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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue zhang Xin-xin YANG Yiguo ZHOU shan-shan zhang Jun-lian YANG Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

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An artificial intelligence diabetes management architecture based on 5G

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Digital Communications and Networks 2024年第1期10卷 75-82页

作者： Ruochen Huang Wei Feng shan Lu Tao shan Changwei zhang Yun Liu Department of Geriatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Information The First Afliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Medical Informatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing211166China Department of Outpatient The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing210003China

Along with the development of 5G network and Internet of Things technologies,there has been an explosion in personalized healthcare *** the 5G and Artificial Intelligence(Al)is introduced into diabetes management architecture,it can increase the efficiency of existing systems and complications of diabetes can be handled more effectively by taking advantage of *** this article,we propose a 5G-based Artificial Intelligence Diabetes Management architecture(AIDM),which can help physicians and patients to manage both acute complications and chronic *** AIDM contains five layers:the sensing layer,the transmission layer,the storage layer,the computing layer,and the application *** build a test bed for the transmission and application ***,we apply a delay-aware RA optimization based on a double-queue model to improve access efficiency in smart hospital wards in the transmission *** application layer,we build a prediction model using a deep forest *** on real-world data show that our AIDM can enhance the efficiency of diabetes management and improve the screening rate of diabetes as well.

关键词： Diabetes 5G Artificial intelligence Deep forest Smart hospital ward

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Enhanced visible light absorption of Bi_(2)WO_(6)/SiO_(2) with abundant adsorbed oxygen for the degradation of organic pollutant

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Particuology 2024年第5期88卷 210-217页

作者： Yuanting Wu Xiaoying Wang Wenlong Zhong shan zhang School of Material Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China

Heterogeneous photocatalysts exhibit high catalytic efficiency in the degradation of pollutants,but their stability and repeatability is not very good and requires high structural *** by nanosizing the pure Bi_(2)WO_(6)(BWO)photocatalyst without constructing a heterojunction,there is a significant improvement in its performance,with an enhancement effect of about 2.3 times(99.43%).The high photocatalytic degradation efficiency of the material can be attributed to the enhanced light absorption effect brought by the three-dimensional inverse-opal structure SiO_(2)(IS)and the abundant surface adsorbed oxygen generated after the formation of Si–O–W *** addition,the introduction of IS greatly increases the surface area of nanostructured BWO,which accelerates the charge transfer process,while the adsorbed oxygen promotes the participation of·O^(2−) in the photocatalytic reaction,thereby accelerating the consumption of photo-generated electrons and ultimately improving the separation of charge ***,the matched photonic bandgap further improves the absorption and utilization of light of the *** this work,we constructs Si–O–W bonds to obtain inverse-opal SiO_(2)/Bi_(2)WO_(6) with uniformly growth of pure phase nano BWO,which provides a feasible strategy for the preparation of high-performance pure-phase photocatalysts.

关键词： Bi_(2)WO_(6) SiO_(2) inverse-opal structure Photocatalysis Adsorbed oxygen

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Recyclable hydrolyzed polymers of intrinsic microporosity-1/Fe_(3)O_(4) magnetic composites as adsorbents for selective cationic dye adsorption

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 113-125页

作者： Feng zhang Shuainan Xu Xiumei Geng Meixia shan Yatao zhang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China

Polymers of intrinsic microporosity shows great potential for dye adsorption and magnetic Fe_(3)O_(4) are easy to be *** this work,hydrolyzed polymers of intrinsic microporosity-1/Fe_(3)O_(4) composite adsorbents were prepared by phase inversion and hydrolysis process for cationic dye *** chemical structure and morphology of the composite adsorbents were systematically characterized by several characterization *** methylene blue as the target dye,the influences of solution pH,contact time,initial dye concentration,and system temperature on the methylene blue adsorption process were *** incorporation of Fe_(3)O_(4) particle into hydrolyzed polymers of intrinsic microporosity-1 endow the adsorbent with high magnetic saturation(20.7 emu·g^(–1))which allows the rapid separation of the ***,the adsorption process was simulated by adsorption kinetics,isotherms and thermodynamics to gain insight onto the intrinsic adsorption *** addition,the composite adsorbents are able to selectively adsorb cationic dyes from mixed dyes *** polymers of intrinsic microporosity/Fe_(3)O_(4) shows only a slight decrease for methylene blue adsorption after 10 adsorption/regeneration cycles,demonstrating the outstanding regeneration *** high adsorption capacity,outstanding regeneration ability,together with simple preparation method,endow the composite adsorbents great potential for selective removal of cationic dyes in wastewater system.

