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A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet's disease in a Chinese Han population

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1315-1320页

作者： Xin-Shu Liu Zi-Yan Wu Si Chen Chan Zhao Fei Gao Ming-Hang Pei shan-shan jia Yong-Zhe Li Pei-Zeng Yang Mei-Fen Zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Clinical Laboratory Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Clinical Laboratory Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteChongqing 400016China

AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han ***:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX ***:A statistically significant association was observed between IL1RL1 rs12712142 and BD *** frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD ***:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.

关键词： Behcet’s disease single nucleotide polymorphism Chinese Han population IL33 IL1RL1

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基于SURF的图像多区域复制粘贴篡改检测

计算机工程与设计 2018年第8期39卷 2593-2597页

作者：陈辉映张大兴杨珊珊郭家伟杭州电子科技大学图形图像研究所浙江杭州310018

针对现有复制粘贴篡改检测算法对多区域复制粘贴篡改图像检测效果差、检测速度较慢的问题,提出一种基于SURF的图像多区域复制粘贴篡改检测方法。将待检测图像从RGB转换到Lab颜色空间并进行SURF特征提取,利用kg2NN方法对得到的特征点进... 详细信息

针对现有复制粘贴篡改检测算法对多区域复制粘贴篡改图像检测效果差、检测速度较慢的问题,提出一种基于SURF的图像多区域复制粘贴篡改检测方法。将待检测图像从RGB转换到Lab颜色空间并进行SURF特征提取,利用kg2NN方法对得到的特征点进行匹配,利用聚类消除误匹配定位篡改区域。实验结果表明,该算法能够准确定位图像的多处复制粘贴篡改区域,在抗几何变换攻击和JPEG压缩等方面具备一定的鲁棒性,检测速度得到了较大提高。

关键词：特征点加速鲁棒特征鲁棒性篡改检测复制粘贴

外周血中性粒细胞CD4对白血病患者细菌感染的诊断价值

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中华医院感染学杂志 2017年第4期27卷 777-780页

作者：马闪珊邵丽佳孙冬梅黄俊伟赵硕金华市中心医院检验科浙江金华321000

目的探讨外周血中性粒细胞CD4(Neutrophil CD4,nCD4)对白血病患者细菌感染的诊断价值,为临床治疗提供依据。方法选择医院2011年1月-2015年12月白血病患者100例及健康体检者100名为研究对象,将其分为白血病组和对照组,白血病患者根据是... 详细信息

目的探讨外周血中性粒细胞CD4(Neutrophil CD4,nCD4)对白血病患者细菌感染的诊断价值,为临床治疗提供依据。方法选择医院2011年1月-2015年12月白血病患者100例及健康体检者100名为研究对象,将其分为白血病组和对照组,白血病患者根据是否合并临床感染分为感染组与未感染组,细菌感染患者根据血培养结果分为阳性组与阴性组,采用流式细胞术测定nCD4平均荧光强度,电化学发光法测定降钙素原(PCT)水平,免疫比浊法测定C-反应蛋白(CRP)水平。结果白血病感染组与未感染组患者nCD4荧光强度为(183.24±67.35、44.25±25.46)、PCT(10.43±1.21ng/ml、3.25±0.42ng/ml)、CRP(72.35±15.34 mg/l、14.32±3.24mg/l)水平均高于对照组(26.87±12.43、0.42±0.13ng/ml、2.12±0.09mg/l),差异有统计学意义(P<0.05);白血病感染患者中,血培养阳性组nCD4荧光强度(247.76±76.23)高于血培养阴性组(154.24±54.45),差异有统计学意义(P<0.05);nCD4、PCT和CRP诊断白血病细菌感染的灵敏度分别为91.80%、79.80%、82.40%,特异度分别为79.70%、75.80%、77.10%,其中nCD4诊断白血病细菌感染的灵敏度和特异度高于PCT和CRP。结论 nCD4在一定程度上可预测白血病细菌感染,可作为白血病患者细菌感染的诊断指标。

