检索结果-南通市图书馆

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

Food Science and human Wellness 2024年第4期13卷 1886-1905页

作者： wei Li Haihong Chen Hongliang Chen Ziyin Li wei hu Qinxuan Zhou Bing Xu Yi Wang Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(huA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on huA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in huA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of huA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LDAS&ET-AD:Learnable Distillation Attack Strategies and Evolvable Teachers Adversarial Distillation

引用

Computers, Materials & Continua 2024年第5期79卷 2331-2359页

作者： Shuyi Li Hongchao hu Xiaohan Yang Guozhen Cheng Wenyan Liu wei Guo National Digital Switching System Engineering&Technological R&D Center The PLA Information Engineering UniversityZhengzhou450000China

Adversarial distillation(AD)has emerged as a potential solution to tackle the challenging optimization problem of loss with hard labels in adversarial ***,fixed sample-agnostic and student-egocentric attack strategies are unsuitable for ***,the reliability of guidance from static teachers diminishes as target models become more *** paper proposes an AD method called Learnable Distillation Attack Strategies and Evolvable Teachers Adversarial Distillation(LDAS&ET-AD).Firstly,a learnable distillation attack strategies generating mechanism is developed to automatically generate sample-dependent attack strategies tailored for distillation.A strategy model is introduced to produce attack strategies that enable adversarial examples(AEs)to be created in areas where the target model significantly diverges from the teachers by competing with the target model in minimizing or maximizing the AD ***,a teacher evolution strategy is introduced to enhance the reliability and effectiveness of knowledge in improving the generalization performance of the target *** calculating the experimentally updated target model’s validation performance on both clean samples and AEs,the impact of distillation from each training sample and AE on the target model’s generalization and robustness abilities is assessed to serve as feedback to fine-tune standard and robust teachers *** evaluate the performance of LDAS&ET-AD against different adversarial attacks on the CIFAR-10 and CIFAR-100 *** experimental results demonstrate that the proposed method achieves a robust precision of 45.39%and 42.63%against AutoAttack(AA)on the CIFAR-10 dataset for ResNet-18 and MobileNet-V2,respectively,marking an improvement of 2.31%and 3.49%over the baseline *** comparison to state-of-the-art adversarial defense techniques,our method surpasses Introspective Adversarial Distillation,the top-performing method in terms of robustne

关键词： Adversarial training adversarial distillation learnable distillation attack strategies teacher evolution strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Divergent responses of growth rate and antioxidative system of ten Bacillus strains to acid stresses

引用

Soil Ecology Letters 2024年第1期6卷 107-118页

作者： Xiaoran shan Jiayi Chen Jiaen Zhang Ziqiang Liu Shufang Chen hui wei Key Laboratory of Agro-Environment in the Tropics of Ministry of Agriculture and Rural Affairs Guangdong Laboratory for Lingnan Modern AgricultureCollege of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China Guangdong Engineering Research Center for Modern Eco-agriculture and Circular Agriculture South China Agricultural UniversityGuangzhou 510642China

Response of growth rate and antioxidative system of ten Bacillus strains to acid stresses was *** acid treatment significantly decreased the growth rate of the *** stresses increased the GPX activity and GSSG content of the tested *** changes occurred in ROS and antioxidative system(SOD,CAT,GR,MDA and GSH).Environmental changes including soil acidification exert obvi-ous stresses on soil ecosystems and influence soil *** this study,ten microbial strains were incubated under different acid treatments to investigate responses of microbial growth and antioxidative system to acid *** the strains belong to Bacillus genus,but exhibit distinct ecological *** observed that these microbial strains had obviously different pH tolerance threshold,in spite of the close phylogenetic classification among *** stresses exerted significant effects on microbial antiox-idative system,including superoxide dismutase(SOD),cata-lase(CAT)and glutathione transferring enzymes(GPX and GR)and reactants(GSH and GSSH),but the effects were strain ***,we found acid stress effects on total variances of the investigated microbial antioxidative system along the first two principal components(PCs).Activities of CAT and SOD contributed substantially to PC1 that reflected obvious acid effects on NC7 and ZC4,and closely related to intracellular malondialdehyde *** GSSG activities and GSH/GSSG contributed greatly to PC2 that unveiled acid stress effects on most of the microbial *** results highlight substantially heterogeneous responses of microbial strains to acid stress and support that phylogenetic closeness does not imply functional similarity of soil microorganisms under environmental changes.

