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Pore structure evolution of lacustrine organic-rich shale from the second member of the Kongdian formation in the Cangdong Sag,Bohai Bay Basin,China

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Petroleum Science 2022年第2期19卷 459-471页

作者： Xiao-Ping Liu Ming Guan Zhi-Jun Jin Zhe Cao Jin Lai Lun-Ju Zheng Wen-Qi Li Biao Sun shan-yong chen State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing100083China Institute of Energy Peking UniversityBeijing100871China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing100083China Sinopec Petroleum Exploration and Production Research Institute Beijing102206China Wuxi Petroleum Geology Institute Research Institute of Petroleum Exploration and DevelopmentSinopecWuxiJiangsu 214126China Petro China Dagang Oil Field Company Tianjin300280China

Pyrolysis experiments were conducted on lacustrine organic-rich shale from Cangdong Sag in Bohai Bay Basin,China,to investigate the impact of hydrocarbon generation on shale pore structure *** evolution is found to control the transformation of organic matter,hydrocarbon products characteristics,and pore structure ***,pore volume and specific surface area increase with increasing *** low-mature stage,the retained oil content begins to increase,pore volumes show slight changes,and primary pores are occluded by the generated crude oil of high molecular weight and *** the oil-window stage,the retained oil content rapidly increases and reaches maximum,and pore volumes gradually increase with increasing thermal *** high mature stage,the retained oil content begins to decrease,and the pore volume increases considerably owing to the expulsion of liquid *** over mature stage,natural gas content significantly increases and kerogen transforms to *** organic pores are formed and the pore size gradually increases,resulting from the connection of organic pores caused the increasing thermal *** study lays a foundation for understanding variation of hydrocarbon products during the thermal evolution of lacustrine shales and its relationship with the evolution of shale reservoirs.

关键词： Lacustrine shale Pyrolysis Thermal maturity Pore structure evolution Hydrocarbon generation evolution

New Taub-NUT black holes with massive spin-2 hair

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 51-58页

作者： Yu-Qi chen Hai-shan Liu Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China

We consider Einstein gravity extended with quadratic curvature invariants,within which the well-known Ricci-flat Taub-NUT black hole remains a *** analysis of the unstable Lichnerowicz modes in the Taub-NUT background enables us to identify the mass and NUT parameters(m,n)where new Taub-NUT black holes can *** then adopt numerical techniques to construct these new Taub-NUT black holes,which bifurcate away from the Ricci-flat *** the Ricci-flat Taub-NUT,there can exist two new black holes for an appropriate given temperature,making it a total of three if we include the Ricci-flat one.

关键词： higher derivative gravity black hole solution Taub-NUT spacetime

The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： shan-shan Jiang Zi-Ran Kang Ying-Xuan chen Jing-Yuan Fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China(Life Sciences) 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo shan Bian yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level,limiting their applications in biological ***,we introduce ImSpiRE,an image feature-aided spatial resolution enhancement method for in situ capturing spatial *** the information stored in histological images,ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution,together with extending the gene expression profiles into unmeasured *** to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains,signaling communication patterns,and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

Dative B–N bonds weaven toward two-dimensional purely organic materials for single crystals

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Science China Chemistry 2025年第1期68卷 12-14页

作者： Wei-Lei Zhou Siwei Wang yong chen College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional MoleculesInnovation Team of Optical Functional Molecular DevicesInner Mongolia Minzu UniversityTongliao 028000China College of Chemistry Nankai UniversityTianjin 300071China

Molecular topology is one of the important topics to study and understand the relationship between molecular structure and properties^([1]).Particularly,two-dimensional(2D)materials with extremely high surface area and ultra-thin morphology have attracted considerable attention due to their unexpected properties in materials and chemistry^([2,3]).

