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H_(2)S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection

Chinese Chemical Letters 2024年第1期35卷 392-400页

作者： Peng shan Jing Liao Jiayi Li Chengyan wang Jie Zhou Linqiang Mei Yunlu Dai Qiang wang Wenyan Yin Laboratory for Micro-sized Functional Materials Department of Chemistry and College of Elementary EducationCapital Normal UniversityBeijing 100048China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Pharmacy Southwest HospitalThe Third Military Medical UniversityChongqing 400038China Cancer Centre and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China

Radiation damage can cause a series of gastrointestinal(GI)tract *** development of safe and effective GI tract radioprotectants still remains a great challenge ***,we firstly report an oral radioprotectant Gel@GYY that integrates a porous gelatin-based(Gel)hydrogel and a pH-responsive hydrogen sulfide(H2S)donor GYY4137(morpholin-4-ium 4 methoxyphenyl(morpholino)phosphinodithioate).Gel@GYY has a remarkable adhesion ability and long retention time,which not only enables responsive release of low-dose H2S in stomach and subsequently sustained release of H2S in the whole intestinal tract especially in the colon,but also ensures a close contact between H2S and GI *** released H2S can effectively scavenge free radicals induced by X-ray radiation,reduce lipid peroxidation level,repair DNA damage and recover vital superoxide dismutase and glutathione peroxidase ***,the released H2S inhibits radiation-induced activation of nuclear factorκB(NF-κB),thus reducing inflammatory cytokines levels in GI *** treatment,Gel@GYY displays efficient excretion from mice body due to its *** work provides a new insight for therapeutic application of intelligent H2S-releasing oral delivery system and potential alternative to clinical GI physical damage protectant.

关键词： Radiation Gastrointestinal tract radioprotection Hydrogen sulfide gas therapy Gelatin-based hydrogel Free radicals scavenging

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Ocular surface in patients with different degrees of myopia

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1313-1321页

作者： Yan-Yun Lyu Shuang wang Xiao-Niao Chen Zhen-Yu wang shan-shan Huang Yan yuan Hong-Shuang Lu Wen-Li Yang Li-Ya Qiao Lei Tian Ying Jie Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical University and Beijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Department of Ophthalmology the Third Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100039China Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan

AIM:To investigate the clinical features of the ocular surface in patients with different degrees of ***:A cross-sectional study was conducted involving 122 participants with myopia in beijing Tongren Hospital from February to June,*** completing the Ocular Surface Disease Index(OSDI)score scale,measurements were taken for refraction,biometric parameters and ocular surface *** prevalence,severity and related parameters of the dry eye among different groups based on axial length(AL)were *** analysis was performed between ocular surface parameters and refraction/biometric measurement ***:Statistically significant differences were observed in refractive error,corneal thickness,anterior chamber depth,and subfoveal choroidal thickness among the groups(all P<0.05).With the increase in AL,the incidence and severity of dry eye increased significantly(P<0.05).Moreover,the tear film break-up time(BUT)shortened(P<0.05),and the corneal fluorescein staining(CFS)points increased significantly(P<0.05).OSDI scores were positively correlated with AL and spherical equivalent(SE;both P<0.05);BUT was negatively correlated with AL,SE,and corneal astigmatism(AST;all P<0.05);Schirmer I test(SIT)results were negatively correlated with AL and SE(both P<0.05).CONCLUSION:AL elongation is a risk factor for dry eye onset in myopic *** longer the AL,the more severe the dry eye is,with the increased CFS spots and tear film ***,SE and AST exhibit negative correlations with dry eye symptom scores and ocular surface parameters.

