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Ensemble multi-objective evolutionary algorithm for gene regulatory network reconstruction based on fuzzy cognitive maps

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CAAI Transactions on Intelligence Technology 2019年第1期4卷 24-36页

作者： Jing Liu Yaxiong Chi Zongdong Liu shan he School of Artificial Intelligence Xidian UniversityXi’anPeople’s Republic of China School of Computer Science University of BirminghamBirminghamUK

Many methods aim to use data,especially data about gene expression based on high throughput genomic methods,to identify complicated regulatory relationships between *** authors employ a simple but powerful tool,called fuzzy cognitive maps(FCMs),to accurately reconstruct gene regulatory networks(GRNs).Many automated methods have been carried out for training FCMs from *** methods focus on simulating the observed time sequence data,but neglect the optimisation of network *** fact,the FCM learning problem is multi-objective which contains network structure information,thus,the authors propose a new algorithm combining ensemble strategy and multi-objective evolutionary algorithm(MOEA),called EMOEAFCM-GRN,to reconstruct GRNs based on *** EMOEAFCM-GRN,the MOEA first learns a series of networks with different structures by analysing historical data simultaneously,which is helpful in finding the target network with distinct optimal local ***,the networks which receive small simulation error on the training set are selected from the Pareto front and an efficient ensemble strategy is provided to combine these selected networks to the final *** experiments on the DREAM4 challenge and synthetic FCMs illustrate that EMOEAFCM-GRN is efficient and able to reconstruct GRNs accurately.

关键词： FCMs GRNs

Friction self-piercing riveting(F-SPR)of aluminum alloy to magnesium alloy using a flat die

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Journal of Magnesium and Alloys 2022年第5期10卷 1207-1219页

作者： Bingxin Yang Yunwu Ma he shan Sizhe Niu Yongbing Li shanghai Key Laboratory of Digital Manufacture for Thin-walled Structures School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240PR China State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240PR China Joining and Welding Research Institute Osaka UniversityOsaka 567-0047Japan

Friction self-piercing riveting(F-SPR)process based on a pip die has been invented to solve the cracking problems in riveting high-strength and low-ductility light metals,such as magnesium alloys,cast aluminum,and 7 series aluminum *** this paper,in order to solve quality issues caused by the misalignment between rivet and pip-die in F-SPR,a flat-die based F-SPR process was proposed and employed to join 1.27 mm-thick AA6061-T6 to 3 mm-thick *** results indicate that a 1.0 mm die distance is effective to avoid rivet upset and insufficient *** the feed rate increases,the heat input in the whole process decreases,resulting in a larger riveting force,which in turn increases both the bottom thickness and interlock ***,solid-state bonding,including Al-Mg intermetallic compounds(IMCs),Al-Mg mechanical mixture,and Al-Fe atom interdiffusion was observed at the joint *** upper Al layer was softened,but the lower Mg layer was hardened,and both sheets exhibited a narrowed affected region with the increase of feed rate,while the rivet hardness shows no obvious *** fracture modes appeared accompanying the variations in lap-shear strength and energy absorption as the feed rate increased from 2 mm/s to 8 mm/***,the F-SPR process using a flat die was compared to those using a pip die and a flat bottom die to show the advantage of flat die on coping with the misalignment problem.

关键词： Friction self-piercing riveting(F-SPR) Flat die Aluminum alloy Magnesium alloy Mechanical joining Solid-state bonding

Crystal Structure of Macrocalyxin J

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Chinese Journal of Structural Chemistry 2007年第3期26卷 299-302页

作者： he shan WU Bin SHI Hao SUN Cui-Rong Department of Chemistry. Zhejiang University Hangzhou 310027 China

The title compound, （1α,6β, 11β,14α）-1,7：6,20-diepoxy-6,1 1-dihydroxy- 6,7-secoent- kaur- 16-ene-7,15-dione- 14-acetate （macrocalyxin J）, is a diterpenoid which was isolated from the leaves of Rabdosia macrocalyx and characterized by single-crystal X-ray diffraction. It crystallizes in orthorhombic, space group P212121 with α= 9.3608（8）, b = 14.9787（12）, c = 15.5750（13） A, Z = 4, V = 2183.8（3） A^3, C22H30O9, Mr= 438.46, Dc= 1.334 g/m^3,μ（MoKα） = 0.103 mm^-1, F（000） = 936, the final R = 0.0532 and wR = 0.1262 for 2252 observed reflections （I 〉 2σ（I））. In the molecule, three six-membered rings adopt chair, boat and slightly distorted boat conformations, respectively, while both five-membered rings have approximate envelope conformations.

