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核糖体脱嘌呤分析法分析检测核糖体失活蛋白

青岛大学学报（工程技术版） 2006年第1期21卷 1-17页

作者： S.Ranil Wickramasinghe shane E bower 科罗拉多州立大学化学与生物工程系美国科罗拉多co805231370

针对核糖体脱嘌呤分析法经常被用来分析检测新的核糖体失活蛋白(RIP),检测了由酸性苯胺催化在RIP催化脱嘌呤位点断裂产生的核糖体rRNA片段。利用文献发表的一级动力学速度常数,计算分析了核糖体失活蛋白含量对核糖体失活蛋白催化脱嘌呤... 详细信息

针对核糖体脱嘌呤分析法经常被用来分析检测新的核糖体失活蛋白(RIP),检测了由酸性苯胺催化在RIP催化脱嘌呤位点断裂产生的核糖体rRNA片段。利用文献发表的一级动力学速度常数,计算分析了核糖体失活蛋白含量对核糖体失活蛋白催化脱嘌呤分析的敏感性,并进行了部分实验验证。实验中核糖体失活蛋白和核糖体溶液混合后进行了30 min的恒温培养,结果表明:核糖体失活蛋白脱嘌呤分析法的敏感性取决于核糖体失活蛋白催化核糖体脱嘌呤反应的速度常数。还分析了核糖体失活蛋白脱嘌呤分析中可能出现的假阳性和假阴性结果及其原因,结果表明:在核糖体失活蛋白的大规模生产中使用核糖体脱嘌呤分析法作为定量分析的手段是比较复杂和困难的,该方法应该和一些常用的经典方法例如SDS PAGE分析法联合使用,而且联合使用时两种方法的最小检测限应该相近,以避免其中之一引起的假阳性结果。

关键词：核糖体脱嘌呤分析法核糖体失活蛋白敏感性最小检测限 SDS-PAGE分析法

中国2型糖尿病的管理:快乐生活俱乐部,采用健康教练的实用性群组随机对照试验

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英国医学杂志中文版 2016年第9期6卷 499-507页

作者： colette browning Anna chapman Hui Yang Shuo Liu Tuohong Zhang Joanne c Enticott shane A Thomas RDNS Institute Melbourne Victoria Australia Faculty of Medicine Nursing and Health Sciences School of Primary Health Care Monash University Melbourne Victoria Australia International Institute for Primary Health Care Research Shenzhen China. RDNS Institute Melbourne Victoria Australia Faculty of Medicine Nursing and Health Sciences School of Primary Health Care Monash University Melbourne Victoria Australia. Faculty of Medicine Nursing and Health Sciences School of Primary Health Care Monash University Melbourne Victoria Australia International Institute for Primary Health Care Research Shenzhen China. beijing Office for cancer Prevention and control Peking University Cancer Hospital and Institute Beijing China. School of Public Health Peking University Health Science Centre Beijing China. RDNS Institute Melbourne Victoria Australia Faculty of Medicine Nursing and Health Sciences School of Primary Health Care Monash University Melbourne Victoria Australia School of Clinical Sciences Monash University Melbourne Victoria Australia.

目的与常规服务相比,评估健康教练使用动机谈话(MI)的干预对改善2型糖尿病(T2DM)患者的血糖控制,以及临床、心理社会和自我保健结果的影响。设计实用性群组随机对照试验。研究地点中国北京市丰台区社区卫生服务站(cHSs)。参与者在41家... 详细信息

