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Science china(Information Sciences) 2012年第5期55卷 1162-1171页

作者： YIN RuMing,wang Jian,yuan Jian,shan XiuMing & wang XiQin Department of Electronic Engineering,Tsinghua university,beijing 100084,china 1. Department of Electronic Engineering Tsinghua University Beijing 100084 China

Weak key analysis is a key issue in the design of chaotic *** most of the existing research focusing on the degradation of the chaotic sequences which causes weak keys,we point out that the parameters for which the chaotic sequences do not degrade are still possible to be weak *** this paper,we propose a new approach based on the rigorous statistical test to improve the weak key *** weak keys of a specific chaotic cipher are investigated by using our method and a large number of new weak keys are *** results verify that our method is more *** the other hand,although statistical tests are now widely adopted to test the chaos-based bit sequences,there are few reports of analysis results on the weak keys or weak sequences of chaotic *** our work may be helpful for current research on statistical tests of chaotic cipher.

关键词： chaos cryptography statistical test weak keys sequence randomness

Influence of high lipid food and treadmill exercises on levels of ghrelin and testosterone of rats

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Influence of high lipid food and treadmill exercises on leve...

Partial Synthesis of Macrolide Alkaloid Euonine

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Jun wang,rui-yuan wang sport Science College,beijing sport university,beijing 100084,china

Purpose This study is to show the effects of high lipid food and treadmill exercises on levels of ghrelin and testosterone,and to research the influences of obesity and exercises on sexual *** the level of ghrelin might have significant effects on hypophysial-gonadal axis(HPA).Methods Diet induced obese rats were divided into obese rats(OB),obese-resisting rats(OR) and ordinary dieting rats(CB).OB rats were used to go through short-(40 min) and long-(40 min every 5 days for 8 weeks) *** the exercise,the rats ran at a speed of 20 m/min on a 5 slope *** for the short-term exercise were divided into two groups,namely C(control) and E(sacrificed after exercise).Rats from the long-term exercise(LE) were compared with long-term control(LC) *** of blood GLU,TG and TC were measured through with an Automatic Chemistry Analyzer(ACA).The concentrations of ghrelin were measured from plasma samples and hypothalamus by using *** of blood testosterone was done by chemiluminescence method and GHSR-1a mRNA by quantitative *** Body weight and lee’s index on OB group are higher than those on OR and CB group. Except the levels of blood TC on OB and OR were higher than CB,the concentrations of GLU and TG were not changed significantly on the three *** were not changed on high lipid dieting groups(OB and OR) on plasma,but it decreased sharply on *** the same time,the level of blood testosterone decreased significantly on OB compared with CB and *** to CB group,expressions of GHSR-1a on OB were low, but high on *** exercise(short-term and 8 weeks),the concentrations of blood GLU,TG,TC and ghrelin were not changed *** of GHSR-la were not changed also on *** hypothalamic ghrelin decreased sharply and blood testosterone increased significantly by exercise(E compared with C group,LE compared with LC group).Interestingly,blood testosterone was lower on LE

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Chinese Chemical Letters 1998年第10期9卷 927-928页

作者： yuan Chao LI shan Hao JIANG Xiao Yi wang (shanghai Institute of Materia Medica, Chinese Academy of Sciences, shanghai, 200031 Department of Environmental Chemistry and Engineering, beijing Polytechnic university,beijing, 100022) Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China beijing Polytech Univ Dept Environm Chem & Engn Beijing 100022 Peoples R China

The macrolide alkaloid euonine 1 with pharmacologic activity was prepared from the alkaloid wilforgine 2. Their structures were confirmed by IR, NMR, MS and optical rotation.

