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技术相关性对海外并购创新绩效的影响--基于技术获取型海外并购的实证研究

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东北大学学报（社会科学版） 2020年第6期22卷 42-49页

作者：宁烨鞠阳王姗姗东北大学工商管理学院辽宁沈阳110169

基于资源基础观、组织学习理论和技术获取型海外并购创新绩效理论等,提出了技术相似性和互补性与开发性和探索性创新之间的关系以及海外并购经验的调节作用,并构建了理论模型。选取2003—2013年间完成技术获取型海外并购交易的中国企业... 详细信息

基于资源基础观、组织学习理论和技术获取型海外并购创新绩效理论等,提出了技术相似性和互补性与开发性和探索性创新之间的关系以及海外并购经验的调节作用,并构建了理论模型。选取2003—2013年间完成技术获取型海外并购交易的中国企业作为研究样本,利用负二项回归模型,对技术相似性和互补性与开发性和探索性创新之间的关系以及海外并购经验的调节作用进行了实证分析,结果表明:并购双方的技术相关性(技术相似性与互补性)对收购方的开发性创新和探索性创新均有积极影响;海外并购经验对技术相关性与开发性创新之间的关系具有正向调节作用。提出了并购企业应选择与自身技术资源相匹配的目标企业并合理运用海外并购经验等建议。

关键词：技术获取型海外并购技术相关性开发性创新探索性创新

浅表组织后向散射检测中偏振门的蒙特卡罗研究

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光学学报 2007年第8期27卷 1465-1469页

作者：鞠栅邓勇骆清铭鲁强华中科技大学生物医学光子学教育部重点实验室武汉光电国家实验室生物医学光子学研究部武汉430074

已有实验表明偏振门和斜入射技术能有效地抑止深层散射光子,实现浅表组织光学特性的检测。采用蒙特卡罗方法,分析了斜入射、偏振门的特性,研究了组织光学参量和入射角等参量对平均探测深度的影响。结果表明,组织的各向异性因子和入射角... 详细信息

已有实验表明偏振门和斜入射技术能有效地抑止深层散射光子,实现浅表组织光学特性的检测。采用蒙特卡罗方法,分析了斜入射、偏振门的特性,研究了组织光学参量和入射角等参量对平均探测深度的影响。结果表明,组织的各向异性因子和入射角对平均探测深度影响较大。当各向异性因子较小(小于0.8)或者入射角较大(大于1.4 rad)时,组织的平均探测深度能满足小于2倍平均自由程的要求。偏振门和斜入射技术均可使探测光子经历的散射次数和探测深度有明显减小,因此,结合偏振门和斜入射技术能够更有效地分辨来自浅层的信号光,抑止来自深层的背景光。

关键词：医用光学与生物技术偏振门斜入射蒙特卡罗模拟

Liver targeting and the delayed drug release of the nanoparticles of adriamycin polybutylcyanoacrylate in mice

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Chinese Medical Journal 2006年第15期119卷 1287-1293页

作者： SHEN Liang-fang ZHANG Yang-de SHEN Hai-ju ZENG shan WANG Xin WANG Cheng LE Yuan SHEN Hong Department of Tumor Xiangya Hospital Central South University of China Changsha 410008 China National Key Laboratory of Nanobiological Technology Central South University of China Changsha 410008 China Medical Research Center Xiangya Hospital Central South University of China Changsha 410008 China

Background Liver targeting drug delivery systems can improve the curative effects and relieve the cytotoxicity of the chemotherapy drugs in the treatment of liver diseases. Nanoparticles carrying therapeutic drugs are currently under hot investigation with great clinical significance. This study was aimed to investigate the different tissue distribution of the adriamycin polybutylcyanoacrylate nanoparticle （ADM-PBCA-NP） in the mice body after an injection via lateral tail vein, and to study the liver targeting effects of ADM-PBCA-NP in different diameters on normal mice liver. Methods One hundred and eighty Kunming mice were randomly divided into 6 groups with 30 mice in each group （5 treatment groups of ADM-PBCA-NP in the different diameter ranges, non-conjugated free adriamycin injection was employed as the control group）. A single dose of either conjugated or free adriamycin equaled 2 mg/kg of body weight was delivered via the tail vein. Five mice in each trail were sacrificed at 5, 15, 30 minutes, 1, 5 and 12 hours postinjection, respectively. The adriamycin cOncentrations in the respectively collected liver, kidney, spleen, heart, lung and plasma were demonstrated using a high performance liquid chromatography with fluorescence detector. Results Compared with the control group, adriamycin was hardly detected in the heart muscle of the treatment groups （P〈0.05）. The nanoparticle-conjugated adriamycin was cleaned up quickly from the kidney tissue. The adriamycin concentrations of the mice liver and spleen in the experimental groups were significantly higher than that in the control group, except for the group with the nanoparticles diameters of （22.3 ±6.2） nm （P〈0.05）. The ADM-PBCA-NP in （101.0±20.3） nm diameter had the highest liver distribution, and the second highest adriamycin distribution in liver was the group of （143.0±23.5） run diameter （P〈0.05）. Moreover, adriamycin was released slowly in the liver during the detection period in the experimental groups.