关键词： soil acidification microbial strain acid tolerance capacity microbial growth oxidative stress antioxidative system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study

引用

World Journal of Clinical Cases 2024年第5期12卷 880-890页

作者： Ning wei Ming-hui Liu Yu-hu Song Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Clinical studies have reported that patients with gastroesophageal reflux disease(GERD)have a higher prevalence of *** To performed a bidirectional Mendelian randomization(MR)analysis to investi-gate the causal link between GERD and essential *** Eligible single nucleotide polymorphisms(SNPs)were selected,and weighted median,inverse variance weighted(IVW)as well as MR egger(MR-Egger)re-gression were used to examine the potential causal association between GERD and *** MR-Pleiotropy RESidual Sum and Outlier analysis was used to detect and attempt to reduce horizontal pleiotropy by removing outliers *** MR-Egger intercept test,Cochran’s Q test and“leave-one-out”sen-sitivity analysis were performed to evaluate the horizontal pleiotropy,heterogen-eities,and stability of single instrumental *** IVW analysis exhibited an increased risk of hypertension(OR=1.46,95%CI:1.33-1.59,P=2.14E-16)in GERD *** the same result was obtained in replication practice(OR=1.002,95%CI:1.0008-1.003,P=0.000498).Meanwhile,the IVW analysis showed an increased risk of systolic blood pressure(β=0.78,95%CI:0.11-1.44,P=0.021)and hypertensive heart disease(OR=1.68,95%CI:1.36-2.08,P=0.0000016)in GERD ***,we found an decreased risk of Barrett's esophagus(OR=0.91,95%CI:0.83-0.99,P=0.043)in essential hypertension *** We found that GERD would increase the risk of essential hypertension,which provided a novel prevent and therapeutic perspectives of essential hypertension.

关键词： Gastroesophageal reflux disease Essential hypertension Hypertensive heart disease Mendelian randomization study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new model simulating the development of gas condensate reservoirs

引用

Energy Geoscience 2024年第1期5卷 239-248页

作者： Yang Yang Zengmin Lun Rui Wang Maolei Cui wei hu Petroleum Exploration and Production Research Institute SINOPECBeijing100083China

A new simulation model for the development of gas condensate reservoirs is introduced based on the influence that phase change,non-Darcy flow,and capillary pressure have on the production of gas *** model predicts well performance,including bottom-hole pressure,oil/gas production rate,oil/gas recovery,gaseoil ratio,and the change in produced fluid *** also calculates dynamic characters,such as the change of pressure field and oil/gas saturation field during the development of gas condensate *** model is applicable to different boundary conditions(both constant-pressure and sealed boundary)and different production modes(both constant-pressure and constant-volume production modes).Model validation attempted using numerical simulation results for sealed boundary conditions with constant-pressure production mode has shown a relatively good match,proving its *** constant-pressure boundary conditions with constant-volume production mode,four stages are defined according to the dynamic behavior of production performance in the development of gas condensate reservoirs.

关键词： Gas condensate reservoir Phase behavior Numerical simulation Pseudo-pressure method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Weak interaction-steered evolution of polyoxovanadate-based metal-organic polyhedra from transformation via interlock to packing

引用

Chinese Chemical Letters 2024年第2期35卷 527-533页

作者： Yan-hu Wang Ke-wei Tong Chao-Qin Chen Jing Du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China College of Chemistry and Materials Science Testing and Analysis CenterHebei Normal UniversityShijiazhuang 050024China

A bottleneck in biomimetic synthesis consists in the full copy of,for example,the hierarchical structure of proteins directed by weak *** contrast with covalent bonds bearing definite orientation and high stability,weak intermolecular forces within a continuous dynamic equilibrium can be hardly tamed for molecular *** this endeavor,a ligand-dominated strategy that embodies tunable electrostatic repulsion andπ···πstacking was first employed to shape polyoxovanadate-based metal-organic polyhedra(VMOPs).Structural evolution involving transformation,interlock,and discovery of an unprecedented prototype of the Star of David was hence *** only as a handy tool for the primary structural control over VMOPs,these weak forces allow for an advanced management on the spatial distribution of such manmade macromolecules as well as the associated physicochemical behaviors,representing an ideal model for simulating and interpreting the conformation-function relationship of proteins.

