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Piezo1 suppression reduces demyelination after intracerebral hemorrhage

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Neural Regeneration Research 2023年第8期18卷 1750-1756页

作者： Jie Qu Hang-Fan Zong Yi shan shan-chun zhang Wei-Ping Guan Yang Yang Heng-Li Zhao Department of Emergency The Sixth Medical Center of Chinese PLA General HospitalBeijingChina The Second Medical Center&National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijingChina Department of Neurology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Department of Neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Piezo1 is a mechanically-gated calcium *** studies have shown that Piezo1,a mechanically-gated calcium channel,can attenuate both psychosineand lipopolysaccharide-induced *** oligodendrocyte damage and demyelination occur in intracerebral hemorrhage,in this study,we investigated the role of Piezo1 in intracerebral *** established a mouse model of cerebral hemorrhage by injecting autologous blood into the right basal ganglia and found that Piezo1 was largely expressed soon(within 48 hours)after intracerebral hemorrhage,primarily in *** injection of Dooku1 to inhibit Piezo1 resulted in marked alleviation of brain edema,myelin sheath loss,and degeneration in injured tissue,a substantial reduction in oligodendrocyte apoptosis,and a significant improvement in neurological *** addition,we found that Dooku1-mediated Piezo1 suppression reduced intracellular endoplasmic reticulum stress and cell apoptosis through the PERK-ATF4-CHOP and inositol-requiring enzyme 1 signaling *** findings suggest that Piezo1 is a potential therapeutic target for intracerebral hemorrhage,as its suppression reduces intracellular endoplasmic reticulum stress and cell apoptosis and protects the myelin sheath,thereby improving neuronal function after intracerebral hemorrhage.

关键词： apoptosis Ca^(2+)homeostasis endoplasmic reticulum stress intracerebral hemorrhage myelin basic protein myelin degradation oligodendrocyte Piezo1 stroke white matter injury

Metabolic syndrome and gallstone disease

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World Journal of Gastroenterology 2012年第31期18卷 4215-4220页

作者： Li-Ying Chen Qiao-Hua Qiao shan-chun zhang Yu-Hao Chen Guan-Qun Chao Li-Zheng Fang Department of Family Medicine Sir RunRun Shaw Hospital Zhejiang University Hangzhou 310016Zhejiang Province China Department of Epidemiology and Biosta-tistics School of Public Health Zhejiang University Hangzhou310058 Zhejiang Province China

AIM： To investigate the association between metabolic syndrome （NetS） and the development of gallstone disease （GSD）. METHODS： A cross-sectional study was conducted in 7570 subjects （4978 men aged 45.0：1：8.8 years, and 2592 women aged 45.3：1：9.5 years） enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones （653 men and 265 women） and 6652 healthy controls （4325 men and 2327 women） without gallstones. Body mass index （BII）, waist circumference, blood pressure, fasting plasma glucose （FPG） and serum lipids and lipoproteins levels were measured. Colorimetric method was used to measure cholesterol, high-density lipoprotein cho- lesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C）. Dextrose oxidizing enzyme method was used to measure FPG. Subjects were asked to complete a questionnaire that enquired about the information on demographic data, age, gender, histories of diabetes mellitus, hypertension, and chronic liver disease and so on. Metabolic syndrome was diagnosed according to the Adult Treatment Panel HI （ATP ]3） criteria. Gall- stones were defined by the presence of strong intralu- minal echoes that were gravity-dependent or attenu- ated ultrasound transmission. RESULTS： Among the 7570 subjects, the prevalence of the gallstone disease was 12.1% （13.1% in men and 10.2% in women）. BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and serum triglyceride （TG） in cases group were higher than in controls, while serum high-density lipid was lower than in controls. There were significant differences in the waist circumference, blood pressure, FPG and TG between cases and controls. In an age- adjusted logistic regression model, metabolic syndrome was associated with gallstone disease. The age-adjust- ed odds ratio of MetS for GSD in men was 1.29 [95% confidence interval （CI）, 1.09-1.52; P = 0.0030], and 1.68 （95% CI, 1.26-2.25; P = 0.0004） in women; the overa

关键词： Gallstone disease Obesity Hypertension Dyslipidemia Metabolic syndrome

Association of CASP9,CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 47-57页

作者： He LIU Ming-wu zhang Yi-feng PAN Yun-xian YU shan-chun zhang Xin-yuan MA Qi-long LI Kun CHEN Department of Epidemiology and Health Statistics School of Medicine Zhejiang University Hangzhou 310058 China Institute of Cancer Research and Prevention of Jiashan County Jiashan 314100 China

