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Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

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Neural Regeneration Research 2022年第11期17卷 2537-2543页

作者： Jun Xu Qian Li Chen-Yu Xu shan Mao Jia-Jia Jin Wei gu Ying Shi Chun-Fang Zou Liang ye Department of Respiration Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Respiration Nanjing Yuhua HospitalYuhua Branch of Nanjing First HospitalNanjingJiangsu ProvinceChina

Obstructive sleep apnea can worsen the prognosis of subarachnoid *** r,the underlying mechanism remains *** this study,we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method and exposed the mice to intermittent hypoxia for 8 hours daily for 2 consecutive days to simulate sleep *** found that sleep apnea aggravated brain edema,increased hippocampal neuron apoptosis,and worsened neurological function in this mouse model of subarachnoid ***,we established an in vitro HT-22 cell model of hemin-induced subarachnoid hemorrhage/intermittent hypoxia and found that the cells died,and lactate dehydrogenase release increased,after 48 *** further investigated the underlying mechanism and found that sleep apnea increased the expression of hippocampal neuroinflammatory factors interleukin-1β,interleukin-18,inte rleukin-6,nuclear factorκB,pyro ptosis-related protein caspase-1,pro-caspase-1,and NLRP3,promoted the prolife ration of astrocytes,and increased the expression of hypoxia-inducible factor 1αand apoptosis-associated speck-like protein containing a CARD,which are the key proteins in the hypoxia-inducible factor 1α/apoptosis-associated speck-like protein containing a CARD signaling *** also found that knockdown of hypoxia-inducible factor 1αexpression in vitro greatly reduced the damage to HY22 *** findings suggest that sleep apnea aggravates early brain injury after subarachnoid hemorrhage by aggravating neuroinflammation and pyroptosis,at least in part through the hypoxia-inducible factor 1α/apoptosis-associated speck-like protein containing a CARD signaling pathway.

关键词： apoptosis associated speck like protein containing a CARD early brain injury hypoxia-inducible factor 1α nucleotide-binding domain and leucine-rich repeat protein 3 obstructive sleep apnea pyroptosis neuroinflammation subarachnoid hemorrhage

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Super-selective arterial embolization in the control of acute lower gastrointestinal hemorrhage

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World Journal of Clinical Cases 2019年第22期7卷 3728-3733页

作者： Liang-shan Lv Jing-Tao gu Department of Gastroenterology and Interventional Radiography Xi’an Gaoxin HospitalXi’an Jiaotong UniversityXi’an 710075Shaanxi ProvinceChina Department of Vascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Acute gastrointestinal bleeding is an emergency condition that can lead to significant morbidity and *** is considered the preferred therapy in the treatment of lower gastrointestinal bleeding when it is unrealistic to perform the surgery or vasopressin infusion in this *** of acute lower gastrointestinal(GI)bleeding(any site below the ligament of Treitz)using this technique has not reached a consensus,because of the belief that the risk of intestinal infarction in this condition is extremely *** purpose of the study is to evaluate the effectiveness and safety of this technique in a retrospective group of patients who underwent embolization for acute lower GI *** To evaluate the efficacy and safety of super-selective arterial embolization in the management of acute lower GI *** A series of 31 consecutive patients with angiographically demonstrated small intestinal or colonic bleeding was retrospectively *** success rate and complication rate of super-selective embolization were *** Five out of thirty-one patients(16.1%)could not achieve sufficiently selective catheterization to permit *** control of bleeding was achieved in 26 patients(100%),and relapsed GI bleeding occurred in 1 of them at 1 wk after the *** clinically apparent bowel infarctions were observed in patients undergoing *** Super-selective embolization is a safe therapeutic method for acute lower GI bleeding,and it is suitable and effective for many patients suffering this ***,careful technique and suitable embolic agent are essential to the successful operation.

关键词： Lower gastrointestinal bleeding Embolization Infarction Bowel Hemorrhage Selective arterial embolization

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Numerical Modeling of the Dynamic Response of an Elastoplastic Seabed Under Wave-Current Interactions

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Journal of Ocean University of China 2023年第1期22卷 43-52页

作者： shan Zhigang ZHU Zhipeng WANG Dong ye guanlin Zhejiang Huadong Construction Engineering Corporation Limited Hangzhou 310014China MOE Key Laboratory of Marine Environment and Ecology Ocean University of ChinaQingdao 266100China Laboratory of Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Department of Civil Engineering and State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Wave-induced liquefaction of the seabed is a geohazard frequently encountered in shallow *** widely discussed,most studies paid attention to the seabed response under a single sequence of wave ***,the seabed suffers from repeated‘wave loading–dissipation’phases in a real ocean *** this study,a homogeneous sandy seabed model is established to investigate the mechanism of wave-induced liquefaction by considering the existence of *** element analyses are conducted by incorporating a kinematic hardening elastoplastic model into the commercial package *** constitutive model is validated against centrifugal wave *** studies are conducted to demonstrate the effects of relative densities,current,and wave-loading history on the seabed *** predicted excess pore pressure,effective stress paths,and associated variation of relative density are discussed in *** results show that the densification of soils significantly enhances the resistance against liquefaction,which provides new insight into the mechanism of residual liquefaction during wave sequences.