关键词：中性粒细胞CD4 白血病细菌感染

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基于ANSYS人体膝关节的生物力学分析

生物医学工程与临床 2017年第5期21卷 459-464页

作者：石更强吴山山陆嘉苑周泽上海理工大学上海200093

目的研究作为膝关节置换前虚拟移植的第一阶段工作,重建人体膝关节股骨的三维有限元模型,并基于股骨模型进行应变方面的有限元分析,得到可供下一阶段假体设计的可靠数据。方法选择1例上海市闵行区中心医院35岁女性股骨截面进行自上而下... 详细信息

目的研究作为膝关节置换前虚拟移植的第一阶段工作,重建人体膝关节股骨的三维有限元模型,并基于股骨模型进行应变方面的有限元分析,得到可供下一阶段假体设计的可靠数据。方法选择1例上海市闵行区中心医院35岁女性股骨截面进行自上而下的、层厚为1 mm CT断层图像。采用ANSYS软件对CT图像进行重建膝关节三维模型并进行网格划分,之后进一步进行应力及生物力学特性方面的研究,模拟正常人在静止站立情况在不同载荷条件下的受力分析及应变情况,来验证所建模型的可行性。结果建立一个节点数为155 522、四面体单元数为107 833的股骨三维体网格模型;分别赋予1、5、10种材料值,再施加450、600、700、800、900 N的集中载荷,得到垂直载荷下的最小应力值为45.2~45.4 MPa,最大应力值为90.5~90.8 MPa。结论膝关节的生物力学分析对于膝关节假体的植入角度和位置及今后膝关节假体的外形设计及材料方面的研究具有重要的参考价值。

关键词：膝关节股骨模型生物力学 ANSYS软件仿真研究

Synthesis of gold nanocubes/PEI-wrinkled CoSe_(2) nanomaterials and its application in electrochemical immunosensors for detection of dipropyl phthalate

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Rare Metals 2021年第5期40卷 1099-1109页

作者： Bao-shan He jia-Wen Li School of Food Science and Technology Henan University of TechnologyZhengzhou 450001China

CoSe_(2) nanosheet materials with a wrinkled sheet structure and large surface area were synthesized via a simple hydrothermal *** polyethyleneimine(PEI)was used to functionalize wrinkled CoSe_(2)(w-CoSe_(2))to make gold nanocubes(AuNCs)uniformly anchored onto the surface of PEI-w-CoSe_(2) via Au-N *** its application in electrochemical immunosensors for the detection of dipropyl phthalate(DPrP)was *** obtained material was characterized by the Fourier transform infrared spectroscopy(FTIR),transmission electron microscope(TEM),energydispersive spectroscopy(EDS),X-ray diffraction(XRD)and Raman *** effective surface area and conductivity of the electrode were enhanced by the introduction of AuNCs/PEI-w-CoSe_(2) *** voltammetry(CV),differential pulse voltammetry(DPV)and electrochemical impedance spectroscopy(EIS)were used to characterize the performance of *** DPrP binds to antibodies via the antigen-antibody interaction,[Fe(CN)6]3-/4-was used as a signal probe to monitor the change of oxidation current of different DPrP *** optimal conditions,the electrochemical responses of the prepared immunosensor were linear when the DPrP concentrations ranged from 1×10^(-11) to 1×10^(-5) mol·L-1,with a detection limit of 1.39×10^(-12) mol·L^(-1).The coefficient of determination(R2)is 0.995,indicating that the degree of fitting is ***,the constructed immunosensor exhibited acceptable reproducibility,selectivity,and ***,it may be found that the composite material has good application prospects in the electrochemical sensors field.

关键词： CoSe_(2)nanosheets Polyethyleneimine Gold nanocubes Dipropyl phthalate

Adenovirus and severe acute hepatitis of unknown etiology in children:Offender or bystander?

