检索结果-南通市图书馆

Theoretical characterization of hole mobility in BTBPD

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2013年第10期24卷 945-948页

作者： Tie-Chao Jiang Zhong-Yu Wang Bei-Bei Du shan-shan zhao China-Japan Union Hospital of Jilin University Jilin University State Key Laboratory of Supramolecular Structure and Materials Jilin University

（ E）-5,5＇-Bis（ 5-（ benzo[ b ]thiophen- 2-yl ）thiophen-2-yl ）-1,1＇-bis（ 2-ethylhexyl ）-[ 3,3＇-bipyrrolylidene ]- 2,2＇（1H, l＇H）-dione （BTBPD） has been reported by Zhang and co-workers. To further understand the charge-transporting nature of BTBPD, the density-functional theory （DFF） and the Marcus charge transfer theory were performed. The character of the frontier molecular orbitals, reorganization energies and transfer integrals in different directions were considered in details. The results revealed that the BTBPD has high hole transport efficiency （μ = 0.29 cm2 V-1 s-1 ）. The intermolecular π-π interaction and S...S interaction provide the holes transport channels.

关键词： BTBPD DFT Marcus charge transport theory

C-X-C chemokine receptor type 7 antibody enhances neural plasticity after ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第9期18卷 1976-1982页

作者： Xiao-Qian Zhang Xiao-Yin Wang Bing-Chao Dong Mei-Xuan Li Yu Wang Ting Xiao shan-shan zhao Department of Neurology The First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Key Laboratory of Immunodermatology Ministry of HealthMinistry of EducationShenyangLiaoning ProvinceChina

Stromal cell-derived factor-1 and its receptor C-X-C chemokine receptor 4(CXCR4) have been shown to regulate neural regeneration after *** r,whether stromal cell-derived factor-1 receptor CXCR7,which is widely distributed in the develo ping and adult central nervous system,participates in neural regeneration remains poorly unde *** this study,we established rat models of focal cerebral ischemia by injecting endothelin-1 into the cerebral co rtex and *** on day 7 after injury,CXCR7-neutralizing antibody was injected into the lateral ventricle using a micro drug delivery system for 6 consecutive *** results showed that CXCR7-neutralizing antibody increased the total length and number of sprouting co rticospinal tra ct fibers in rats with cerebral ischemia,increased the expression of vesicular glutamate transporter 1 and growth-related protein 43,marke rs of the denervated spinal cord synapses,and promoted the differentiation and maturation of oligodendrocyte progenitor cells in the *** addition,CXCR7 antibody increased the expression of CXCR4 in the striatum,increased the protein expression of RAS and ERK1/2 associated with the RAS/ERK signaling pathway,and im proved rat motor *** findings suggest that CXCR7 improved neural functional recovery after ischemic stroke by promoting axonal regeneration,synaptogenesis,and myelin regeneration,which may be achieved by activation of CXCR4 and the RAS/ERK1/2 signaling pathway.

关键词： axonal regeneration cerebral ischemia C-X-C chemokine receptor 4 CXCR7 antibody neural plasticity RAS/ERK pathway remyelination stroke stromal cell-derived factor-1 synaptogenesis

Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第6期15卷 1079-1085页

作者： Bing-Chao Dong Mei-Xuan Li Xiao-Yin Wang Xi Cheng Yu Wang Ting Xiao Jukka Jolkkonen Chuan-Sheng zhao shan-shan zhao Department of Neurology The First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Key Laboratory of Immunodermatology Ministry of HealthMinistry of EducationShenyangLiaoning ProvinceChina Department of Neurology Institute of Clinical MedicineUniversity of Eastern FinlandKuopioFinland