关键词： myopia axial length ocular surface dry eye

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安徽省社区体育发展战略研究

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体育科学 2004年第10期24卷 21-25,30页

作者：高维岭邵苏华李燕汪伟信袁守龙金广江安徽省体育局安徽合肥230001 安徽省体育科学研究所安徽合肥230001 中国科学技术大学体育部安徽合肥230052 北京体育大学研究生院北京100084

采用文献研究、问卷调查、现场观察、数理统计和逻辑分析法 ,对安徽省不同地域和不同经济发展水平的 7个省级市和 4个县 (市 )社区体育发展规模、活动内容、组织结构、经费来源、健身动机等进行了研究分析 ,总结了安徽省社区体育发展的... 详细信息

采用文献研究、问卷调查、现场观察、数理统计和逻辑分析法 ,对安徽省不同地域和不同经济发展水平的 7个省级市和 4个县 (市 )社区体育发展规模、活动内容、组织结构、经费来源、健身动机等进行了研究分析 ,总结了安徽省社区体育发展的一般规律与特征 ,并对安徽省社区体育在新世纪中的发展战略。

关键词：社区体育发展战略研究安徽

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One-pot Synthesis of Lewis Acidic Ionic Liquids for Friedel-Crafts Alkylation

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Chinese Chemical Letters 2006年第3期17卷 321-324页

作者： Ling HE Guo Hong TAO Wei shan LIU Wei XIONG Tao wang yuan KOU Green Chemistry Centre College of Chemistry and Molecular Engineering State Key Laboratory for Structural Chemistry of Unstable and Stable Species Peking University Beijing 100871

Novel Lewis acidic ionic liquids containing thionyl cations and chloroaluminate anions were obtained by one-pot synthesis for the first time. Their acidities were determined by acetonitrile probe on IR spectrography. The ionic liquids were used as catalyst for Friedel-Crafts alkylation of benzene and 1-dodecene. The turnovers of l-dodecene were higher than 99%. Monoalkylbenzene selectivity was 98%, while the 2-substituent product selectivity was 45%.

关键词： Ionic liquids green chemistry one-pot synthesis Lewis acidity alkylation.

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ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis

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Journal of Molecular Cell Biology 2015年第2期7卷 154-167页

作者： shan wang Siying wang Lihua Yang Hua Guo Xue Kong Lin yuan Guichun Xing Fuchu He Lingqiang Zhang StateKeyLaboratory of Proteomics Beijing Proteome Research CenterBeijing Institute of Radiation MedicineCollaborative Innovation Center for Cancer MedicineBeijing 100850China Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116044China Department of Biochemistry and Molecular Biology Anhui Medical UniversityHefei 230032China Department of Scientific Research Xiang-Ya HospitalCentral South UniversityChangsha 410008China

Ribosomes are among the most fundamental molecular machines in all cells,as they are required for protein *** structural rRNA components are generated in the nucleolus and assembled into pre-ribosomal *** we show Apak,a previously identified p53 inhibitor,as a novel ribosomal stress response *** unstressed cells,Apak is bound to the deSUMOylase SENP1 in the nucleoplasm and targeted for proteasomal degradation by MDM2 ubiquitin *** ribosomal stress,SENP1 dissociates fromApak and the tumor suppressor protein ARF couplesUbc9 with Apak to promote Apak SUMOylation on zinc *** results in Apak protein stabilization and translocation to the nucleolus,where Apak inhibits the pre-rRNA *** findings provide a molecular mechanism whereby ARF coordinates Apak to regulate ribosome biogenesis upon cellular stress.

关键词： nucleolus nucleolar stress Apak ARF SUMOylation

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CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells

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World Journal of Gastroenterology 2016年第15期22卷 3992-4001页

作者： Ying-Lin Niu Ya-Jun Li Jing-Bo wang yuan-yuan Lu Zhen-Xiong Liu shan-shan Feng Jian-Guo Hu Hui-Hong Zhai Department of Gastroenterology Beijing Friendship Hospital Affiliated to Capital Medical University Department of Digestive Diseases General Hospital of Ningxia Medical University State Key Laboratory of Cancer Biology Institute of Digestive Diseases Xijing Hospital Fourth Military Medical University

