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Effects of the mid-air collision on sand saltation

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Science China(Physics,Mechanics & Astronomy) 2008年第9期51卷 1416-1426页

作者： HUANG Ning ren shan ZHENG XiaoJing Key Laboratory of Mechanics on Western Disaster and Environment Ministry of EducationDepartment of MechanicsLanzhou UniversityLanzhou 730000China

As to the fact that the effects of saltating particles’ mid-air collision on the sand transport rate are often neglected in the current theoretical models describing sand saltation movement,expressions to calculate velocity diversity of saltating parti-cles after mid-air collision are presented through collision theory of hard ball in this paper. Then,the theoretical model of the wind blown sand movement at the steady state,taking account of coupled interaction between saltation particles and wind,is combined with the model of the mid-air collision probability to calculate the sal-tating particles’ mass flux at heights,the sand transport rate,and further,their changing rules. The comparison of the results with those when the mid-air collision is not considered suggests that the mass flux at heights and the sand transport rate in this paper are less,and much closer,respectively,to the corresponding experi-mental values. The difference between the sand mass fluxes without and with con-sideration of mid-air collision increases at first,and then decreases as the height increases,exhibiting the stratified characteristics.

关键词： mid-air collision sand transport rate saltation

Current early diagnostic biomarkers of prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 549-554页

作者： Min Qu shan-Cheng ren Yinghao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai China.

Prostate cancer （PCa） has become to have the highest incidence and the second mortality rate in western countries, affecting men＇s health to a large extent. Although prostate-specific antigen （PSA） was discovered to help diagnose the cancer in an early stage for decades, its specificity is relative low, resulting in unnecessary biopsy for healthy people and over-treatment for patients. Thus, it is imperative to identify more and more effective biomarkers for early diagnosis of PCa in order to distinguish patients from healthy populations, which helps guide an early treatment to lower disease-related mortality by noninvasive or minimal invasive approaches. This review generally describes the current early diagnostic biomarkers of PCa in addition to PSA and summarizes the advantages and disadvantages of these biomarkers.

关键词： early diagnostic biomarkers MALATl-derived miniRNA PCA3 prostate cancer PSA

Investigating intratumour heterogeneity by single-cell sequencing

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Asian Journal of Andrology 2013年第6期15卷 729-734,I0005页

作者： shan-Cheng ren Min Qu Ying-Hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China

Intratumour heterogeneity is a longstanding field of focus for both researchers and clinicians. It refers to the diversity amongst cells within the same tumour. Two major hypotheses have attempted to explain the existence of intratumour heterogeneity：（i） the clonal evolution （CE） theory and （ii） the cancer stem cell （CSC） model. CE theory emphasizes the evolutionary biological characteristics of the tumour, underscoring the initiation and progression of the disease. In contrast, the CSC model focuses on stem cell differentiation into distinct functions in order to stabilize the tumour microenvironment. Here we consider single-cell sequencing （SCS） as a newly developed technique for application to the investigation of intratumour heterogeneity and assess its relevance within research and clinical environments. Early detection of rare tumour cells, monitoring of circulating tumour cells （CTCs） and control of the occurrence of drug resistance are imoortant goals in early diagnosis, prognosis prediction and individualized medicine.

关键词： clinical applications intratumour heterogeneity single-cell sequencing

A BIOREDUCIBLE POLYPEPTIDE FOR EFFICIENT GENE TRANSFECTION BOTH IN VITRO AND IN VIVO

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Chinese Journal of Polymer Science 2013年第5期31卷 713-713,714-718页

作者： Wei Qu Si Chen shan ren Xue-jun Jiang ren-xi Zhuo 张先正 Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Wuhan University Department of Cardiology Renmin Hospital of Wuhan University

A disulfide bond containing polypeptide, PolyK6-R8, was designed and prepared by oxidative polymerization between terminal cysteinyl thiol groups of CHK6HC and CR8C. The molar ratio between CHK6HC and CR8C within obtained PolyK6-Rs was 9：1, and PolyK6-R8 could combine DNA compactly when weight ratio reached 5. Through in vitro investigation, it was found that PolyK6-R8 was an efficient gene vector with low cytotoxicity for delivering DNA in both COS-7 and HeLa cells. Cellular uptake of DNA mediated by PolyK6-R8/DNA complexes was promoted after incubation for 4 h. Moreover, by examining the histological sections of hindlimb ischemia rats through immunohistochemistry, PolyK6- R8/VEGF complexes were proved to be effective in both VEGF protein expression and succeeding vessel formation. The results indicated that polypeptide-based PolyK6-R8 is a promising gene vector for the limb ischemia treatment.

关键词： Gene vector Polypeptide Angiogenesis Limb ischemia.

Prostate cancer research in China

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Asian Journal of Andrology 2013年第3期15卷 350-353页

作者： shan-Cheng ren Rui Chen Ying-Hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China

Prostate cancer （PCa） research in China has been on a rocketing trend in recent years. The first genome-wide association study （GWAS） in China identified two new PCa risk associated single nucleotide polymorphisms （SNPs）. Next generation sequencing is beginning to be used, yielding novel findings： gene fusions, long non-coding RNAs and other variations. Mechanisms of PCa progression have been illustrated while various diagnosis biomarkers have been investigated extensively. Personalized therapy based on genetic factors, nano-medicine and traditional Chinese medicine has been the focus of experimental therapeutic research for PCa. This review intends to shed light upon the recent progress in PCa research in China and points out the possible breakthroughs in the future.