关键词： polymers of intrinsic microporosity magnetic adsorbent cationic dye adsorption

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Overexpression of Twist1 in vascular endothelial cells promotes pathological retinal angiogenesis in mice

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Zoological Research 2022年第1期43卷 64-74页

作者： Lin zhang shan-shan zhang Kai-Fang Wang Yi-Hui Li Hui-Juan Xu Kuan-Xiang Sun Shi Ma Hong-Mei Leng Si-Zhu Chen Wen-Jing Jia Xian-Jun Zhu Jie Li Department of Ophthalmology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine Sichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan 610072China Qinghai Key Laboratory of Qinghai-Tibetan Plateau Biological Resources Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningQinghai 810008China University of Chinese Academy of Science Beijing 100049China

Retinal angiogenesis is a critical process for normal retinal ***,uncontrolled angiogenesis can lead to pathological neovascularization(NV),which is closely related to most irreversible blindness-causing retinal *** the molecular basis behind pathological NV is important for the treatment of related ***-related protein 1(TWIST1)is a well-known transcription factor and principal inducer of epithelial-mesenchymal transition(EMT)in many human *** previous study showed that Twist1 expression is elevated in pathological retinal *** date,however,the role of TWIST1 in retinal pathological angiogenesis remains to be *** study the role of TWIST1 in pathological retinal NV and identify specific molecular targets for antagonizing pathological NV,we generated an inducible vascular endothelial cell(EC)-specific Twist1 transgenic mouse model(Tg-Twist1iEC+).Whole-mount retinas from Tg-Twist1iEC+mice showed retarded vascular progression and increased vascular density in the front end of the growing retinal vasculature,as well as aneurysm-like pathological retinal ***,overexpression of Twist1 in the ECs promoted cell proliferation but disturbed cell polarity,thus leading to uncontrolled retinal ***1 promoted pathological NV by activating the Wnt/β-catenin signaling pathway and inducing the expression of NV formation-related genes,thereby acting as a‘valve’in the regulation of pathological *** study identified the critical role of TWIST1 in retinal pathological NV,thus providing a potential therapeutic target for pathological NV.

关键词： Pathological angiogenesis TWIST1 Molecular markers Mouse model Retinal

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Energy-Efficient Traffic Offloading for RSMA-Based Hybrid Satellite Terrestrial Networks with Deep Reinforcement Learning

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China Communications 2024年第2期21卷 49-58页

作者： Qingmiao zhang Lidong Zhu Yanyan Chen shan Jiang National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China The Higher Educational Key Laboratory for Flexible Manufacturing Equipment Integration of Fujian Province Xiamen Institute of TechnologyXiamen 361021China China Mobile(Jiangxi)Communications Group Co. LtdYichun 336000China

As the demands of massive connections and vast coverage rapidly grow in the next wireless communication networks, rate splitting multiple access(RSMA) is considered to be the new promising access scheme since it can provide higher efficiency with limited spectrum resources. In this paper, combining spectrum splitting with rate splitting, we propose to allocate resources with traffic offloading in hybrid satellite terrestrial networks. A novel deep reinforcement learning method is adopted to solve this challenging non-convex problem. However, the neverending learning process could prohibit its practical implementation. Therefore, we introduce the switch mechanism to avoid unnecessary learning. Additionally, the QoS constraint in the scheme can rule out unsuccessful transmission. The simulation results validates the energy efficiency performance and the convergence speed of the proposed algorithm.

关键词： deep reinforcement learning energy efficiency hybrid satellite terrestrial networks rate splitting multiple access traffic offloading

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Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： shan-shan Jin Si-Nong Wang Yan-Yan Huang Jing-Yu zhang Peng Liu Hui Yu Hong-Dong zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

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Empowering smart city situational awareness via big mobile data

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 286-307页

作者： Zhiguang shan Lei SHI Bo LI Yanqiang zhang Xiatian zhang Wei CHEN State Information Center Beijing100045China School of Computer Science and Engineering Beihang UniversityBeijing100191China Zhongguancun Laboratory Beijing100094China Beijing Tendcloud Tianxia Technology Co. Ltd.Beijing100027China The State Key Lab of CAD&CG Zhejiang UniversityHangzhou310027China