关键词： tripterygium macrolide alkaloid wilforgin euonine

Microstructural characteristics and aging response of Zn-containing Al-Mg-Si-Cu alloy

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International Journal of Minerals,Metallurgy and Materials 2013年第7期20卷 659-664页

作者： yuan-hua Cai Cong wang Ji-shan Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

Al-Mg-Si-Cu alloys with and without Zn addition were fabricated by conventional ingot metallurgy method. The microstructures and properties were investigated using optical microscopy （OM）, field emission scanning electron microscopy （FE-SEM）, transmission electron microscopy （TEM）, tensile test, hardness test, and electrical conductivity measurement. It is found that the as-cast A1-Mg-Si-Cu-Zn alloy is composed of coarse dendritic grains, long needle-like ~/5-A1FeSi white intermetallics, and Chinese script-like a-A1FeSi compounds. During high temperature homogenization treatment, only harmful needle-like ^-A1FeSi phase undergoes fragmentation and spheroidizing at its tips, and the destruc- tive needle-like 5-phase does not show any morphological and size changes. Phase transitions from ^-A1FeSi to ^-A1FeSi and from 6-A1FeSi to [3-A1FeSi are also not found. Zn addition improves the aging hardening response during the former aging stage and postpones the peak-aged hardness to a long aging time. In T4 condition, Zn addition does not obviously increase the yield strength and decrease the elongation, but it markedly improves paint-bake hardening response during paint-bake cycle. The addition of 0.5wt% Zn can lead to an increment of 99 MPa in yield strength compared with the value of 69 MPa for the alloy without Zn after paint-bake cycle.

关键词： aluminum alloys zinc hardening mechanical properties microstructure

急性低氧及力竭运动对大鼠骨骼肌肌球蛋白重链(MHC)亚型基因表达的影响

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体育科学 2005年第1期25卷 30-33页

作者：潘同斌毛杉杉王瑞元袁建琴扬州大学体育学院江苏扬州225002 北京体育大学人体运动科学学院北京100084

研究急性低氧及力竭运动对大鼠骨骼肌肌球蛋白重链 (MHC)亚型基因表达的影响。取健康 SD雌性大鼠 80只 ,随机分成 4大组 :常氧对照组 (C) ,常氧力竭组 (NE) ,低氧对照组 (HC)和低氧力竭组 (HE)。采用半定量反转录聚合酶链式反应 (RT- P... 详细信息

研究急性低氧及力竭运动对大鼠骨骼肌肌球蛋白重链 (MHC)亚型基因表达的影响。取健康 SD雌性大鼠 80只 ,随机分成 4大组 :常氧对照组 (C) ,常氧力竭组 (NE) ,低氧对照组 (HC)和低氧力竭组 (HE)。采用半定量反转录聚合酶链式反应 (RT- PCR)法 ,测定各组骨骼肌 MHCI、IIa、IIx、IIb4种亚型的 m RNA基因表达。结果表明 ,MHC各亚型 m RNA所占百分比分析显示 ,单纯低氧能刺激 MHC亚型 m RNA表达出现“由慢到快”的趋势 ;力竭运动则能刺激 MHCm RNA表达出现“由快到慢”的趋势。关于 MHC亚型转变在功能上的意义还有待进一步研究。

关键词：急性低氧力竭运动肌球蛋白重链(MHC)亚型基因表达

Effects of acupuncture at Shu,yuan,and Mu acupoints on blood se-rum uric acid and xanthine oxidase levels in a rat model of gout and hyperuricemia

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Journal of Traditional Chinese Medicine 2017年第6期37卷 841-845页

作者： wang Xinyi Liu Bingyun wang shan Sui Minghe Institute of Acupuncture and Tuina Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE: To investigate the effects of needling the Shu, yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and ***: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using ***: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly *** the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the ***: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.

关键词： Hyperuricemia Uric acid Xanthine oxidase Points,Shu Points,yuan(Source) Points,front Mu

Origin and circulation of saline springs in the Kuqa Basin of the Tarim Basin,Northwest china

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Journal of Arid Land 2020年第2期12卷 331-348页

作者： shan Junjie wang Jianping shan Fashou TENG Xueming FAN Qishun LIQingkuan QIN Zhanjie ZHANG Xiangru Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China Key Laboratory of Salt Lake Geology and Environment of Qinghai Province Xining 810008China university of Chinese Academy of Sciences Beijing 100085China Tianjin Center China Geological SurveyTianjin 300170China

