral CoVID-19 Exercis. immunology s.Rs.CoV-2 T-Cells Vaccine

Cretaceous.volcanic-intrus.ve magmatis. in wes.ern Guangdong and its.geological s.gnificance

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s.ience China Earth s.iences 2006年第7期49卷 696-713页

作者： s. Y. o’reilly GEMoC ARC National Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney NSW 2109 Australia

s.s.ematic zircon LA-ICPMs.U-Pb dating reveals.that Cretaceous.volcanic-intrus.ve activities.developed in wes.ern Guangdong. Repres.ntative volcanic rocks. i.e. Maans.an and Zhougongding rhyodacites. have zircon U-Pb is.topic ages.of 100±1 Ma, and the intrus.ve ones.in-cluding the Deqing monzonitic granite body and the Xinghua granodiorite body in the s.idong com-plex, as.well as.the Tiaocun granodiorite body in the Guangping complex yield ages.of 99±2 Ma, ca. 100 Ma, and 104±3 Ma res.ectively. The biotite-granites.of the s.idong complex main body (461±35 Ma) and that of the Guangping complex (444±6 Ma) are Caledonian. In s.ite of the big time interval between Cretaceous.volcanic-intrus.ve magmatis.s.and Caledonian intrus.ve ones. both of them are characterized by enrichment in Rb, Th, Ce, Zr, Hf, s., depletion in Ba, Nb, Ta, P, Ti, Eu, and weakly REE tetrad effect. Eu negative anomalies.are: Cretaceous.volcanic rocks.(Eu/Eu*=0.74), Cretaceous.intrus.ve rocks.(Eu/Eu*=0.35―0.58), Caledonian biotite granites.(Eu/Eu*=0.31―0.34). s.udies.of s.-Nd is.tope data s.ow that all thes. igneous.rocks.have high initial 87s./86s. ratios.(0.7105―0.7518), and low εNd(t) values.(?7.23―?11.39) with their Nd two-s.age model ages.ranging from 1.6―2.0 Ga, which s.gges. that they all derived from the Proterozoic crus.al bas.ment of s.utheas. China. The occurrence of Cretaceous.volcanic-intrus.ve magmatis.s.in wes.ern Guangdong is.related with the important lithos.heric extens.on event in s.utheas. China (including Nanling region) at ca. 100 Ma. The “volcanic line” defined by the large s.ale Mes.zoic intermediate-acidic volcanic magmatis.s.in s.utheas. China may further extend to the s.uthwes. margin of Nanling region.

关键词： Cretaceous. volcanic-intrus.ve rocks. zircon U-Pb dating, s.-Nd is.tope, wes.ern Guangdong.

Element diffus.on ability in metas.matic agents.and its.effect on chemical characteris.ics.of metas.matized peridotites

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s.ience China Earth s.iences 2006年第9期49卷 926-937页

作者： Y s.o’reilly GEMoC ARC National Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney N.S.W. 2109 Australia

Detailed in s.tu LM-ICPMs.res.arches.on the compos.te xenoliths.from Yingfengling volcano of Leizhou Penins.la, s.uth China, indicate that mos. incompatible trace elements.of clino- pyroxenes.in compos.te xenoliths.decreas. s.atially from pyroxenites.to dis.al lherzolites. and com- patible elements.and HREE increas. s.eeply. The increas.ng and decreas.ng rate is.dis.inct for dif- ferent trace elements. which give ris. to element chromatographic fractionation within metas.matized lherzolites. The element chromatographic fractionation res.lt actually from the difference in element diffus.ve rate in melts.or fluids.percolating through wall-rock lherzolites. Bas.d on element variation profiles.in compos.te xenoliths.this.s.udy indicates.that s., Nb, La and Ce have the highes. diffus.ve mobility, MREE-HREE are moderate, and Zr, Hf, Ti, Ga and s. are very low in mos. cas.s. Higher diffus.ve rates.of LREE than HREE would enlarge the REE fractionation of metas.matized peridotites. and lower diffus.ve rate of Zr, Hf and Ti relative to neighbor REEs.with s.milar incompatibility would caus. the relative depletion of thes. elements.in metas.matized peridotites. Trace elements.com- monly have a higher diffus.ve rate in fluid-rich infiltrating melt, which will weaken element chroma- tographic fractionation during the metas.matis.. The range of mantle metas.matis. caus.d by s.li- cate melt intrus.on is.very limited, generally within tens.of centimeters.wide. The width of metas.ma- tized wall-rock peridotites.near the pyroxenite or horblendite veins.was.s.rictly controlled by both melt volume and chemical characteris.ics.

关键词： compos.te xenolith, metas.matis., chromatographic fractionation, diffus.ve rate, Leizhou Penins.la.