关键词： crystal structure macrocalyxin J Rabdosia macrocalyx

Effects of dietary tert-butylhydroquinone on domoic acid metabolism and transcription of detoxification-related liver genes in red sea bream Pagrus major

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Chinese Science Bulletin 2013年第16期58卷 1906-1911页

作者： he shan LIANG XuFang SheN Dan ZHANG WenBing MAI KangSen Key Laboratory of Freshwater Animal Breeding of Ministry of Agriculture College of Fisheries Huazhong Agricultural University Key Laboratory of Mariculture of Ministry of Education Ocean University of China

Domoic acid (DA) is a neuroexcitatory amino acid that is produced by Pseudo-nitzschia during harmful algal blooms (HAB). Accumulation of DA can be transferred through food chain and cause neuronal damage in marine animal and in human. Like other algal toxins, DA was suggested to increase the oxidative stress and increase the detoxification-related gene expression in fish. The widely used food antioxidant, tert-butylhydroquinone (tBHQ), was known to induce a wide range of antioxidative potentials such as elevation of the glutathione levels and glutathione S-transferases (GSTs), via the activation of antioxidant response elements (AREs). In this study, the influences of dietary tBHQ on domoic acid (DA) metabolism and detoxification-related gene transcription were investigated both in vivo and in vitro. Oral administration of tBHQ resulted in significant decreases of DA accumulation of liver tissues in which red sea bream were fed with a single dose of 10 mg DA and 100 mg tBHQ per kg body weight per fish. Real-time PCR further revealed that the mRNA levels of AHR/ARNT/CYP1A1/GSTA1/GSTR were up-regulated in the above liver tissues at 72 h post tBHQ treatment. In consistence, tBHQ exposure also resulted in increased mRNA transcription of GSTA1, GSTA2 and GSTR in cultured red sea bream hepatocytes. Collectively, our findings in this research suggested that the dietary intake of tBHQ accelerated DA metabolism in fish, through mechanisms involving altered transcription of detoxification- related liver genes.

关键词： mRNA转录相关基因软骨藻酸特丁基对苯二酚酸代谢真鲷解毒肝脏

Intraspecific DNA methylation polymorphism in the non-edible oilseed plant castor bean

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Plant Diversity 2017年第5期39卷 300-307页

作者： shan he Wei Xu Fei Li Yue Wang Aizhong Liu Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Investigation of the relationships of phenotypic and epigenetic variations might he a good way to dissect the genetic or molecular basis of phenotypic variation and plasticity in plants, Castor bean （Ricinus cornraunis L）, an important non-edible oilseed crop, is a mono-species genus plant in the family Euphorbiaceae. Since it displays rich phenotypic variations with low genetic diversity, castor bean is a good model to investigate the molecular basis of phenotypic and epigenetic variations. Cytosine DNA methylation represents a major molecular mechanism of epigenetic occurrence. In this study, epigenetic diversity of sixty landrace accessions collected worldwide was investigated using the methylation- sensitive amplification polymorphism （MSAP） technique, Results showed that the epigenetic diversity （based on the polymorphism of DNA methylated loci） exhibited a medium variation （Ne = 1.395, he = 0.242, I = 0.366） at the population level though the variation was great, ranging from 3,80% to 3431% among accessions. Both population structure analysis and the phylogenetic construction （using the neighbor-joining criteria） revealed that the two main clades were identified, but they did not display a distinct geographic structure, After inspecting the location of polymorphic methylated loci on genome we identified that the polymorphic methylated loci occur widely in nuclear and organelle genomes. This study provides new data to understand phenotypic and epigenetic variations in castor bean,

关键词： jRicinus communis L. Epigenetic diversity Methylation-sensitive amplification polymorphism DNA methylation

基于数据挖掘的清热解毒方治疗银屑病用药规律及其作用机制研究

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药物评价研究 2024年第4期47卷 850-861页

作者：姜昊马文珂时沙沙王振国宋咏梅满帅何珊山东中医药大学药学院山东济南250355 山东中医药大学实验中心山东济南250355 山东中医药大学中医药创新研究院山东济南250355 山东中医药大学中医文献与文化研究院山东济南250355

目的探讨银屑病使用清热解毒类方剂治疗的用药规律,预测清热解毒类方治疗银屑病的常用药物组合,针对最常用药物组合,分析其单用及合用的擅治证型和临床常用剂量,并探讨其分用与合用治疗银屑病的潜在作用机制,为临床用药提供依据。方法... 详细信息