Smart city situational awareness has recently emerged as a hot topic in research societies,industries,and governments because of its potential to integrate cutting-edge information technology and solve urgent challenges that modern cities *** example,in the latest five-year plan,the Chinese government has highlighted the demand to empower smart city management with new technologies such as big data and Internet of Things,for which situational awareness is normally the crucial first *** traditional static surveillance data on cities have been available for decades,this review reports a type of relatively new yet highly important urban data source,i.e.,the big mobile data collected by devices with various levels of mobility representing the movement and distribution of public and private agents in the *** especially focus on smart city situational awareness enabled by synthesizing the localization of hundreds of thousands of mobile software Apps using the Global Positioning System(GPS).This technique enjoys advantages such as a large penetration rate(∼50%urban population covered),uniform spatiotemporal coverage,and high localization *** first discuss the pragmatic requirements for smart city situational awareness and the challenges *** we introduce two suites of empowering technologies that help fulfill the requirements of(1)cybersecurity insurance for smart cities and(2)spatiotemporal modeling and visualization for situational awareness,both via big mobile *** main contributions of this review lie in the description of a comprehensive technological framework for smart city situational awareness and the demonstration of its feasibility via real-world applications.

关键词： Smart city Mobile data Situational awareness

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Design and verification of an FPGA programmable logic element based on Sense-Switch pFLASH

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 485-499页

作者： Zhengzhou CAO Guozhu LIU Yanfei zhang Yueer shan Yuting XU No.58 Research Institute China Electronics Technology Group CorporationWuxi 214035China

This paper proposes a kind of programmable logic element(PLE)based on Sense-Switch pFLASH *** programming Sense-Switch pFLASH,all three-bit look-up table(LUT3)functions,partial four-bit look-up table(LUT4)functions,latch functions,and d flip flop(DFF)with enable and reset functions can be *** PLE uses a choice of operational logic(COOL)approach for the operation of logic functions,it allows any logic circuit to be implemented at any ratio of combinatorial logic to *** intrinsic property makes it close to the basic application specific integrated circuit(ASIC)cell in terms of fine granularity,thus allowing ASIC-like cell-based mappers to apply all their optimization *** measuring Sense-Switch pFLASH and PLE circuits,the results show that the“on”state driving current of the Sense-Switch pFLASH is about 245.52μA,and that the“off”state leakage current is about 0.1 *** programmable function of PLE works *** delay of the typical combinatorial logic operation AND3 is 0.69 ns,and the delay of the sequential logic operation DFF is 0.65 ns,both of which meet the requirements of the design technical index.

关键词： Field programmable gate array(FPGA) Programmable logic element(PLE) Boolean logic operation Look-up table Sense-Switch pFLASH Threshold voltage

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Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2022年第4期11卷 29-42页

作者： Yiguo Zhou Wan-Xue zhang Eljah Tembo Ming-Zhu Xie shan-shan zhang Xin-Rui Wang Ting-Ting Wei Xin Feng Yi-Lin zhang Juan Du Ya-Qiong Liu Xuan zhang Fuqiang Cui Qing-Bin Lu Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing 100191People's Republic of China Department of Public Health Emergency Management School of Public HealthPeking UniversityBejing 100191People's Republic of China institute for Hospital Management Research Chinese PLA General HospitalBeijing 100039People's Republic of China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191People's Republic of China

Background:Indoor residual spraying(IRS)is one of the key interventions recommended by World Health Organization in preventing malaria *** aimed to conduct a systematic review and meta-analysis of global studies about the impact of IRS on malaria ***:We searched PubMed,Web of Science,Embase,and Scopus for relevant studies published from database establishment to 31 December ***-effects models were used to perform meta-analysis and subgroup analysis to pool the odds ratio(OR)and 95%confidence interval(CI).Meta-regression was used to investigate potential factors of heterogeneity across ***:Thirty-eight articles including 81 reports and 1,174,970 individuals were included in the *** was associated with lower rates of malaria infection(OR=0.35,95%CI:0.27-0.44).The significantly higher effectiveness was observed in IRS coverage≥80%than in IRS coverage<80%.Pyrethroids was identified to show the greatest performance in malaria *** addition,higher effectiveness was associated with a lower gross domestic product as well as a higher coverage of IRS and bed net ***:IRS could induce a positive effect on malaria infection *** high IRS coverage and the use of pyrethroids are key measures to reduce malaria *** efforts should focus on increasing IRS coverage,developing more effective new insecticides against malaria,and using multiple interventions comprehensively to achieve malaria control goals.

关键词： Indoor residual spraying Malaria Meta-analysis Effectiveness evaluation

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