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Research on the macro-and meso-mechanical properties of frozen sand mold based on Hertz-Mindlin with Bonding model

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Particuology 2024年第5期88卷 176-191页

作者： Jianpei shi Zhongde shan Haoqin Yang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Material Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this study,macro-and meso-mechanical properties of frozen sand molds were discussed based on the Hertz-Mindlin with Bonding(HMB)***-Burman,steepest ascent,and central composite designs were utilized to propose a parameter calibration *** effects of mesoscopic parameter variations on the compressive strength and average gradient of stress-strain were investigated through response surface method *** showed that the relative error between the simulated and measured repose angle is 3.1%under calibrated intrinsic contact *** compressive strength and average stress-strain gradient primarily depend on the normal and shear stiffness per unit area,as well as the particle size and porosity of the silica ***,taking load-displacement curves of three frozen sand molds with different geometric characteristics as the target value,the reliability and effectiveness of the frozen sand mold HMB model were verified through uniaxial compression tests and discrete element simulations.

关键词： Frozen sand mold Hertz-Mindlin with Bonding model Uniaxial compression test Discrete element method Mechanical properties

Research progress of the electrochemical impedance technique applied to the high-capacity lithium-ion battery

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 538-552页

作者： Li-fan Wang Meng-meng Geng Xia-nan Ding Chen Fang Yu Zhang shan-shan shi Yong Zheng Kai Yang Chun Zhan Xin-dong Wang Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China China Electric Power Research Institute Beijing 100192China Electric Power Research Institute State Grid Shanghai Municipal Electric Power CompanyShanghai 200437China

The world's energy system is changing ***-ion battery,as a powerful and highly effective energy storage technique,is crucial to the new energy revolution for its continuously expanding application in electric vehicles and *** the entire lifetime of these power batteries,it is essential to monitor their state of health not only for the predicted mileage and safety management of the running electric vehicles,but also for an"end-of-life"evaluation for their *** impedance spectroscopy(EIS)has been widely used to diagnose the health state of batteries quickly and *** this review,we have outlined the working principles of several electrochemical impedance techniques and further evaluated their application prospects to achieve the goal of nondestructive testing of battery *** can scientifically and reasonably perform real-time monitoring and evaluation of electric vehicle power batteries in the future and play an important role in vehicle safety and battery gradient utilization.

关键词： electric vehicle Li-ion battery gradient utilization electrochemical impedance technology

Gonadotropin-releasing hormone positively regulates steroidogenesis via extracellular signal-regulated kinase in rat Leydig cells

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Asian Journal of Andrology 2011年第3期13卷 438-445,512页

作者： Bing Yao Hai-Yan Liu Yu-Chun Gu shan-shan shi Xiao-Qian Tao Xiao-Jun Li Yi-Feng Ge Ying-Xia Cui Guo-Bin Yang Department of Reproduction and Genetics Nanjing Jingling Hospital Nanjing 210002 China Nanjing Normal University Nanjing 210046 China Department of Physiology The Medical School University of Birmingham Edgbaston B15 2TT UK Medical Administration Division Nanjing Jingling Hospital Nanjing 210002 China

Gonadotropin-releasing hormone （GnRH） is secreted from neurons within the hypothalamus and is necessary for reproductive function in all vertebrates. GnRH is also found in organs outside of the brain and plays an important role in Leydig cell steroidogenesis in the testis. However, the signalling pathways mediating this function remain largely unknown. In this study, we investigated whether components of the mitogen-activated protein kinase （MAPK） pathways are involved in GnRH agonist （GnRHa）-induced testis steroidogenesis in rat Leydig cells. Primary cultures of rat Leydig cells were established. The expression of 3β-hydroxysteroid dehydrogenase （3β-HSD） and the production of testosterone in response to GnRHa were examined at different doses and for different durations by RT-PCR, Western blot analysis and radioimmunoassay （RIA）. The effects of GnRHa on ERK1/2, JNK and p38 kinase activation were also investigated in the presence or absence of the MAPK inhibitor PD-98059 by Western blot analysis. GnRHa induced testosterone production and upregulated 3β-HSD expression at both the mRNA and protein levels; it also activated ERK1/2, but not JNK and p38 kinase. Although the maximum effects of GnRHa were observed at a concentration of 100 nmnol L-1 after 24 h, activation of ERKI/2 by GnRHa reached peak at 5 min and it returned to the basal level within 60 min. PD-98059 completely blocked the activation of ERKI/2, the upregulation of 3β-HSD and testosterone production. Our data show that GnRH positively regulates steroidogenesis via ERK signalling in rat Leydig cells. ERK1/2 activation by GnRH may be responsible for the induction of 3β-HSDgene expression and enzyme production, which may ultimately modulate steroidogenesis in rat Leydig cells.

