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Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 700-706页

作者： li Zhang Hai-Zhang You Guo-Hui Wang Wei Xu Jian-shan li Qing-liang Zhao Shu Du Department of Hospital-Acquired Infection Control Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Administrative Office Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Clinical Laboratory Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Pharmacy Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Corneal and Lacrimal Passage Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Fundus Diseases and Ocular Trauma Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina

AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial ***:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were ***:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were ***-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at ***-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at *** of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(Plications caused by eye infections.

关键词： eye infection pathogenic bacteria drug resistance antimicrobial sensitivity test

Headwear design:Relationship between the headwear and the overall styling

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China Textile 2024年第3期 59-61页

作者： li shan Beijing Institute of Fashion Technology

This article examines the relationship between headwear design and overall clothing styling,emphasizing the importance of headwear in conveying personal style and cultural *** traces the evolution of Chinese and Western headwear throughout history,highlighting the interplay between headwear and the wearer's personal charac-teristics,life events,and cultural *** article concludes by emphasizing that headwear design is not only a reflection of fashion,but also a manifestation of cultural depth and individuality.

关键词： Headwear design headwear design and overall styling cultural expression

Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

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Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin liu li lian li-li Hou Cai-Xia liu Jin-Hong Ren Yuan-Biao Qiao Shi-Yuan Wen Qing-shan li College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese MedicineTaiyuanChina shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity

Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

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Signal Transduction and Targeted Therapy 2024年第1期9卷 51-54页

作者： Leili Jia Haihua Luo lizhong li Mingyao Wang Jiangfeng liu Yuan liang shan li Yong Jiang Juntao Yang Hongbin Song Institute for Disease Control and Prevention of PLA BeijingChina Guangdong Provincial Key Laboratory of Proteomics State Key Laboratory of Organ Failure ResearchSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Science and Peking Union Medical College100005 BeijingChina

Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fatalities are attributed to secondary bacterial pneumonia,a severe complication commonly caused by ubiquitous respiratory pathogens such as Staphylococcus aureus(***).2 Of particular concern is the increased morbidity and mortality rates in individuals infected simultaneously with influenza virus and methicillin-resistant ***(MRSA).3 The concurrent presence of bacteria and influenza virus usually causes acute respiratory distress syndrome(ARDS),which is associated with acute lung injury(Ali),severe lung tissue edema,and widespread ***,determining the complex mechanisms underlying the synergistic interplay will require further investigation with a suitable coinfection mouse *** our previous study,we utilized different sequential coinfections at various time points to model influenza A virus and MRSA coinfection.

关键词： influenza pneumonia lung

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： li-Min Yang Hong-Juan Wang shan-lin li Guan-Hua Gan Wen-Wen Deng Yong-Sheng Chang lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib liver cancer Portal hypertension Efficacy Prognosis analysis

Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

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Zoological Research 2024年第2期45卷 233-241页

作者： Peng li Ting Zhang Ruo Wu Jun-Yu Zhang Yan Zhuo shan-Gang li Jiao-Jian Wang Wen-Ting Guo Zheng-Bo Wang Yong-Chang Chen State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Neural tube defects(NTDs)are severe congenital neurodevelopmental disorders arising from incomplete neural tube *** folate supplementation has been shown to mitigate the incidence of NTDs,some cases,often attributable to genetic factors,remain *** SHROOM3 gene has been implicated in NTD cases that are unresponsive to folate supplementation;at present,however,the underlying mechanism remains *** tube morphogenesis is a complex process involving the folding of the planar epithelium of the neural *** determine the role of SHROOM3 in early developmental morphogenesis,we established a neuroepithelial organoid culture system derived from cynomolgus monkeys to closely mimic the in vivo neural plate *** of SHROOM3 resulted in shorter neuroepithelial cells and smaller *** morphological changes were attributed to the insufficient recruitment of cytoskeletal proteins,namely fibrous actin(F-actin),myosin II,and phospho-myosin light chain(PMLC),to the apical side of the neuroepithelial ***,these defects were not rescued by folate *** sequencing revealed that differentially expressed genes were enriched in biological processes associated with cellular and organ *** summary,we established an authentic in vitro system to study NTDs and identified a novel mechanism for NTDs that are unresponsive to folate supplementation.

