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Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities

The Innovation 2024年第2期5卷 42-50页

作者： Yali Liu Jianqing Du Yanfen Wang Xiaoyong Cui Jichang Dong Pan gu Yanbin Hao Kai Xue Hongbo Duan Anquan Xia Yi Hu zhi Dong Bingfang Wu Jüurgen P.Kropp Bojie Fu School of Grassland Science Beijing Forestry UniversityBeijing 100083China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Humanities University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China School of Innovation and Entrepreneurship University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Potsdam Institute for Climate Impact Research 14412 PotsdamGermany Institute for Environmental Science and Geography University of Potsdam14412 PotsdamGermany State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Differences in progress across sustainable development goals(SDGs)are widespread globally;meanwhile,the rising call for prioritizing specific SDGs may exacerbate such ***,how these progress differences would influence global sustainable development has been long ***,we present the first quantitative assessment of SDGs’progress differences globally by adopting the SDGs progress evenness *** results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because(1)it is strongly associated with many public health risks(e.g.,air pollution),social inequalities(e.g.,gender inequality,modern slavery,wealth gap),and a reduction in life expectancy;(2)it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems,increasing the challenges related to biodiversity conservation;(3)most countries with low average SDGs performance show lower progress evenness,which further hinders their fulfillment of SDGs;and(4)many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness,which is partly ascribed to the antagonism between climate actions and other *** findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors,caution must be exercised to avoid new problems from intensifying uneven progress across ***,our study reveals that the urgent needs regarding SDGs of different regions seem complementary,emphasizing that regional collaborations(e.g.,demand-oriented carbon trading between SDGs poorly performed and well-performed countries)may promote sustainable development achievements at the global scale.

关键词： globally priori inequality

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Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae

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Science China(Life Sciences) 2024年第4期67卷 803-816页

作者： Kun-Li Xiang Sheng-Dan Wu Lian Lian Wen-Chuang He Dan Peng Huan-Wen Peng Xiao-Ni Zhang Hong-Lei Li Jia-Yu Xue Hong-Yan shan gui-Xia Xu Yang Liu zhi-Qiang Wu Wei Wang State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing 100093China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyLaboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China China National Botanical Garden Beijing 100093China State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Landscape Architecture and Life Science/Institute of Special Plants Chongqing University of Arts and SciencesChongqing 402160China College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Fairylake Botanical Garden Shenzhen&Chinese Academy of SciencesShenzhen 518004China

Living fossils are evidence of long-term sustained ecological ***,whether living fossils have little molecular changes remains poorly known,particularly in ***,we have introduced a novel method that integrates phylogenomic,comparative genomic,and ecological niche modeling analyses to investigate the rate of molecular evolution of Eupteleaceae,a Cretaceous relict angiosperm family endemic to East *** assembled a high-quality chromosome-level nuclear genome,and the chloroplast and mitochondrial genomes of a member of Eupteleaceae(Euptelea pleiosperma).Our results show that Eupteleaceae is most basal in Ranunculales,the earliest-diverging order in eudicots,and shares an ancient whole-genome duplication event with the other *** document that Eupteleaceae has the slowest rate of molecular changes in the observed *** unusually low rate of molecular evolution of Eupteleaceae across all three independent inherited genomes and genes within each of the three genomes is in association with its conserved genome architecture,ancestral woody habit,and conserved niche *** findings reveal the evolution and adaptation of living fossil plants through large-scale environmental change and also provide new insights into early eudicot diversification.

关键词： conservation genomics eudicots evolutionary rates niche conservatism phylogenomics

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Molecular features of gastroenteropancreatic neuroendocrine carcinoma: A comparative analysis with lung neuroendocrine carcinoma and digestive adenocarcinomas

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Chinese Journal of Cancer Research 2024年第1期36卷 90-102页