Stromal cell-derived factor-1 and its receptor CXCR4 are essential regulators of the neurogenesis that occurs in the adult hippocampal dentate ***,the effects of CXCR7,a new atypical receptor of stromal cell-derived factor-1,on hippocampal neurogenesis after a stroke remain largely *** study is the first to investigate the effect of a CXCR7-neutralizing antibody on neurogenesis in the dentate gyrus and the associated recovery of cognitive function of rats in the chronic stage of cerebral *** rats were randomly divided into sham,sham+anti-CXCR7,ischemia and ischemia+anti-CXCR7 ***-1 was injected in the ipsilateral motor cortex and striatum to induce focal cerebral *** group rats were injected with saline instead of endothelin-1 via intracranial *** sham and ischemic rats were treated with intraventricular infusions of CXCR7-neutralizing antibodies for 6 days 1 week after *** staining with doublecortin,a marker for neuronal precursors,was performed to assess the neurogenesis in the dentate *** found that anti-CXCR7 antibody infusion enhanced the proliferation and dendritic development of doublecortin-labeled cells in the dentate gyrus in both ischemic and sham-operated *** learning and memory functions were assessed by Morris water maze tests 30-32 days after ***7-neutralizing antibody treatment significantly reduced the escape latency of the spatial navigation trial and increased the time spent in the target quadrant of spatial probe trial in animals that received ischemic insult,but not in sham operated *** results suggest that CXCR7-neutralizing antibody enhances the neurogenesis in the dentate gyrus and improves the cognitive function after cerebral ischemia in *** animal experimental protocols and procedures were approved by the Institutional Animal Care and Use Committee of China Medical University(CMU16089 R)on December 8,2016.

关键词： cerebral ischemia cognitive function CXCR7 dendritic development dentate gyrus doublecortin neurogenesis neutralizing antibody stroke stromal cell-derived factor-1

Current rice production is highly vulnerable to insect-borne viral diseases

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第9期9卷 142-144页

作者： Jian-guo Wu Guo-yi Yang shan-shan zhao Shuai Zhang Bi-xia Qin Yong-sheng Zhu Hui-ting Xie Qing Chang Lu Wang Jie Hu Chao Zhang Bao-gang Zhang Da-li Zeng Jian-fu Zhang Xian-bo Huang Qian Qian Shou-wei Ding Yi Li Vector-borne Virus Research Center Fujian Province Key Laboratory of Plant Virology Institute of Plant Virology Fujian Agriculture and Forestry University Institute of Plant Protection Guangxi Academy of Agricultural Sciences Rice Research Institute Fujian Academy of Agricultural Sciences State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural Sciences Rice Research Institute Sanming Academy of Agricultural Sciences Department of Microbiology and Plant Pathology Center for Plant Cell Biology Institute for Integrative Genome Biology University of California The State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University

Rice is one of the most important food crops and feeds more than half of the world’s population [1]. Arthropod-borne rice viruses have caused devastating epidemics in Asian countries and are a major threat to food security [2]. However,lile is known about the vulnerability of rice crops to viral pathogens [3,4], especially southern rice black-streaked dwarf virus (SRBSDV), rice black-streaked dwarf virus (RBSDV) and rice gall dwarf virus (RGDV), known to induce annual outbreaks by insect transmission in some localities in Asia.

关键词：

益肺解毒汤对人肺腺癌A549细胞侵袭迁移的影响及相关机制

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国实验方剂学杂志 2017年第22期23卷 108-113页

作者：王珊珊赵新鲜郭立中南京中医药大学南京210029 南京市江宁医院南京210029

目的:观察益肺解毒汤对肺癌A549细胞侵袭转移的影响,并探讨该方对细胞上皮-间充质转化(EMT)的影响及其作用机制。方法:常规培养肺癌A549细胞,Co Cl2化学模拟肺癌A549细胞缺氧微环境,设空白组,以150μmol·L^(-1)Co Cl2,150μmol·L^(-1)... 详细信息

目的:观察益肺解毒汤对肺癌A549细胞侵袭转移的影响,并探讨该方对细胞上皮-间充质转化(EMT)的影响及其作用机制。方法:常规培养肺癌A549细胞,Co Cl2化学模拟肺癌A549细胞缺氧微环境,设空白组,以150μmol·L^(-1)Co Cl2,150μmol·L^(-1)Co Cl2+15 g·L^(-1)益肺解毒汤,15 g·L^(-1)益肺解毒汤处理细胞,镜下观察细胞形态学改变,transwell实验观察细胞侵袭能力;细胞划痕实验测细胞迁移能力;蛋白免疫印迹法(Western blot)测定A549细胞上皮细胞-间充质转化(EMT)过程中上皮细胞、间质细胞标志物E-钙黏蛋白(E-cadherin)、波形蛋白(Vimentin)表达,转录因子Snail蛋白表达,信号分子β-链蛋白(β-catenin)、磷酸化糖原合成酶激酶-3(p-gsk-3β)表达。结果:缺氧可诱导A549细胞发生形态改变,益肺解毒汤可抑制缺氧诱导的形态改变。与空白组比较,Co Cl2组细胞侵袭和迁移能力增强(P<0.05);与Co Cl2组比较,Co Cl2+益肺解毒汤组的细胞侵袭能力明显减弱(P<0.01),迁移能力亦减弱(P<0.05)。与空白组比较,Co Cl2组细胞EMT相关蛋白,E-cadherin表达下调,Vimentin,Snail表达上调(P<0.05),说明缺氧使细胞发生了EMT;与Co Cl2组比较,Co Cl2+益肺解毒汤组可上调Ecadherin,p-gsk-3β,下调Vimentin,Snail,β-catenin蛋白表达(P<0.05)。结论:益肺解毒汤能抑制缺氧诱导的A549细胞的形态变化、侵袭及迁移能力,还能抑制缺氧诱导的EMT的发生,其机制可能与Wnt/β-catenin通路有关。