关键词： Neural tube defects SHROOM3 Neuroepithelial Organoids Cynomolgus monkey

Improvement of Ga_(2)O_(3)vertical Schottky barrier diode by constructing NiO/Ga_(2)O_(3)heterojunction

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Journal of Semiconductors 2024年第4期45卷 63-68页

作者： Xueqiang Ji Jinjin Wang Song Qi Yijie liang Shengrun Hu Haochen Zheng Sai Zhang Jianying Yue Xiaohui Qi shan li Zeng liu Lei Shu Weihua Tang Peigang li School of Integrated Circuits&State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China Beijing Microelectronics Technology Institute Beijing 100076China

The high critical electric field strength of Ga_(2)O_(3)enables higher operating voltages and reduced switching losses in power electronic *** Schottky metals and epitaxial films are essential for further enhancing device *** this work,the fabrication of vertical Ga_(2)O_(3)barrier diodes with three different barrier metals was carried out on an n--Ga_(2)O_(3)homogeneous epitaxial film deposited on an n+-β-Ga_(2)O_(3)substrate by metal-organic chemical vapor deposition,excluding the use of edge *** ideal factor,barrier height,specific on-resistance,and breakdown voltage characteristics of all devices were investigated at room *** addition,the vertical Ga_(2)O_(3)barrier diodes achieve a higher breakdown volt-age and exhibit a reverse leakage as low as 4.82×10^(-8)A/cm^(2)by constructing a NiO/Ga_(2)O_(3)***,Ga_(2)O_(3)power detailed investigations into Schottky barrier metal and NiO/Ga_(2)O_(3)heterojunction of Ga_(2)O_(3)homogeneous epitaxial films are of great research potential in high-efficiency,high-power,and high-reliability applications.

关键词： Ga_(2)O_(3) Schottky barrier diode NiO/Ga_(2)O_(3)heterojunction

Sea-level change in coastal areas of China:Status in 2021

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Advances in Climate Change Research 2024年第3期15卷 515-524页

作者： Wen-shan li Hui WANG Wen-Xi XIANG Ai-Mei WANG Wei-Qing XU Yu-Xi JIANG Xin-Hui WU Meng-Yuan QUAN National Marine Data and Information Service Tianjin 300171China Ocean University of Chin1 Qingdao 266100China University of Michigan‒shanghai Jiao Tong University Joint Institute Shanghai 200030China

The sea level in coastal areas of China reached the second highest in 2021,just after that recorded in *** force and dynamic analyses based on tide gauges,satellite observations,reanalysis data and regional numerical outputs were conducted to understand these abnormally high sea levels and determine their possible *** show that the coastal sea level of China had increased at an annual rate of 3.4±0.3 mm during 1980-2021,with an acceleration of 0.06±0.02 mm per *** superposition of significant oscillations of quasi-2,3-7,quasi-9,quasi-11,quasi-19 and 20-30 years contributed to the anomalously high sea *** negative-phased El Nino/Southern Oscillation was correlated with the anomalously high sea level and the north-south anti-phase pattern of the coastal sea level in ***,phase lags of 1-4 months occurred with the sea-level *** a decadal timescale,the Pacific Decadal Oscillation(PDO)was negatively correlated with the anomalous mean sea level(MSL),and the negative-phased PDO contributed to the anomalous sea-level change in ***,the monthly MSL peaked in April and July,and the contribution of wind stress to the anomalously high sea level was 38.5%in the south of the Taiwan Strait in April and 30%along the coast of China in *** results were consistent with the tide gauge and satellite *** agreement was also observed between the coastal sea-level fingerprint and the air and sea surface temperatures.

关键词： Sealevel La Nina PDO Wind stress

Creep rupture life predictions for Ni-based single crystal superalloys with automated machine learning

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Rare Metals 2024年第6期43卷 2884-2890页

作者： Chang-Lu Zhou Rui-Hao Yuan Wei-Jie liao Ting-Huan Yuan Jiang-Kun Fan Bin Tang Ping-Xiang Zhang Jin-shan li Turab Lookman State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China Chongqing Innovation Center Northwestern Polytechnical UniversityChongqing 401120China AiMaterials Research LLC Santa FeNM 87501USA

The state of the art for data-driven creep rupture life predictions incorporates microstructural and deformation characteristics into machine ***,the microstructures and deformation mechanisms for unknown alloys are inaccessible and uncertain before experiments are carried out,and therefore prevents extrapolations of the learned models.

关键词： deformation life creep