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 354-355页

作者： shan shan Ji-Dong jia Liver Research Center Beijing Friendship HospitalCapital Medical University/Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis/National Clinical Research Center for Digestive DiseasesBeijing 100050China

On April 6,2022,the United Kingdom Health Security Agency(UKHSA)released an alert on cases of hepatitis of unknown etiology in children[1].On April 15,2022,World Health Organization(WHO)published the first notice of this condition[2].Later on,similar cases were reported from the UK,other European countries,and other parts of the world.

关键词： etiology hepatitis cases

A review on charging behavior of electric vehicles:data,model,and control

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Control Theory and Technology 2020年第3期18卷 217-230页

作者： Qing-shan jia Teng LONG Center for Intelligent and Networked Systems(CFINS) Department o f AutomationBeijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084China

The adoption and usage of electric vehicles(EVs)have emerged recently due to the increasing concerns on the greenhouse gas issues and energy *** a part of the smart grid,EVs can provide valuable ancillary services beyond consumers of ***,EVs are gradually considered as nonnegligible loads due to their increasing penetration,which may result in negative effects such as voltage deviations,lines saturation,and power *** and interaction among EVs,charging stations,and micro grid have to be considered in the next generation of smart ***,the topic of smart charging has been the focus of many works where a wide range of control methods have been *** one of the bases of simulation,the EV charging behavior and characteristics have also become the focus of many *** this work,we review the charging behavior of EVs from the aspects of data,model,and *** provide the links for most of the data sets reviewed in this work,based on which interested researchers can easily access these data for further investigation.

关键词： Electric vehicle charging behavior data and model

On large action space in EV charging scheduling optimization

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Science China(Information Sciences) 2022年第2期65卷 45-60页

作者： Zhaoyu jiaNG Qing-shan jia Xiaohong GUAN Center for Intelligent and Networked Systems Beijing National Research Center for Information Science and Technology Department of Automation Tsinghua University MOE KLINNS Lab Xi'an Jiaotong University

In order to reduce the air pollution by traditional fossil fuel and save the charging cost, much attention has been paid to the charging scheduling of electric vehicles(EVs) in the uncertain supplement of wind power and solar power. Owing to the randomness in the renewable power generation and the EV charging demand, simulation-based policy improvement(SBPI) has been well adopted for making charging decision. However, it is challenging to explore the large action space which grows exponentially with respect to the system scale. We consider this important problem in this paper and make the following ***, we explore the structural property of the problem and develop an urgency index to rank the ***, we apply three methods to search in the action space. Third, we numerically demonstrate the performance of the urgency index and the search methods, and compare the SBPI methods with the CPLEXbased method. It shows that SBPI improves the base policies in all these cases.

关键词： EV simulation-based policy improvement large action space sampling

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Gut microbiota in antiviral strategy from bats to humans:a missing link in COVID-19

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Science China(Life Sciences) 2021年第6期64卷 942-956页

作者： jia Luo shan Liang Feng Jin Department of Psychology Sichuan Normal UniversityChengdu 610068China Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100101China

Bats are a potential natural reservoir for SARS-CoV-2 virus and other viruses detrimental to *** evidence has shown that,in their adaptation to a flight-based lifestyle,remodeling of the gut microbiota in bats may have contributed to immune tolerance to *** evidence from bats provides profound insights into the potential influence of gut microbiota in COVID-19 disease in ***,we highlight recent advances in our understanding of the mechanisms by which the gut microbiota helps bats tolerate deadly viruses,and summarize the current clinical evidence on the influence of gut microbiota on the susceptibility to SARS-CoV-2 infection and risk of COVID-19 leading to a fatal *** addition,we discuss the implications of gut microbiota-targeted approaches for preventing infection and reducing disease severity in COVID-19 patients.

关键词： COVID-19 SARS-CoV-2 gut microbiota bat anti-inflammatory antiviral