关键词： bonds purely dimensional

Wave effect of gravitational waves intersected with a microlens field II:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 237-250页

作者： Xikai shan Guoliang Li Xuechun chen Wen Zhao Bin Hu Shude Mao Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Department of Astronomy Tsinghua UniversityBeijing 100084China Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China School of Physics and Astronomy Beijing Normal UniversityBeijing 100875China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves(SLGWs).This effect presents both challenges and opportunities for the detection and appli-cation of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses(10^(3)-10^(6)).Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algo-rithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work(***.66,239511,2023),this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs(from saddle position of the time delay surface)due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%(11%)of SLGWs have a mismatch larger than 1%(3%)compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10^(−3),and 61%(25%)of signal pairs have a mismatch larger than 1%(3%).Theref

关键词： gravitational lensing diffractional integral algorithm gravitational wave

Immune cells:potential carriers or agents for drug delivery to the central nervous system

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Military Medical Research 2025年第1期12卷 121-153页

作者： shan-shan Zhang Ruo-Qi Li Zhong chen Xiao-Ying Wang Aaron S.Dumont Xiang Fan School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053China Clinical Neuroscience Research Center Department of Neurosurgery and NeurologyTulane University School of MedicineNew OrleansLA 70122USA

Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted ***,the access of nanoparticles/drugs to the central nervous system(CNS)remains a challenge mainly due to the obstruction from brain *** cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug ***,we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain *** subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS,as well as recent progress in rationally engineering immune cell-based DDS for CNS ***,we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.

关键词： Drug delivery systems Immune cells Blood-brain barrier Central nervous system

Efficient photodegradation of perfluoroalkyl substances under visible light by hexagonal ZnIn_(2)S_(4) nanosheets

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Journal of Environmental Sciences 2025年第2期148卷 116-125页

作者： Fuyu Liu Hui Xue Tingshuo Kang Qiupei Lei Jiazhe chen Zhihong Zuo Bin Han Xize Lu Xiao Yang Xiangcheng shan Xiaoyang Song Qingzhe Zhang yongguang Yin yong Cai shandong Key Laboratory of Environmental Processes and Health Qingdao Key Laboratory of Marine Pollutant PreventionSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shenzhen Research Institute of shandong University A301 Virtual University Park in South DistrictShenzhen 518057China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 10085China Department of Chemistry and Biochemistry Florida International UniversityMiamiFlorida 33199USA

Perfluoroalkyl substances(PFASs)are typical persistent organic pollutants,and their removal is urgently required but *** has shown potential in PFASs degradation due to the redox capabilities of photoinduced charge carriers in ***,hexagonal ZnIn_(2)S_(4)(ZIS)nanosheets were synthesized by a one-pot oil bath method and were well characterized by a series of *** the degradation of sodium p-perfluorous nonenoxybenzenesulfonate(OBS),one kind of representative PFASs,the assynthesized ZIS showed activity superior to P25 TiO_(2) under both simulated sunlight and visible-light *** good photocatalytic performance was attributed to the enhanced light absorption and facilitated charge *** pH conditions were found crucial in the photocatalytic process by influencing the OBS adsorption on the ZIS *** e−and h+were the main active species involved in OBS degradation in the ZIS *** work confirmed the feasibility and could provide mechanistic insights into the degradation and defluorination of PFASs by visible-light photocatalysis.

关键词： PFASs Defluorination Photocatalysis Visible light ZnIn_(2)S_(4)

Femtosecond laser small incision lenticule extraction on binocularity for myopia with glasses-free 3D technique

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 125-131页

作者： Bing-Jie chen Yu-chen Fan yong-Chuan Liao Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Optometry and Visual Science West China School of MedicineSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To evaluate the effect of femtosecond laser small incision lenticule extraction(SMILE)on the binocular visual function in myopic patients with glasses-free threedimensional(3D)***:Totally 50 myopic patients(39 females and 11 males)with SMILE were enrolled in this prospective *** glasses-free 3D technique was used to evaluate the binocular visual function in these subjects including static stereopsis,dynamic stereopsis,foveal suppression,and binocular balance point of signal to noise ratio(s/n ratio).All subjects received measurements in 1d before operation,and 1d,1wk,and 1mo ***:Both static and dynamic stereopsis showed no significant difference after *** foveal suppression improved significantly 1wk and 1mo after SMILE(P=0.005 and P=0.007 respectively).The binocular balance point of signal to noise ratio showed a significant improvement 1d,1wk and 1mo after SMILE for both eyes(P<0.001 for each eye respectively).CONCLUSION:Glasses-free 3D technique can be used to evaluate the effect of SMILE on the binocular visual function in myopic patients perceptively,and SMILE can improve both foveal suppression and binocular imbalance in these patients.

关键词： myopia small incision lenticule extraction foveal suppression binocular imbalance glasses-free threedimensional technique