检索结果-南通市图书馆

Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of Gualou Qumai Wan in clear cell renal cell carcinoma

引用

TMR Modern Herbal Medicine 2024年第2期7卷 11-18页

作者： Zhi-Qiang Wang Zhen-Yu Mu Bo Yang Tao Wang Zhi-Yong Su shan-chun guo Jiang-Xia Yin Department of Urology Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Medical Insurance Office Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Intensive Care Unit Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Department of Anal Surgery Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Department of Neurosurgery Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China RCMI Cancer Research Center Xavier University of LouisianaLA 1870125USA Department of Medical Oncology Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China

Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking ***:The screening of bioactive components and targets of GQW was based on the Traditional Chinese Medicine System Pharmacology(TCMSP)and the UniProt platform served for standardizing their *** Mendelian Inheritance in Man(OMIM),PharmGkb,TTD,DrugBank and GeneCards databases were searched to collect the disease targets of *** assisted in constructing herb-compound-target(H-C-T)*** STRING database was searched for constructing the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential *** of core genes related to survival and tumor microenvironment(TME)were conducted respectively based on the GEPIA2 database and TIMER 2.0 *** Protein Atlas(HPA)and The Cancer Genome Atlas(TCGA)helped to obtain core genes’protein expression as well as transcriptome expression *** Vina software validated the molecular docking regarding GQW components and pivotal ***:The constructed H-C-T networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKT1,HIF1A,PTGS2,TP53 and VEGFA serve as core targets in the way GQW affects *** to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling ***1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to *** docking and molecular dynamics simulations showed that diosgenin has

关键词： Gualou Qumai Wan AKT1 PI3K-Akt signaling pathway network pharmacology diosgenin clear cell renal cell carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling of LF refining process:a review

引用

Journal of Iron and Steel Research International 2024年第2期31卷 289-317页

作者： Zi-cheng Xin Jiang-shan Zhang Kai-xiang Peng Jun-guo Zhang chun-hui Zhang Qing Liu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Tangshan Branch Hebei Iron and Steel Co.Ltd.Tangshan063000HebeiChina Xinjiang Bayi Iron and Steel Co. Ltd.Baosteel GroupWulumuqi830022XinjiangChina

With the increasing demand for energy conservation and emission reduction,more attentions have been paid to the intelligentization,greenization and low carbonization during the transformation and upgrading of steelmaking *** furnace(LF)refining is one of the key procedures in steelmaking process and has been widely used in steelmaking plants for its high equipment matching degree,low equipment investment and outstanding refining *** to the main tasks of LF refining process,the modeling methods of temperature prediction model,slag-making model,alloying model,argon blowing model and model of inclusions behavior were systematically reviewed,and the advantages and disadvantages of each modeling method were *** addition,the technical framework for the future has also been proposed based on existing works,including classification of raw materials,graphic representation of knowledge,introduction,upgradation and management of device/equipment,customization of steelmaking,modeling of refining process,synergy of models,intelligentization of decision-making,automation of control,and digitization of processes and operations,aiming to provide a reference for the modeling and intelligent development of LF refining process.

关键词： LF refining Temperature prediction Slag-making Alloying Argon blowing Inclusion behavior Modeling method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cryptic diversity and rampant hybridization in annual gentians on the Qinghai-Tibet Plateau revealed by population genomic analysis

引用

Plant Diversity 2024年第2期46卷 194-205页

作者： Peng-Cheng Fu Qiao-Qiao guo Di Chang Qing-Bo Gao shan-shan Sun School of Life Science Luoyang Normal UniversityLuoyang 471934PR China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001PR China

Understanding the evolutionary and ecological processes involved in population differentiation and speciation provides critical insights into biodiversity formation. In this study, we employed 29,865 single nucleotide polymorphisms(SNPs) and complete plastomes to examine genomic divergence and hybridization in Gentiana aristata, which is endemic to the Qinghai-Tibet Plateau(QTP) region. Genetic clustering revealed that G. aristata is characterized by geographic genetic structures with five clusters(West, East, Central, South and North). The West cluster has a specific morphological character(i.e., blue corolla) and higher values of FSTcompared to the remaining clusters, likely the result of the geological barrier formed by the Yangtze River. The West cluster diverged from the other clusters in the Early Pliocene;these remaining clusters diverged from one another in the Early Quaternary. Phylogenetic reconstructions based on SNPs and plastid data revealed substantial cyto-nuclear conflicts. Genetic clustering and D-statistics demonstrated rampant hybridization between the Central and North clusters,along the Bayankala Mountains, which form the geological barrier between the Central and North clusters. Species distribution modeling demonstrated the range of G. aristata expanded since the Last Interglacial period. Our findings provide genetic and morphological evidence of cryptic diversity in G. aristata, and identified rampant hybridization between genetic clusters along a geological *** findings suggest that geological barriers and climatic fluctuations have an important role in triggering diversification as well as hybridization, indicating that cryptic diversity and hybridization are essential factors in biodiversity formation within the QTP region.