AIM: To investigate the mechanism of calcyclin binding protein/Siah-1 interacting protein(Cacy BP/SIP) nuclear translocation in promoting the proliferation of gastric cancer(GC) cells. METHODS: The effect of Cacy BP/SIP nuclear translocation on cell cycle was investigated by cell cycle analysis. Western blot analysis was used to assess the change in expression of cell cycle regulatory proteins and proteasome-mediated degradation of p27Kip1. Coimmunoprecipitation(co-IP) analysis was performed to examine the binding of Cacy BP/SIP with Skp1. A Cacy BP/SIP truncation mutant which lacked the Skp1 binding site was constructed and fused to a fluorescent protein. Subsequently, the effect on Skp1 binding with the fusion protein was examined by co-IP, while localization of fluorescent fusion protein observed by confocal laser microscopy, and change in p27Kip1protein expression assessed by Western blot ***: Cacy BP/SIP nuclear translocation induced by gastrin promoted progression of GC cells from G1 phase. However, while Cacy BP/SIP nuclear translocation was inhibited using si RNA to suppress Cacy BP/SIP expression, cell cycle was clearly inhibited. Cacy BP/SIP nuclear translocation significantly decreased the level of cell cycle inhibitor p27Kip1, increased Cyclin E protein expression whereas the levels of Skp1, Skp2, and CDK2 were not affected. Upon inhibition of Cacy BP/SIP nuclear translocation, there were no changes in protein levels of p27Kip1 and Cyclin E, while p27Kip1 decrease could be prevented by the proteasome inhibitor MG132. Moreover, Cacy BP/SIP was found to bind to Skp1 by immunoprecipitation, an event that was abolished by mutant Cacy BP/SIP, which also failed to stimulate p27Kip1 degradation, even though the mutant could still translocate into the ***: Cacy BP/SIP nuclear translocation contributes to the proliferation of GC cells, and Cacy BP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation o

关键词： Calcyclin binding protein/Siah-1 interacting protein Gastric cancer Cell cycle P27kip1 Ubiquitin

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Novel magnetic carbon supported molybdenum disulfide catalyst and its application in residue upgrading

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Green Energy & Environment 2021年第6期6卷 952-960页

作者： Xiangyang Zhu Dong Qiao Liangrong Yang Qinling Bi Huifang Xing shan Ni Menglei yuan Huizhou Liu Luhai wang An Ma CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China c china university of Petroleum Beijing102249China Petrochemical Research Institute PetrochinaBeijing102206China

A novel hybrid material consisted of carbon covered Fe_(3)O_(4)nanoparticles and MoS_(2)nanoflower(FCM)was designed and prepared by micelle-assisted hydrothermal *** techniques,including X-Ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM)and X-ray photoelectron spectroscopy(XPS)were employed to characterize *** results show that FCM has a flower-like morphology with a 330 nm Fe_(3)O_(4)core as well as 70 nm highly crystalline MoS_(2)*** is superparamagnetic with a saturation magnetization of 35 emu *** hydrocracking of Canadian bitumen residue(CBR)was applied to estimate its catalytic *** results show that FCM exhibits superior catalytic hydrocracking activity compared to bulk MoS_(2)and commercial oil-dispersed Mo(CO)6 by the same Mo *** measurement by elemental analysis,XPS and XRD reveals that the MoS_(2)nanoflower with abundant catalytic active sites and covered carbon layer with anti-coke ability donate to the superior upgrading ***,the catalysts can be easily recovered by the external magnetic *** work provides a novel kind magnetic nanocatalyst which is potential for slurry-phase hydrocracking applications.■2020,Institute of Process Engineering,Chinese Academy of *** services by Elsevier *** behalf of KeAi Communications Co.,*** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Magnetic Carbon MoS_(2) Catalyst Heavy oil

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Male reproductive function before and after the adjustment of the COVID-19 prevention policy:a multicenter study in china

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Asian Journal of Andrology 2024年第3期26卷 308-314页