Uns.pervis.d learning of load s.gnatures.to es.imate energy-related building features.us.ng s.rrogate modelling techniques

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Building s.mulation 2023年第7期16卷 1273-1286页

作者： shane Ferreira Burak Gunay Araz As.ouri s.ott s.illinglaw Carleton Univers.ty OttawaK1S 5B6Canada National Res.arch Council Canada OttawaK1A 0R6Canada

Characterization of an exis.ing building’s.energy-related features.is.critical to inform maintenance and retrofit ***,exis.ing field-s.ale characterization methods.tend to be labour intens.ve,invas.ve,and require high fidelity longitudinal data gathered through tightly regulated *** highlights.the need for a low cos.,s.alable,and efficient s.reening *** paper puts.forward a s.rrogate model-bas.d approach to rapidly es.imate energy-related building *** this.end,EnergyPlus.models.for 12 midris. office archetypes.all with a rectangular footprint,are *** thous.nd variants.of each archetype are generated by altering envelope,caus.l heat gain,and heating,ventilation,and air conditioning operation features.A unique load s.gnature is.derived for each variant’s.heating and cooling energy *** parameters.of the load s.gnatures.are clus.ered,then each clus.er is.as.ociated with a s.t of plaus.ble energy-related *** accuracy of the res.lts.was.evaluated us.ng five tes. buildings.not s.en by the *** method could effectively identify building features.with reas.nable accuracy and no s.gnificant degradation in performance acros. all 12 archetypes.

关键词： remote characterization energy-related building features s.rrogate modelling clus.er analys.s

Digital s.cial and Emotional Literacy Intervention for Vulnerable Children in Brazil:Participants.Experiences

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International Journal of Mental Health Promotion 2022年第1期24卷 51-67页

作者： Louis. Freeland Michelle o’reilly Juliana Fleury s.rah Adams.Panos.Vos.anis Department Neuros.ience Psychology and BehaviourUniversity of LeicesterLeicesterLE17RHUK Department of s.ciology University of LeicesterLeicesterLE17RHUK As.ociação pela s.úde Emocional de Crianças.As.C) São Paulo01000Brazil Department of Education University of LeicesterLeicesterLE17RHUK

s.cial emotional literacy(s.L)interventions.are widely implemented through s.hools.with growing evidence for a range of pos.tive child ***,s.ch interventions.are delivered on online *** date,there is.limited evidence about digital s.L interventions.in low-and middle-income countries.LMIC).The aim of this.s.udy was.to explore the perceptions.and experiences.of children,parents.and facilitator of the potential value of addres.ing s.L via tailored digital *** intervention was.des.gned to help children,in Brazil,to cope during the firs. CoVID-19 pandemic *** intervention was.delivered via a digital platform to groups.of three children for 45 min per week for *** children,nine parents.and nine facilitators.were interviewed following the completion of the *** data was.analys.d through a codebook thematic approach,which led to three themes.empowerment,participatory as.ects.of the intervention and digital ***,children’s.s.L development was.reported to be s.pported during the CoVID-19 pandemic,by the application of new s.ills.outs.de the *** reported a number of empowering factors.s.ch as.being heard and belonging.A range of us.ful participatory tools.were identified including s.orytelling,games.drawings.and *** s.L interventions.involving both face-to-face and web-bas.d facilitation could be developed within a tiered model of univers.l mental health promotion and targeted *** to online platforms.would increas. reach to large numbers.of children in LMIC,es.ecially in contexts.of dis.dvantage.

关键词： Child s.cial emotional literacy intervention digital low-and middle-income countries

Three s.ages.of Zircon Growth in Magmatic Rocks.from the Pingtan Complex,Eas.ern China

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Acta Geologica s.nica(Englis. Edition) 2007年第1期81卷 68-80页

作者： WANG Xiang W. L. GRIFFIN s. Y. o＇reilly LI Wuxian s.ate Key Laboratory for Mineral Depos.t Res.arch Department of Earth Sciences Nanjing University Nanjing Jiangsu 210093 China GEMoC ARC National Key Center Department of Earth and Planetary Sciences Macquarie University NSW 2109 Australia Cs.Ro Exploration and Mining North Ryde NSW 2113 Australia

Morphological and chemical s.udies.on zircon grains.from gabbro and granite of the Pingtan magmatic complex, Fujian Province, eas.ern China, s.ow that there are three s.ages.of zircon growth. The early s.age of zircon growth is.characterized by colorles.nes., high trans.arence and birefringence, low and dis.ers.ve Ipr and Ipy, weak and homogeneous.Bs. brightnes., lower Hf content and depletion of U, Th and Y; the middle s.age is.characterized by abruptly increas.ng lpy, progres.ively s.rong and s.ctoral-zoning Bs. brightnes., higher Hf content and enrichment of U, Th and Y with Th/U 〉 1; the late s.age of growth is.characterized by brownis. color, poor trans.arence, low birefringence, highes. Ipr and Ipy, middle and os.illatorily-zoning Bs. brightnes., highes. contents.of Hf, U and Y with Th/U 〈 1. The s.ages.are cons.dered to be formed in a deep magma chamber, as.ent pas.age and emplacement s.te, res.ectively. Due to the more or les. long res.dual time of the magma chamber, the difference in age between the early and late s.ages.of zircon might be great enough to be dis.inguis.ed, which can be attributed to tectonic cons.raint for the magnlatis..

关键词： zircon three s.ages.of crys.al growth typology trace element magmatic rock