关键词： Gentiana aristata Hybrid zone Qinghai-Tibet Plateau Plastome Nuclear SNPs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models

引用

Nuclear Science and Techniques 2024年第2期35卷 1-2页

作者： Jian-guo Li Bai-shan Hu Shuang Zhang Fu-Rong Xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting *** unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear *** atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N.

关键词： testing quantum system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-performance self-powered GaN/PEDOT:PSS hybrid heterojunction UV photodetector for optical communication

引用

Science China(Technological Sciences) 2024年第2期67卷 608-615页

作者： LI shan LIU Zeng ZHANG MaoLin YANG LiLi guo YuFeng TANG WeiHua College of Integrated Circuit Science and Engineering&National and Local Joint Engineering Laboratory for RF Integration and Micro-Packing Technologies Nanjing University of Posts and TelecommunicationsNanjing 210023China

Self-powered ultraviolet photodetectors(UVPDs)provide great possibility for the next-generation energy conservation optical communication technology;while the high photodetection performance at zero bias is still a tremendous ***,ntype GaN film with Si-doping concentration of~1018cm^(-3)and p-type organic PEDOT:PSS were adopted to construct a planar hybrid heterojunction via the simple spin-coating *** from typical type-Ⅱenergy band alignment and giant photovoltaic effect at GaN/PEDOT:PSS inorganic-organic interface,the fabricated UVPD achieved excellent self-powered photoelectrical properties in dual-band with large R of 0.96 A/W(2.8 A/W),superior D*of 5.7×1012Jones(1.7×10^(13)Jones),prominent EQE of 325%(1371%),high on/off ratio of 9.65×10^(3)(6.15×10^(3))and fast rise/decay time of 60.7/124.5 ms(30.9/26.7 ms)for UVA(UVC)band,as well as outstanding UV/visible rejection ratio and great detection *** as an optical signal receiver,this designed self-powered UVPD decoded a message of“NJUPT”from a simple optical communication *** results open a new avenue for GaN/PEDOT:PSS heterojunction in UV communications and related applications.

关键词： GaN UV photodetector self-powered heterojunction optical communication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Picotesla fiberized diamond-based AC magnetometer

引用

Photonics Research 2024年第6期12卷 1250-1261页

作者： SHAO-chun ZHANG YONG LIU LONG-KUN shan XUE-DONG GAO JIA-QI GENG CUI YU YANG DONG XIANG-DONG CHEN GUANG-CAN guo FANG-WEN SUN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China National Key Laboratory of ASIC Hebei Semiconductor Research InstituteShijiazhuang 050051China Electric Power Quantum Sensing Joint Laboratory of Anhui Province State Grid Anhui Electric Power Research InstituteHefei 230601China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Portable quantum sensors are crucial for developing practical quantum sensing and metrology *** nitrogen-vacancy(NV)centers in diamonds have emerged as one of the most promising candidates for compact quantum ***,due to the difficulty of coherently controlling the ensemble spin and noise suppression in a large volume,it often faces problems such as reduced sensitivity and narrowed bandwidth in integrated lensless ***,we propose a fluorescence signal treatment method for NV spin ensemble manipulation by the exponential fitting of spin polarization processes,instead of integrating the photon *** enables spin state readout with a high signal-to-noise ratio and applies to the pulse sensing protocols for large-volume NV *** on this,we further developed a fiberized diamond-based AC *** an XY8-N dynamical decoupling pulse sequence,we demonstrated a T_(2)-limited sensitivity of 8pT/√Hz and T_(1)-limited frequency resolution of 90 Hz over a wide frequency band from 100 kHz to 3 *** integrated diamond sensor leverages quantum coherence to achieve enhanced sensitivity in detecting AC magnetic fields,making it suitable for implementation in a compact and portable endoscopic sensor.

关键词： magnetometer quantum ensemble

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Viscoacoustic generalized screen propagator in constant-Q model

引用

Petroleum Science 2024年第4期21卷 2356-2369页

作者： Zhong-Kui Dai Jia-chun You Xing-guo Huang Wei Liu College of Geophysics Chengdu University of Technology College of Instrumentation and Electrical Engineering Jilin University

When seismic waves propagate through the geological formation, there is a significant loss of energy and a decrease in imaging resolution, because of the viscoacoustic properties of subsurface medium. This profoundly impacts seismic wavefield propagation, imaging and interpretation. To accurately image the true structure of subsurface medium, the consensus among geophysicists is to no longer treat subsurface medium as ideal homogeneous medium, but rather to incorporate the viscoacoustic properties of subsurface medium. Based on the generalized screen propagator using conventional acoustic wave equation(acoustic GSP), our developed method introduces viscoacoustic compensation strategy, and derives a one-way wave generalized screen propagator based on time-fractional viscoacoustic wave equation(viscoacoustic GSP). In numerical experiments, we conducted tests on two-dimensional multi-layer model and the Marmousi model. When comparing with the acoustic GSP using the acoustic data, we found that the imaging results of the viscoacoustic GSP using the viscoacoustic data showed a significant attenuation compensation effect, and achieved imaging results for both algorithms were essentially consistent. However, the imaging results of acoustic GSP using viscoacoustic data showed significant attenuation effects, especially for deep subsurface imaging. This indicates that we have proposed an effective method to compensate the attenuated seismic wavefield. Our application on a set of real seismic data demonstrated that the imaging performance of our proposed method in local areas surpassed that of the conventional acoustic GSP. This suggests that our proposed method holds practical value and can more accurately image real subsurface structures while enhancing imaging resolution compared with the conventional acoustic GSP. Finally, with respect to computational efficiency, we gathered statistics on running time to compare our proposed method with conventional Q-RTM, and it is evid

