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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic n-methyl-D-aspartate receptors and n-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via n-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** n-methyl-D-aspartate receptor subunit Glun3A,primarily at the extrasynaptic site,serves as a gatekeeper for the n-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an n-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration n-methyl-D-aspartate receptors n-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li shan Guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University national Energy Metal Resources and new Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//nH4V4O10（nVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

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Glutamine metabolism in cancer therapy

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Cancer Drug Resistance 2018年第3期1卷 126-138页

作者： tra-Ly nguyen Raúl V.Durán Institut Européen de Chimie et Biologie INSERM U1218Universitéde Bordeaux2 Rue Robert Escarpit33607 PessacFrance.

The amino acid glutamine plays a key role in the metabolism of highly proliferating *** malignant transformation,cancer cells modify the consumption and processing of glutamine to sustain cell growth and *** some cases,these cancer cells become addicted to ***,targeting the metabolism of glutamine has been developed during last years as a potential strategy against *** this review,we summarized the last advances in our knowledge about the role of glutamine metabolism in cancer therapy.

关键词： Cancer glutamine glutamoptosis metabolism mammalian target of rapamycin

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低腐蚀、高效相变吸收体系CO_(2)捕集性能及机理研究

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现代化工 2025年第1期45卷 163-169,177页

作者：秦森戴姗姗范伟李梅杨嘉龙西南石油大学化学化工学院四川成都610500 教育部油田化学工程研究中心四川成都610500 中国石油天然气股份有限公司长庆油田勘探开发研究院陕西西安710016

液-液相变吸收剂作为碳捕集领域最具节能潜力的新兴吸收剂仍存在CO_(2)容量有限、腐蚀性强等缺点。以富含氨基的聚酰胺-胺树状大分子(PAMAM)为阳离子、具有含n杂环的2-甲基咪唑(2-MI)为阴离子合成离子液体(ILs),并与水和二乙二醇丁醚(DG... 详细信息

液-液相变吸收剂作为碳捕集领域最具节能潜力的新兴吸收剂仍存在CO_(2)容量有限、腐蚀性强等缺点。以富含氨基的聚酰胺-胺树状大分子(PAMAM)为阳离子、具有含n杂环的2-甲基咪唑(2-MI)为阴离子合成离子液体(ILs),并与水和二乙二醇丁醚(DGBE)构建液-液相变吸收剂。以多氨基协同吸收的方式大幅度提升CO_(2)吸收性能,其CO_(2)容量可达4.98 mol CO_(2)/mol ILs,富CO_(2)相体积分数仅为28.7%,且腐蚀性仅为单乙醇胺(MEA)溶液的13.87%。^(13)CnMR分析结果表明,吸收机理遵循两性离子机理及碱性水合机制。用Kamlet-Taft法量化极性发现,相分离现象的发生与极性、密度、黏度变化密切相关。

关键词： CO_(2)捕集功能化离子液体相变吸收剂吸收机理相变机理

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Parameter Survey of Thermally Highly Loaded,Porous and Cooled Multi-Layer Systems for Turbine Blades

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Journal of Thermal Science 2007年第2期16卷 181-185页

作者： Peng shan Dieter Bohn Jing Ren n.Surken Department of Jet Propulsion Beijing University of Aeronautics & AstronauticsBeijing 100083China Institute of Steam and Gas Turbines RWTH Aachen52056 AachenGermany

This study is an advanced investigation for the cooling of high temperature turbine vanes and blades. The efficient heat exchanging near the surface of a blade may be achieved by forcing a cooling air flow emitting out of a thin layer of the porous metal which is pasted on the structural high strength metal. The contents include the consideration on the computational model of heat transfer through a layer of porous material, the concrete modeling and the analysis of the model, the numerical survey of key parameters for both the two-layer porous materials and the heat transfer fluid flow passing through the model channels. The results revealed that the constructed system is reasonable. Proposed an evaluation formula for the porous material heat transfer efficiency.