The initiators caspase-9 （CASP9） and caspase-10 （CASPIO） are two key controllers of apoptosis and play important roles in carcinogenesis. This study aims to explore the association between CASPs gene polymorphisms and colorectal cancer （CRC） susceptibility in a population-based study. A two-stage designed population-based case-control study was carried out, including a testing set with 300 cases and 296 controls and a validation set with 206 cases and 845 controls. A total of eight tag selected single nucleotide polymorphisms （SNPs） in CASP9 and CASPIO were chosen based on HapMap and the National Center of Biotechnology Information （NCBI） datasets and genotyped by restriction fragment length polymorphism （RFLP） assay. Multivariate logistic regression models were applied to evaluate the association of SNPs with CRC risk. In the first stage, from eight tag SNPs, three polymorphisms rs4646077 （odds ratio （OR）AA＋AG： 0.654, 95% confidence interval （CI）： 0.406-1.055; P=0.082）, rs4233532 （ORcc： 1.667, 95% CI： 0.967-2.876; Oacm： 1.435, 95% CI： 0.998-2.063; P=0.077）, and rs2881930 （ORcc： 0.263, 95% CI： 0.095-0.728, P=0.036） showed possible association with CRC risk. However, none of the three SNPs, rs4646077 （ORAA＋AG： 1.233, 95% CI： 0.903-1.683）, rs4233532 （ORcc： 0.892, 95% CI： 0.640-1.243; ORcT： 1.134, 95% CI： 0.897-1.433）, and rs2881930 （ORcc： 1.096, 95% CI： 0.620-1.938; ORcT： 1.009, 95% CI： 0.801-1.271）, remained significant with CRC risk in the validation set, even after stratification for different tumor locations （colon or rectum）. In addition, never tea drinking was associated with a significantly increased risk of CRC in testing set together with validation set （OR： 1.755, 95% CI： 1.319-2.334）. Our results found that polymorphisms of CASP9 and CASPIO genes may not contribute to CRC risk in Chinese population and thereby the large-scale case-control studies might be in consideration. In addition, tea drinking was a protective factor for CRC.

关键词： CASP9 CASPIO Colorectal cancer Single nucleotide polymorphisms Susceptibility to cancer Tea drinking

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing zhang chun-Lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia zhang Jianghui shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

二氯化钴预处理对大鼠脑梗死体积及SDF-1α/CXCR4表达水平的影响

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中国动脉硬化杂志 2016年第9期24卷 919-923页

作者：穆珊珊张春阳石秋艳王德龙刘春景陈历华北理工大学附属医院神经内科河北省唐山市063000

目的观察二氯化钴预处理对大鼠脑梗死体积百分比、基质细胞衍生因子1α(SDF-1α)/趋化因子受体4(CXCR4)表达的影响;探讨缺氧缺血环境中SDF-1α/CXCR4生物轴对脑的保护作用。方法将168只成年雄性SD大鼠随机分为缺氧预处理组(n=84)、模型... 详细信息

目的观察二氯化钴预处理对大鼠脑梗死体积百分比、基质细胞衍生因子1α(SDF-1α)/趋化因子受体4(CXCR4)表达的影响;探讨缺氧缺血环境中SDF-1α/CXCR4生物轴对脑的保护作用。方法将168只成年雄性SD大鼠随机分为缺氧预处理组(n=84)、模型组(n=84)。按缺血后再灌注时间不同分为再灌注6 h、24 h、3天、5天、7天、14天6个亚组。采用改良Longa方法制备局灶性脑缺血模型。观察缺氧缺血后脑组织病理学改变,通过氯化三苯基四氮唑(TTC)染色法观察脑缺血后再灌注两组大鼠脑梗死体积百分比的变化;免疫组织化学法检测大鼠脑组织皮层区各个时间点SDF-1α及CXCR4的表达变化。结果 TTC染色显示,缺氧预处理组及模型组大鼠6 h时即可见明显梗死灶,24 h脑梗死体积趋于稳定。两组大鼠24 h、3天、5天、7天、14天5个时间点脑梗死体积百分比比较,差异无统计学意义(P>0.05);缺氧预处理组各时间点脑梗死体积百分比均明显小于模型组(P<0.05)。免疫组织化学法结果显示,两组于脑缺血再灌注6 h皮层区SDF-1α、CXCR4表达明显增加,7天表达至高峰,随后表达逐渐减少,14天仍有表达。缺氧预处理组各时间点皮层区SDF-1α、CXCR4的阳性细胞数均显著多于模型组(P<0.05)。结论二氯化钴预处理能缩小脑梗死体积,其可能通过上调SDF-1α、CXCR4的表达水平,诱导脑缺氧耐受,促进间充质干细胞向缺血组织迁移,发挥脑保护作用。

关键词：脑梗死缺氧预处理二氯化钴梗死体积基质细胞衍生因子1α 趋化因子受体4

Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： Xiao You Huiying Ouyang Ruixiang Deng Qiuqi zhang Zhenzhong Xing Xiaowu Chen Qingliang shan Jinshan Yang Shaoming Dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Academy of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou chun-Li zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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杏仁内侧核的纤维投射与功能

解剖科学进展 2004年第1期10卷 56-59页

作者：张善春张吉强第三军医大学组织学与胚胎学教研室重庆400038

杏仁内侧核属于杏仁复合体内侧核群 ,内侧紧靠梨状皮质 ,外侧与屏状核相邻 ,背侧部分被豆状核覆盖 ,嘴侧毗邻前穿质 ,尾侧与尾状核相连 ,与嗅脑、大脑新皮质、隔核、丘脑和下丘脑有丰富的纤维联系 ,已经在该部位检测到多种物质的表达 ,... 详细信息

杏仁内侧核属于杏仁复合体内侧核群 ,内侧紧靠梨状皮质 ,外侧与屏状核相邻 ,背侧部分被豆状核覆盖 ,嘴侧毗邻前穿质 ,尾侧与尾状核相连 ,与嗅脑、大脑新皮质、隔核、丘脑和下丘脑有丰富的纤维联系 ,已经在该部位检测到多种物质的表达 ,提示该核团参与了对中枢神经系统多种重要功能的调节 ,如学习记忆、情绪。

关键词：杏仁内侧核纤维投射生理功能传出纤维杏仁复合体大脑