关键词： One-way wave equation Viscoacoustic wave equation Generalized screen propagator Attenuation and dispersion effects

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Molecular investigation into the transformation of recalcitrant dissolved organic sulfur in refinery sour water during stripping process

引用

Petroleum Science 2024年第3期21卷 2112-2119页

作者： Yu-guo Li Chen He chun-Mao Chen Fan Liu Quan Shi State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China State Key Laboratory of Coal Mining and Clean Utilization Beijing 100013China PetroChina Ningxia Petrochemical Company Yinchuan 750021NingxiaChina

Refinery sour water primarily originates from the tops of towers in various units and coker condensate,and cannot be discharged directly to a wastewater treatment plant due to high levels of chemical oxygen demand(COD)and organic sulfur *** after the recovery of H_(2)S from the sour water by the stripping process,the effluent still contains a high concentration of dissolved organic sulfur(DOS),which can have a huge bad *** chemical composition of dissolved organic matter(DOM)in refinery wastewater has been extensively studied,the investigation of recalcitrant DOS from sour waters remains *** the present study,chemical composition of sour water DOMs(especially DOS)was investigated using fluorescence spectroscopy(excitation-emission matrix,EEM)and mass spectrometry,including gas chromatography-mass spectrometry(GC-MS)and high-resolution Orbitrap *** GC-MS and EEM results showed that volatile and low-aromaticity compounds were effectively removed during the stripping process,while compounds with high hydrophilicity and humification degree were found to be more *** Orbitrap MS results showed that weak-polar oxygenated sulfur compounds were easier to be removed than oxygenated ***,the effluent still contained significant amounts of sulfur-containing compounds with multiple sulfur atoms,particularly in the form of highly unsaturated and aromatic *** Orbitrap MS/MS results of CHOS-containing compounds from the effluent indicate that the sulfur atoms may exist as sulfonates,disulfide bonds,*** the composition and structure of sour water DOS is crucial for the development of effective treatment processes that can target polysulfide compounds and minimize their impact on the environment.

关键词： Molecular transformation Dissolved organic sulfur Stripping process Refinery sourwater Orbitrap MS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental study on temperature fluctuations on plate surface induced by coaxial-jet flow

引用

Nuclear Science and Techniques 2024年第5期35卷 139-153页

作者： Xue-Yao Xiong Zun-Quan Liu guo-Yan Zhou Xing Luo shan-Tung Tu Key Laboratory of Pressure Systems and Safety(MOE) East China University of Science and TechnologyShanghai 200237China Institute of Thermodynamics Gottfried Wilhelm Leibniz University Hannover30823 GarbsenGermany

In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal *** on thermal striping in the upper plenum has mainly focused on fluid *** experimental studies have been reported on solid structures in a fluid field with a coaxial *** study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial *** temperature fluctuations of the fluid and plate surfaces located at different heights were *** cause of the temperature fluctuation was analyzed using a transient temperature *** results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial *** average surface temperatures tended to be *** the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature *** intensity of the temperature fluctuation was affected by the *** attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.

关键词： Temperature fluctuation Thermal striping Coaxial jet Thermal mixing The upper plenum of nuclear reactor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research Progress on the Pathogenesis and Treatment of Neoathero-sclerosis

引用

当代医学科学（英文） 2024年第4期44卷 680-685页

作者： Yi-shan guo Ning YANG Zhen WANG Yu-miao WEI Department of Cardiology Hubei Key Laboratory of Biological Targeted TherapyHubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Cardiology Binzhou Medical University HospitalBinzhou 256600China Department of Gynecology Binzhou Medical University HospitalBinzhou 256600China Department of Cardiology Binzhou Medical University HospitalBinzhou 256600China Department of Cardiology Hubei Key Laboratory of Biological Targeted TherapyHubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Neoatherosclerosis(NA)within stents has become an important clinical problem after coronary artery stent ***-stent restenosis and in-stent thrombosis are the two major complications following coronary stent placement and seriously affect patient *** the common pathological basis of these two complications,NA plaques,unlike native atherosclerotic plaques,often grow around residual oxidized lipids and stent *** main components are foam cells formed by vascular smooth muscle cells(VSMCs)engulfing oxidized lipids at lipid residue *** research mainly focuses on optical coherence tomography(OCT)and intravascular ultrasound(1VUS),but the specific pathogenesis of NA is still unclear.A thorough understanding of the pathogenesis and pathological features of NA provides a theoretical basis for clinical *** article reviews the previous research of our research group and the current situation of domestic and foreign research.

关键词： neoatherosclerosis vascular smooth muscle cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：