关键词： heat transfer thermally highly loaded porous multi-layer

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Double Optimal Regularization Algorithms for Solving Ill-Posed Linear Problems under Large noise

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Computer Modeling in Engineering & Sciences 2015年第1期104卷 1-39页

作者： Chein-shan Liu Satya n.Atluri Department of Civil Engineering National Taiwan UniversityTaipeiTaiwan Center for Aerospace Research&Education University of CaliforniaIrvine

A double optimal solution of an n-dimensional system of linear equations Ax=b has been derived in an affine m-dimensional Krylov subspace with m <<*** further develop a double optimal iterative algorithm(DOIA),with th... 详细信息

A double optimal solution of an n-dimensional system of linear equations Ax=b has been derived in an affine m-dimensional Krylov subspace with m nt direction z being solved from the residual equation Az=r0 by using its double optimal solution,to solve ill-posed linear problem under large *** DOIA is proven to be absolutely convergent step-by-step with the square residual error ||r||^2=||b-Ax||^2 being reduced by a positive quantity ||Azk||^2 at each iteration step,which is found to be better than those algorithms based on the minimization of the square residual error in an m-dimensional Krylov *** order to tackle the ill-posed linear problem under a large noise,we also propose a novel double optimal regularization algorithm(DORA)to solve it,which is an improvement of the Tikhonov regularization *** numerical tests reveal the high performance of DOIA and DORA against large *** methods are of use in the ill-posed problems of structural health-monitoring.

关键词： Ill-posed linear equations system Double optimal solution Affine Krylov subspace Double optimal iterative algorithm Double optimal regularization algorithm

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Influence of Isotope Effects on Product Polarizations of n(~2D)+D_2, n(~2D)+H_2 and n(~2D)+HD Reactive Systems

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Chemical Research in Chinese Universities 2012年第5期28卷 897-902页

作者： nIE shan-shan CHU Tian-shu State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China Institute for Computational Sciences and Engineering Laboratory of New Fiber Materials and Modern Textilethe Growing Base for State Key LaboratoryQingdao UniversityQingdao 266071P.R.China

To figure out the influence of isotope effect on product polarizations of the n（2D）＋D2 reactive system and its isotope variants, quasi-classical trajectory（QCT） calculation was performed on Ho＇s potential energy surface（PES） of 2A″ state. Product polarizations such as product distributions of P（θr）, P（φr） and P（θr,φr）, as well as the generalized polarization-dependent differential cross sections（PDDCSs） were discussed and compared in detail among the four product channels of the title reactions. Both the intermolecular and intramolecular isotope effects were proved to be influential on product polarizations.

关键词： Isotope effect Product polarization Quasi-classical trajectory calculation Potential energy surface

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novel approach for determining the optimal axial preload of a simulating rotary table spindle system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 812-817页

作者： shan Xiao-biao XIE Tao CHEn Wei-shan School of Mechatronics Engineering Harbin Institute of Technology Harbin 15001 China

This paper presents a new theoretical model to determine the optimal axial preload of a spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stiffness was treated as the sum of the spindle modal stiffness and the framework elastic stiffness, based on a novel concept that magnitude of preloads can be controlled by measuring the resonant frequency of a spindle system. By employing an example of a certain type of aircraft simulating rotary table, the modal stiffness was measured on the Agilent 35670A Dynamic Signal Analyzer by experimental modal analysis. The equivalent elastic stiffness was simulated by both finite element analysis in AnSYS? and a curve fitting in MATLAB?. Results showed that the static preloading stiffness of the spindle was 7.2125×107 n/m, and that the optimal preloading force was 120.0848 n. Practical application proved the feasibility of our method.

关键词： Three-axis simulating rotary table Axial position preload Stiffness Experimental modal analysis Finite elementanalysis

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Creep behavior of plasma sprayed niCr and niCrAl coating-based systems

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 183-189页

作者： shan-Tung TU Key Laboratory of Safety Science of Pressurized System Ministry of EducationEast China University of Science and Technology

The creep behavior of the plasma sprayed niCr and niCrA1 coating/nickel alloy 690 substrate systems at 1033 K was investigated. Results showed that there was almost no difference in the creep lives between the niCr and niCrA1 coated specimens at a given stress level, since the contents of Cr used in the niCr and niCrA1 powders are almost same. The relationship between the minimum creep rate and the applied stress followed the well-known norton＇s power law, εmin=Aσ^n, with the values of A=2.66×10^-16 MPa^-n·h^-1 and n=6.48. The relation between the applied stress and time to rupture of the coated specimens can be estimated by using Larson-Miller equation. The θ projection method can be used to accurately characterize the creep behavior of the coated specimens.

关键词： Creep Coating θ projection method Minimum creep strainrate

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Augmentation Quotients for Complex Representation Rings of Generalized Quaternion Groups

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Chinese Annals of Mathematics,Series B 2016年第4期37卷 571-584页

作者： shan CHAnG School of Mathematics Hefei University of Technology

Abstract Denote by Qm the generalized quaternion group of order 4m. Let R（Qm） be its complex representation ring, and △（Qm） its augmentation ideal. In this paper, the author gives an explicit Z-basis for the △n... 详细信息

关键词： Generalized quaternion groups Representation ring Augmentation quotients

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