作者： Jianwei Zhang Hanxiao Chen Junli Zhang Sha Wang Yanfang guan Wenguang gu Jie Li Xiaotian Zhang Jian Li Xicheng Wang zhihao Lu Jun Zhou zhi Peng Yu Sun Yang Shao Lin Shen Minglei Zhuo Ming Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Radiation Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518172China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department I of Thoracic OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Medical Department Nanjing Geneseeq Technology Inc.Nanjing 210061China Geneplus-Beijing Beijing 102200China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: There is an ongoing debate about whether the management of gastroenteropancreatic(GEP)neuroendocrine carcinoma(NEC) should follow the guidelines of small-cell lung cancer(SCLC). We aim to identify the genetic differences of GEPNEC and its ***: We recruited GEPNEC patients as the main cohort, with lung NEC and digestive adenocarcinomas as comparative cohorts. All patients undergone next-generation sequencing(NGS). Different gene alterations were compared and analyzed between GEPNEC and lung NEC(LNEC), GEPNEC and adenocarcinoma to yield the remarkable ***: We recruited 257 patients, including 99 GEPNEC, 57 LNEC, and 101 digestive *** the mutations, KRAS, RB1, TERT, IL7R, and CTNNB1 were found to have different gene alterations between GEPNEC and LNEC samples. Specific genes for each site were revealed: gastric NEC(TERT amplification),colorectal NEC(KRAS mutation), and bile tract NEC(ARID1A mutation). The gene disparities between small-cell NEC(SCNEC) and large-cell NEC(LCNEC) were KEAP1 and CDH1. Digestive adenocarcinoma was also compared with GEPNEC and suggested RB1, APC, and KRAS as significant genes. The TP53/RB1 mutation pattern was associated with first-line effectiveness. Putative targetable genes and biomarkers in GEPNEC were identified in22.2% of the patients, and they had longer progression-free survival(PFS) upon targetable treatment [12.5 months vs. 3.0 months, HR=0.40(0.21-0.75), P=0.006].Conclusions: This work demonstrated striking gene distinctions in GEPNEC compared with LNEC and adenocarcinoma and their clinical utility.

关键词： Neuroendocrine carcinoma gastroenteropancreatic lung genetic alterations molecular markers

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Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 87-103页

作者： shan Long Yibing Zhao Yuanyuan Xu Bo Wang Haixia Qiu Hongyou Zhao Jing Zeng Defu Chen Hui Li Jiakang Shao Xiaosong Li Ying gu School of Medicine Nankai University Tianjin300072P.R.China Department of Laser Medicine The First Medical Center of Chinese PLA General Hospital Beijing 100853 P.R.China Department of Oncology The Seventh Medical Center of Chinese PLA General Hospital Beijing 100039 P.R.China School of Basic Medicine Guizhou Medical University Guiyang 550025GuizhouP.R.China College of Medical Technology Beijing Institute of Technology Beijing 100081P.R.China Medical School of Chinese PLA Beijing 100853 P.R.China

Photodynamic therapy(PDT)has limited effects in treating metastatic breast *** checkpoints can deplete the function of immune cells;however,the expression of immune checkpoints after PDT is *** study investigates whether the limited e±cacy of PDT is due to upregulated immune checkpoints and tries to combine the PDT and immune checkpoint inhibitor to observe the e±cacy.A metastatic breast cancer model was treated by PDT mediated by hematoporphyrin derivatives(HpD-PDT).The anti-tumor effect of HpD-PDT was observed,as well as CD4þT,CD8þT and calreticulin(CRT)by immunohistochemistry and *** checkpoints on T cells were analyzed byflow cytometry after *** combining PDT with immune checkpoint inhibitors,the antitumor effect and immune effect were *** HpD-PDT at 100 mW/cm2 and 40,60 and 80 J/cm2,primary tumors were suppressed and CD4þT,CD8þT and CRT were elevated;however,distant tumors couldn't be inhibited and survival could not be *** checkpoints on T cells,especially PD1 and LAG-3 after HpD-PDT,were upregulated,which may explain the reason for the limited HpD-PDT *** PDT combined with anti-PD1 antibody,but not with anti-LAG-3 antibody,both the primary and distant tumors were signi-cantly inhibited and the survival time was prolonged,additionally,CD4þT,CD8þT,IFN-þCD4þT and TNF-þCD4þT cells were signi-cantly increased compared with ***-PDT could not combat metastatic breast ***1 and LAG-3 were upregulated after ***-PD1 antibody,but not anti-LAG-3 antibody,could augment the antitumor effect of HpD-PDT for treating metastatic breast cancer.