目的与常规服务相比,评估健康教练使用动机谈话(MI)的干预对改善2型糖尿病(T2DM)患者的血糖控制,以及临床、心理社会和自我保健结果的影响。设计实用性群组随机对照试验。研究地点中国北京市丰台区社区卫生服务站(cHSs)。参与者在41家随机选取的cHSs(21家干预组和20家对照组),有21家干预组cHSs(372名患者)和18家对照组(296名患者)在开始时参与试验。干预干预组患者接受电话和面对面MI健康教练服务,并同时在cHSs接受常规的服务。对照组只接受常规的服务。2组的医疗费用均得到减免。结局指标在基线、6个月和12个月进行结果评估。主要指标是糖化血红蛋白(HbAlc)。次要指标包括一组人体测量学指标、血压、空腹血糖、社会心理和自我保健。结果在12个月时,没有发现HbA1c的治疗效果差别,[调整后差别为0.02,95%可信区间(cI)-0.40~0.44,P=0.929],干预组和对照组都显示出明显的改善。不过,2个次要指标:心理忧郁(调整后差别为-2.38,95%cI-4.64~-0.12,P=0.039)和收缩压(调整后差别为-3.57,95%cI-6.08~-1.05,P=0.005)显示为明显改善的结果,与明显的治疗效果差别相一致,并得到敏感性分析的支持。有意义的是,在HbA1c之外,两组均显示出甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇上的明显改善。结论在当今中国初级卫生保健改革的形势下,本研究是在中国第一个在cHSs实际现场开展的、特别针对T2DM的大规模群组随机对照研究。虽然没有在HbA1c上发现治疗效果差别,但在2组的很多结果(包括HbAlc)上呈现改善,该结果支持在中国对T2DM患者进行常规和免费的临床健康检查。

关键词：社区卫生服务站干预组群组随机对照试验健康教练自我保健快乐生活俱乐部血糖控制动机谈话

A Depth Resolved Insight into benzoyl coA Reductase and benzoate Dioxygenase Gene copy Numbers within a Marine Sediment Associated with Methane Seepage

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Open Journal of Marine Science 2013年第4期3卷 175-181页

作者： Paul V. Flanagan brian P. Kelleher shane S. O’Reilly Michal T. Szpak Xavier Monteys Paul P. Kelly Anna N. Kulakova Leonid A. Kulakov christopher c. R. Allen Geological Survey of Ireland Beggar’s Bush Dublin Ireland School of biological Sciences Queen’s University Belfast Belfast UK School of chemical Sciences Dublin City University Dublin Ireland

A marine sediment core obtained from a methane seepage site off the northern coast of Irelandwas analysed, at 3 depths, for catabolic genes associated with the aerobic and anaerobic degradation of aromatic compounds. catabolic gene copy numbers varied through the core peaking at 2.1 meters below sediment surface (mbsf)-just above the sulphate boundary. beyond the sulphate boundary gene copy numbers fell considerably, suggesting the boundary may be a critical factor in the degradation of aromatic compounds within marine sediments. At the 2.1 mbsf depth our data also suggest that known benzoyl coA reductase utilizing bacteria are readily detectable.

关键词： Aromatic compounds qPcR bcr bdo

Facilitators and constraints:Perceptions of Gender Differences on Women’s career Advancement

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Journal of Tourism and Hospitality Management 2018年第2期6卷 61-72页

作者： Yan(Grace)Zhong shane c.blum Sue couch Virginia State University(VSU) VirginiaUSA Texas Tech University(TTU) TexasUSA

The underrepresentation in top management positions has made women’s status in the hospitality industry a great *** study examined hospitality students’,educators’,and industry recruiters’perceptions of facilitators and constraints on women’s career advancement and identified if there were any significant differences among *** were collected through an online *** of gender differences of facilitators and constraints in women’s career advancement and gender issues were analyzed within the three groups(students,educators,and recruiters).Results revealed significant gender differences between male and female educators and *** findings suggested that hospitality education should make a contribution and reveal barriers and gender issues in the industry.