关键词： 3β-HSD ERK1/2 GnRH JNK Leydig cell p38

Perioperative extracorporeal membrane oxygenation in pediatric congenital heart disease:Chinese expert consensus

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World Journal of Pediatrics 2023年第1期19卷 7-19页

作者： Ru Lin Wei Wang Xu Wang Zhuo-Ming Xu Jin-Ping Liu Cheng-Bin Zhou Xiao-Yang Hong Xu-Ming Mo shan-shan shi Li-Fen Ye Qiang Shu Department of Extracorporeal Life Support Heart InstituteNational Clinical Research Center for Child HealthChildren's HospitalZhejiang University School of MedicineHangzhouChina Department of Thoracic and Cardiovascular Surgery Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pediatric Intensive Care Unit National Center for Cardiovascular Disease and Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina Department of Cardiopulmonary Bypass National Center for Cardiovascular Disease and Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouChina Pediatric Intensive Care Unit Faculty of PediatricsChinese PLA General HospitalBeijingChina Department of Cardiothoracic Children's Hospital of Nanjing Medical UniversityNanjingChina Department of CICU Heart InstituteNational Clinical Research Center for Child HealthChildren's HospitalZhejiang University School of MedicineHangzhouChina Department of Cardiac Surgery National Clinical Research Center for Child HealthChildren's HospitalZhejiang University School of MedicineBinsheng Road 3333Hangzhou 310052China

Background Congenital heart disease(CHD)is one of the main supportive diseases of extracorporeal membrane oxygena-tion in *** management of extracorporeal membrane oxygenation(ECMO)for pediatric CHD faces more severe challenges due to the complex anatomical structure of the heart,special pathophysiology,perioperative complications and various concomitant *** survival rate of ECMO for CHD was significantly lower than other classifica-tions of diseases according to the Extracorporeal Life Support Organization *** expert consensus aims to improve the survival rate and reduce the morbidity of this patient population by standardizing the clinical *** The editing group of this consensus gathered 11 well-known experts in pediatric cardiac surgery and ECMO field in China to develop clinical recommendations formulated on the basis of existing evidences and expert *** The primary concern of ECMO management in the perioperative period of CHD are patient selection,cannulation strategy,pump flow/ventilator parameters/vasoactive drug dosage setting,anticoagulation management,residual lesion screening,fluid and wound management and weaning or transition *** and treatment of complications of bleeding,thromboembolism and brain injury are emphatically discussed *** conditions of ECMO management related to the cardiovascular anatomy,haemodynamics and the surgical procedures of common complex CHD should be *** The consensus could provide a reference for patient selection,management and risk identification of periop-erative ECMO in children with CHD.

关键词： Circulatory support Congenital heart disease Extracorporeal membrane oxygenation Pediatric Respiratory support

High shear stress-induced pulmonary hypertension alleviated by endothelial progenitor cells independent of autophagy

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World Journal of Pediatrics 2015年第2期11卷 171-176页

作者： Bi-Jun Xu Jian Chen Xi Chen Xi-Wang Liu Shu Fang Qiang Shu Lei Hu shan-shan shi Li-Zhong Du Lin-Hua Tan Department of Cardiothoracic Surgery Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadHangzhou 310051China Department of Cardiothoracic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China Central Laboratory Children's HospitalZhejiang University School of MedicineHangzhou 310051China Department of SICU Children's HospitalZhejiang University School of MedicineHangzhou 310051China

Background:Pulmonary hypertension(PH)is a progressive disease characterized by lung endothelial cell dysfunction and Vascular *** progenitor cells(EPCs)have been proved to be a potential therapeutic strategy to treat *** has been found to be protective to hypoxia-induced *** this study,we applied high shear stress(HSS)-induced PH,and examined whether EPCs confer resistance against HSS-induced PH through ***:Pulmonary microvascular endothelial cells(PMVECs)were cultured under HSS with pro-inflammatory factors in an artificial capillary system to mimic the PH *** of p62,a selective autophagy substrate,were quantified by western *** viability was determined by trypan blue exclusion ***:The p62 level in PMVECs was increased at 4 hours after HSS,peaked at 12 hours and declined at 24 *** cell viability gradually *** with PMVECs cultured by empty medium,in cells cultured by EPC-conditioned medium(EPC-CM),the cell viability was significantly higher;however,p62 levels were also significantly higher,suggesting inhibition of autophagy by *** choloquine to suppress autophagy decreased the cell viability of PMVECs under ***:EPC-CM could suppress the autophagic activity of PMVECs in HSS-induced ***,suppression of autophagy leads to ceil *** could fight against PH through cellular or molecular pathways independent of *** it is not proved if induction of autophagy could be a potential strategy to treat HSS-induced PH as hypoxia-induced PH.