关键词： Photodynamic therapy anti-PD1 antibody anti-LAG-3 antibody anti-tumor im-mune effects metastatic breast cancer

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拓扑层结构中的光学双稳态及其在光神经网络中的应用

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物理学报 2024年第16期73卷 110-117页

作者：李昀衡喻可朱天宇于桐单思超谷亚舟李志曈北京邮电大学信息光子学与光通信国家重点实验室北京100876 北京邮电大学未来学院北京100876 北京邮电大学信息与通信工程学院北京100876 北京邮电大学理学院北京100876

具有光学双稳态的非线性微纳光学器件在光集成电路和光神经网络中有着重要的应用.然而,传统光学双稳态特性会受到内部系统无序和外部系统扰动的影响,不利于应用.本文利用SiO_(2)和TiO_(2)的拓扑多层薄膜结构,在拓扑模式电场强度最大的... 详细信息

具有光学双稳态的非线性微纳光学器件在光集成电路和光神经网络中有着重要的应用.然而,传统光学双稳态特性会受到内部系统无序和外部系统扰动的影响,不利于应用.本文利用SiO_(2)和TiO_(2)的拓扑多层薄膜结构,在拓扑模式电场强度最大的区域引入非线性介电常数,探究拓扑模式的光学双稳态特性,并分析了双稳态特性在层厚度变化和折射率变化下的鲁棒性.最后,本文将双稳态特性作为非线性激活函数应用到了光神经网络计算中,相比于传统的非线性激活函数ReLu和Sigmoid,双稳态非线性激活函数展示出了更好的图像识别精度.本文结果对研发下一代鲁棒性强的光神经网络有着重要研究意义.

关键词：光学双稳态拓扑层结构鲁棒性

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基于TLR-4/MyD88/NF-κB对健脾化滞丸治疗溃疡性结肠炎的机制进行拆方研究

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中国免疫学杂志 2024年第5期40卷 1075-1081页

作者：景姗顾玮刘小丽顾庆华南京中医药大学附属南通医院(南通市中医院)脾胃病科南通226001 南通卫生高等职业技术学校南通226010

目的:通过建立脾虚湿蕴型溃疡性结肠炎(UC)大鼠模型,探讨健脾化滞丸及其不同拆方对TLR-4/MyD88/NF-κB通路的影响。方法:64只Wistar大鼠随机分为正常对照组8只、模型组56只,采用中医证候联合乙醇-2,4,6-三硝基苯磺酸灌肠法复制UC大鼠模... 详细信息

目的:通过建立脾虚湿蕴型溃疡性结肠炎(UC)大鼠模型,探讨健脾化滞丸及其不同拆方对TLR-4/MyD88/NF-κB通路的影响。方法:64只Wistar大鼠随机分为正常对照组8只、模型组56只,采用中医证候联合乙醇-2,4,6-三硝基苯磺酸灌肠法复制UC大鼠模型,造模成功后,将模型大鼠随机分为模型组(M)、美沙拉嗪组(A)、健脾化滞丸全方组(B)、健脾清化方组(C)、健脾清化活血方组(D)、健脾清化导滞方组(E)、清化导滞活血方组(F),每组8只,给予相应药物灌胃4周,疗程结束后处死所有大鼠并取材,观察大鼠体质量变化、疾病活动度及结肠病理改变,ELISA及免疫组化检测大鼠结肠组织TNF-α表达;RT-PCR及Western blot检测大鼠结肠组织TLR-4、MyD88、NF-κB mRNA及蛋白表达。结果:健脾化滞丸全方、健脾清化方、健脾清化活血方组及健脾清化导滞方组大鼠体质量明显高于模型组(P0.05)。结论:健脾化滞丸及各拆方均可能通过TLR-4/MyD88/NF-κB通路发挥作用,其中黄连、煨木香、凤尾草、炮姜可能为本方核心药物,对临床具有一定指导意义。

关键词：溃疡性结肠炎健脾化滞丸 TLR-4/MyD88/NF-κB通路 TNF-α

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物流业智慧化发展对经济韧性的影响:效应及机制

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广东财经大学学报 2024年第3期39卷 20-34页

作者：谷城张树山东北师范大学经济与管理学院吉林长春130117

科学评估物流业智慧化发展对经济韧性的影响具有重要现实意义。基于2006—2021年我国286个城市的面板数据,构建物流业智慧化与经济韧性指标,探究物流业智慧化对经济韧性的影响及作用机制。结果表明,物流业智慧化显著提升了经济韧性,且... 详细信息