关键词： polybutylcyanoacrylate nanoparticles fiver targeting adriamycin

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用于偏振散射光谱术研究的并行蒙特卡罗程序

光学学报 2007年第3期27卷 510-514页

作者：鞠栅邓勇鲁强骆清铭华中科技大学生物医学光子学教育部重点实验室武汉光电国家实验室生物医学光子学研究部武汉430074

偏振散射光谱术是一种新型的早期癌症无损光学检测技术。目前,对这一技术的机理研究缺乏较好的理论手段。引入并行计算方法,采用斯托克斯(Stokes)参量和米勒(Müller)矩阵分别描述光子包和介质的偏振特性,实现了可用于模拟偏振散射光谱... 详细信息

偏振散射光谱术是一种新型的早期癌症无损光学检测技术。目前,对这一技术的机理研究缺乏较好的理论手段。引入并行计算方法,采用斯托克斯(Stokes)参量和米勒(Müller)矩阵分别描述光子包和介质的偏振特性,实现了可用于模拟偏振散射光谱的并行偏振蒙特卡罗程序。程序基于消息传递接口(Message passing interface, MPI)并行开发平台,采用主-从(Master-slaver)并行计算模型,并用任务池方法实现动态负载平衡。混浊介质后向偏振散射光谱的模拟和实验结果对照证实了程序的正确性;程序并行效率分析表明了程序在任务规模和节点规模上具有良好的可扩展性,对于较大规模的任务,使用n个从节点的模拟时间约为使用1个从节点模拟时间的1/n倍。

关键词：生物光学蒙特卡罗模拟并行计算偏振散射光谱术

Polycrystalline model for FE-simulation of micro forming processes

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Transactions of Nonferrous Metals Society of China 2011年第6期21卷 1362-1366页

作者：王春举郭斌单德彬哈尔滨工业大学材料科学与工程学院哈尔滨150001

A new polycrystal model was presented from the viewpoint of polycrystal structure of the billets considering free surface *** the model,the billet was divided into three portions,such as free surface portion,transition portion and internal *** grains in free surface portion were considered the single grains,and the anisotropy of the grains was taken into account by introducing grain orientation to explain the inhomogeneous *** the transition portion,the effects of the neighbouring grains were adopted in the *** grains in the internal portion were considered the polycrystalline *** the developed model,the upsetting deformation process was simulated by the MSC Superform *** scatter of the flow stress and inhomogeneous deformation was observed by analysis of the *** comparisons show that the computational results are good agreed with the experimental *** means that the presented model is effective.

关键词： micro forming size effect polycrystal model inhomogeneous deformation

The Formation of Nano-Size SiO_2 Thin Film on an Aluminum Plate with Hexamethyldisilazane (HMDSA) and Hexamethyldisiloxane (HMDSO)

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Journal of Thermal Science 2003年第1期12卷 89-96页

作者： H.K.Ma E.Zhao K.M.Chung C.L.yeh Dept of Mechanical Engineering National Taiwan UniversityDept of Mechanical Engineering National Taiwan UniversityDept of Mechanical Engineering National Taiwan UniversityDept of Mechanical Engineering Da-Yeh University 112 Taipei Taiwan 10764 China Taipei Taiwan 10764 ChinaTaipei Taiwan 10764 ChinaShan-Jeau Rd Dah-Tsuen Chang-Hwa Taiwan 51505 China

This study is using HMDSA (C6H19NSi2) or HMDSO (C6H18OSi2) vapor into C3H8/air premixed flames to form SiO2 thin film on the surface of an aluminum plate. With the addition of HMDSO or HMDSA to premixed flames, an orange secondary flame or a flame brush appeared and was contributed to the formation of Sio2 particles. Based upon the EDS, XPS and FTIR analysis, it is believed that the synthesized products consist of mainly SiO2 and a small amount of SiO. The pure SiO2 crystal structure, was proved by XRD analysis, which may form from the SiO2 amorphous structure after high temperature (1300C) thermal treatment. The nano-size SiO2 particles, which ranged from 2.5-25 nm, are proved by analysis of the BET and TEM. A 2-D CFD-RC code with 12 reduced chemical reaction mechanism, based upon the SIMPLER procedure, was successfully employed to predict the flame temperature and both of the SiO2 and SiO concentration profiles. Compared with the experimental results, the calculated temperature profiles in the post-flame region are in good agreement with the measured data and observation phenomena.