关键词： autophagy endothelial progenitor cells pulmonary hypertension

Engineering high-performance dielectric chiral shells with enhanced chiral fields for sensitive chiral biosensor

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Rare Metals 2024年第3期43卷 1197-1206页

作者： Yi-Fan Wang shan-shan Huang Zhen-Dong Dai shi-Lin Xian Xuan-Nan Wu Fu-Hua Gao Yi-Dong Hou College of Physics Sichuan UniversityChengdu610065China Graduate School of Sichuan University Sichuan UniversityChengdu610065China

Chiral metamaterials have been a topic of significant research interest in recent years due to their potential for various applications in nanophotonic devices and chiral ***,the intrinsic Ohmic loss in surface plasmonic resonance has limited their practical use,resulting in large light dissipation and weak chiroptical ***,we report on the development of high-performance dielectric chiral shells(DCS)through a two-step Si deposition process on a self-assembled microsphere *** form DCS sample completely oyercomes the cancelation effect originated from the disorder property of the micro-sphere monolayer in macroscale,and at a wavelength of approximately 710 nm,the measured optimal chiral signal(g-factor)and transmittance can reach up to 0.7 and 0.3,*** strong chiroptical effect comes from the asymmetric circular displacement currents(i.e.,magnetic modes)enabled by the specific shell *** chiral shell geometry,electromagnetic properties,sensor sensitivity of chiral molecules and figure of merit are systematically *** DCSs demonstrate highly sensitive detection of chiral biomolecules owing to their easily accessible geometry and enhanced uniform chiral field.

关键词： Dielectric chiral shells(DCS) Si deposition Magnetic resonance Highly sensitive sensor Chiral field

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： shan-shan Li Yu-shi Jiang Xue-Ling Luo Xuming Ran Yuqiang Li Dong Wu Cheng-Xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Empowering smart city situational awareness via big mobile data

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 286-307页

作者： Zhiguang shan Lei shi Bo LI Yanqiang ZHANG Xiatian ZHANG Wei CHEN State Information Center Beijing100045China School of Computer Science and Engineering Beihang UniversityBeijing100191China Zhongguancun Laboratory Beijing100094China Beijing Tendcloud Tianxia Technology Co. Ltd.Beijing100027China The State Key Lab of CAD&CG Zhejiang UniversityHangzhou310027China

Smart city situational awareness has recently emerged as a hot topic in research societies,industries,and governments because of its potential to integrate cutting-edge information technology and solve urgent challenges that modern cities *** example,in the latest five-year plan,the Chinese government has highlighted the demand to empower smart city management with new technologies such as big data and Internet of Things,for which situational awareness is normally the crucial first *** traditional static surveillance data on cities have been available for decades,this review reports a type of relatively new yet highly important urban data source,i.e.,the big mobile data collected by devices with various levels of mobility representing the movement and distribution of public and private agents in the *** especially focus on smart city situational awareness enabled by synthesizing the localization of hundreds of thousands of mobile software Apps using the Global Positioning System(GPS).This technique enjoys advantages such as a large penetration rate(∼50%urban population covered),uniform spatiotemporal coverage,and high localization *** first discuss the pragmatic requirements for smart city situational awareness and the challenges *** we introduce two suites of empowering technologies that help fulfill the requirements of(1)cybersecurity insurance for smart cities and(2)spatiotemporal modeling and visualization for situational awareness,both via big mobile *** main contributions of this review lie in the description of a comprehensive technological framework for smart city situational awareness and the demonstration of its feasibility via real-world applications.

关键词： Smart city Mobile data Situational awareness

Science Letters:Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 221-226页

作者： Xu-fei TAN Feng CHEN shan-shan WU Yu shi Dong-cheng LIU Zhi CHEN State Key Laboratory for Diagnosis and Treatment of lnfectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To find new protein biomarkers for the detection and evaluation of liver injury and to analyze the relationship between such proteins and disease progression in concanavalin A （Con A）-induced hepatitis. Methods： Twenty-five mice were randomly divided into five groups： an untreated group, a control group injected with phosphate buffered saline （PBS）, and groups with Con A-induced hepatitis evaluated at 1, 3 and 6 h. Two-dimensional gel electrophoresis （2-DE） and mass spectrometry （MS） were used to identify differences in protein expression among groups. Quantitative real-time polymerase chain reaction （qRT-PCR） was performed to verify the results. Results： In mice with Con A-induced hepatitis, expression levels of four proteins were increased： RIKEN, fructose bisphosphatase 1 （fbp1）, ketohexokinase （khk）, and Chain A of class pi glutathione S-transferase. Changes in fbpl and khk were confirmed by qRT-PCR. Conclusion： Levels of two proteins, fbp1 and khk, are clearly up-regulated in mice with Con A-induced hepatitis.

关键词： Concanavalin A (Con A) Liver injury Protein Two-dimensional electrophoresis (2-DE)