关键词： prostate cancer (PCa) genome-wide association study (GWAS) single nucleotide polymorphisms (SNPs) China

New theoretical framework for OFDM/CDMA systems with peak-limited nonlinearities

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Science in China(Series F) 2007年第5期50卷 783-792页

作者： WANG Jian ZHANG Lin shan XiuMing ren Yong Department of Electronic Engineering Tsinghua University Beijing 100084 China

A new theoretical framework for the evaluation of the in-band nonlinear distortion effects on the performance of OFDM systems is presented. In contrast to previous works that approximate the nonlinear noise as a Gaussian additive random process, the new framework is based on the properties of the large deviations of a stationary Gaussian process and shot noise theories, which can evaluate the performance of the OFDM system with high accuracy, especially at realistic scenarios where the Gaussian approximation of the nonlinear noise is no longer valid. The approach can be used to evaluate many communication systems with peak-limited nonlinearities and high PAPR, such as the downlink performance analysis of large capacity DS-CDMA systems.

关键词： OFDM CDMA nonlinearities impulse noise

Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice

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Biomedical and Environmental Sciences 2018年第2期31卷 155-158页

作者： GUO San Jun ren shan XIE Yong En The Research Institute of Immunology and Molecular Biology North Sichuan Medical College

Acinetobocter baumannfi （A. Baumannii） is an emerging opportunistic pathogen responsible for hospital-acquired infections, and which now constitutes a sufficiently serious threat to public health to necessitate the development of an effective vaccine. In this study, a recombinant fused protein named OmpK/Omp22 and two individual proteins OmpK and Omp22 were obtained using recombinant expression and Ni-affinity purification. Groups of BALB/c mice were immunized with these proteins and challenged with a clinically isolated strain of A. boumonnii. The bacterial load in the blood, pathological changes in the lung tissue and survival rates after challenge were evaluated. Mice immunized with OmpK/Omp22 fused protein provided significantly greater protection against A. boumonnfi challenge than those immunized with either of the two proteins individually. The results provide novel clues for future design of vaccines against A. boumonnii.

关键词： Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice

Sintering flue gas desulfurization with different carbon materials modified by microwave irradiation

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Journal of Iron and Steel Research International 2017年第10期24卷 979-984页

作者： shan ren Fu-qiang Guo Qi Zhao Jie Yang Lu Yao Ming Kong College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Modification of metallurgical coke,biomass char and semi-coke was carried out using a microwave device with power of 450-850 W and irradiation time of 6-12 *** desulfurization rates of three carbon materials before and after modification were *** effects of microwave power and irradiation time on the pore texture and surface chemical characteristics of the three carbon materials were examined by SEM,BET and Fourier transform infrared spectroscopy（FTIR）.The results showed that the specific surface area,total pore volume and pore diameter of biomass char and semi-coke after irradiation decreased ***,the pore diameter turned small and the acidic functional groups on their surface decomposed,thereby the basicity of carbon surface increased by microwave *** optimal promotion of desulfurization rate of three carbon materials was semi-coke irradiated at 850 W for 9 min and the sulfur dioxide adsorption rate was up to 45%.

关键词： Microwave modification Carbon material Sintering flue gas Desulfurization

Total conversion of centimeter-scale nickel foam into single atom electrocatalysts with highly selective CO_(2)electrocatalytic reduction in neutral electrolyte

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Nano Research 2023年第2期16卷 2003-2010页

作者： Qikui Fan Pengfei Gao shan ren Yunteng Qu Chuncai Kong Jian Yang Yuen Wu Ministry of Education Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic PhysicsSchool of PhysicsXi’an Jiaotong UniversityXi’an 710049China Shenzhen Key Laboratory of Special Functional Materials Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Northwest Institute of Nuclear Technology Xi’an 710024China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China State Key Laboratory of Photoelectric Technology and Functional Materials International Collaborative Center on Photoelectric Technology and Nano Functional MaterialsInstitute of Photonics and Photon-TechnologyNorthwest UniversityXi’an 710069China Department of Chemistry iChEM(Collaborative Innovation Center of Chemistry for Energy Materials)University of Science and Technology of ChinaHefei 230026China

To improve the atomic utilization of metals and reduce the cost of industrialization,the one-step total monoatomization of macroscopic bulk metals,as opposed to nanoscale metals,is *** this study,we used a thermal diffusion method to directly convert commercial centimeter-scale Ni foam to porous Ni single-atom-loaded carbon nanotubes(CNTs).As expected,owing to the coating of single-atom on porous,highly conductive CNT carriers,Ni single-atom electrocatalysts(Ni-SACs)exhibit extremely high activity and selectivity in CO_(2)electroreduction(CO_(2)RR),yielding a current density of>350 mA/cm^(2),a selectivity for CO of>91%under a flow cell configuration using a 1 M potassium chloride(KCl)*** on the superior activity of the Ni-SACs electrocatalyst,an integrated gas-phase electrochemical zero-gap reactor was introduced to generate a significant amount of CO current for potential practical *** overall current can be increased to 800 mA,while maintaining CO Faradaic efficiencies(FEs)at above 90%per unit *** findings and insights on the active site transformation mechanism for macroscopic bulk Ni foam conversion into single atoms can inform the design of highly active single-atom catalysts used in industrial CO_(2)RR systems.

关键词： Ni single atom electrocatalyst CO_(2)electroreduction to CO neutral electrolyte thermal diffusion