关键词：中药复方益肺解毒汤上皮-间充质转化 Wnt/β-链蛋白信号通路

Lamivudine prophylaxis of liver allograft HBV reinfection in HBV related cirrhotic patients after liver transplantation

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 26-32页

作者： Shi-Chun Lu, Lu-Nan Yan, Bo Li, Tian-Fu Wen, Ji-Chun zhao, Nan-Sheng Cheng, Chong Liu, Jun Liu, Xiao-Bo Wang, Xiao-Dong Li, shan Qin, Lian-shan zhao, Bin-Jun Lei and Xiu-Hui Zhang Chengdu, China Department of Surgery Viral Hepa- titis Research Center Department of Pathology , West China Hospital, Sichuan University, Cheng- du 610041 , China Department of General Surgery West China Hospital Sichuan University Chengdu 610041 China. lsc620213@***

BACKGROUND: Liver allograft hepatitis B virus (HBV) reinfection and hepatitis B (HB) recurrence jeopardize the long-term survival of recipient and liver allograft. Lamivu- dine has been referred as a novel antiviral agent against HBV in HBV cirrhotic patients even in liver transplantation setting. We assessed the prophylatic effect of lamivudine on liver allograft HBV reinfection and clarified the dynamic changes of HBV markers in HBV related decompensated liver cirrhosis after liver transplantation. METHODS: Twenty-five recipients were divided into three groups: HBV active replication group (15 recipients), HBV inactive replication group (7), and control group (3). 100 mg/d lamivudine was administered preoperatively except in the control group. The HBV markers of serial sera and liver biopsy samples of the 25 recipients were evaluated re- gularly with enzyme-linked radioimmunoassay, HBV DNA fluorecent quantitative assay, immunohistochemical stain- ing , labelled streptavidin biotin ( LSAB) and digoxin la- belled HBV DNA hybridization in situ. The dynamic alter- nation of HBV markers under lamivudine prophylaxis was observed. RESULTS: In the HBV active replication group who had received lamivudine 2 weeks before liver transplantation, serum HBV DNA positive converted to negative by 80%. HBsAg of all recipients disappeared after liver transplanta- tion , but corresponding antibodies of HBV appeared within one week after the operation. HBsAb 9/15, HBcAb 13/15 and HBeAb 11/15 appeared and subsided gradually within 24 weeks. HBV DNA in sera was kept negative; HBsAg, HBcAg and HBV DNA hybridization in situ of liver biopsy samples remained negative after use of lamivudine. Ten of the 15 recipients showed clearance of HBV, and per se HBV markers were undetectable both in serum and liver bi- opsy samples between 12 to 44 weeks (24 weeks on ave- rage). The 1-, 2-year survival rates were 83% in this group. Two of the 15 recipients developed HBV allograft reinfection or recurr

关键词： liver cirrhosis hepatitis B virus liver transplantation lamivudine

恶性血液病患者侵袭性真菌感染的影响因素及感染前后肠道菌群结构变化分析

在线全文

学校读者我要写书评

暂无评论

中华医院感染学杂志 2017年第5期27卷 1039-1042页

作者：马闪珊赵硕孙冬梅黄俊伟金华市中心医院检验科浙江金华321000

目的探讨恶性血液病侵袭性真菌感染(IFI)的影响因素及真菌感染前后肠道菌群结构的变化情况,为恶性血液病侵袭性真菌感染的诊治提供依据。方法选择医院2010年1月-2015年12月血液科恶性血液病患者1000例,将其中164例IFI患者作为观察组,另... 详细信息