作者： Jian-Zheng Li Han Wu Li wang Yun-shan wang Feng Kong Long-Qiao Cao Ming Liang Xiong wang Ming-Zhen yuan shandong Provincial Hospital Affiliated to shandong First Medical university Jinan 250000China Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China Engineering Laboratory of Urinary Organ and Functional Reconstruction of shandong Province Jinan 250000China The First People’sHospital of Jining Jining 272000China Department of Reproductive Medicine The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in china resulted in alarge-scale increase in public *** compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in china,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different *** were divided into five groups according tothe timeline of the policy *** data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square *** total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone *** showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy *** comparison revealed an initial decrease and gradual recovery in progressive motility *** morphology analysisshowed increased neck and tail abnormalities after the policy *** significant change in hormone levels was *** the adjustment of the COVID-19 prevention policy in china,a decline in sperm motility and morphology was *** trend may gradually recover over 2 *** the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.

关键词： COVID-19 multicenter study reproduction SARS-CoV-2 semen analysis

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Defects and failure types of solid insulation in gas‐insulated switchgear:In situ study and case analysis

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High Voltage 2022年第1期7卷 158-164页

作者： Yunqi Xing Zhiwen wang Lin Liu yuan Xu Yang Yang shan Liu Fusheng Zhou Shun He Chuanyang Li State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjinChina Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province Hebei University of TechnologyTianjinChina School of Electric Power South China University of TechnologyGuangzhouChina High Voltage Institute China Electric Power Research InstituteBeijingChina Simpson Querrey Institute Northwestern UniversityEvanstonIllinoisUSA HVDC Transmission Technology Department Globe Energy Interconnection Research InstituteBeijingChina Electric Power Research Institute China Southern Power GridGuangzhouChina High Voltage Institute Yunnan Institute of Electrical ScienceYunnanChina Institute of Material Science University of ConnecticutStorrsConnecticutUSA

The gas‐insulated switchgear(GIS)has been widely used in modern ultra‐high voltage ***,once it fails,its fully enclosed feature brings challenges in its diagnosis and *** the failure rate of GIS due to insulator failure has been increasing in recent years,it is necessary and important to understand the commonly existing defects presented in the ***,the manufacturing process of GIS insulators is intro-duced *** defect types commonly existing in the insulator are *** failure of GIS due to insulator defects that occurred in recent years are reviewed and *** content in this study is useful for engineers and scientists to study on the GIS solid insulation defects and their failure mechanisms.

关键词： (GIS) insulation solid

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Progress in ab initio in-medium similarity renormalization group and coupled-channel method with coupling to the continuum

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Nuclear Science and Techniques 2024年第12期35卷 312-342页

作者： Xin‑Yu Xu Si‑Qin Fan Qi yuan Bai‑shan Hu Jian‑Guo Li Si‑Min wang Fu‑Rong Xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Southern Center for Nuclear‑Science Theory(SCNT)Institute of Modern Physics Chinese Academy of SciencesHuizhou 516000China National Center for Computational Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Physics Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Modern Physics Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Fudan UniversityShanghai 200433China shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China

Over the last decade,nuclear theory has made dramatic progress in few-body and ab initio many-body *** great advances stem from chiral efective feld theory(xEFT),which provides an efcient expansion and consistent treatment of nuclear forces as inputs of modern many-body calculations,among which the in-medium similarity renormalization group(IMSRG)and its variants play a vital *** the other hand,signifcant eforts have been made to provide a unifed description of the structure,decay,and reactions of the nuclei as open quantum *** a fully comprehensive and microscopic model has yet to be realized,substantial progress over recent decades has enhanced our understanding of open quantum systems around the dripline,which are often characterized by exotic structures and decay *** study these interesting phenomena,Gamow coupled-channel(GCC)method,in which the open quantum nature of few-body valence nucleons coupled to a deformed core,has been *** review focuses on the developments of the advanced IMSRG and GCC and their applications to nuclear structure and reactions.

关键词： Ab initio calculations Chiral efective feld theory In-medium similarity renormalization group Gamow coupled channel Resonance and continuum Open quantum systems

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