关键词： nano size thin film SiO2.

Two new neolignans from Manglietia insignis

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Natural Products and Bioprospecting 2012年第5期2卷 227-230页

作者： shan-Zhai shanG ju-Ming YAN Hai-Bo ZHANG Yi-Ming SHI Zhong-Hua GAO Xue DU Yan LI Wei-Lie XIAO Han-Dong SUN State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China

Two new neolignans,manneoinsigins A(1)and B(2),together with four known lignans,were isolated from the leaves and stems of Manglietia *** new compounds were established on the basis of extensive spectroscopic *** compounds except 2 were tested for their cytotoxic *** 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC50 value of 23.5μM.

关键词： Magnoliaceae Manglietia insignis neolignan cytotoxic activity

Mechanisms of treatment of cancer pain with a topical Chinese herbal formula in rats

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Chinese Medical Journal 2009年第17期122卷 2027-2031页

作者： YU shan PENG Hai-dong ju Da-wei WEI Pin-kang XU Ling LAO Li-xing LI jun Department of Chinese Medicine Shanghai ChangzhengHospital Second Military Medical University Shanghai 200003China

Background Pain has a substantial impact on patients＇ activities and overall quality of life, but current conventional drugs have debilitating side effects, including gastrointestinal disorders. Thus there is a pressing need for new therapies with fewer side effects to alleviate cancer pain. We recently developed a topical herbal formula Xiaotan Tongluo analgesic gel （X＇I-IL gel） based on the principles of traditional Chinese herbalism, and we have received positive feedback from bone cancer pain patients. The aim of this study was to determine the analgesic effects and explore the mechanisms of XTI-L gel in a rat model of bone cancer pain. Methods The rat model of bone cancer pain was established by inoculating Walker-256 rat carcinoma cells directly into the right tibial medullary cavity of Wistar rats. The rats were randomly assigned to three groups （n=-10 per group）：（1） sham bone cancer control （sham group）： vehicle （PBS） inoculation without carcinoma cells plus topical administration of blank gel; （2） Sham treatment control （vehicle group）： Walker-256 cell inoculation plus topical administration of blank gel; （3） XTTL gel treatment （treatment group）： Walker-256 cell inoculation plus topical administration of XTTL gel. XTTL gel treatments were applied daily for 7 days starting on day 14 following inoculation. Outcomes were assessed 21 days after inoculation by mechanical allodynia, histological staining, and by measuring concentrations of type I collagen carboxy-terminal telopeptide （ICTP） and bone-specific alkaline phosphatase （BAP） in serum. Results Fourteen days after cancer cell incubation, significant mechanical allodynia in the ipsilateral hind paw and tumor growth in proximal end of the tibia were observed in the vehicle and treatment groups but not in the sham group. At day 21, mechanical withdrawal thresholds in treatment group rats were significantly higher （（4.8557±0.8336） g） compared with those of the vehicle group （（1.8630±1.4369） g, P 〈0.05）. ICTP

关键词： bone cancer pain topical Chinese herbal medicine type I collagen carboxy-terminal telopeptide bone-specific alkaline phosphatase

Downregulation of alpha-fetoprotein siRNA inhibits proliferation of SMMC-7721 cells

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World Journal of Gastroenterology 2005年第38期11卷 6053-6055页

作者： Yun-shan Wang Xiao-Li Ma Tong-Gang Qi Xiang-Dong Liu Yue-Sheng Meng Guang-ju Guan Central Laboratory Jinan Central Hospital Clinical Medical College of Shandong University Jinan 250013 Shandong Province China Laboratory of Clinical Molecular Biology The Second Hospital of ShandongUniversity Jinan 250015 Shandong Province China shandong Provincial Hospital Jinan 250020Shandong Province China

AIM: To study the function of α-fetoprotein (AFP) in SMMC-7721 hepatoma ***: A hairpin siRNA expressing plasmid pSilencer3.0-H1-afp was constructed and transfected into SMMC-7721 cells with Lipofectamine 2000. The expression of AFP was monitored by real-time RT-PCR and immunoassays, its effect on SMMC-7721 cell proliferation and cell death was detected by MTT and fluorescenceactivated cell sorter (FACS).RESULTS: The AFP-siRNA expressing plasmid downregulated the expression of AFP obviously (about 34%), and inhibited SMMC-7721 cell proliferation, but did not induce ***: Downregulation of AFP siRNA inhibits proliferation of SMMC-7721 cells, but cannot cause apoptosis.

关键词： siRNAs AFP SMMC-7721 cell Proliferation Apoptosis