关键词： Polyoxometalates Polyoxovanadates Metal-organic polyhedron Interlock Weak intermolecular forces

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geometric phase-encoded stimuli-responsive cholesteric liquid crystals for visualizing real-time remote monitoring:humidity sensing as a proof of concept

引用

Light(Science & Applications) 2024年第2期13卷 283-293页

作者： Shi-Long Li Zhao-Yi Chen Peng Chen wei hu Chaohong huang Sen-Sen Li Xuejia hu Yan-Qing Lu Lu-Jian Chen Department of Electronic Engineering School of Electronic Science and EngineeringXiamen University361005 XiamenChina College of Engineering and Applied Sciences Nanjing University210093 NanjingChina Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen University361005 XiamenChina

Liquid crystals are a vital component of modern photonics,and recent studies have demonstrated the exceptional sensing properties of stimuli-responsive cholesteric liquid ***,existing cholesteric liquid crystal-based sensors often rely on the naked eye perceptibility of structural color or the measurement of wavelength changes by spectrometric tools,which limits their practical ***,developing a platform that produces recognizable sensing signals is *** this study,we present a visual sensing platform based on geometric phase encoding of stimuli-responsive cholesteric liquid crystal polymers that generates real-time visual patterns,rather than frequency *** demonstrate this platform’s effectiveness,we used a humidity-responsive cholesteric liquid crystal polymer film encoded with a q-plate pattern,which revealed that humidity causes a shape change in the vortex beam reflected from the encoded cholesteric liquid crystal ***,we developed a prototype platform towards remote humidity monitoring benefiting from the high directionality and long-range transmission properties of laser beams carrying orbital angular *** approach provides a novel sensing platform for cholesteric liquid crystals-based sensors that offers promising practical *** ability to generate recognizable sensing signals through visual patterns offers a new level of practicality in the sensing field with stimuli-responsive cholesteric liquid *** platform might have significant implications for a broad readership and will be of interest to researchers working in the field of photonics and sensing technology.

关键词： humidity visual liquid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sperm acrosin activity may be a useful factor in choosing between ICSI and IVF for infertile male patients

引用

Asian Journal of Andrology 2024年第1期26卷 85-90页

作者： Ye-Na hu Liang hu Xin-Yu Yin huan Zhang Yang-Qin Peng Gang Liu Ge Lin wei-Na Li The Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Department of Andrology Reproductive and Genetic Hospital of CITiC-XiangyaChangsha 410013China Clinical Research Center for Reproduction and Genetics in hunan Province Changsha 410013China hunan Guangxiu Hi-tech Life Technology Co. Ltd.Changsha 410013China

The clinical applications of acrosin activity are *** analyzed 61578 male partners in infertile couples who visited the outpatient department of the Reproductive and Genetic Hospital of CITIC-Xiangya(Changsha,China)between August 2014 and December 2019 to determine the reference ranges and thresholds for acrosin activity in infertile Chinese men;to determine whether correlations exist between acrosin activity and age,sperm concentration,sperm morphology,or sperm motility;and to evaluate whether acrosin activity could serve as an effective prognostic indicator for choosing between in vitro fertilization(IvF)and intracytoplasmic sperm injection(icsl)in the *** cut-off value for the normal reference range of acrosin activity for male partners in infertile couples was 24.78μlU per 106 *** was no significant association between acrosin activity and age,sperm concentration,semen volume,total sperm count,progressive motility,or total motile spermatozoa.A weak positive correlation was found between acrosin activity and normal sperm *** was a statistically significant difference in abnormal acrosome morphology between the group with high acrosin activity(>24.78μlU per 106 sperm)and the group with low acrosin activity(<24.78μlU per 106 sperm).The group with a low IVF fertilization rate had a high index of abnormal acrosomal morphology at 21.2%,while the group with a high IVF fertilization rate had a low index of 0.2%.At an acrosin activity of<24.78μlU per 10 sperm,in one cycle of the same patient,the fertilization rate,normal fertilization rate,and good-quality embryo rate for Icsl were significantly higher than those for ***,the most promising application of acrosin activity could be in the selection of IcsI over IVF for infertile male patients with complete fertilization failure or a low fertilization rate.