关键词： seabed liquefaction wave current finite element methods cyclic loading

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Exploring the stimulative effect on following drivers in a consecutive lane change using microscopic vehicle trajectory data

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Transportation Safety and Environment 2023年第2期5卷 47-58页

作者： Ruifeng gu ye Li Xuekai Cen School of Traffic and Transportation Engineering Central South UniversityChangsha 410075HunanChina

Improper lane-changing behaviours may result in breakdown of traffic flow and the occurrence of various types of *** study investigates lane-changing behaviours of multiple vehicles and the stimulative effect on following drivers in a consecutive lanechanging *** microscopic trajectory data from the HighD dataset are used for driving behaviour *** discretionary lane-changing vehicle groups constitute a consecutive lane-changing scenario,and not only distance-and speed-related factors but also driving behaviours are taken into account to examine the impacts on the utility of following lane-changing vehicles.A random parameters logit model is developed to capture the driver’s psychological heterogeneity in the consecutive lane-changing ***,a lane-changing utility prediction model is established based on three supervised learning algorithms to detect the improper lane-changing *** indicate that 1)the consecutive lane-changing behaviours have a significant negative effect on the following lane-changing vehicles after lane change;2)the stimulative effect exists in a consecutive lane-change situation and its influence is heterogeneous due to different psychological activities of drivers;and 3)the utility prediction model can be used to detect an improper lane-changing decision.

关键词： lane change driver’s psychology and behaviour random parameters logit model unobserved heterogeneity supervised learning

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Effects of Atomic Mixing in Inertial Confinement Fusion by Multifluid Interpenetration Mix Model

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Communications in Theoretical Physics 2009年第12期52卷 1102-1106页

作者： gu Jian-Fa ye Wen-Hua Institute of Applied Physics and Computational Mathematics Beijing 100094 China

The effects of atomic-level rnixing are systemically investigated in a multifluid interpenetration mix model ,and results are compared with the single-fluid model＇s simulations and experimental data. It is shown that increasing the model free parameter α, shock Mach number, and the initial density discontinuity makes the mix length and fraction of mixing particle increase, resulting in the lower shock temperatures compared with the results of single-fluid model without mixing. Recent high-compressibility direct-drive spherical implosions on OMEGA are simulated by the interpenetration mix modal. The calculations with atomic mixing between fuel and shell match quite well with the observations. Without considering any mixing, the calculated neutron yields and ion temperatures are overpredicted; while inclusion of the interpenetration mix model with the adjustable parameter α could fit the simulated neutron yields and ion temperatures well with experimental data.

关键词： multifluid interpenetration mix model atomic mixing inertial confinement fusion

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Conditions for galaxy quenching at 0.5

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Research in Astronomy and Astrophysics 2020年第8期20卷 143-156页

作者： Xue Ge Feng-shan Liu Qiu-Sheng gu Emanuele Contini Yi-Zhou gu School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Modern Astronomy and Space Exploration Nanjing 210093China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China

We investigate two classes of conditions for galaxy quenching at 0.510^10 M⊙)have much higher stellar mass surface densities within the central 1 kpc(∑1)and smaller sizes than star-forming galaxies in the same stellar mass *** addition,the quiescent fractions significantly increase with the increase of∑1 regardless of whether galaxies are centrals or *** contrast,we find that the overall lower-mass quiescent galaxies(M*<~10^10M⊙)have slightly higher E1 and comparable sizes compared to starforming galaxies of the same mass and at the same *** z<1.5,satellites have higher halo masses and larger quiescent fractions than those of centrals at a given∑1(stellar mass).Our findings indicate that the significant growth of the galaxy cores is closely related to the quenching of massive galaxies since z^2.5,while the environmental effect plays an important role in the quenching of low-mass galaxies at z≤1.5.

关键词： galaxies:evolution galaxies:formation galaxies:high-redshift

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Geography of Talent in China During 2000-2015:An Eigenvector Spatial Filtering Negative Binomial Approach

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Chinese Geographical Science 2021年第2期31卷 297-312页

作者： gu Hengyu Francisco ROWE LIU ye SHEN Tiyan School of Government Peking UniversityBeijing 100871China Geographic Data Science Lab Department of Geography and PlanningUniversity of LiverpoolLiverpool L69United Kingdom School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China guangdong Key Laboratory for Urbanization and Geo-Simulation Sun Yat-sen UniversityGuangzhou 510275China

The increase in China’s skilled labor force has drawn much attention from policymakers,national and international firms and *** how educated talent locates and re-locates across the country can guide future policy discussions of equality,firm localization and service *** studies have tended to adopt a static cross-national approach providing valuable insights into the relative importance of economic and amenity differentials driving the distribution of talent in ***,few adopt longitudinal analysis to examine the temporal dynamics in the stregnth of existing *** released official statistical data now enables space-time analysis of the geographic distribution of talent and its determinants in *** four-year city-level data from national population censuses and 1%population sample surveys conducted every five years between 2000 and 2015,we examine the spatial patterns of talent across Chinese cities and their underpinning drivers evolve over *** reveal that the spatial distribution of talent in China is persistently unequal and spatially concentrated between 2000 and *** also shows gradually strengthened and significantly positive spatial autocorrelation in the distribution of *** eigenvector spatial filtering negative binomial panel is employed to model the spatial determinants of talent *** indicate the influences of both economic opportunities and urban amenities,particularly urban public services and greening rate,on the distribution of *** results highlight that urban economic-and amenity-related factors have simultaneously driven China’s talent’s settlement patterns over the first fifteen years of the 21st century.