关键词： women in hospitality management women’s career advancement hospitality education

Effects of Side-chain on conformational characteristics of Poly(3,5-Dimethyl-Phenyl Acrylate) in Toluene at 40℃

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Advances in chemical Engineering and Science 2012年第4期2卷 435-443页

作者： Nasrollah Hamidi Stanley Ihekweazu christopher A. Wiredu Onize H. Isa Kevin Watley christopher Rowe briante’ Nimmons Alexis Prezzy Traniqua Govan shane Scoville Quentin Hills Judith Salley Department of biological and Physical Sciences South Carolina State University Orangeburg SC USA Department of civil and Mechanical Engineering Technology South Carolina State University Orangeburg SC USA North High School North SC USA Orangeburg Wilkinson High School Orangeburg SC USA

The intrinsic viscosity [η] of poly(3,5-dimethylphenylacrylate) (35PDMPA)solutions were evaluated throughout the measurements of the flow times of toluene and polymer solutions by classical Huggins, and Kraemer’s methods using a cannon-Ubbelohde semi-micro-dilution capillary viscometer in a cannon thermostated water bath at 40℃ ± 0.02℃. The values of Huggins’ constant estimated ranged from 0.2 to 0.4 which were within expectations. The intrinsic viscosities and molecular weight relationship was established with the two-parameter classical models of Staudinger-Mark-Houwink-Sakurada and Stockmayer-Fixman. conformational parameter c∞ and σ indicated 35PDMPA be semi flexible. Also, the rigidity of 35PDMPA was confirmed by Yamakawa-Fuji wormlike theory modified by bohdanecky. The molecular parameters were estimated and compared. The results showed that 35PDMPA behaves like a semi-rigid polymer in toluene at 40℃ rather than a random coil flexible macromolecule.

关键词： Intrinsic Viscosity Poly(3 5-Dimethyl-Phenyl Acrylate) conformational Parameters Rigidity Factor Kuhn Statistical Length

Diabetes is Associated with Worse Executive Function in both Eastern and Western populations:Shanghai Aging Study and Mayo clinic Study of Aging

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Diabetes is Associated with Worse Executive Function in both...

Review of advanced road materials, structures, equipment, and detection technologies

第四届全国痴呆与认知障碍学术研讨会及高级讲授班

作者： zhao qianhua Roberts Rosebud O ding ding cha Ruth guo qihao luo jianfeng Machulda Mary M Pankratz shane bei wang christianson Teresa J.H Aakre Jeremiah A Knopman David S boeve bradley F zhen hong Petersen Ronald c 复旦大学附属华山医院神经内科

background and Objectives It remains unknown whether the association between diabetes mellitus(DM)and cognitive function differs in Eastern and Western *** study aimed to elucidate whether DM is associated with worse cognitive performance in both *** The Shanghai Aging Study(SAS)and the Mayo clinic Study of Aging(McSA)are two population-based studies with similar design and methodology in Shanghai,china and

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Journal of Road Engineering 2023年第4期3卷 370-468页

作者： JRE Editorial Office Maria chiara cavalli De chen Qian chen Yu chen Augusto cannone Falchetto Mingjing Fang Hairong Gu Zhenqiang Han Zijian He Jing Hu Yue Huang Wei Jiang Xuan Li chaochao Liu Pengfei Liu Quantao Liu Guoyang Lu Yuan Ma Lily Poulikakos Jinsong Qian Aimin Sha Liyan Shan Zheng Tong b.shane Underwood chao Wang chaohui Wang Di Wang Haopeng Wang Xuebin Wang chengwei Xing Xinxin Xu Min Ye Huanan Yu Huayang Yu Zhe Zeng You Zhan Fan Zhang Henglong Zhang Wenfeng Zhu Editorial Office of Journal of Road Engineering Chang’an UniversityXi’an 710064China Department of civil and Architectural Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden School of civil Engineering Southwest Jiaotong UniversityChengdu 610031China School of Highway Chang’an UniversityXi’an 710064China Department of civil Engineering Aalto UniversityAalto 00076Finland School of civil Engineering and Architecture Wuhan University of TechnologyWuhan 430070China National Engineering Research center of Highway Maintenance Equipment Chang’an UniversityXi’an 710064China Department of civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Transportation Southeast UniversityNanjing 211189China Institute for Transport Studies University of LeedsLeeds LS29JTUK School of Traffic and Transportation Engineering Changsha University of Science&TechnologyChangsha 410114China Institute of Highway Engineering RWTH Aachen UniversityAachen 52074Germany State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Department of Architecture and civil Engineering City University of Hong KongHong KongChina Empa Swiss Federal Laboratories for Materials Science and TechnologyDübendorf 8600Switzerland college of Transportation Engineering Tongji UniversityShanghai 200092China School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China Department of civil Constructionand Environmental EngineeringNorth Carolina State UniversityRaleighNC 27695USA Department of Road&Urban Railway Engineering Beijing University of TechnologyBeijing 100124China Department of civil and Environmental Engineering University of LiverpoolLiverpool L693GHUK School of civil Engineering&Transportation South China University of TechnologyGuangzhou 510640China college of civil Engineering Hunan UniversityChangsha 410082China