目的探讨银屑病使用清热解毒类方剂治疗的用药规律,预测清热解毒类方治疗银屑病的常用药物组合,针对最常用药物组合,分析其单用及合用的擅治证型和临床常用剂量,并探讨其分用与合用治疗银屑病的潜在作用机制,为临床用药提供依据。方法检索中国学术期刊全文数据库(CNKI)、万方数据库(Wanfang Data)、维普生物医学数据库(VIP)和PubMed数据库中使用清热解毒类方治疗银屑病的相关文献,并对文献处方中所用的中药进行频数、聚类及关联分析,基于关联规则,选择具有较高置信度和较高支持度的药物组合,检索筛选其活性成分和靶点,并进行基因本体(GO)功能富集和京都基因与基因组百科全书(KEGG)通路富集分析。结果经过检索,根据纳入和排除标准,共纳入文献162篇,包含处方129首,涉及中药159味,累计使用频次1448次,生地黄、土茯苓、赤芍、牡丹皮、甘草等高频药物21味,其中以清热药、苦寒药居多,大多归入肝经;关联分析得到支持度最高、关联性较强的药物组合为“生地黄-赤芍”;聚类分析得到3个聚类。网络药理学得到生地黄的潜在活性成分17个,与银屑病相关靶点79个,赤芍的潜在活性成分15个,与银屑病相关的靶点91个,“生地黄-赤芍”与银屑病相关的靶点114个,“生地黄-赤芍”所富集的信号通路包含了两者共有的多条经典信号通路,主要涉及癌症相关通路、脂质与动脉粥样硬化通路、磷脂酰肌醇-3-羟激酶(PI3K)/蛋白激酶B(Akt)信号通路、缺氧诱导因子(HIF)-1信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、Th17细胞分化通路等。结论清热解毒类方治疗银屑病中的核心药物组合为生地黄-赤芍,单用可能通过不同的信号通路来治疗单一证型银屑病,组合使用则可能通过多个成分干预多个靶点、进而调控多条银屑病相关的信号通路来对不同证型或多证型的银屑病发挥治疗作用。

关键词：银屑病清热解毒数据挖掘网络药理学配伍规律生地黄赤芍

塑料加工行业实际建设项目环境影响评价与分析

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广州化工 2024年第9期52卷 148-151页

作者：余芳蔡河山叶永梅广东标定环境科学有限公司广东珠海519090 佛山大学广东佛山528200 佛山市绿途环保科技有限公司广东佛山528216

环境影响评价是控制环境风险的“安全阀”,也是在发展中守住绿水青山的第一道防线,对协同推进经济高质量发展和生态环境高水平保护发挥着重要作用。本文针对某塑料加工项目在生产过程中可能产生的环境影响(地表水、大气、声和固体废物)... 详细信息

环境影响评价是控制环境风险的“安全阀”,也是在发展中守住绿水青山的第一道防线,对协同推进经济高质量发展和生态环境高水平保护发挥着重要作用。本文针对某塑料加工项目在生产过程中可能产生的环境影响(地表水、大气、声和固体废物)进行识别、评价和分析,并根据各污染物状况提出相应的环保治理和管理措施。若运营期间项目能够认真落实做好本次环境影响评价中所提出的各项污染防控措施和环境管理对策,确保污染物达标排放,则该项目投入运营后不会对周围环境产生明显的影响,从环境保护角度分析、论证,该项目的建设是可行的。

关键词：塑料项目环境影响评价环保措施

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软头枕对某款座椅鞭打损伤的影响分析

汽车实用技术 2024年第10期49卷 88-91,119页

作者：张爱法何山丛艳军中汽研汽车检验中心(天津)有限公司天津300300

佩戴软头枕会改变座椅在追尾事故中的保护效果,但是目前针对佩戴软头枕时的鞭打性能研究几乎没有。为探索软头枕在追尾事故中的作用,设计并完成了佩戴软头枕和未佩戴软头枕两种工况下的鞭打对比试验。结果表明,座椅佩戴软头枕会使假人... 详细信息

佩戴软头枕会改变座椅在追尾事故中的保护效果,但是目前针对佩戴软头枕时的鞭打性能研究几乎没有。为探索软头枕在追尾事故中的作用,设计并完成了佩戴软头枕和未佩戴软头枕两种工况下的鞭打对比试验。结果表明,座椅佩戴软头枕会使假人头部较早的接触座椅,支撑并缓冲假人的头部运动,减缓假人头部向后甩动的剧烈程度;并使假人各部位的损伤减小,颈部伤害峰值明显降低;同时,具有提高座椅鞭打得分的作用。研究成果作为追尾事故的一种预研数据积累,将服务于后续新版鞭打规程的制修订工作。

关键词：软头枕鞭打试验假人损伤对比研究

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基于物联网与几何模型的起重机械防碰撞技术研究

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起重运输机械 2024年第18期 83-87页

作者：蒋秉栋何山江爱华广州特种设备检测研究院广州430063

目前,起重机械防碰撞技术主要通过激光或红外传感器测量距离实现。由于起重机械金属结构复杂,多台起重机协同工作时导致更加复杂的空间干涉问题,激光或红外传感器很难全方位实现起重机防碰撞功能。文中利用编码器获取起重机各个机构的... 详细信息

目前,起重机械防碰撞技术主要通过激光或红外传感器测量距离实现。由于起重机械金属结构复杂,多台起重机协同工作时导致更加复杂的空间干涉问题,激光或红外传感器很难全方位实现起重机防碰撞功能。文中利用编码器获取起重机各个机构的实时位置,将位置信息通过网络实时传递给计算机几何模型,采用WebGL技术实现几何模型与实物实时同步,同时进行干涉计算,当距离小于预警值时给予报警信号或控制信号,实现了起重机械全方位防碰撞。

关键词：起重机防碰撞几何模型编码器物联网

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