检索结果-南通市图书馆

Small bowel perforation from a migrated biliary stent: A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2021年第10期13卷 543-554页

作者： Konstantinos A Zorbas shane Ashmeade William Lois Daniel T Farkas Department of Surgery Bronx Care Health SystemNew YorkNY 10457United States

BAcKGROUND Bowel perforation from biliary stent migration is a serious potential complication of biliary stents,but fortunately has an incidence of less than 1%.cASE SUMMARY We report a case of a 54-year-old caucasian woman with a history of Human Immunodeficiency virus with acquired immunodeficiency syndrome,chronic obstructive pulmonary disease,alcoholic liver cirrhosis,portal vein thrombosis and extensive past surgical history who presented with acute abdominal pain and local *** further evaluation she was diagnosed with small bowel perforation secondary to migrated biliary stents and underwent exploratory laparotomy with therapeutic *** This case presentation reports on the unusual finding of two migrated biliary stents,with one causing *** addition,we review the relevant literature on migrated stents.

关键词： Biliary stent Biliary stent migration Small bowel perforation Endoscopic retrograde cholangiopancreatography case report

Potentially life-threatening intravenous acetaminophen overdose in a 3-month-old (40 weeks’ post-menstrual age), 2.3 kg baby girl

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2013年第3期3卷 186-187页

作者： shane campbell Thomas Engelhardt James McLay Brian Anderson Department of Anaesthesia Royal Aberdeen Children’s Hospital Aberdeen UK Intensive care Medicine Auckland Children’s Hospital Auckland New Zealand

A case is presented of a serious, potentially life-threatening intravenous acetaminophen overdose in a 3-month-old (40 weeks’ post menstrual age),2.3 kgbaby girl. The neonate was scheduled for urgent laser therapy for retinopathy of prematurity. Instead of an intended intravenous Hartmann’s solution bolus of 10 ml·kgˉ1, the neonate received a 17 ml bolus of correctly labelled intravenous 1% acetaminophen. The National Poisons Bureau was immediately contacted for advice and in the absence of data suggested a treatment with N-acetylcysteine for a 24-hour period. Baseline blood samples for clotting, liver function, urea and electrolytes, full blood count and plasma acetaminophen concentration were taken 30 min, 8.25 h, 12.5 h, 18.5 h and 120 h after the overdose. Acetaminophen concentration was 78 mg·Lˉ1 at 30 min, but it was undetectable at any other time. Using a recent and complete PK-PD dataset we are able to show that the measured plasma acetaminophen concentration fits well on PK estimates for acetaminophen in this neonate. The non-detectable (low) plasma acetaminophen concentration at >8 h is also consistent with this model, especially if clearance is slightly increased in the premature nursery graduate. Medical errors are rarely the fault of an individual and they are often due to a combination of factors. contributing factors, in this case, are described under the following headings: catalyst event, system fault, loss of situational awareness, and human error.

关键词： Neonate Acetaminophen Overdose No Sequelae PK Models Drug Error

Assessment of Biosafety Practices in clinical Laboratories in Khartoum State, Sudan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2022年第11期10卷 93-103页

作者： Mohammad shane Alam Saif Elden B. Abdalla Fakhra Jabeen Faculty of Medical Laboratory Science Department of Medical Laboratory Technology Jazan University Jazan Saudi Arabia Faculty of Medical Laboratory Science Jazan University Jazan Saudi Arabia Department of chemistry University College in Samtah Jazan University Jazan Saudi Arabia

Background: Several related accidents occur in the laboratories due to insufficient regulation, inappropriate implementation of safety measures or unawareness attitude and practice toward safety precaution. Biosafety is a tool through which we are managing safety and security related to any kinds of hazards that may be either to the human, animals, plants and environment as well. We can implement good laboratory practice to minimize the risk while performing any kind of test procedures, either handling to the samples like blood and other body fluids which is playing important role for infections and transmissible diseases. If we will provide facilities and training to the lab personnel, then we can protect public, agriculture, and the environment from which is leading cause of infections as well as hazards such as biological, chemical, electrical and glassware. For achieving effective and necessary biosafety and security, it should make sure that any unauthorized person is not able to handle, process, transport to minimize loss and misuse of the any kind of hazards especially biohazards. Therefore, it’s highly recommended to make an international system to avoid any kind of biosafety related issues. Objective: Because biosafety is an important element in quality management system (QMS) and it is a fundamental tool for compliance with accreditation and certification standards, the aim of this study was to assess the practices of lab personnel towards biosafety measures in their laboratories. Method: The study was cross-sectional study that conducted among 70 laboratories by use of structured questionnaire. Data analysis was done by using statistical package for social science (SPSS). Result: Among 70 laboratories, 2 (3%) were appointing a biosafety officer, 16 (23%) have fire detection system and fire alarm system, and 20 (29%) of all laboratories were provided by fire extinguisher. Among provision of personnel protection, 56 (80%) always wearied lab coat and gloves,

关键词： Biosafety Quality Management System Data Analysis Biohazard

The Epigenome as a therapeutic target for Parkinson's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第11期11卷 1735-1738页

作者： shane V.Hegarty Aideen M.Sullivan Gerard W.O'Keeffe Department of Anatomy and Neuroscience Biosciences InstituteUniversity College Cork