科学评估物流业智慧化发展对经济韧性的影响具有重要现实意义。基于2006—2021年我国286个城市的面板数据,构建物流业智慧化与经济韧性指标,探究物流业智慧化对经济韧性的影响及作用机制。结果表明,物流业智慧化显著提升了经济韧性,且这一结论具有较强的稳健性。机制检验发现,物流业智慧化主要通过降低外部扰动风险、实现供需两端协调及激发经济活跃程度增强了经济韧性。拓展分析表明,物流业智慧化有助于促进市场一体化发展和市场潜力的释放,且在市场分割程度高的地区和低市场化地区,物流业智慧化对经济韧性的促进作用更强。物流业智慧化对经济韧性的促进作用还存在网络效应,物流网络越完善,物流业智慧化促进经济韧性的效应越强。因而应推动新一代信息技术与物流技术的深度融合,加强数字基础和交通基础设施建设,优化运输结构,完善地区间的物流体系,以更好地畅通国民经济循环、增强经济韧性。

关键词：物流业智慧化经济韧性数字经济外部扰动风险供需协调经济活跃度网络效应

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权益区分理论下数据法益保护模式

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西北大学学报（哲学社会科学版） 2024年第4期54卷 126-139页

作者：席志国纪雨杉中国政法大学民商经济法学院北京100088

大数据时代各种数据权益保护学说值得进一步反思与检讨。数据权益保护问题在我国既有规则体系内完全能够得到妥善解决。因数据的非排他性与权利的排他效力间的根本冲突,数据权益难以被纳入绝对权或相对权中进行保护,而各类新型数据权利... 详细信息

大数据时代各种数据权益保护学说值得进一步反思与检讨。数据权益保护问题在我国既有规则体系内完全能够得到妥善解决。因数据的非排他性与权利的排他效力间的根本冲突,数据权益难以被纳入绝对权或相对权中进行保护,而各类新型数据权利混淆了权利在民法体系中的定位,忽视了体系功能,甚至阻遏数据的共享与流通。从体系逻辑、制度调适成本与数据治理全球发展方向来看,数据权益应当被纳入法益保护模式中。数据法益保护应以事实控制状态为基础,将数据权益直接归属于事实控制人,保护范围以各个主体享有的事实利益范围为限。数据产权分置政策应经法律解释还原为数据法益归属确认的基础前提与数据主体行为规范的设计方向。

关键词：数据确权数据法益权益区分理论数据保护模式

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Enhanced back-illuminated GaO-based solar-blind ultraviolet photodetectors

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Science China Technological Sciences 2024年

作者： YAN ZuYong zhi Yu Song JI XueQiang YUE JianYing WANG JinJin LIU Zeng LI shan LI PeiGang HOU shangLin WU Gang LEI JingLi TANG WeiHua School of Science State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology China Academy of Launch Vehicle Technology School of Integrated Circuits & State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications School of Electronic Information Engineering Inner Mongolia University College of Electronic and Optical Engineering & College of Microelectronics National and Local Joint Engineering Laboratory for RF Integration and Micro-Packing Technologies Nanjing University of Posts and Telecommunications

Ga2O3is a promising material for deep-ultraviolet （DUV） photodetectors due to its ultra-wide bandgap and high thermal and chemical ***,because of their relatively low responsivity,Ga2O3-based photodetectors still have difficulty meeting the requirements of practical ***,we construct a high-performance Ga2O3photodetector realized by *** high-crystallinity epitaxially grown Ga2O3as the DUV absorbing layer and the double-polished Al2O3substrate as the transparent window for injection of photons,the device operating in the back-illuminated mode exhibits a higher DUV photoresponse and faster response speed than in the front-illuminated ***,our experimental results have led to the development of a novel strategy for designing and fabricating high-performance Ga2O3photodetectors.

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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： Yu-Qin Wang Di Pan zhi-Yuan Yao Yu-Qi Li Peng-Fei Qu Run-Bang Wang Qing-Hao gu Jie Jiang Zheng-Xiang Han Hao-Nan Liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First College of Clinical Medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic Liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent *** Retrospective data were collected from 126 HCC patients treated with lenvatinib plus *** were divided into two groups based on BMI:The non-overweight group(BMIgue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety

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