关键词： talent distribution determinants eigenvector spatial filtering panel data analysis China

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Alternative splicing and cancer: a systematic review

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Signal Transduction and Targeted Therapy 2021年第3期6卷 807-820页

作者： Yuanjiao Zhang Jinjun Qian Chunyan gu ye Yang The Third Affiliated Hospital of Nanjing University of Chinese Medicine NanjingChina School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjingChina

The abnormal regulation of alternative splicing is usually accompanied by the occurrence and development of tumors,which would produce multiple different isoforms and diversify protein *** aim of the present study was to conduct a systematic review in order to describe the regulatory mechanisms of alternative splicing,as well as its functions in tumor cells,from proliferation and apoptosis to invasion and metastasis,and from angiogenesis to *** abnormal splicing events contributed to tumor progression as oncogenic drivers and/or bystander *** alterations in splicing factors detected in tumors and other mis-splicing events(i.e.,long non-coding and circular RNAs)in tumorigenesis were also *** findings of recent therapeutic approaches targeting splicing catalysis and splicing regulatory proteins to modulate pathogenically spliced events(including tumor-specific neo-antigens for cancer immunotherapy)were *** emerging RNA-based strategies for the treatment of cancer with abnormally alternative splicing isoforms were also ***,further studies are still required to address the association between alternative splicing and cancer in more detail.

关键词： expression. invasion alterations

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Service-Driven Coded Forward Scheme Based on Streaming Transmission Model for Lunar Space Communication Networks

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China Communications 2020年第7期17卷 15-26页

作者： Shushi gu ye Wang guoqing Chen Shuo Shi School of Electronic and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Peng Cheng Laboratory Shenzhen 518055China School of Electronic and Information Engineering Harbin Institute of TechnologyHarbin 150001China

With the rapid development of lunar exploration,a large amount of scientific data and media stream service needs to be transmitted through Lunar Space Communication Networks(LSCNs).Due to limited transmitter power and intermittent,long delay and packet loss connections,the reliable and efficient multi-priority services’transmission in LSCNs becomes an urgent ***,we propose a Streaming Transmission Model(STM)based on temporal and spatial topology graph to describe the delay and energy consumption for data transmission in ***,we further devise a Coded Forward Scheme based on STM,termed CFS-STM,to achieve multi-priority service in two steps:i).Link Stability Function(LSF)is established by solving an optimization problem to choose the appropriate single-hop ***).Raptor code is employed to further save delay and energy with adjustable code-rate according to the different channel *** results show that,CFS-STM can significantly improve the transmission efficiency of multi-service priority streaming delivery in LSCNs.

关键词： Streaming service delay

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Retroperitoneal Versus Transperitoneal Laparoscopic Partial Nephrectomy: A Systematic Review and Meta-analysis

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Chinese Medical Sciences Journal 2015年第4期30卷 239-244页

作者： Jing Fu shan ye Hua-jian ye Department of Urology Shaoxing Branch the First Affiliated Hospital of Zhejiang University School of Medicine (Shaoxing Second Hospital) Department of Public Health Tashan Community Health Service Center

Objective To review published literatures comparing the safety and effectiveness of retroperitoneal laparoscopic partial nephrectomy(RLPN) with transperitoneal laparoscopic partial nephrectomy(TLPN) and provide reference for clinical work. Methods The search strategy was performed to identify relevant papers from the Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, Google Scholar, China Hospital Knowledge Database, Wangfang Chinese Periodical Database, and VIP Chinese Periodical Database. All papers comparing RLPN with TLPN were included from 2000 to 2015. Two to three reviewers independently screened, evaluated, and extracted the included papers. A Meta-analysis was executed by using Review Manager 5.3 software. The interesting outcomes were tumor size, operating time, estimated blood loss, warm ischaemia time, length of hospital stay, positive margin rate, open conversion rate, overall complication rate, and recurrence rate. Results The literature search obtained 378 papers, then 10 of them were ultimately met the inclusion criteria and included in the systematic review. Finally, 6 of the 10 papers were included in the Meta-analysis. RLPN had significantly less operating time [P = 0.01, mean difference(MD)=-33.68, 95% confidence interval(CI) within(-60.35,-7.01)] and shorter length of hospital stay [P < 0.0001, MD=-1.47, 95% CI within(-2.18,-0.76)] than TLPN. Significant differences were not found between RLPN and TLPN in other outcomes. Conclusions RLPN may be equally safe and be faster than TLPN. Each center can choose a modality according to your own operating habits and experience.

关键词： retroperitoneal transperitoneal laparoscopy partial nephrectomy systematic review

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