关键词： acrosin activity fertilization rate ICSI IVF semen parameters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Population Reference Curves for Ultrasound-Measured Amniotic Fluid Deepest Vertical Pocket in Dichorionic Twin Pregnancies,and Their Associations With Pregnancy Outcomes

引用

Maternal-Fetal Medicine 2024年第1期6卷 29-36页

作者： Zhengxin Lyu Tianchen Wu shan Lu Pengbo Yuan Yangyu Zhao Yuan wei Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Objective:To establish the Chinese population's amniotic fluid deepest vertical pocket(DVP)reference curves for dichorionic twin pregnancies and to investigate DVP links with adverse perinatal ***:This retrospective cohort study,conducted at Peking University Third Hospital from August 2011 to December 2020,used data from 375 women aged 20 to 45 years who had dichorionic twin pregnancies that were confirmed through first-trimester *** exclusions,reference curves were developed using 318 women with 3,299 DVP scans,and the data analyzed included maternal demographics,pregnancy outcomes,ultrasound measurements,and neonatal *** were assessed via ultrasound at regular intervals and grouped by gestational age(GA)for *** mixed models were used to create amniotic fluid reference *** between abnormalities and adverse perinatal outcomes were examined using Chi-squared or Fisher's exact *** regression provided both crude and adjusted odds ratios,adjusting for pre-pregnancy weight,age,ethnicity,parity,and conception *** was set at P<0.05 with 95%confidence intervals(CI),and the analyses were conducted using SPSS ver.26.0(IBM Corp.,Armonk,NY)and SAS ver.9.4(SAS Institute Inc.,Cary,NC,USA)***:DVP increased from the first trimester to a maximum at 26 weeks(95%confidence interval(CI),2.7–8.3 cm for twin 1 and 2.8–7.9 cm for twin 2)and then decreased gradually toward *** between twins 1 and 2 were significant after 26 weeks(95%CI for twin 1:5.3,5.5;95%CI for twin 2:4.4,4.5;P<0.010).Polyhydramnios of twin 1 increased the risk of large for *** of twin 1 increased the risk of small for *** of twin 2 increased the risk of small for GA,premature birth,and neonatal *** of twin 2 increased the risk of preeclampsia,hypertensive disorder complicating pregnancy,and premature rupture of ***:Reference curves

关键词： Amniotic fluid Amniotic fluid deepest vertical pocket Reference curve Dichorionic twin Pregnancy outcome Ultrasound examination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种应用于物联网传感器的伪三阶Delta-Sigma调制器

引用

电子学报 2024年第6期52卷 2123-2130页

作者：魏聪黄黎杰胡炜魏榕山福州大学物理与信息工程学院福建福州350108

针对物联网传感器难以同时满足高分辨率与低功耗的瓶颈问题,本文设计了一种伪三阶离散时间delta-sigma调制器.该架构将一阶无源噪声整形SAR(Successive Approximation Register)量化器嵌入传统二阶delta-sigma调制器以实现更强的噪声整... 详细信息

针对物联网传感器难以同时满足高分辨率与低功耗的瓶颈问题,本文设计了一种伪三阶离散时间delta-sigma调制器.该架构将一阶无源噪声整形SAR(Successive Approximation Register)量化器嵌入传统二阶delta-sigma调制器以实现更强的噪声整形能力.本文设计允许系统在更低的过采样率(Over Sampling Ratio,OSR)下获取更高的峰值SQNR(Signal-to-Quantizing Noise Ratio),有效缓解了系统精度和功耗之间的设计矛盾,并且减少了有源积分器的使用.针对传统有源加法器高功耗和无源加法器存在衰减不确定性的问题,本文提出了一种新型前馈求和量化电路,它具有对衰减不敏感的优势并且降低了第二级有源积分器的驱动压力,这进一步降低了系统的功耗.本文提出的delta-sigma调制器采用180 nm CMOS(Complementary Metal Oxide Semiconductor)工艺制造并测试.在电源电压1.4 V下,芯片测试功耗为47.2μW.在带宽为8 kHz的测试条件下,调制器的DR(Dynamic Range)、峰值SNDR(Signal-to-Noise and Distortion Ratio)和SFDR(Spurious-Free Dynamic Range)分别为97.2 dB,96.6 dB和114.4 dB.因此,Schreier和Walden的SNDR FoM(Figure of Merit)优值达到了178.9 dB和0.053 pJ/step.本文提出的伪三阶delta-sigma调制器在功耗和分辨率之间实现了较好的权衡,为物联网领域的低功耗高分辨率调制器设计提供了较好的解决方案.

关键词：物联网 delta-sigma调制器低功耗高分辨率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：