Parkinson＇s disease （PD） is a common, progressive neurodegenerative disease characterised by degeneration of nigrostriatal dopaminergic neurons, aggregation of α-synuclein and motor symptoms. current dopamine-replacement strategies provide symptomatic relief, however their effectiveness wear off over time and their prolonged use leads to disabling side-effects in PD patients. There is therefore a critical need to develop new drugs and drug targets to protect dopaminergic neurons and their axons from degeneration in PD. Over recent years, there has been robust evidence generated showing that epigenetic dysregulation occurs in PD patients, and that epigenetic modulation is a promising therapeutic approach for PD. This ar- ticle first discusses the present evidence implicating global, and dopaminergic neuron-specific, akerations in the methylome in PD, and the therapeutic potential of pharmacologically targeting the methylome. It then focuses on another mechanism of epigenetic regulation, histone acetylation, and describes how the histone acetyltransferase （HAT） and histone deacetylase （HDAc） enzymes that mediate this process are attractive therapeutic targets for PD. It discusses the use of activators and/or inhibitors of HDAcs and HATs in models of PD, and how these approaches for the selective modulation of histone acetylation elicit neuroprotective effects. Finally, it outlines the potential of employing small molecule epigenetic modulators as neuroprotective therapies for PD, and the future research that will be required to determine and realise this therapeutic potential.

关键词： Parkinson's disease epigenetics methylation acetylation histone acetyltransferase histonedeacetyIase small molecules

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2014年第19期9卷 1708-1711页

作者： shane V.Hegarty Gerard W.O’Keeffe Aideen M.Sullivan Department of Anatomy and Neuroscience Biosciences InstituteUniversity College Cork

Neuroprotection and neuroregeneration are two of the most promising disease-modifying ther- apies for the incurable and widespread Parkinson＇s disease. In Parkinson＇s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinsoffs disease. Several neurotrophic fac- tors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors： glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.

关键词： Parkinson's disease neuroprotection neurotrophic factors nervous system development nigrostriatal dopaminergic neurons glial cell line-derived neurotrophic factor, neurturin, growth/differentiation factor 5

The development of a subject specific tunable foot orthosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The development of a subject specific tunable foot orthosis

Mochi: composing Data Services for High-Performance computing Environments

中国力学大会-2015

作者： Johnson shane Qaiser Zeeshan Kang Liping 上海交通大学密西根学院上海交通大学机械系统与振动国家重点实验室

The hypothesis of this research is that custom fit and function is needed on a subject specific basis to measure the parameter dependent efficacy of *** manuscript outlines the first step in testing this hypothesis—the development of a subject specific tunable foot *** intended function of the orthosis is to control the medial longitudinal *** finite

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of computer Science & Technology 2020年第1期35卷 121-144页

作者： Robert BRoss George Amvrosiadis Philip carns charles Dcranor Matthieu Dorier Kevin Harms Greg Ganger Garth Gibson Samuel KGutierrez Robert Latham Bob Robey Dana Robinson Bradley Settlemyer Galen Shipman shane Snyder Jerome Soumagne Qing Zheng Argonne National Laboratory LemontIL 60439U.S.A Parallel Data Laboratory Carnegie Mellon UniversityPittsburghPA 15213U.S.A Vector Institute for Artificial Intelligence TorontoOntarioCanada Los Alamos National Laboratory Los Alamos NMU.S.A The HDF Group Champaign ILU.S.A

Technology enhancements and the growing breadth of application workflows running on high-performance computing(HPc)platforms drive the development of new data services that provide high performance on these new platforms,provide capable and productive interfaces and abstractions for a variety of applications,and are readily adapted when new technologies are *** Mochi framework enables composition of specialized distributed data services from a collection of connectable modules and *** than forcing all applications to use a one-size-fits-all data staging and I/O software configuration,Mochi allows each application to use a data service specialized to its needs and access *** paper introduces the Mochi framework and *** Mochi core components and microservices are *** of the application of the Mochi methodology to the development of four specialized services are ***,a performance evaluation of a Mochi core component,a Mochi microservice,and a composed service providing an object model is *** paper concludes by positioning Mochi relative to related work in the HPc space and indicating directions for future work.

关键词： storage and I/O data-intensive computing distributed services high-performance computing

从单次覆盖和cMP资料生成三维数据体——美国得克萨斯州米德兰县的实例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国外油气勘探 1992年第6期 114-118页

作者： shane P.coperude 于锋玉

我们把得克萨斯州米德兰县的单次覆盖资料与cMP资料合并在一起,构成2.5维插值方法所需的输入数据。2.5维插值有关问题之一是测线的密度不够。单次覆盖与cMP数据集的合并被证明是改善输入测线覆盖的有效手段。首先,将单次覆盖资料的振幅... 详细信息

我们把得克萨斯州米德兰县的单次覆盖资料与cMP资料合并在一起,构成2.5维插值方法所需的输入数据。2.5维插值有关问题之一是测线的密度不够。单次覆盖与cMP数据集的合并被证明是改善输入测线覆盖的有效手段。首先,将单次覆盖资料的振幅、频率和相位与cMP资料进行匹配,然后把在单次覆盖与主要的cMP测线的交点上通过互相关生成的匹配滤波器,应用于单次覆盖资料。交点图可以作为质量控制手段,以检验匹配滤波器的效果。经插值和三维偏移后,将成果数据集输入工作站进行解释。利用该数据集对泥盆系层段作的解释,与根据井资料所作的解释吻合得很好。

关键词：多维分析地震数据采样内插法三维地震解释