It is widely accepted that hydrogeochemistry of saline springs is extremely important to understand the water circulation and evolution of saline basins and to evaluate the potential of potassium-rich *** Kuqa Basin,located in the northern part of the Tarim Basin in Northwest china,is a saline basin regarded as the most potential potash-seeking ***,the origin and water circulation processes of saline springs have yet to be fully characterized in this saline *** this study,a total of 30 saline spring samples and 11 river water samples were collected from the Qiulitage Structural Belt(QSB)of the Kuqa *** were analyzed for major(K^+,Ca2^+,Na^+,Mg2^+,SO42-,Cl-and HCO3-)and trace(Sr2^+and Br-)ion concentrations,stable H-O-Sr isotopes and tritium concentrations in combination with previously published hydrogeochemical and isotopic(H-O)data in the same *** is found that the water chemical type of saline springs in the study area belonged to the Na-Cl type,and that of river water belonged to the Ca-Mg-HCO3-SO4 *** total dissolved solid(TDS)of saline springs in the QSB ranged from 117.77 to 314.92 g/L,reaching the brine *** the basis of the general chemical compositions and the characteristics of the stable H-O-Sr isotopes of saline springs,we infer that those saline springs mainly originated from precipitation following river water *** addition,we found that saline springs were not formed by evapo-concentration because it is unlikely that the high chloride concentration of saline springs resulted in evapo-concentration and high ***,we conclude that saline spring water may have experienced intense evapo-concentration before dissolving the salty minerals or after returning to the *** results show that the origin of salinity was mainly dominated by dissolving salty minerals due to the river water and/or precipitation that passed through the halite-rich ***,there are two possible origins

关键词： H-O-Sr isotopes tritium concentration saline springs meteoric water Qiulitage Structural Belt

How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation

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World Journal of Stem Cells 2024年第3期16卷 245-256页

作者： shan-shan Liu Xiang Fang Xin Wen Ji-shan Liu Miribangvl Alip Tian Sun yuan-yuan wang Hong-Wei Chen Department of Reumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Emergency Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Anhui Key Laboratory of Infection and Immunity Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and *** transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into *** studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in ***,the mechanism underlying the adipogenic differentiation of MSCs is not fully ***,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC ***,the relationship between maladipogenic differentiation and diseases is briefly *** hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes.

关键词： Mesenchymal stem cell Adipogenic differentiation Signaling pathway Noncoding RNA Epigenetic regulation

Environmental conditions and genetic differentiation:what drives the divergence of coexisting Leymus chinensis ecotypes in a large-scale longitudinal gradient?

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Journal of Plant Ecology 2016年第5期9卷 616-628页

作者： shan yuan Chengyuan Guo Linna Ma Renzhong wang State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China university of Chinese Academy of Sciences Beijing100093 China

Aims The two coexisting Leymus chinensis ecotypes exhibit remarkable divergences in adaptive strategies under drought and salinity in semi-humid meadows and semi-arid *** order to detect the major genetic and environmental factors dominating the intraspecific phenotype variations and ecotype formation,the questions regarding the two distinct phenotypic forms(ecotypes)in ***-ensis were addressed:(i)did environments drive the *** ecotype formation?(ii)was there a molecular basis for the morphological divergence between the two ecotypes?(iii)which driving force dominated the intraspecies divergence,divergent natural selection,genetic drift or stabilizing selection?Methods We applied a series experiments on demographical,morphological and physiological traits of two Leymus chinensis ecotypes with gray green(GG)and yellow green(YG)leaf color in nine wild sites along a longitudinal gradient from 114°to 124°E in northeast *** environmental data including mean annual precipitation,mean annual temperature,elevation and soil properties were *** compared the differences of morphological,physiological and genetic differentiations between the two *** FindingsThe GG type exhibited stronger fitness than YG type from the population densities,morphological traits(*** height,leaf area,leaf and seed weights et al.),leaf mass per area(LMA)and physiological traits[relative water content(RWC),proline,soluble sugar contents].Most of above phenotypes(*** shoot densities,spike length et al.)were significantly correlated with mean annual precipitation,mean annual temperature and soil water content(SWC),rarely a correlated with soil pH and soil *** populations showed convergence trend by their leaf chlorophyll contents and osmotic adjustments(proline and soluble sugar contents)in the greenhouse,but still exhibited their divergences between two ecotypes in the outdoor transplantation,suggesting that whether ***

关键词： genetic differentiation large-scale gradient microsatellites phenotypic traits Leymus chinensis ecotypes