目的探讨恶性血液病侵袭性真菌感染(IFI)的影响因素及真菌感染前后肠道菌群结构的变化情况,为恶性血液病侵袭性真菌感染的诊治提供依据。方法选择医院2010年1月-2015年12月血液科恶性血液病患者1000例,将其中164例IFI患者作为观察组,另选取164例健康者为对照组,采用单因素及多因素logistic分析IFI的影响因素及PCR法检测肠道菌群情况。结果急性白血病和骨髓增生异常综合征、有基础疾病、应用糖皮质激素、抗菌药物应用时间>7d、抗菌药物种类>2种、白细胞计数≤1.0×109/L者IFI的发生率高于淋巴瘤+慢性白血病+多发性骨髓瘤、无基础疾病、未应用糖皮质激素、抗菌药物应用时间≤7d、抗菌药物种类≤2种、白细胞计数>1.0×109/L者(P2种、白细胞计数≤1.0×109/L是IFI的独立危险因素(P2种、白细胞计数≤1.0×109/L是恶性血液病侵袭性真菌感染的独立危险因素,恶性血液病侵袭性真菌感染和肠道真菌量增加、细菌量减少有关。

关键词：侵袭性真菌恶性血液病肠道菌群

在线全文

学校读者我要写书评

暂无评论

川中气田卤水处理中钙镁沉淀的絮凝剂研究

西南石油大学学报（自然科学版） 2009年第5期31卷 147-149页

作者：刘长坤李春福朱闪闪赵海杰西南石油大学材料科学与工程学院四川成都610500

为综合利用气田卤水,最有效的方法是卤水制盐。但川中气田卤水含有较高质量浓度的钙镁离子。为防止制盐工艺中蒸发浓缩设备结垢,一般是预先将其沉淀除去。由于钙镁沉淀的颗粒太细、沉降时间较长,已严重影响了制盐的生产效率,故需要采用... 详细信息

为综合利用气田卤水,最有效的方法是卤水制盐。但川中气田卤水含有较高质量浓度的钙镁离子。为防止制盐工艺中蒸发浓缩设备结垢,一般是预先将其沉淀除去。由于钙镁沉淀的颗粒太细、沉降时间较长,已严重影响了制盐的生产效率,故需要采用沉淀絮凝法来解决,关键是恰当地选择及使用性能优良的絮凝剂。为此,以沉降时间和水体浊度为指标,通过模拟卤水,研究了絮凝剂对其钙镁沉淀的絮凝性能。结果表明,阴离子聚丙烯酰胺在25℃、最佳用量50mg/L及搅拌速度500r/min时,沉淀的沉降时间最短,水体浊度最低。

关键词：气田沉淀絮凝卤水絮凝剂

泰山灰树花母种及液体菌种最佳培养条件的研究

在线全文

学校读者我要写书评

暂无评论

食品研究与开发 2018年第14期39卷 177-181页

作者：刘姗姗孟丽赵姣姣王丽颖朱孟娟山东农业大学植物保护学院山东泰安271018

以泰山灰树花菌丝为试验材料,以菌丝生长速度和菌丝体干重为主要指标,用平板培养法和液体摇瓶培养法,通过单因素试验和正交试验,对泰山灰树花母种及液体菌种最佳培养条件进行了研究。结果表明:适合泰山灰树花母种生长的最佳碳源为葡萄糖... 详细信息

以泰山灰树花菌丝为试验材料,以菌丝生长速度和菌丝体干重为主要指标,用平板培养法和液体摇瓶培养法,通过单因素试验和正交试验,对泰山灰树花母种及液体菌种最佳培养条件进行了研究。结果表明:适合泰山灰树花母种生长的最佳碳源为葡萄糖,最佳氮源为酵母膏,添加栗树木屑可以促进菌丝的生长,菌丝生长的最适温度为24℃,最适p H值为6。泰山灰树花液体菌种的最佳培养条件为:转速120 r/min,接种量20 m L,温度24℃,培养10天后的菌丝体干重为7.32 g/L。

关键词：泰山灰树花母种液体菌种培养基配方菌丝体干重