As a vital and integral component of transportation infrastructure,pavement has a direct and tangible impact on socio-economic *** recent years,an influx of groundbreaking and state-of-the-art materials,structures,equipment,and detection technologies related to road engineering have continually and progressively emerged,reshaping the landscape of pavement *** is a pressing and growing need for a timely summarization of the current research status and a clear identification of future research directions in these advanced and evolving ***,Journal of Road Engineering has undertaken the significant initiative of introducing a comprehensive review paper with the overarching theme of“advanced road materials,structures,equipment,and detection technologies”.This extensive and insightful review meticulously gathers and synthesizes research findings from 39 distinguished scholars,all of whom are affiliated with 19 renowned universities or research institutions specializing in the diverse and multidimensional field of highway *** covers the current state and anticipates future development directions in the four major and interconnected domains of road engineering:advanced road materials,advanced road structures and performance evaluation,advanced road construction equipment and technology,and advanced road detection and assessment technologies.

关键词： Road engineering Advanced road material Advanced road structure Advanced road equipment Advanced road detection technology

In vivo miniature robots for natural orifice surgery:State of the art and future perspectives

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World Journal of Gastrointestinal Surgery 2010年第6期2卷 217-223页

作者： Manish M Tiwari Jason F Reynoso Amy c Lehman Albert W Tsang shane M Farritor Dmitry Oleynikov Department of Surgery University of Nebraska Medical Center985126 Nebraska Medical Center OmahaNE 68198-5126United States Department of Mechanical Engineering University of Nebraska-LincolnN104 Scott Engineering CenterLincolnNE 68588-0656United States

Natural orifice translumenal endoscopic surgery(NOTES) is the integration of laparoscopic minimally invasive surgery techniques with endoscopic *** the advances in NOTES technology,the approach presents several unique instrumentation and techniquespecific *** ? exible endoscopy platforms for NOTES have several drawbacks including limited stability,triangulation and dexterity,and lack of adequate visualization,suggesting the need for new and improved instrumentation for this *** of the current focus is on the development of flexible endoscopy platforms that incorporate robotic *** alternative approach to access the abdominal viscera for either a laparoscopic or NOTES procedure is the use of small robotic devices that can be implanted in an intracorporeal ***,independent,miniature robots can be simultaneously inserted into the abdominal cavity to provide a robotic platform for NOTES *** capabilities of the robots include imaging,retraction,tissue and organ manipulation,and precise maneuverability in the abdominal *** a platform affords several advantages including enhanced visualization,better surgical dexterity and improved triangulation for *** review discusses the current status and future perspectives of this novel miniature robotics platform for the NOTES *** these technologies are still in pre-clinical development,a miniature robotics platform provides a unique method for addressing the limitations of minimally invasive surgery,and NOTES in particular.

关键词： Robotic surgery In vivo robots Natural orifice surgery Robotic surgical platforms

Immunopathology and the Myeloid Response to Neurotropic Flavivirus Infection

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Immunopathology and the Myeloid Response to Neurotropic Flav...